Blood and marrow transplantation activities among adult patients in Turkey.


BACKGROUND:Since 1978, 856 hematopoietic stem-cell transplantations have been performed for adult patients in Turkey. METHODS AND RESULTS:Data were collected on the source of hematopoietic progenitor cells, recipient diagnosis, conditioning regimen, DFS and mortality. The data were analyzed by the national registry system of the Blood and Marrow Transplantation Subcommittee of the Turkish Society of Hematology. This analysis allowed the examination of national trends in survival, outcome and transplant-related complications in certain diseases. DISCUSSION:In the allogeneic setting, the results of transplants for acute and chronic leukemia, with the exception of severe aplastic anemia, were similar to those found in the European and international registries. Likewise, in the autologous setting, the transplant results from Turkey paralleled those in European and international registries.






Blood and Marrow Transplantation Subcommittee, Turkish Societ of Hematology.





Has Abstract


2000-01-01 00:00:00














  • A decade of marketing approval of gene and cell-based therapies in the United States, European Union and Japan: An evaluation of regulatory decision-making.

    abstract::There is a widely held expectation of clinical advance with the development of gene and cell-based therapies (GCTs). Yet, establishing benefits and risks is highly uncertain. We examine differences in decision-making for GCT approval between jurisdictions by comparing regulatory assessment procedures in the United Sta...


    pub_type: 历史文章,杂志文章


    authors: Coppens DGM,de Wilde S,Guchelaar HJ,De Bruin ML,Leufkens HGM,Meij P,Hoekman J

    更新日期:2018-06-01 00:00:00

  • A robust, good manufacturing practice-compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy.

    abstract::Regulatory T cells (Tregs) play a fundamental role in the maintenance of self-tolerance and immune homeostasis. Defects in Treg function and/or frequencies have been reported in multiple disease models. Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting upper and lower motor neur...


    pub_type: 杂志文章


    authors: Alsuliman A,Appel SH,Beers DR,Basar R,Shaim H,Kaur I,Zulovich J,Yvon E,Muftuoglu M,Imahashi N,Kondo K,Liu E,Shpall EJ,Rezvani K

    更新日期:2016-10-01 00:00:00

  • Co-transfusion of haplo-identical hematopoietic and mesenchymal stromal cells to treat a patient with severe aplastic.

    abstract::A 3-year-old girl with severe aplastic anemia (SAA) that was unresponsive to steroid, cyclosporine and filgrastim treatments received bone marrow (BM) mesenchymal stromal cells (MSC; 1.25 x 10(6)/kg), granulocyte colony-stimulating factor (G-CSF)-mobilized BM and peripheral blood stem cell grafts from her father. Prio...


    pub_type: 信件


    authors: Wang H,Wang Z,Xue M,Liu J,Yan H,Guo Z

    更新日期:2010-07-01 00:00:00

  • Development of a surrogate angiogenic potency assay for clinical-grade stem cell production.

    abstract:BACKGROUND AIMS:Clinical results from acute myocardial infarction (AMI) patients treated with MultiStem®, a large-scale expanded adherent multipotent progenitor cell population (MAPC), have demonstrated a strong safety and benefit profile for these cells. The mechanism of benefit with MAPC treatment is a result, in par...


    pub_type: 杂志文章


    authors: Lehman N,Cutrone R,Raber A,Perry R,Van't Hof W,Deans R,Ting AE,Woda J

    更新日期:2012-09-01 00:00:00

  • Effect of exposure to interleukin-21 at various time points on human natural killer cell culture.

    abstract:BACKGROUND AIMS:Interleukin-21 (IL-21) can enhance the effector function of natural killer (NK) cells but also limits their proliferation when continuously combined with IL-2/IL-15. Paradoxically, membrane-bound (mb)-IL-21 has been shown to improve human NK cell proliferation when cultured with IL-2/mb-IL-15. To clarif...


