Abstract:
:For more than a decade, Ab conjugated to a radionuclide emitting particulate radiation has been used in the management of leukemia in an effort to deliver targeted doses of radiation to BM, spleen and other sites of disease, while sparing normal organs. This radioimmunotherapy (RIT) approach has been employed to achieve significant remissions in patients with AML, particularly when used at high doses of radioactivity in conjunction with myeloablation. This report focuses on the therapeutic aspects of radiolabeled Ab for leukemia. Clinical results from recent leukemia RIT studies are reviewed, with emphasis on approaches being evaluated to improve rates of response and survival. Discussion of pre-clinical studies are limited to those that offer insights into future directions for clinical RIT studies of leukemia.
journal_name
Cytotherapyjournal_title
Cytotherapyauthors
Pagel JMdoi
10.1080/14653240701679881subject
Has Abstractpub_date
2008-01-01 00:00:00pages
13-20issue
1eissn
1465-3249issn
1477-2566pii
787738400journal_volume
10pub_type
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