BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells.

abstract：BACKGROUND AIMS:Enumeration of CD34(+) cells in leukocyte-rich cell suspensions is important for clinical decision-making in stem cell transplantation. Single-platform flow cytometry assays offer the significant advantages of speed and reproducibility, and have therefore become the gold standard in stem cell enumeratio...

journal_title：Cytotherapy

authors： Dauber K,Becker D,Odendahl M,Seifried E,Bonig H,Tonn T

更新日期：2011-04-01 00:00:00

abstract：:MAb have become an important treatment modality in cancer therapy.Genetically engineered chimeric and humanized Ab have demonstrated activity against a variety of tumors. While the humanized anti-CD33MAb lintuzumab has only modest single-agent activity against overt AML, it can eliminate minimal residual disease detec...

journal_title：Cytotherapy

authors： Jurcic JG

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSCs), derived from several tissues including bone marrow and adipose tissue, are being evaluated in clinical trials for a range of diseases. Virtually all tissues of the body contain stromal cells, yet it is unknown whether these sources are similar in phenotype and function....

journal_title：Cytotherapy

authors： Kellner J,Sivajothi S,McNiece I

更新日期：2015-11-01 00:00:00

abstract：:Infusion of viral-specific T cells (VSTs) is an effective treatment for viral infection after stem cell transplant. Current manufacturing approaches are rapid, but growth conditions can still be further improved. To optimize VST cell products, the authors designed a high-throughput flow cytometry-based assay using 40 ...

journal_title：Cytotherapy

authors： Lazarski CA,Datar AA,Reynolds EK,Keller MD,Bollard CM,Hanley PJ

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AIMS:Immunomodulatory properties of human umbilical cord-derived mesenchymal stromal cells (UCMSCs) can be differentially modulated by toll-like receptors (TLR) agonists. Here, the therapeutic efficacy of short TLR3 and TLR4 pre-conditioning of UCMSCs was evaluated in a dextran sulfate sodium (DSS)-induced c...

journal_title：Cytotherapy

authors： Fuenzalida P,Kurte M,Fernández-O'ryan C,Ibañez C,Gauthier-Abeliuk M,Vega-Letter AM,Gonzalez P,Irarrázabal C,Quezada N,Figueroa F,Carrión F

更新日期：2016-05-01 00:00:00

abstract：:For more than a decade, Ab conjugated to a radionuclide emitting particulate radiation has been used in the management of leukemia in an effort to deliver targeted doses of radiation to BM, spleen and other sites of disease, while sparing normal organs. This radioimmunotherapy (RIT) approach has been employed to achie...

journal_title：Cytotherapy

authors： Pagel JM

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:The authors aim to analyze the evidence in the literature regarding the efficacy and safety of mesenchymal stem cell (MSC) therapy in human subjects with traumatic spinal cord injury (SCI) and identify its potential role in the management of SCI. METHODS:The authors conducted independent and duplicate ...

journal_title：Cytotherapy

authors： Muthu S,Jeyaraman M,Gulati A,Arora A

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND AIMS:Bone marrow mononuclear cells (BM-MNCs) and bone marrow-derived mesenchymal stem stromal cells (BM-MSCs) could have therapeutic potential for numerous conditions, including ischemia-related injury. Cells transplanted intravascularly may become entrapped in the lungs, which potentially decreases their th...

journal_title：Cytotherapy

authors： Mäkelä T,Takalo R,Arvola O,Haapanen H,Yannopoulos F,Blanco R,Ahvenjärvi L,Kiviluoma K,Kerkelä E,Nystedt J,Juvonen T,Lehenkari P

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) have been used to minimize and repair radiation-induced normal tissue injury in the intestine, salivary gland, liver, skin, lungs and cardiac muscle. This study investigated the ability of adipose tissue-derived MSCs (aMSCs) to minimize and/or repair single dose radiatio...

journal_title：Cytotherapy

authors： Maria OM,Shalaby M,Syme A,Eliopoulos N,Muanza T

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Hematopoietic progenitor cells (HPC) circulate at high levels at birth and disappear rapidly afterwards, but the underlying mechanism it is not known. The aim of this study was to assess circulating HPC in cord blood at different gestational ages and shortly after birth and concomitantly study the biologic m...

journal_title：Cytotherapy

authors： Gonzalez S,Amat L,Azqueta C,Madrigal JA,Laïlla JM,Garcia J,Querol S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:Our previous study has demonstrated the stem cell-like properties of human umbilical cord lining epithelial cells (CLECs) and their capability for epidermal reconstitution in organotypic skin culture; however, the immunogenicity of these cells has not been clearly defined. We assessed several aspects of...