    pub_type: 杂志文章


    authors: Lim DP,Jang YY,Kim S,Koh SS,Lee JJ,Kim JS,Thi Phan MT,Shin DJ,Shin MG,Lee SH,Yoon M,Kim SK,Yoon JH,Park MH,Cho D

    更新日期:2014-10-01 00:00:00

  • Improved expansion of T cells in culture when isolated with an equipment-free, high-throughput, flow-through microfluidic module versus traditional density gradient centrifugation.

    abstract:BACKGROUND:The isolation of lymphocytes - and removal of platelets (PLTs) and red blood cells (RBCs) - from an initial blood sample prior to culture is a key enabling step for effective manufacture of cellular therapies. Unfortunately, currently available methods suffer from various drawbacks, including low cell recove...


    pub_type: 杂志文章


    authors: Strachan BC,Xia H,Vörös E,Gifford SC,Shevkoplyas SS

    更新日期:2019-02-01 00:00:00

  • Immunological and clinical effects of post-transplant G-CSF versus placebo in T-cell replete allogeneic blood transplant patients: results from a randomized double-blind study.

    abstract:BACKGROUND:Immunological and clinical effects of post-transplant growth factor administration have not been well studied. This report describes the outcome and immune functions of a total of 50 HLA-matched related donor allogeneic blood stem-cell transplantation patients who received post-transplant G-CSF (10 microg/kg...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Joshi SS,Bishop MR,Lynch JC,Tarantolo SR,Abhyankar S,Bierman PJ,Vose JM,Geller RB,McGuirk J,Foran J,Bociek RG,Hadi A,Day SD,Armitage JO,Kessinger A,Pavletic ZS

    更新日期:2003-01-01 00:00:00

  • Transiently redirected T cells for adoptive transfer.

    abstract:BACKGROUND AIMS:T cells can be redirected to reject cancer by retroviral transduction with a chimeric antigen receptor (CAR) or by administration of a bispecific T cell engager (BiTE). We demonstrate that transfection of T cells with messenger (m) RNA coding for CAR is an alternative strategy. METHODS:We describe the ...


    pub_type: 杂志文章


    authors: Almåsbak H,Rian E,Hoel HJ,Pulè M,Wälchli S,Kvalheim G,Gaudernack G,Rasmussen AM

    更新日期:2011-05-01 00:00:00

  • Neural stem cells transplanted to the subretinal space of rd1 mice delay retinal degeneration by suppressing microglia activation.

    abstract:BACKGROUND AIMS:Retinal degeneration (RD) is an inherited eye disease characterized by irreversible photoreceptor loss. Conventionally, the activation of the resident microglia is secondary to the disease. Stem cell-based therapy has recently made rapid progress in treating RD. Although it has been demonstrated that th...


    pub_type: 杂志文章


    authors: Li Z,Zeng Y,Chen X,Li Q,Wu W,Xue L,Xu H,Yin ZQ

    更新日期:2016-06-01 00:00:00

  • Catastrophic failures of freezing bags for cellular therapy products: description, cause, and consequences.

    abstract:BACKGROUND:Container integrity is critical for maintaining sterility of cryopreserved cellular therapy products. We investigated a series of catastrophic bag failures, first noticed in early 2001. METHODS:Process records were reviewed for all PBPC and lymphocyte products cryopreserved in bags from January 2000 through...


    pub_type: 杂志文章


    authors: Khuu HM,Cowley H,David-Ocampo V,Carter CS,Kasten-Sportes C,Wayne AS,Solomon SR,Bishop MR,Childs RM,Read EJ

    更新日期:2002-01-01 00:00:00

  • Cytokine flow cytometry: multiparametric approach to immune function analysis.

    abstract::More precise quantitation of cellular immune responses has become possible with the advent of single-cell assays of immune function, such as cytokine flow cytometry, enzyme-linked immunospot (ELISPOT), and MHC-peptide multimers. Cytokine flow cytometry is an attractive technique because it allows the detection of resp...


