Abstract:
BACKGROUND AIMS:Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated. METHODS:MSC isolated from human umbilical cord blood (UCB) and adipose tissue (AD) were transplanted in a mouse cancer metastasis model. The effects of MSC on tumor growth and metastasis were analyzed. The effects of transplantation of MSC into the mouse model at very early stage carcinogenesis were also evaluated. RESULTS:Human MSC reduced lung metastasis and inhibited the growth of human breast cancer cells by inducing apoptosis. In addition, transplantation of both UCB and AD MSC into a cancer model with no detectable clinical symptoms did not appear to promote tumor growth or metastasis. CONCLUSIONS:We evaluated the effect of MSC derived from human UCB and AD tissue in a tumor model. Our findings may help to elucidate the interaction between cancer cells and MSC, as well as the application of MSC to clinical trials.
journal_name
Cytotherapyjournal_title
Cytotherapyauthors
Sun B,Roh KH,Park JR,Lee SR,Park SB,Jung JW,Kang SK,Lee YS,Kang KSdoi
10.1080/14653240902807026subject
Has Abstractpub_date
2009-01-01 00:00:00pages
289-98, 1 p following 298issue
3eissn
1465-3249issn
1477-2566pii
909786028journal_volume
11pub_type
杂志文章相关文献
CYTOTHERAPY文献大全abstract:BACKGROUND AIMS:The aim was to investigate the therapeutic effect of granulocyte-colony-stimulating factor (G-CSF) administration following implantation of autologous bone marrow mononuclear cells (BM MNC) for patients with lower limb ischemia. METHODS:The design was a randomized controlled trial. Fifteen patients wit...
journal_title:Cytotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/14653240903518163
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND AIMS:Circulating monocytes have been exploited as an important progenitor cell resource for hepatocytes in vitro and are instrumental in the removal of fibrosis. We investigated the significance of monocytes in peripheral blood stem cells (PBSC) for the treatment of liver cirrhosis. METHODS:Rat CD14+ monocy...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.3109/14653249.2010.515578
更新日期:2010-12-01 00:00:00
abstract::Not all patients with Hodgkin's disease (HD) respond to standard chemotherapy and/or radiation, and hematopoietic stem-cell transplantation has been gaining increasing acceptance in the management of HD. Phase II and, to a lesser extent, phase III studies of high-dose chemotherapy and autologous stem cell transplantat...
journal_title:Cytotherapy
pub_type: 杂志文章,评审
doi:10.1080/146532402320219754
更新日期:2002-01-01 00:00:00
abstract::The efficacy of cord blood (CB) transplantation is limited by the low cell dose available. Low cell doses at transplant are correlated with delayed engraftment, prolonged neutropenia and thrombocytopenia and elevated risk of graft failure. To potentially improve the efficacy of CB transplantation, approaches have been...
journal_title:Cytotherapy
pub_type: 杂志文章,评审
doi:10.1080/14653240510027172
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AIMS:Intrauterine adhesion (IUA) is a common uterine cavity disease characterized by the unsatisfactory regeneration of damaged endometria. Recently, stem cell transplantation has been proposed to promote the recovery process. Here we investigated whether human amniotic mesenchymal stromal cells (hAMSCs), a ...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2017.02.003
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND AIMS:Apoptosis of radiosensitive cells in the bone marrow and gut is a serious, at times life-threatening, complication arising from radiation exposure. METHODS:We investigated whether adoptive transfer of allogeneic bone marrow-derived mesenchymal stromal cells (MSC) could exert cytoprotective and life-spa...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.3109/14653249.2012.684378
更新日期:2012-11-01 00:00:00
abstract::There is a widely held expectation of clinical advance with the development of gene and cell-based therapies (GCTs). Yet, establishing benefits and risks is highly uncertain. We examine differences in decision-making for GCT approval between jurisdictions by comparing regulatory assessment procedures in the United Sta...
journal_title:Cytotherapy
pub_type: 历史文章,杂志文章
doi:10.1016/j.jcyt.2018.03.038
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AIMS:The authors aim to analyze the evidence in the literature regarding the efficacy and safety of mesenchymal stem cell (MSC) therapy in human subjects with traumatic spinal cord injury (SCI) and identify its potential role in the management of SCI. METHODS:The authors conducted independent and duplicate ...
journal_title:Cytotherapy
pub_type: 杂志文章,评审
doi:10.1016/j.jcyt.2020.09.007
更新日期:2020-11-09 00:00:00
abstract:BACKGROUND AIMS:Endoscopy is the gold standard for the diagnosis and follow-up of patients with Crohn disease (CD). However, a less invasive approach is now being sought for the management of these patients. The objective of this study was to examine whether (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (...
journal_title:Cytotherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.jcyt.2015.10.010
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) enhance islet function both in vitro and in vivo, at least in part by secreting ligands that activate islet G-protein coupled receptors (GPCRs). We assessed whether pre-treatment with a defined "cocktail" of MSC-secreted GPCR ligands enhances islet functional survival in...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2018.07.007
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Since 1978, 856 hematopoietic stem-cell transplantations have been performed for adult patients in Turkey. METHODS AND RESULTS:Data were collected on the source of hematopoietic progenitor cells, recipient diagnosis, conditioning regimen, DFS and mortality. The data were analyzed by the national registry sy...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1080/146532400539288
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Transplantation of mesenchymal stem cells (MSC) in rodent models has proved to be an effective therapeutic approach for spinal cord injury (SCI). However, further studies in primate models are still needed before clinical application of MSC to patients. METHODS:MSC were isolated from rhesus monkey BM and in...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1080/14653240600760808
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AIMS:Our previous study has demonstrated the stem cell-like properties of human umbilical cord lining epithelial cells (CLECs) and their capability for epidermal reconstitution in organotypic skin culture; however, the immunogenicity of these cells has not been clearly defined. We assessed several aspects of...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2013.10.008
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND AIMS:Adipose tissue represents a practical source of autologous mesenchymal stromal cells (MSCs) and vascular-endothelial progenitor cells, available for regenerative therapy without in vitro expansion. One of the problems confronting the therapeutic application of such cells is how to immobilize them at the...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2012.10.009
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Immunological and clinical effects of post-transplant growth factor administration have not been well studied. This report describes the outcome and immune functions of a total of 50 HLA-matched related donor allogeneic blood stem-cell transplantation patients who received post-transplant G-CSF (10 microg/kg...
