Cellular transplants in amyotrophic lateral sclerosis patients: an observational study.

abstract：BACKGROUND AIMS:Tissue engineering technology is a promising therapeutic strategy in peripheral nerve injury. Schwann cells (SCs) are deemed to be a vital component of cell-based nerve regeneration therapies. Many methods for producing SC-like cells derived from adipose-derived stromal cells (ADSCs) have been explored,...

journal_title：Cytotherapy

authors： Kang Y,Liu Y,Liu Z,Ren S,Xiong H,Chen J,Duscher D,Machens HG,Liu W,Guo G,Zhan P,Chen H,Chen Z

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) are the most efficient antigen-presenting cells and act at the center of the immune system owing to their ability to control both immune tolerance and immunity. In cancer immunotherapy, DCs play a key role in the regulation of the immune response against tumors and can be generated ex v...

journal_title：Cytotherapy

authors： Bulgarelli J,Fiammenghi L,Cassan S,Granato AM,Petrini M,Pancisi E,Soldati V,De Rosa F,Ridolfi L,Riccobon A,Guidoboni M

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND AIMS:It is important to improve the migratory ability of dendritic cells (DCs) and to increase DC potency for successful DC-based cancer immunotherapy. The intracellular Ca(2+) signaling pathway has an important role on the regulation of DC migration. Our preliminary studies revealed that sarco/endoplasmic r...

journal_title：Cytotherapy

authors： Choi NR,Lee HJ,Jung SH,Hong CY,Vo MC,Hoang MD,Kim HJ,Lee JJ

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AIMS:Retinal degeneration (RD) is an inherited eye disease characterized by irreversible photoreceptor loss. Conventionally, the activation of the resident microglia is secondary to the disease. Stem cell-based therapy has recently made rapid progress in treating RD. Although it has been demonstrated that th...

journal_title：Cytotherapy

authors： Li Z,Zeng Y,Chen X,Li Q,Wu W,Xue L,Xu H,Yin ZQ

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND AIMS:The term "cerebral palsy" (CP) encompasses many syndromes that emerge from brain damage at early stages of ontogenesis and manifest as the inability to retain a normal body position or perform controlled movements. Existing methods of CP treatment, including various rehabilitation strategies and surgica...

journal_title：Cytotherapy

authors： Romanov YA,Tarakanov OP,Radaev SM,Dugina TN,Ryaskina SS,Darevskaya AN,Morozova YV,Khachatryan WA,Lebedev KE,Zotova NS,Burkova AS,Sukhikh GT,Smirnov VN

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AIMS:The therapeutic potential of human mesenchymal stromal cells (MSCs) has generated considerable interest in a wide variety of areas. MSC banking is feasible, but the optimal technique of cryopreservation remains to be determined. METHODS:To reduce dimethyl sulfoxide (DMSO) concentration in cryopreservat...

journal_title：Cytotherapy

authors： Briquet A,Halleux A,Lechanteur C,Beguin Y

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AIMS:Interleukin-21 (IL-21) can enhance the effector function of natural killer (NK) cells but also limits their proliferation when continuously combined with IL-2/IL-15. Paradoxically, membrane-bound (mb)-IL-21 has been shown to improve human NK cell proliferation when cultured with IL-2/mb-IL-15. To clarif...

journal_title：Cytotherapy

authors： Lim DP,Jang YY,Kim S,Koh SS,Lee JJ,Kim JS,Thi Phan MT,Shin DJ,Shin MG,Lee SH,Yoon M,Kim SK,Yoon JH,Park MH,Cho D

更新日期：2014-10-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) as a pharmaceutical for ailments characterized by pathogenic autoimmune, alloimmune and inflammatory processes now cover the spectrum of early- to late-phase clinical trials in both industry and academic sponsored studies. There is a broad consensus that despite different tissue sourci...

journal_title：Cytotherapy

authors： Galipeau J,Krampera M,Barrett J,Dazzi F,Deans RJ,DeBruijn J,Dominici M,Fibbe WE,Gee AP,Gimble JM,Hematti P,Koh MB,LeBlanc K,Martin I,McNiece IK,Mendicino M,Oh S,Ortiz L,Phinney DG,Planat V,Shi Y,Stroncek DF,Vi

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Hematopoietic progenitor cells (HPC) circulate at high levels at birth and disappear rapidly afterwards, but the underlying mechanism it is not known. The aim of this study was to assess circulating HPC in cord blood at different gestational ages and shortly after birth and concomitantly study the biologic m...

journal_title：Cytotherapy

authors： Gonzalez S,Amat L,Azqueta C,Madrigal JA,Laïlla JM,Garcia J,Querol S

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AIMS:The Quantum® Cell Expansion System (Quantum; Terumo BCT, Inc, Lakewood, CO, USA) is a novel hollow fiber-based device that automates and closes the cell culture process, reducing labor intensive tasks such as manual cell culture feeding and harvesting. The manual cell selection and expansion processes f...

journal_title：Cytotherapy

authors： Jones M,Varella-Garcia M,Skokan M,Bryce S,Schowinsky J,Peters R,Vang B,Brecheisen M,Startz T,Frank N,Nankervis B

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Mesenchymal stromal cells (MSC) are pluripotent progenitor cells that can be found in human bone marrow (BM). These cells have low immunogenicity and could suppress alloreactive T-cell responses. In the current study, MSC were tested for their capacity to carry and deliver the erythropoietin (EPO) gene in vi...

journal_title：Cytotherapy

authors： Mok PL,Cheong SK,Leong CF,Othman A

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AIMS:Pooled human platelet lysate (HPL) is becoming the new gold standard as supplement for ex vivo cell culture for clinical protocols. However, the risk of pathogen contamination of HPL increases with the platelet pool size. We hypothesized that hollow fiber anion exchange membrane chromatography using Qyu...

