Mesenchymal stromal cells and immunomodulation: A gathering of regulatory immune cells.

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) are the focus of research in regenerative medicine aiming at the regulatory approval of these cells for specific indications. To cope with the regulatory requirements for somatic cell therapy, novel approaches that do not interfere with the natural behavior of the cells a...

journal_title：Cytotherapy

authors： Schmidtke-Schrezenmeier G,Urban M,Musyanovych A,Mailänder V,Rojewski M,Fekete N,Menard C,Deak E,Tarte K,Rasche V,Landfester K,Schrezenmeier H

更新日期：2011-09-01 00:00:00

abstract：:The process of wound healing restores skin homeostasis but not full functionality; thus, novel therapeutic strategies are needed to accelerate wound closure and improve the quality of healing. In this context, tissue engineering and cellular therapies are promising approaches. Although sharing essential characteristic...

journal_title：Cytotherapy

authors： Zomer HD,Jeremias TDS,Ratner B,Trentin AG

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Mismatched family donor and unrelated donor BM transplants are associated with a high risk of acute GvHD. White T-cell depletion is the best method to reduce risk of acute GvHD, there was a reluctance to use T-cell depletion in the mismatched setting because of increased risk of rejection and relapse. Partia...

journal_title：Cytotherapy

authors： Gajewski JL,Nimer S,Saliba RM,Thomas M,Przepiorka D,Giralt S,von Besien K,Mehra R,Andersson B,Chan KW,Ippoliti C,Warkinten D,Feigs S,Territo M,Schiller G,Lebkowski J,Moseley AM,Lloyd K,von Hoeff M,Okarma T,Champli

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Ex vivo T-cell depletion of allogeneic BM (BM) grafts can effectively reduce graft versus host disease (GvHD) and may also apply to transplantation of allogeneic peripheral blood stem cell (PBSC) transplants. METHODS:Here we have evaluated T-cell depletion and progenitor cell recovery by antibody-mediated c...

journal_title：Cytotherapy

authors： Williams RJ,Clarke E,Blair A,Evely R,Hale G,Waldmann H,Brookes S,Pamphilon DH

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND AIMS:Our previous study has demonstrated the stem cell-like properties of human umbilical cord lining epithelial cells (CLECs) and their capability for epidermal reconstitution in organotypic skin culture; however, the immunogenicity of these cells has not been clearly defined. We assessed several aspects of...

journal_title：Cytotherapy

authors： Cai YJ,Huang L,Leung TY,Burd A

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated. METHODS:MSC isolated...

journal_title：Cytotherapy

authors： Sun B,Roh KH,Park JR,Lee SR,Park SB,Jung JW,Kang SK,Lee YS,Kang KS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:Recent evidence has suggested that transplanted bone marrow (BM)-derived mesenchymal stromal cells (MSC) are able to engraft and repair non-hematopoietic tissues successfully, including central nervous system, renal, pulmonary and skin tissue, and may possibly contribute to tissue regeneration. We exami...

journal_title：Cytotherapy

authors： Jung EJ,Kim SC,Wee YM,Kim YH,Choi MY,Jeong SH,Lee J,Lim DG,Han DJ

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AIMS:Adipose tissue is a critical organ that plays a major role in energy balance regulation and the immune response through intricate signals. METHODS:We report on the inter-relation between mature adipocytes and lymphocytes in terms of adipocyte-derived T-cell chemo-attractants and adipocyte metabolic eff...

journal_title：Cytotherapy

authors： Poloni A,Maurizi G,Ciarlantini M,Medici M,Mattiucci D,Mancini S,Maurizi A,Falconi M,Olivieri A,Leoni P

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND AIMS:Defocused low-energy shock wave (DLSW) therapy has shown effectiveness in regenerative medicine. The mechanism of action was mainly focused on the pathophysiological improvement at the wound tissues. In this study, the activation of stem cells treated by DLSW was first examined as an important pathway d...

journal_title：Cytotherapy

authors： Zhao Y,Wang J,Wang M,Sun P,Chen J,Jin X,Zhang H

更新日期：2013-12-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BM-MSCs) hold great promise for tissue regeneration. With increasing numbers of clinical trials, the safety of BM-MSCs attracts great interest. Previously, we determined that rat BM-MSCs possessed spontaneous calcification without osteogenic induction after continuous cultur...

journal_title：Cytotherapy

authors： Huang YZ,Cai JQ,Lv FJ,Xie HL,Yang ZM,Huang YC,Deng L

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AIMS:Cytotherapy is a promising option for neurodegenerative disease treatment. Because of the fatal prognosis and imperative need for effective treatment, amyotrophic lateral sclerosis (ALS) patients request this therapy before its effectiveness has been verified. The increase in clinics offering cytotherap...

