Shipping of therapeutic somatic cell products.

abstract：BACKGROUND:Traditionally, following high-dose therapy (HDT), unmanipulated autologous PBPC are infused. Alternatively, purified CD34+ cells can now be obtained by immunomagnetic separation using the CliniMACS device. Limited data currently exist examining hemopoietic recovery with such cells. METHODS:Ten patients with...

journal_title：Cytotherapy

authors： Prince HM,Wall D,Rischin D,Toner GC,Seymour JF,Blakey D,Haylock D,Simmons P,Wolf M,Januszewicz EH,Westerman D,Richardson G,Scarlett J,Briggs P

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AIMS:Chimeric antigen receptors (CARs) designed for adoptive immunotherapy need to achieve two functions: antigen recognition and triggering of the lytic machinery of reprogrammed effector cells. Cytotoxic T cells have been engineered with FcγRIII (CD16) chimeric molecules to be redirected against malignant ...

journal_title：Cytotherapy

authors： D'Aloia MM,Caratelli S,Palumbo C,Battella S,Arriga R,Lauro D,Palmieri G,Sconocchia G,Alimandi M

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AIMS:Multiple steps are required to produce chimeric antigen receptor (CAR)-T cells, involving subset enrichment or depletion, activation, gene transduction and expansion. Open processing steps that increase risk of contamination and production failure are required. This complex process requires skilled pers...

journal_title：Cytotherapy

authors： Zhu F,Shah N,Xu H,Schneider D,Orentas R,Dropulic B,Hari P,Keever-Taylor CA

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AIMS:T cells can be redirected to reject cancer by retroviral transduction with a chimeric antigen receptor (CAR) or by administration of a bispecific T cell engager (BiTE). We demonstrate that transfection of T cells with messenger (m) RNA coding for CAR is an alternative strategy. METHODS:We describe the ...

journal_title：Cytotherapy

authors： Almåsbak H,Rian E,Hoel HJ,Pulè M,Wälchli S,Kvalheim G,Gaudernack G,Rasmussen AM

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND AIMS:Multiple cell-therapy products require density separation as a part of manufacturing. The traditional method for Ficoll separation, layering cell suspensions over Ficoll in tubes, followed by centrifugation and collection of cells from the interface, is too cumbersome and poses too high a risk of contam...

journal_title：Cytotherapy

authors： Janssen WE,Ribickas A,Meyer LV,Smilee RC

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Adipose-derived stromal cells (ASCs) are a promising new therapeutic option for patients with acute myocardial infarction (AMI). Previously, we found that ASCs coupled to antibody-targeted microbubbles (StemBells [StBs]) improved cardiac function when administered intravenously 7 days post-AMI in rats. In th...

journal_title：Cytotherapy

authors： Emmens RW,Oedayrajsingh-Varma M,Woudstra L,Kamp O,Meinster E,van Dijk A,Helder MN,Wouters D,Zeerleder S,van Ham SM,de Jong N,Niessen HW,Juffermans LJ,Krijnen PA

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Multiple myeloma (MM) is a hematologic cancer caused by the abnormal expansion of plasma cells, but the exact mechanism underlying MM development is not completely known. Recently, multiple long noncoding RNAs (lncRNAs) were implicated in the regulation of MM development. METHODS:Samples from patients with ...

journal_title：Cytotherapy

authors： Deng M,Yuan H,Liu S,Hu Z,Xiao H

更新日期：2019-01-01 00:00:00

abstract：:MAb have become an important treatment modality in cancer therapy.Genetically engineered chimeric and humanized Ab have demonstrated activity against a variety of tumors. While the humanized anti-CD33MAb lintuzumab has only modest single-agent activity against overt AML, it can eliminate minimal residual disease detec...

journal_title：Cytotherapy

authors： Jurcic JG

更新日期：2008-01-01 00:00:00

abstract：:Despite improved prophylaxis and treatment, GvHD remains a major limitation to optimal allogeneic stem cell transplantation. Ex vivo selective depletion (SD) is a strategy to prevent GvHD, in which host-reactive donor lymphocytes are selectively eliminated from a PBSC allograft while useful donor immune function is pr...

journal_title：Cytotherapy

authors： Mielke S,Solomon SR,Barrett AJ

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AIMS:Apoptosis of radiosensitive cells in the bone marrow and gut is a serious, at times life-threatening, complication arising from radiation exposure. METHODS:We investigated whether adoptive transfer of allogeneic bone marrow-derived mesenchymal stromal cells (MSC) could exert cytoprotective and life-spa...

