Abstract:
:Broader application of adoptive transfer of tumor-specific T-lymphocytes is accompanied by the need for effective suicide genes to ensure the safety of this cell-based therapy. In vivo elimination of T-lymphocytes expressing the herpes simplex virus-derived thymidine kinase gene has demonstrated the feasibility of this suicide gene as safety switch. However, improvements are required to overcome initial problems, such as immunogenicity. Here, newly developed suicide genes, including inducible Fas, inducible caspase and CD20 are discussed. In addition, problems of clinical application of marker genes and gene transfer techniques, which are prerequisites for suicide gene therapy, are addressed.
journal_name
Cytotherapyjournal_title
Cytotherapyauthors
Straathof KC,Spencer DM,Sutton RE,Rooney CMdoi
10.1080/14653240310001497keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
227-30issue
3eissn
1465-3249issn
1477-2566pii
7FYRW0WY2E9GB71Cjournal_volume
5pub_type
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