The significance of CD14+ monocytes in peripheral blood stem cells for the treatment of rat liver cirrhosis.

abstract：BACKGROUND:Cells from AML patients can differentiate into the phenotype of DC when cultured with GM-CSF and IL-4. Such cytokine-treated AML-derived DC (AML-DC) can stimulate autologous T cells. In this study we examined whether an anti-CTLA-4 MAb (MDX-010) could enhance the generation of autologous anti-AML T cells. M...

journal_title：Cytotherapy

authors： Zhong RK,Loken M,Lane TA,Ball ED

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The mechanism of platelet recovery after hematopoietic stem cell transplantation and the factors that influence its time-course are not fully understood. Rapid hematopoietic recovery results in a reduction of transplantation-related complications. In the present study, we questioned and analyzed whether ther...

journal_title：Cytotherapy

authors： Woo KS,Goh RY,Kim SH,Kwon HC,Kim HJ,Lee YH,Han JY

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AIMS:The therapeutic potential of human mesenchymal stromal cells (MSCs) has generated considerable interest in a wide variety of areas. MSC banking is feasible, but the optimal technique of cryopreservation remains to be determined. METHODS:To reduce dimethyl sulfoxide (DMSO) concentration in cryopreservat...

journal_title：Cytotherapy

authors： Briquet A,Halleux A,Lechanteur C,Beguin Y

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AIMS:Stem cell therapy for liver diseases has recently emerged as a promising alternative to liver transplantation. Eligible cells should have an appropriate immunophenotype. The aim of the present study was to define the immunological profile of two human liver-derived mesenchymal stromal cell populations, ...

journal_title：Cytotherapy

authors： Raicevic G,Najar M,Najimi M,El Taghdouini A,van Grunsven LA,Sokal E,Toungouz M

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:We have previously demonstrated that bovine dialyzable leukocyte extract (bDLE) induces death through an apoptosis mechanism in MCF-7 breast cancer cells. Depending on the cell type and stimulus, activating protein-1 (AP-1) has been shown to regulate cell proliferation and differentiation, the stress respons...

journal_title：Cytotherapy

authors： Mendoza-Gamboa E,Franco-Molina MA,Zapata-Benavides P,Castillo-Tello P,Vera-García ME,Tamez-Guerra RS,Rodríguez-Padilla C

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:The immunomodulatory and anti-inflammatory effects of mesenchymal stromal cells (MSC) could prove to be a potential therapeutic approach for prolongation of survival of cell xenotransplantation. Adipose (Ad) MSC from genetically modified pigs could be an abundant source of pig donor-specific MSC. METHO...

journal_title：Cytotherapy

authors： Kumar G,Hara H,Long C,Shaikh H,Ayares D,Cooper DK,Ezzelarab M

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND AIMS:We recently demonstrated that injection of conditioned medium (CM) generated from cells of the mesenchymal region of human amniotic membrane (AMTCs) reduces bleomycin-induced lung fibrosis in mice, suggesting a crucial role of paracrine factor(s) secreted by AMTCs in these beneficial effects. We fur...

journal_title：Cytotherapy

authors： Cargnoni A,Piccinelli EC,Ressel L,Rossi D,Magatti M,Toschi I,Cesari V,Albertini M,Mazzola S,Parolini O

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AIMS:Chimerism is an important outcome measure in hematopoietic cell transplantation as well as somatic cell therapy. Commonly used methods to estimate chimerism are restricted by either gender or inefficient sensitivity. In principle, real-time polymerase chain reaction (PCR)-based assays can be used to ass...

journal_title：Cytotherapy

authors： Chen X,Hofmann TJ,Otsuru S,Jethva R,Lind C,Monos D,Horwitz EM

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AIMS:The types of proteins released from mesenchymal stromal cells (MSC) are still unclear. Our aim was to compare apoptosis scores and the expression of myelin-associated glycoprotein (MAG), myelin basic protein (MBP), neural cell adhesion molecule (NCAM)-1,matrix metalloproteinase (MMP)-1A, tissue inhibito...

journal_title：Cytotherapy

authors： Satar B,Hidir Y,Serdar MA,Kucuktag Z,Ural AU,Avcu F,Safali M,Oguztuzun S

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AIMS:During bone formation, angiogenesis and osteogenesis are regulated by hypoxia, which is able to induce blood vessel formation, as well as recruit and differentiate human mesenchymal stromal cells (hMSCs). The molecular mechanisms involved in HIF-1α response and hMSC differentiation during bone formation...