journal_title:Cytotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/14653240310003648
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AIMS:Dendritic cells (DCs) are the most potent antigen presenting cells of the immune system and have been under intense study with regard to their use in immunotherapy against cancer and infectious disease agents. In the present study, DCs were employed to assess their value in protection against live virus...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2012.11.012
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND AND AIMS:We recently demonstrated that injection of conditioned medium (CM) generated from cells of the mesenchymal region of human amniotic membrane (AMTCs) reduces bleomycin-induced lung fibrosis in mice, suggesting a crucial role of paracrine factor(s) secreted by AMTCs in these beneficial effects. We fur...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2013.07.002
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AIMS:Adipose-derived stem cells are easily accessed and have a relatively high density compared with other mesenchymal stromal cells. Isolation protocols of adipose-derived stem cells (ASC) rely on the cell's ability to adhere to tissue culture plastic overnight. It was evaluated whether the floating ASC fra...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2013.04.009
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND AIMS:We have confirmed that aortic aneurysm (AA) can be regressed by the administration of bone marrow-derived mesenchymal stromal cells (BM-MSCs). We investigated the kinetics of signaling pathways in AA following treatment with BM-MSCs. METHODS:Angiotensin II-infused apolipoprotein E-deficient mice were t...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2017.07.010
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Lentiviral vectors have the capacity to transduce stably non-dividing, differentiated and undifferentiated cells of various tissues, including liver. To obtain high-level expression of transgenes, vectors often rely on viral promoters. However, recent data suggest that the supraphysiologic expression from ub...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1080/14653240701656053
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Cell therapy has been proposed as a salvage limb procedure in critical limb ischemia (CLI). In spite of the fact that clinical trials found some efficacy, the mechanism of action remains elusive. The objective of this study was to characterize two autologous cell therapy products (CTPs) obtained from patient...
journal_title:Cytotherapy
pub_type: 临床试验,杂志文章
doi:10.1016/j.jcyt.2016.10.013
更新日期:2017-02-01 00:00:00
abstract::The emergence of cell-based therapeutics has increased the need for high-quality, robust and validated measurements for cell characterization. Cell count, being one of the most fundamental measures for cell-based therapeutics, now requires increased levels of measurement confidence. The National Institute of Standards...
journal_title:Cytotherapy
pub_type: 杂志文章,评审
doi:10.1016/j.jcyt.2018.03.031
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The use of myeloma Ag-loaded mature DC vaccines, cryopreserved in single-use aliquots, is an attractive immunotherapeutic strategy. In this study we investigated the retention of phenotype, viability and potency of DC vaccines after freezing and thawing. METHODS:Plastic-adherent monocytes, derived from a st...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1080/14653240510027235
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AIMS:The purpose of this study was to observe the clinical effect and safety of umbilical cord mesenchymal stem cells (UC-MSCs) in treating spinal cord injury (SCI) by intrathecal injection. METHODS:From January 2008 to October 2010, we treated 22 patients with SCI with UC-MSCs by intrathecal injection; dos...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2012.09.005
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND AIMS:Stem cell therapy for liver diseases has recently emerged as a promising alternative to liver transplantation. Eligible cells should have an appropriate immunophenotype. The aim of the present study was to define the immunological profile of two human liver-derived mesenchymal stromal cell populations, ...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2014.10.001
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND AIMS:Mesenchymal stromal cells (MSCs) suppress T-cell proliferation, especially after activation with inflammatory cytokines. We compared the dynamic action of unprimed and interferon (IFN)-γ plus tumor necrosis factor (TNF)-α-pretreated human bone marrow-derived MSCs on resting or activated T cells. METHOD...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2013.11.008
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Umbilical cord blood (UCB) has been used as an alternative source of donor hematopoietic stem cells for hematologic transplant setting over the past decade. This study attempted to evaluate potential predictors of cord blood quality. METHODS:A total of 750 UCB samples were studied (male, n = 365; female, n ...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2014.09.002
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND AIMS:Bone marrow (BM) mesenchymal stromal cells (MSC) represent a novel therapy for severe heart failure with extensive myocardial scarring, especially when performed concurrently with conventional revascularization. However, stem cells are difficult to transport in culture media without risk of contaminatio...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.3109/14653240903313966
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND AIMS:Pooled human platelet lysate (HPL) is becoming the new gold standard as supplement for ex vivo cell culture for clinical protocols. However, the risk of pathogen contamination of HPL increases with the platelet pool size. We hypothesized that hollow fiber anion exchange membrane chromatography using Qyu...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2016.04.002
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Clinical studies have shown the efficacy of combination therapy for various malignancies. In this study, the characteristics, safety and feasibility of use of cascade-primed (CAPRI) cells for the combination treatment of non-small-cell lung cancer (NSCLC) were evaluated both in vitro and in vivo. METHODS:Si...
journal_title:Cytotherapy
pub_type: 杂志文章
doi:10.1016/j.jcyt.2019.12.002
更新日期:2020-01-01 00:00:00