journal_title：Cytotherapy

authors： Gamez J,Carmona F,Raguer N,Ferrer-Sancho J,Martín-Henao GA,Martí-Beltrán S,Badia M,Gratacós M,Rodriguez-Gónzalez E,Seoane JL,Pallero-Castillo M,Burgos R,Puiggros C,Pasarin A,Bori-Fortuny I

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AIMS:Human gamma-delta (γδ) T cells are potent effector lymphocytes of innate immunity involved in anti-tumor immune surveillance. However, the Vδ1 γδ T-cell subset targeting multiple myeloma (MM) has not previously been investigated. METHODS:Vδ1 T cells were purified from peripheral blood mononuclear cells...

journal_title：Cytotherapy

authors： Knight A,Mackinnon S,Lowdell MW

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Hematopoietic progenitor cells (HPC) circulate at high levels at birth and disappear rapidly afterwards, but the underlying mechanism it is not known. The aim of this study was to assess circulating HPC in cord blood at different gestational ages and shortly after birth and concomitantly study the biologic m...

journal_title：Cytotherapy

authors： Gonzalez S,Amat L,Azqueta C,Madrigal JA,Laïlla JM,Garcia J,Querol S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:Tissue engineering technology is a promising therapeutic strategy in peripheral nerve injury. Schwann cells (SCs) are deemed to be a vital component of cell-based nerve regeneration therapies. Many methods for producing SC-like cells derived from adipose-derived stromal cells (ADSCs) have been explored,...

journal_title：Cytotherapy

authors： Kang Y,Liu Y,Liu Z,Ren S,Xiong H,Chen J,Duscher D,Machens HG,Liu W,Guo G,Zhan P,Chen H,Chen Z

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Adipose tissue contains a stromal vascular fraction that can be easily isolated and provides a rich source of adipose tissue-derived mesenchymal stem cells (ASC). These ASC are a potential source of cells for tissue engineering. We studied whether the yield and growth characteristics of ASC were affected by ...

journal_title：Cytotherapy

authors： Oedayrajsingh-Varma MJ,van Ham SM,Knippenberg M,Helder MN,Klein-Nulend J,Schouten TE,Ritt MJ,van Milligen FJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AIMS:The therapeutic potential of human mesenchymal stromal cells (MSCs) has generated considerable interest in a wide variety of areas. MSC banking is feasible, but the optimal technique of cryopreservation remains to be determined. METHODS:To reduce dimethyl sulfoxide (DMSO) concentration in cryopreservat...

journal_title：Cytotherapy

authors： Briquet A,Halleux A,Lechanteur C,Beguin Y

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AIMS:Virus-specific T-cell immunotherapy is emerging as a promising management strategy for virus infections in patients after hematopoietic stem cell transplant (HSCT). Here we present outcomes of 10 adult patients who received multi-virus-specific T cells prophylactically after HSCT. METHODS:Donor-derived...

journal_title：Cytotherapy

authors： Ma CK,Blyth E,Clancy L,Simms R,Burgess J,Brown R,Deo S,Micklethwaite KP,Gottlieb DJ

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Cells from AML patients can differentiate into the phenotype of DC when cultured with GM-CSF and IL-4. Such cytokine-treated AML-derived DC (AML-DC) can stimulate autologous T cells. In this study we examined whether an anti-CTLA-4 MAb (MDX-010) could enhance the generation of autologous anti-AML T cells. M...

journal_title：Cytotherapy

authors： Zhong RK,Loken M,Lane TA,Ball ED

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AIMS:The term "cerebral palsy" (CP) encompasses many syndromes that emerge from brain damage at early stages of ontogenesis and manifest as the inability to retain a normal body position or perform controlled movements. Existing methods of CP treatment, including various rehabilitation strategies and surgica...

journal_title：Cytotherapy

authors： Romanov YA,Tarakanov OP,Radaev SM,Dugina TN,Ryaskina SS,Darevskaya AN,Morozova YV,Khachatryan WA,Lebedev KE,Zotova NS,Burkova AS,Sukhikh GT,Smirnov VN

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) may be useful in a range of clinical applications. The placenta has been suggested as an abundant, ethically acceptable, less immunogenic and easily accessible source of MSC. The aim of this study was to evaluate the capacity of induced placental MSC to differentiate into...