journal_title：Cytotherapy

authors： Cai YJ,Huang L,Leung TY,Burd A

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AIMS:Circulating monocytes have been exploited as an important progenitor cell resource for hepatocytes in vitro and are instrumental in the removal of fibrosis. We investigated the significance of monocytes in peripheral blood stem cells (PBSC) for the treatment of liver cirrhosis. METHODS:Rat CD14+ monocy...

journal_title：Cytotherapy

authors： Wang J,Zhou X,Cui L,Yan L,Liang J,Cheng X,Qiao L,Shi Y,Han Z,Cao Y,Han Y,Fan D

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:The molecular mechanisms underlying the biologic effects or differentiation of mesenchymal stromal cells (MSC) have not been clarified. Screening for genes differentially expressed at different stages is an important step in determining these molecular mechanisms. METHODS:In this study, we analyzed the gene...

journal_title：Cytotherapy

authors： Oh I,Ozaki M,Miyazato A,Sato K,Meguro A,Muroi K,Nagai T,Mano H,Ozawa K

更新日期：2007-01-01 00:00:00

abstract：:A 3-year-old girl with severe aplastic anemia (SAA) that was unresponsive to steroid, cyclosporine and filgrastim treatments received bone marrow (BM) mesenchymal stromal cells (MSC; 1.25 x 10(6)/kg), granulocyte colony-stimulating factor (G-CSF)-mobilized BM and peripheral blood stem cell grafts from her father. Prio...

journal_title：Cytotherapy

authors： Wang H,Wang Z,Xue M,Liu J,Yan H,Guo Z

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AIMS:Adipose tissue is a critical organ that plays a major role in energy balance regulation and the immune response through intricate signals. METHODS:We report on the inter-relation between mature adipocytes and lymphocytes in terms of adipocyte-derived T-cell chemo-attractants and adipocyte metabolic eff...

journal_title：Cytotherapy

authors： Poloni A,Maurizi G,Ciarlantini M,Medici M,Mattiucci D,Mancini S,Maurizi A,Falconi M,Olivieri A,Leoni P

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Multiple studies have demonstrated that 'purging' of autografts with 4-hydroperoxycyclophosphamide (4HC) or the related compound mafosfamide (Mf), to eradicate residual leukemia, produces the best results associated with autologous blood and marrow transplantation for AML. However, 4HC purging results in pro...

journal_title：Cytotherapy

authors： McNiece I,Civin C,Harrington J,Kellner J,Malehorn M,Turney J,Barber J,Jones R

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AIMS:Dendritic cell (DC)-based therapies could be important strategies for lymphoma treatment. METHODS:AKR/J mice with Dalton's lymphoma were treated with recombinant interleukin-15 (rIL-15)-activated autologous DCs and pulsed with whole tumor cell lysates in the presence or absence of suboptimal doses of t...

journal_title：Cytotherapy

authors： Hira SK,Mondal I,Manna PP

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AIMS:Endoscopy is the gold standard for the diagnosis and follow-up of patients with Crohn disease (CD). However, a less invasive approach is now being sought for the management of these patients. The objective of this study was to examine whether (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (...

journal_title：Cytotherapy

authors： Kuwaki K,Mitsuyama K,Kaida H,Takedatsu H,Yoshioka S,Yamasaki H,Yamauchi R,Fukunaga S,Abe T,Tsuruta O,Torimura T

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:BM mesenchymal stem cells (MSC) have the capacity for renewal and the potential to differentiate into multiple tissues. In this study, we compared different enrichment methods to obtain MSC from BM. METHODS:Three different methods were compared with a view to obtaining MSC more rapidly from BM: negative sel...

journal_title：Cytotherapy

authors： Tondreau T,Lagneaux L,Dejeneffe M,Delforge A,Massy M,Mortier C,Bron D

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) are gaining in popularity as an experimental therapy for a number of conditions that often require expansion ex vivo prior to use. Data comparing clinical-grade MSC from various ages of donors are scant. We hypothesized that MSC from older donors may display differences i...

journal_title：Cytotherapy

authors： Lund TC,Kobs A,Blazar BR,Tolar J

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AIMS:Hepatic stellate cells (HSCs) are liver-resident mesenchymal cells involved in essential processes in the liver. However, knowledge concerning these cells in human livers is limited because of the lack of a simple isolation method. METHODS:We isolated fetal and adult human liver cells by immunomagnetic...