journal_title：Cytotherapy

authors： Costa V,Raimondi L,Conigliaro A,Salamanna F,Carina V,De Luca A,Bellavia D,Alessandro R,Fini M,Giavaresi G

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AIMS:Enumeration of CD34(+) cells in leukocyte-rich cell suspensions is important for clinical decision-making in stem cell transplantation. Single-platform flow cytometry assays offer the significant advantages of speed and reproducibility, and have therefore become the gold standard in stem cell enumeratio...

journal_title：Cytotherapy

authors： Dauber K,Becker D,Odendahl M,Seifried E,Bonig H,Tonn T

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND AIMS:The purpose of this study was to investigate the neuroprotective effects of bone marrow bone marrow-derived and adipose tissue-derived mesenchymal stromal cells (MSCs) that were intravitreally transplanted in an experimental ocular hypertension (OHT) model. METHODS:An OHT rat model was generated by mea...

journal_title：Cytotherapy

authors： Emre E,Yüksel N,Duruksu G,Pirhan D,Subaşi C,Erman G,Karaöz E

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Post-infarct congestive heart failure is one of the leading causes of morbidity and mortality in industrialized countries. The main purpose of this study was to investigate whether transplantation of embryonic stem cell-derived cardiomyocytes (ESCM) directly into the infarcted myocardium could improve cardia...

journal_title：Cytotherapy

authors： Cai J,Yi FF,Yang XC,Lin GS,Jiang H,Wang T,Xia Z

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AIMS:Traditionally, stem cell therapy for myocardial infarction (MI) has been administered as a single treatment in the acute or subacute period after MI. These time intervals coincide with marked differences in the post-infarct myocardial environment, raising the prospect that repeat cell dosing could provi...

journal_title：Cytotherapy

authors： Richardson JD,Psaltis PJ,Frost L,Paton S,Carbone A,Bertaso AG,Nelson AJ,Wong DT,Worthley MI,Gronthos S,Zannettino AC,Worthley SG

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:BM mesenchymal stem cells (MSC) have the capacity for renewal and the potential to differentiate into multiple tissues. In this study, we compared different enrichment methods to obtain MSC from BM. METHODS:Three different methods were compared with a view to obtaining MSC more rapidly from BM: negative sel...

journal_title：Cytotherapy

authors： Tondreau T,Lagneaux L,Dejeneffe M,Delforge A,Massy M,Mortier C,Bron D

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSC) have the potential to differentiate into distinct mesenchymal tissues including cartilage, suggesting that these cells are an attractive cell source for cartilage tissue engineering approaches. Various methods, such as using hyaluronan-based materials, have been employed to im...

journal_title：Cytotherapy

authors： Kayakabe M,Tsutsumi S,Watanabe H,Kato Y,Takagishi K

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AIMS:Endothelial apoptosis underlies the pathophysiology of pulmonary arterial hypertension (PAH). Some factors/cytokines released by endothelial progenitor cells (EPC) have been revealed as potent inhibitors of apoptosis. The aim of this study was to investigate the effects of EPC on pulmonary microvascular...

journal_title：Cytotherapy

authors： Xia L,Fu GS,Yang JX,Zhang FR,Wang XX

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:Imatinib (IM), a tyrosine kinase inhibitor targeting the BCR-ABL oncoprotein, remains a major therapeutic strategy for patients with chronic myelogenous leukemia (CML). However, IM resistance is still a challenge in the treatment of CML. Recently, it was reported that exosomes (Exo) were involved in dru...

journal_title：Cytotherapy

authors： Liu Y,Song B,Wei Y,Chen F,Chi Y,Fan H,Liu N,Li Z,Han Z,Ma F

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Naphthalene-induced respiratory tract toxicity in mice is characterized by specific and rapid loss of the Clara cell population, which is restored only after several days. The sources of restoration of this cell population remain unclear. We investigated whether BM-derived cells participated in the process o...

journal_title：Cytotherapy

authors： Serikov VB,Popov BV,Kropotov AV,Tomilin NV

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AIMS:Bone marrow (BM) stromal cells, also referred to as mesenchymal stromal cells (MSC), can be expanded ex vivo and are able to differentiate along multiple lineages, including chondrocytes, osteoblasts and adipocytes. MSC are known to secrete a number of cytokines and regulatory molecules implicated in di...

journal_title：Cytotherapy

authors： Lazzarotto-Silva C,Binato R,Rocher BD,Costa JA,Pizzatti L,Bouzas LF,Abdelhay E

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated. METHODS:MSC isolated...

