当前位置： SCI文献检索 > CYTOTHERAPY期刊下所有文献 > Long-term outcome of a phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients.

Long-term outcome of a phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients.

Abstract：

BACKGROUND:Mismatched family donor and unrelated donor BM transplants are associated with a high risk of acute GvHD. White T-cell depletion is the best method to reduce risk of acute GvHD, there was a reluctance to use T-cell depletion in the mismatched setting because of increased risk of rejection and relapse. Partial T-cell depletion, by the panning of CDS and CD8 positive T cells may reduce complications related to GvHD without compromising outcomes. METHOD:In a long-term follow-up of a Phase II study of partial T-cell depletion by panning for BM transplant, 32 recipients received transplants from a single-Ag (HLA A, B, or DR) mismatched family donor; or an HLA serologically-matched unrelated donor. Patients were studied for engraftment, GHD, relapse and survival. RESULTS:30 (94%) of the patients marrow engrafted. The cumulative risk of Grade 2-4 acute GvHD was 62 - 9%; of Grade 3-4 GvHD, 11 - 6%. The 4-year cumulative risk of relapse was 18 - 8% and actuarial survival was 44 - 9%. DISCUSSION:Partial T-cell depletion had a low rate of severe acute GvHD without compromising engrafment or relapse risk.

journal_name

Cytotherapy

journal_title

Cytotherapy

authors

Gajewski JL,Nimer S,Saliba RM,Thomas M,Przepiorka D,Giralt S,von Besien K,Mehra R,Andersson B,Chan KW,Ippoliti C,Warkinten D,Feigs S,Territo M,Schiller G,Lebkowski J,Moseley AM,Lloyd K,von Hoeff M,Okarma T,Champli

doi

10.1080/0032472031000141284

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

401-7

issue

5

eissn

1465-3249

issn

1477-2566

pii

S1465-3249(99)70045-9

journal_volume

1

pub_type

杂志文章

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