journal_title：Cytotherapy

authors： François M,Birman E,Forner KA,Gaboury L,Galipeau J

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:CAMPATH-1 Abs have been used for T-cell depletion in stem-cell transplantation since the early 1980s. During that time there has been substantial progress in manufacturing techniques and quality control procedures. This article summarizes the methods used to produce the Abs for clinical use and describes res...

journal_title：Cytotherapy

authors： Phillips J,Drumm A,Harrison P,Bird P,Bhamra K,Berrie E,Hale G

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Amniotic membrane is a highly promising cell source for tissue engineering. Being part of the placenta, this tissue is abundantly available. It can be processed easily to yield large amounts of epithelial and mesenchymal cells that have shown broad differentiation potential. For tissue-engineering purposes, ...

journal_title：Cytotherapy

authors： Stadler G,Hennerbichler S,Lindenmair A,Peterbauer A,Hofer K,van Griensven M,Gabriel C,Redl H,Wolbank S

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells hold special interest for cell-based therapy because of their tissue-regenerative and immunosuppressive abilities. B-cell involvement in chronic inflammatory and autoimmune pathologies makes them a desirable target for cell-based therapy. Mesenchymal stromal cells are able to r...

journal_title：Cytotherapy

authors： Barrio L,Cuevas VD,Menta R,Mancheño-Corvo P,delaRosa O,Dalemans W,Lombardo E,Carrasco YR

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Bone marrow (BM)-derived mesenchymal stromal cells (MSC) are promising candidate cells for the development of neuroregenerative therapies. We have previously introduced the pro-neural conversion of human MSC to neural stem cell-like cells (m-NSC) by culturing them in suspension culture under serum-free condi...

journal_title：Cytotherapy

authors： Habisch HJ,Fiedler J,Ludolph AC,Storch A,Brenner RE

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:Dendritic cell (DC)-based therapies could be important strategies for lymphoma treatment. METHODS:AKR/J mice with Dalton's lymphoma were treated with recombinant interleukin-15 (rIL-15)-activated autologous DCs and pulsed with whole tumor cell lysates in the presence or absence of suboptimal doses of t...

journal_title：Cytotherapy

authors： Hira SK,Mondal I,Manna PP

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND AIMS:This study evaluated the feasibility, safety and immunological effects of the intravenous administration of mesenchymal stromal cells (MSCs) from a related donor in patients with refractory aplastic anemia (AA). METHODS:A mean of 6 × 10(5)/kg (range, 5.0-7.1 × 10(5)) MSCs were injected intravenously to...

journal_title：Cytotherapy

authors： Xiao Y,Jiang ZJ,Pang Y,Li L,Gao Y,Xiao HW,Li YH,Zhang H,Liu Q

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AIMS:Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide. Developing effective protocols for the administration of mesenchymal stromal cells (MSCs) is a promising therapeutic strategy to treat TBI. It is important to develop alternatives to direct parenchymal injection at the...

journal_title：Cytotherapy

authors： Bonilla C,Zurita M,Aguayo C,Rodríguez A,Vaquero J

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND AIMS:Adipose tissue has therapeutic potential for spinal cord injury (SCI) because it contains multipotent cells known as adipose-derived stem/stromal cells (ASCs). In this study, we attempted intravenous ASC transplantation in rats with SCI to examine the effect on functional recovery. METHODS:ASCs (2.5 × ...

journal_title：Cytotherapy

authors： Ohta Y,Hamaguchi A,Ootaki M,Watanabe M,Takeba Y,Iiri T,Matsumoto N,Takenaga M

更新日期：2017-07-01 00:00:00

abstract：:In the current article we summarize the 15-year experience of the Spanish Cell Therapy Network (TerCel), a successful collaborative public initiative funded by the Spanish government for the support of nationwide translational research in this important area. Thirty-two research groups organized in three programs devo...

journal_title：Cytotherapy

authors： Sánchez-Guijo F,García-Olmo D,Prósper F,Martínez S,Zapata A,Fernández-Avilés F,Toledo-Aral JJ,Torres M,Fariñas I,Badimón L,Labandeira-García JL,García-Sancho J,Moraleda JM,TerCel.