    pub_type: 杂志文章,评审


    authors: Ghanekar SA,Maecker HT

    更新日期:2003-01-01 00:00:00

  • Fifty-Hertz electromagnetic fields facilitate the induction of rat bone mesenchymal stromal cells to differentiate into functional neurons.

    abstract:BACKGROUND AIMS:Research results have shown that bone mesenchymal stromal cells (BMSC) can different into neural cells. Electromagnetic fields (EMF) play a role in regulating cell proliferation and differentiation, but the mechanisms behind this are unknown. In the present study, we explored the efficacy of EMF on the ...


    pub_type: 杂志文章


    authors: Bai WF,Xu WC,Feng Y,Huang H,Li XP,Deng CY,Zhang MS

    更新日期:2013-08-01 00:00:00

  • A study of the immune properties of human umbilical cord lining epithelial cells.

    abstract:BACKGROUND AIMS:Our previous study has demonstrated the stem cell-like properties of human umbilical cord lining epithelial cells (CLECs) and their capability for epidermal reconstitution in organotypic skin culture; however, the immunogenicity of these cells has not been clearly defined. We assessed several aspects of...


    pub_type: 杂志文章


    authors: Cai YJ,Huang L,Leung TY,Burd A

    更新日期:2014-05-01 00:00:00

  • Natural killer cell-based immunotherapeutic strategies.

    abstract::Not until recently have Natural killer (NK) cells stepped out of the shadow of T-cells to be considered for cellular therapy of malignant diseases. This evolution has been facilitated by the discovery of specific receptors on NK cells that interact with HLA molecules on target cells but also the discovery of specific ...


    pub_type: 杂志文章,评审


    authors: Klingemann HG

    更新日期:2005-01-01 00:00:00

  • Cryopreserved mesenchymal stromal cell treatment is safe and feasible for severe dilated ischemic cardiomyopathy.

    abstract:BACKGROUND AIMS:Bone marrow (BM) mesenchymal stromal cells (MSC) represent a novel therapy for severe heart failure with extensive myocardial scarring, especially when performed concurrently with conventional revascularization. However, stem cells are difficult to transport in culture media without risk of contaminatio...


    pub_type: 杂志文章


    authors: Chin SP,Poey AC,Wong CY,Chang SK,Teh W,Mohr TJ,Cheong SK

    更新日期:2010-01-01 00:00:00

  • Selective depletion strategies in allogeneic stem cell transplantation.

    abstract::Despite improved prophylaxis and treatment, GvHD remains a major limitation to optimal allogeneic stem cell transplantation. Ex vivo selective depletion (SD) is a strategy to prevent GvHD, in which host-reactive donor lymphocytes are selectively eliminated from a PBSC allograft while useful donor immune function is pr...


    pub_type: 杂志文章,评审


    authors: Mielke S,Solomon SR,Barrett AJ

    更新日期:2005-01-01 00:00:00

  • Expanded umbilical cord blood T cells used as donor lymphocyte infusions after umbilical cord blood transplantation.

    abstract:BACKGROUND:Umbilical cord blood (UCB) is an alternative graft source for hematopoietic stem cell transplantation and has been shown to give results comparable to transplantation with other stem cell sources. Donor lymphocyte infusion (DLI) is an effective treatment for relapsed malignancies after hematopoietic stem cel...


    pub_type: 杂志文章


    authors: Berglund S,Gertow J,Uhlin M,Mattsson J

    更新日期:2014-11-01 00:00:00

  • Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas.

    abstract::Mesenchymal stromal cells (MSCs) are a type of adult stem cell that has been exploited for the treatment of a variety of diseases, including cancer. In particular, MSCs have been studied extensively for their ability to treat glioblastoma (GBM), the most common and deadly form of brain cancer in adults. MSCs are attra...