journal_title：Cytotherapy

authors： Yust-Katz S,Fisher-Shoval Y,Barhum Y,Ben-Zur T,Barzilay R,Lev N,Hod M,Melamed E,Offen D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Bone marrow (BM)-derived mesenchymal stromal cells (MSC) are promising candidate cells for the development of neuroregenerative therapies. We have previously introduced the pro-neural conversion of human MSC to neural stem cell-like cells (m-NSC) by culturing them in suspension culture under serum-free condi...

journal_title：Cytotherapy

authors： Habisch HJ,Fiedler J,Ludolph AC,Storch A,Brenner RE

更新日期：2008-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial hyperproliferation and dysfunction. Restoration of endothelial function is a common goal of available treatments. In the present study, human adipose-derived mesenchymal stromal cells (ASCs) were co-cultured with monocrotaline pyr...

journal_title：Cytotherapy

authors： Wang P,Zhang C,Li J,Luo L,Zhang S,Dong F,Tang Z,Ni S

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AIMS:The immunomodulatory properties of mesenchymal stromal cells (MSCs), together with their tissue regenerative potential, make them interesting candidates for clinical application. METHODS:In the current study, we analyzed the in vitro immunomodulatory effects of MSCs derived from bone marrow (BM-MSCs) a...

journal_title：Cytotherapy

authors： Valencia J,Blanco B,Yáñez R,Vázquez M,Herrero Sánchez C,Fernández-García M,Rodríguez Serrano C,Pescador D,Blanco JF,Hernando-Rodríguez M,Sánchez-Guijo F,Lamana ML,Segovia JC,Vicente Á,Del Cañizo C,Zapata AG

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The possible functional role of basic fibroblast growth factor (bFGF) in regulating the mitotic and metabolic activity of primary human articular chondrocytes was investigated. METHODS:[EF1]Chondrocytes were enzymatically isolated from femoral head cartilage, and were cultured in vitro in monolayer. bFGF-de...

journal_title：Cytotherapy

authors： Schmal H,Zwingmann J,Fehrenbach M,Finkenzeller G,Stark GB,Südkamp NP,Hartl D,Mehlhorn AT

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Cell therapy has been proposed as a salvage limb procedure in critical limb ischemia (CLI). In spite of the fact that clinical trials found some efficacy, the mechanism of action remains elusive. The objective of this study was to characterize two autologous cell therapy products (CTPs) obtained from patient...

journal_title：Cytotherapy

authors： Tournois C,Pignon B,Sevestre MA,Al-Rifai R,Creuza V,Poitevin G,François C,Nguyen P

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AIMS:Hepatic stellate cells (HSCs) are liver-resident mesenchymal cells involved in essential processes in the liver. However, knowledge concerning these cells in human livers is limited because of the lack of a simple isolation method. METHODS:We isolated fetal and adult human liver cells by immunomagnetic...

journal_title：Cytotherapy

authors： Patil PB,Joshi M,Kuna VK,Xu B,Johannesson L,Olausson M,Sumitran-Holgersson S

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) have been shown to be a promising candidate for tissue regeneration and cancer therapy. However, their therapeutic potential against chemotherapy-induced side-effects remains unclear. METHODS:We treated murine Lewis lung carcinoma (LLC) and xenograft human colon tumors w...

journal_title：Cytotherapy

authors： Di GH,Jiang S,Li FQ,Sun JZ,Wu CT,Hu X,Duan HF

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Transplantation of mesenchymal stem cells (MSC) in rodent models has proved to be an effective therapeutic approach for spinal cord injury (SCI). However, further studies in primate models are still needed before clinical application of MSC to patients. METHODS:MSC were isolated from rhesus monkey BM and in...

journal_title：Cytotherapy

authors： Deng YB,Liu XG,Liu ZG,Liu XL,Liu Y,Zhou GQ

更新日期：2006-01-01 00:00:00

abstract：:Cellular & Gene Therapies (CGTs) are complex products, which have been key foci of the International Society for Cell & Gene Therapy (ISCT). For this ISCT North American Legal & Regulatory Affairs Committee review publication, CGTs include but are not limited to somatic cell-based therapies, pluripotent cell-derived c...

journal_title：Cytotherapy

authors： Mendicino M,Fan Y,Griffin D,Gunter KC,Nichols K

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Naphthalene-induced respiratory tract toxicity in mice is characterized by specific and rapid loss of the Clara cell population, which is restored only after several days. The sources of restoration of this cell population remain unclear. We investigated whether BM-derived cells participated in the process o...

journal_title：Cytotherapy

authors： Serikov VB,Popov BV,Kropotov AV,Tomilin NV

更新日期：2005-01-01 00:00:00