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AIMS:Existing treatments have limited success in modifying the course of peripheral artery disease, which may eventually lead to limb-threatening ulcers and amputation. Cellular therapies have the potential to provide a new treatment option for this condition, but isolation of cells by conventional means has...

journal_title：Cytotherapy

authors： Koch JM,D'Souza SS,Schwahn DJ,Dixon I,Hacker TA

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Retroviral vectors are regularly used to transduce stem cells and their derivatives for experimental and therapeutic purposes. Because these vectors integrate semi-randomly into the cellular genome, analysis of integranated retroviral DNA/host cell DNA junctions (IHJ) facilitates clonality studies of engraft...

journal_title：Cytotherapy

authors： Pule MA,Rousseau A,Vera J,Heslop HE,Brenner MK,Vanin EF

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:PBSC transplant provides 10 times more T cells than BMT However, the incidence and severity of acute GvHD is similar among recipients of both types of transplants. Studies in mouse models suggest that the similar clinical outcome in BMT and PBSCT is due to differences in the lymphokine profiles. METHODS:PBM...

journal_title：Cytotherapy

authors： Vasconcelos ZF,Santos BM,Costa ES,Lima M,Tabak DG,Bouzas LF,Azevedo WM,Barcinski MA,Bonomo A

更新日期：2003-01-01 00:00:00

abstract：:A 3-year-old girl with severe aplastic anemia (SAA) that was unresponsive to steroid, cyclosporine and filgrastim treatments received bone marrow (BM) mesenchymal stromal cells (MSC; 1.25 x 10(6)/kg), granulocyte colony-stimulating factor (G-CSF)-mobilized BM and peripheral blood stem cell grafts from her father. Prio...

journal_title：Cytotherapy

authors： Wang H,Wang Z,Xue M,Liu J,Yan H,Guo Z

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Identification of HLA class I-restricted CMV epitopes, and the subsequent synthesis of HLA class I-peptide tetrameric complexes, have provided investigators with an important tool for visualising and quantifying the precise in vivo CTL response to CMV reactivation following stem cell transplantation. In conj...

journal_title：Cytotherapy

authors： Chen FE,Aubert G,Travers P,Dodi IA,Madrigal JA

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AIMS:Adipose tissue represents a practical source of autologous mesenchymal stromal cells (MSCs) and vascular-endothelial progenitor cells, available for regenerative therapy without in vitro expansion. One of the problems confronting the therapeutic application of such cells is how to immobilize them at the...

journal_title：Cytotherapy

authors： Zimmerlin L,Rubin JP,Pfeifer ME,Moore LR,Donnenberg VS,Donnenberg AD

更新日期：2013-01-01 00:00:00

abstract：:Targeted adoptive immunotherapy with engineered T cells is a promising treatment for refractory hematologic malignancies. However, many patients achieving early complete remissions ultimately relapse. Immunosuppressive ligands are expressed on tumor and supportive cells in the tumor microenvironment (TME). When activa...

journal_title：Cytotherapy

authors： Zolov SN,Rietberg SP,Bonifant CL

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Adipose tissue contains a stromal vascular fraction that can be easily isolated and provides a rich source of adipose tissue-derived mesenchymal stem cells (ASC). These ASC are a potential source of cells for tissue engineering. We studied whether the yield and growth characteristics of ASC were affected by ...

journal_title：Cytotherapy

authors： Oedayrajsingh-Varma MJ,van Ham SM,Knippenberg M,Helder MN,Klein-Nulend J,Schouten TE,Ritt MJ,van Milligen FJ

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AIMS:Regenerative medicine strategies based on cell therapy are considered a promising approach to repair bone defects. The aims of this study were to evaluate the effect of subculturing on the osteogenic potential of osteoblasts derived from newborn rat calvaria and the effect of these osteoblasts on bone r...

journal_title：Cytotherapy

authors： Souza ATP,Freitas GP,Lopes HB,Ferraz EP,Oliveira FS,Beloti MM,Rosa AL

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AIMS:Cytokine-induced killer (CIK) cells have shown cytolytic activity against several tumor cells in vitro and in animal tumor models. Furthermore, CIK cells activated by dendritic cell (DC) stimulation show increased anti-tumor activity. This study aimed to evaluate the clinical efficacy of DC-activated CI...

journal_title：Cytotherapy

authors： Li H,Wang C,Yu J,Cao S,Wei F,Zhang W,Han Y,Ren XB

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:The authors aim to analyze the evidence in the literature regarding the efficacy and safety of mesenchymal stem cell (MSC) therapy in human subjects with traumatic spinal cord injury (SCI) and identify its potential role in the management of SCI. METHODS:The authors conducted independent and duplicate ...

journal_title：Cytotherapy

authors： Muthu S,Jeyaraman M,Gulati A,Arora A

更新日期：2020-11-09 00:00:00