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Human adipose tissue-derived mesenchymal stromal cells promote B-cell motility and chemoattraction.

Abstract：

BACKGROUND AIMS:Mesenchymal stromal cells hold special interest for cell-based therapy because of their tissue-regenerative and immunosuppressive abilities. B-cell involvement in chronic inflammatory and autoimmune pathologies makes them a desirable target for cell-based therapy. Mesenchymal stromal cells are able to regulate B-cell function; although the mechanisms are little known, they imply cell-to-cell contact. METHODS:We studied the ability of human adipose tissue-derived mesenchymal stromal cells (ASCs) to attract B cells. RESULTS:We show that ASCs promote B-cell migration through the secretion of chemotactic factors. Inflammatory/innate signals do not modify ASC capacity to mediate B-cell motility and chemotaxis. Analysis of a panel of B cell-related chemokines showed that none of them appeared to be responsible for B-cell motility. Other ASC-secreted factors able to promote cell motility and chemotaxis, such as the cytokine interleukin-8 and prostaglandin E2, did not appear to be implicated. CONCLUSIONS:We propose that ASC promotion of B-cell migration by undefined secreted factors is crucial for ASC regulation of B-cell responses.

journal_name

Cytotherapy

journal_title

Cytotherapy

authors

Barrio L,Cuevas VD,Menta R,Mancheño-Corvo P,delaRosa O,Dalemans W,Lombardo E,Carrasco YR

doi

10.1016/j.jcyt.2014.07.012

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1692-9

issue

12

eissn

1465-3249

issn

1477-2566

pii

S1465-3249(14)00713-0

journal_volume

16

pub_type

杂志文章

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