Abstract:
:The prognosis of patients with acute myeloid leukemia (AML) remains dismal, with a 5-year overall survival rate of only 5.2% for the continuously growing subgroup of AML patients older than 65 years. These patients are generally not considered eligible for intensive chemotherapy and/or allogeneic hematopoietic stem cell transplantation because of high treatment-related morbidity and mortality, emphasizing the need for novel, less toxic, treatment alternatives. It is within this context that immunotherapy has gained attention in recent years. In this review, we focus on the use of dendritic cell (DC) vaccines for immunotherapy of AML. DC are central orchestrators of the immune system, bridging innate and adaptive immunity and critical to the induction of anti-leukemic immunity. We discuss the rationale and basic principles of DC-based therapy for AML and review the clinical experience that has been obtained so far with this form of immunotherapy for patients with AML.
journal_name
Cytotherapyjournal_title
Cytotherapyauthors
Anguille S,Willemen Y,Lion E,Smits EL,Berneman ZNdoi
10.3109/14653249.2012.693744subject
Has Abstractpub_date
2012-07-01 00:00:00pages
647-56issue
6eissn
1465-3249issn
1477-2566pii
S1465-3249(12)70678-3journal_volume
14pub_type
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