    pub_type: 杂志文章,评审


    authors: Parker Kerrigan BC,Shimizu Y,Andreeff M,Lang FF

    更新日期:2017-04-01 00:00:00

  • Transplantation of autologous rabbit BM-derived mesenchymal stromal cells embedded in hyaluronic acid gel sponge into osteochondral defects of the knee.

    abstract:BACKGROUND:Mesenchymal stromal cells (MSC) have the potential to differentiate into distinct mesenchymal tissues including cartilage, suggesting that these cells are an attractive cell source for cartilage tissue engineering approaches. Various methods, such as using hyaluronan-based materials, have been employed to im...


    pub_type: 杂志文章


    authors: Kayakabe M,Tsutsumi S,Watanabe H,Kato Y,Takagishi K

    更新日期:2006-01-01 00:00:00

  • Immunogenic potential of human bone marrow mesenchymal stromal cells is enhanced by hyperthermia.

    abstract:BACKGROUND AIMS:Bone marrow-derived mesenchymal stromal cells (MSCs) have been reported to suppress T-cell proliferation and used to alleviate the symptoms of graft-versus-host disease (GVHD). MSCs are a mixed cell population and at this time there are no tools to isolate the cells responsible for the T-cell suppressio...


    pub_type: 杂志文章


    authors: McClain-Caldwell I,Vitale-Cross L,Mayer B,Krepuska M,Boyajian M,Myneni V,Martin D,GENOMICS AND COMPUTATIONAL BIOLOGY CORE.,Marko K,Nemeth K,Mezey E

    更新日期:2018-12-01 00:00:00

  • Yield and proliferation rate of adipose-derived stromal cells as a function of age, body mass index and harvest site-increasing the yield by use of adherent and supernatant fractions?

    abstract:BACKGROUND AIMS:Adipose-derived stem cells are easily accessed and have a relatively high density compared with other mesenchymal stromal cells. Isolation protocols of adipose-derived stem cells (ASC) rely on the cell's ability to adhere to tissue culture plastic overnight. It was evaluated whether the floating ASC fra...


    pub_type: 杂志文章


    authors: Buschmann J,Gao S,Härter L,Hemmi S,Welti M,Werner CM,Calcagni M,Cinelli P,Wanner GA

    更新日期:2013-09-01 00:00:00

  • Cytokine-induced killer cells in the treatment of patients with solid carcinomas: a systematic review and pooled analysis.

    abstract:BACKGROUND AIMS:The aim of this study was to evaluate the efficacy and safety of cytokine-induced killer (CIK) cell therapy for solid carcinomas. METHODS:We performed a computerized search of phase II/III clinical trial databases of CIK cell-based therapy using a combination of the terms 'cytokine-induced killer cells...


    pub_type: 杂志文章,meta分析,评审


    authors: Ma Y,Zhang Z,Tang L,Xu YC,Xie ZM,Gu XF,Wang HX

    更新日期:2012-04-01 00:00:00

  • Decrease in circulating hematopoietic progenitor cells by trapping in the pulmonary circulation.

    abstract:BACKGROUND:When stem-cell grafts are infused into the venous circulation and stem/progenitor cells egress from BM, pulmonary capillary beds are the first microcirculation site that they encounter. This provides the potential for circulating progenitor cells to be trapped in the pulmonary circulation. METHODS:We compar...


    pub_type: 杂志文章


    authors: Watanabe T,Kajiume T,Takaue Y,Kawano Y,Kanamaru S,Okamura S,Onishi T,Suzuya H,Nakagawa R,Kuroda Y,Talmadge JE

    更新日期:2001-01-01 00:00:00

  • CTLA-4 blockade by a human MAb enhances the capacity of AML-derived DC to induce T-cell responses against AML cells in an autologous culture system.

    abstract:BACKGROUND:Cells from AML patients can differentiate into the phenotype of DC when cultured with GM-CSF and IL-4. Such cytokine-treated AML-derived DC (AML-DC) can stimulate autologous T cells. In this study we examined whether an anti-CTLA-4 MAb (MDX-010) could enhance the generation of autologous anti-AML T cells. M...