journal_title：Cytotherapy

authors： Sun B,Roh KH,Park JR,Lee SR,Park SB,Jung JW,Kang SK,Lee YS,Kang KS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Patients with ulcerative colitis (UC) have elevated/activated myeloid lineage leucocytes and may respond favorably to adsorptive granulocyte/monocyte apheresis (GMA). However, there are patients who respond well to GMA, and patients who do not benefit. Therefore, predictive factors of GMA efficacy need to be...

journal_title：Cytotherapy

authors： Yokoyama Y,Watanabe K,Ito H,Nishishita M,Sawada K,Okuyama Y,Okazaki K,Fujii H,Nakase H,Masuda T,Fukunaga K,Andoh A,Nakamura S

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AIMS:Adoptive transfer of tumor-infiltrating lymphocytes (TIL) has proven effective in metastatic melanoma and should therefore be explored in other types of cancer. The aim of this study was to examine the feasibility of potentially expanding clinically relevant quantities of tumor-specific T-cell cultures ...

journal_title：Cytotherapy

authors： Junker N,Andersen MH,Wenandy L,Dombernowsky SL,Kiss K,Sørensen CH,Therkildsen MH,Von Buchwald C,Andersen E,Straten PT,Svane IM

更新日期：2011-08-01 00:00:00

abstract：:The process of wound healing restores skin homeostasis but not full functionality; thus, novel therapeutic strategies are needed to accelerate wound closure and improve the quality of healing. In this context, tissue engineering and cellular therapies are promising approaches. Although sharing essential characteristic...

journal_title：Cytotherapy

authors： Zomer HD,Jeremias TDS,Ratner B,Trentin AG

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND AIMS:Immunomodulatory properties of human umbilical cord-derived mesenchymal stromal cells (UCMSCs) can be differentially modulated by toll-like receptors (TLR) agonists. Here, the therapeutic efficacy of short TLR3 and TLR4 pre-conditioning of UCMSCs was evaluated in a dextran sulfate sodium (DSS)-induced c...

journal_title：Cytotherapy

authors： Fuenzalida P,Kurte M,Fernández-O'ryan C,Ibañez C,Gauthier-Abeliuk M,Vega-Letter AM,Gonzalez P,Irarrázabal C,Quezada N,Figueroa F,Carrión F

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Multiple studies have demonstrated that 'purging' of autografts with 4-hydroperoxycyclophosphamide (4HC) or the related compound mafosfamide (Mf), to eradicate residual leukemia, produces the best results associated with autologous blood and marrow transplantation for AML. However, 4HC purging results in pro...

journal_title：Cytotherapy

authors： McNiece I,Civin C,Harrington J,Kellner J,Malehorn M,Turney J,Barber J,Jones R

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AIMS:The aim of this study was to evaluate the efficacy and safety of cytokine-induced killer (CIK) cell therapy for solid carcinomas. METHODS:We performed a computerized search of phase II/III clinical trial databases of CIK cell-based therapy using a combination of the terms 'cytokine-induced killer cells...

journal_title：Cytotherapy

authors： Ma Y,Zhang Z,Tang L,Xu YC,Xie ZM,Gu XF,Wang HX

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Hematopoietic progenitor cells (HPC) circulate at high levels at birth and disappear rapidly afterwards, but the underlying mechanism it is not known. The aim of this study was to assess circulating HPC in cord blood at different gestational ages and shortly after birth and concomitantly study the biologic m...

journal_title：Cytotherapy

authors： Gonzalez S,Amat L,Azqueta C,Madrigal JA,Laïlla JM,Garcia J,Querol S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:Treatment of tendon-derived stem cells (TDSCs) with connective tissue growth factor (CTGF) and ascorbic acid promoted their tenogenic differentiation. We investigated the effects of TDSCs pre-treated with CTGF and ascorbic acid on tendon repair in a patellar tendon window injury rat model. METHODS:Gree...

journal_title：Cytotherapy

authors： Lui PP,Wong OT,Lee YW

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The use of myeloma Ag-loaded mature DC vaccines, cryopreserved in single-use aliquots, is an attractive immunotherapeutic strategy. In this study we investigated the retention of phenotype, viability and potency of DC vaccines after freezing and thawing. METHODS:Plastic-adherent monocytes, derived from a st...

journal_title：Cytotherapy

authors： Szmania S,Yi Q,Cottler-Fox M,Rosen NA,Freeman J,Kordsmeier BJ,Moreno A,Shi J,Barlogie B,Tricot G,van Rhee F

更新日期：2005-01-01 00:00:00