journal_title：Cytotherapy

authors： Patil PB,Joshi M,Kuna VK,Xu B,Johannesson L,Olausson M,Sumitran-Holgersson S

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AIMS:The immunomodulatory properties of mesenchymal stromal cells (MSCs), together with their tissue regenerative potential, make them interesting candidates for clinical application. METHODS:In the current study, we analyzed the in vitro immunomodulatory effects of MSCs derived from bone marrow (BM-MSCs) a...

journal_title：Cytotherapy

authors： Valencia J,Blanco B,Yáñez R,Vázquez M,Herrero Sánchez C,Fernández-García M,Rodríguez Serrano C,Pescador D,Blanco JF,Hernando-Rodríguez M,Sánchez-Guijo F,Lamana ML,Segovia JC,Vicente Á,Del Cañizo C,Zapata AG

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND AIMS:The Quantum® Cell Expansion System (Quantum; Terumo BCT, Inc, Lakewood, CO, USA) is a novel hollow fiber-based device that automates and closes the cell culture process, reducing labor intensive tasks such as manual cell culture feeding and harvesting. The manual cell selection and expansion processes f...

journal_title：Cytotherapy

authors： Jones M,Varella-Garcia M,Skokan M,Bryce S,Schowinsky J,Peters R,Vang B,Brecheisen M,Startz T,Frank N,Nankervis B

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Contaminating breast cancer cells in leukapheresis harvested for reinfusion to rebuild hemopoiesis after high-dose therapy have been described by several investigators. Methods for tumor cell detection are conventional immunocytochemistry, culture techniques and reverse transcriptase PCR. The percentage of t...

journal_title：Cytotherapy

authors： Krüger W,Tögel F,Rössing S,Kröger N,Zander AR

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AIMS:Stem cell therapy for liver diseases has recently emerged as a promising alternative to liver transplantation. Eligible cells should have an appropriate immunophenotype. The aim of the present study was to define the immunological profile of two human liver-derived mesenchymal stromal cell populations, ...

journal_title：Cytotherapy

authors： Raicevic G,Najar M,Najimi M,El Taghdouini A,van Grunsven LA,Sokal E,Toungouz M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:PBSC transplant provides 10 times more T cells than BMT However, the incidence and severity of acute GvHD is similar among recipients of both types of transplants. Studies in mouse models suggest that the similar clinical outcome in BMT and PBSCT is due to differences in the lymphokine profiles. METHODS:PBM...

journal_title：Cytotherapy

authors： Vasconcelos ZF,Santos BM,Costa ES,Lima M,Tabak DG,Bouzas LF,Azevedo WM,Barcinski MA,Bonomo A

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AIMS:The beneficial effect of human (h) mesenchymal stromal cell (MSC) transplantation in a variety of cell-based intervention strategies is widely believed to be because of paracrine mechanisms. The modification of hMSC cytokine and growth-factor expression patterns were studied following exposure to lipopo...

journal_title：Cytotherapy

authors： Montzka K,Führmann T,Müller-Ehmsen J,Wöltje M,Brook GA

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AIMS:Chimerism is an important outcome measure in hematopoietic cell transplantation as well as somatic cell therapy. Commonly used methods to estimate chimerism are restricted by either gender or inefficient sensitivity. In principle, real-time polymerase chain reaction (PCR)-based assays can be used to ass...

journal_title：Cytotherapy

authors： Chen X,Hofmann TJ,Otsuru S,Jethva R,Lind C,Monos D,Horwitz EM

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AIMS:T cells can be redirected to reject cancer by retroviral transduction with a chimeric antigen receptor (CAR) or by administration of a bispecific T cell engager (BiTE). We demonstrate that transfection of T cells with messenger (m) RNA coding for CAR is an alternative strategy. METHODS:We describe the ...

journal_title：Cytotherapy

authors： Almåsbak H,Rian E,Hoel HJ,Pulè M,Wälchli S,Kvalheim G,Gaudernack G,Rasmussen AM

更新日期：2011-05-01 00:00:00

abstract：:Despite improved prophylaxis and treatment, GvHD remains a major limitation to optimal allogeneic stem cell transplantation. Ex vivo selective depletion (SD) is a strategy to prevent GvHD, in which host-reactive donor lymphocytes are selectively eliminated from a PBSC allograft while useful donor immune function is pr...

journal_title：Cytotherapy

authors： Mielke S,Solomon SR,Barrett AJ

更新日期：2005-01-01 00:00:00