    pub_type: 杂志文章


    authors: Zhong RK,Loken M,Lane TA,Ball ED

    更新日期:2006-01-01 00:00:00

  • A roundtable on responsible innovation with autologous stem cells in Australia, Japan and Singapore.

    abstract::We report on a roundtable event hosted in Singapore that sought to identify some of the ethical and regulatory challenges in translating autologous cell-based interventions, particularly those claiming to involve stem cells, into safe and effective therapies and to propose some solutions to encourage responsible innov...




    authors: Lysaght T,Munsie M,Castricum A,Hui JHP,Okada K,Sato Y,Sawa Y,Stewart C,Tan LK,Tan LHY,Sugii S

    更新日期:2018-09-01 00:00:00

  • Safety and biodistribution study of bone marrow-derived mesenchymal stromal cells and mononuclear cells and the impact of the administration route in an intact porcine model.

    abstract:BACKGROUND AIMS:Bone marrow mononuclear cells (BM-MNCs) and bone marrow-derived mesenchymal stem stromal cells (BM-MSCs) could have therapeutic potential for numerous conditions, including ischemia-related injury. Cells transplanted intravascularly may become entrapped in the lungs, which potentially decreases their th...


    pub_type: 杂志文章


    authors: Mäkelä T,Takalo R,Arvola O,Haapanen H,Yannopoulos F,Blanco R,Ahvenjärvi L,Kiviluoma K,Kerkelä E,Nystedt J,Juvonen T,Lehenkari P

    更新日期:2015-04-01 00:00:00

  • Suicide genes as safety switches in T lymphocytes.

    abstract::Broader application of adoptive transfer of tumor-specific T-lymphocytes is accompanied by the need for effective suicide genes to ensure the safety of this cell-based therapy. In vivo elimination of T-lymphocytes expressing the herpes simplex virus-derived thymidine kinase gene has demonstrated the feasibility of thi...


    pub_type: 杂志文章,评审


    authors: Straathof KC,Spencer DM,Sutton RE,Rooney CM

    更新日期:2003-01-01 00:00:00

  • Reprogramming of mouse renal tubular epithelial cells to induced pluripotent stem cells.

    abstract::Kidney disease has reached epidemic proportions and is associated with high mortality and morbidity rates. Stem cell-based therapy may effectively treat kidney damage by cell transplantation. The breakthrough discovery using a combination of four transcription factors to reprogram genetically somatic cells into induce...


    pub_type: 杂志文章


    authors: Wang WW,Wang W,Jiang Y,Han GF,Lu S,Li G,Zhang J

    更新日期:2013-05-01 00:00:00

  • TEMPORARY REMOVAL: CD271 identifies functional human hepatic stellate cells, which localize in peri-sinusoidal and portal areas in liver after partial hepatectomy.

    abstract:BACKGROUND AIMS:Hepatic stellate cells (HSCs) are liver-resident mesenchymal cells involved in essential processes in the liver. However, knowledge concerning these cells in human livers is limited because of the lack of a simple isolation method. METHODS:We isolated fetal and adult human liver cells by immunomagnetic...


    pub_type: 杂志文章


    authors: Patil PB,Joshi M,Kuna VK,Xu B,Johannesson L,Olausson M,Sumitran-Holgersson S

    更新日期:2014-07-01 00:00:00

  • Adipose mesenchymal stromal cells minimize and repair radiation-induced oral mucositis.

    abstract:BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) have been used to minimize and repair radiation-induced normal tissue injury in the intestine, salivary gland, liver, skin, lungs and cardiac muscle. This study investigated the ability of adipose tissue-derived MSCs (aMSCs) to minimize and/or repair single dose radiatio...


    pub_type: 杂志文章


    authors: Maria OM,Shalaby M,Syme A,Eliopoulos N,Muanza T

    更新日期:2016-09-01 00:00:00