journal_title：Cytotherapy

authors： Kao YC,Bailey A,Samminger B,Tanimoto J,Burnouf T

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND AIMS:The aim was to evaluate cartilage regeneration in animal models involving induced knee joint damage. Through cell-mediated gene therapy methods, a cell mixture comprising a 3:1 ratio of genetically unmodified human chondrocytes and transforming growth factor beta-1 (TGF-beta1)-secreting human chondrocyt...

journal_title：Cytotherapy

authors： Noh MJ,Copeland RO,Yi Y,Choi KB,Meschter C,Hwang S,Lim CL,Yip V,Hyun JP,Lee HY,Lee KH

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AIMS:Despite the availability of multiple treatment strategies, patients with gastric carcinoma (GC) have a dismal prognosis. The aim of this study was to evaluate the efficacy and safety of cellular immunotherapy (CIT) with the use of autologous natural killer cells, γδT cells and cytokine-induced killer ce...

journal_title：Cytotherapy

authors： Cui J,Li L,Wang C,Jin H,Yao C,Wang Y,Li D,Tian H,Niu C,Wang G,Han W,Xu J,Chen J,Li W

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The isolation of lymphocytes - and removal of platelets (PLTs) and red blood cells (RBCs) - from an initial blood sample prior to culture is a key enabling step for effective manufacture of cellular therapies. Unfortunately, currently available methods suffer from various drawbacks, including low cell recove...

journal_title：Cytotherapy

authors： Strachan BC,Xia H,Vörös E,Gifford SC,Shevkoplyas SS

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND AIMS:Specific and effective therapy for prevention or reversal of bronchiolitis obliterans (BO) is lacking. In this study, we evaluated the therapeutic effect of hepatocyte growth factor (HGF) gene modified mesenchymal stromal cells (MSCs) on BO. METHODS:A mouse model of experimental BO was established by s...

journal_title：Cytotherapy

authors： Cao XP,Han DM,Zhao L,Guo ZK,Xiao FJ,Zhang YK,Zhang XY,Wang LS,Wang HX,Wang H

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND AIMS:Adipose tissue has therapeutic potential for spinal cord injury (SCI) because it contains multipotent cells known as adipose-derived stem/stromal cells (ASCs). In this study, we attempted intravenous ASC transplantation in rats with SCI to examine the effect on functional recovery. METHODS:ASCs (2.5 × ...

journal_title：Cytotherapy

authors： Ohta Y,Hamaguchi A,Ootaki M,Watanabe M,Takeba Y,Iiri T,Matsumoto N,Takenaga M

更新日期：2017-07-01 00:00:00

abstract：:he concept of particulates, while common to many in the pharmaceutical and blood transfusion disciplines, represents a distinct challenge in the field of cellular therapy. With newly discovered products advancing through clinical trials, the focus has shifted to ensuring products are manufactured in a reliable and saf...

journal_title：Cytotherapy

authors： Clarke D,Harati D,Martin J,Rowley J,Keller J,McCaman M,Carrion M,Karnieli O,Maziarz R,Perry R,Oh S,Stanton J

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND AIMS:Virus-specific T-cell immunotherapy is emerging as a promising management strategy for virus infections in patients after hematopoietic stem cell transplant (HSCT). Here we present outcomes of 10 adult patients who received multi-virus-specific T cells prophylactically after HSCT. METHODS:Donor-derived...

journal_title：Cytotherapy

authors： Ma CK,Blyth E,Clancy L,Simms R,Burgess J,Brown R,Deo S,Micklethwaite KP,Gottlieb DJ

更新日期：2015-10-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial hyperproliferation and dysfunction. Restoration of endothelial function is a common goal of available treatments. In the present study, human adipose-derived mesenchymal stromal cells (ASCs) were co-cultured with monocrotaline pyr...

journal_title：Cytotherapy

authors： Wang P,Zhang C,Li J,Luo L,Zhang S,Dong F,Tang Z,Ni S

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AIMS:Mesenchymal stromal cells (MSC) have been shown to be a promising candidate for tissue regeneration and cancer therapy. However, their therapeutic potential against chemotherapy-induced side-effects remains unclear. METHODS:We treated murine Lewis lung carcinoma (LLC) and xenograft human colon tumors w...

journal_title：Cytotherapy

authors： Di GH,Jiang S,Li FQ,Sun JZ,Wu CT,Hu X,Duan HF

更新日期：2012-04-01 00:00:00

abstract：:Kidney disease has reached epidemic proportions and is associated with high mortality and morbidity rates. Stem cell-based therapy may effectively treat kidney damage by cell transplantation. The breakthrough discovery using a combination of four transcription factors to reprogram genetically somatic cells into induce...

journal_title：Cytotherapy

authors： Wang WW,Wang W,Jiang Y,Han GF,Lu S,Li G,Zhang J

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND AIMS:Multiple cell-therapy products require density separation as a part of manufacturing. The traditional method for Ficoll separation, layering cell suspensions over Ficoll in tubes, followed by centrifugation and collection of cells from the interface, is too cumbersome and poses too high a risk of contam...

journal_title：Cytotherapy

authors： Janssen WE,Ribickas A,Meyer LV,Smilee RC

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Mismatched family donor and unrelated donor BM transplants are associated with a high risk of acute GvHD. White T-cell depletion is the best method to reduce risk of acute GvHD, there was a reluctance to use T-cell depletion in the mismatched setting because of increased risk of rejection and relapse. Partia...

journal_title：Cytotherapy

authors： Gajewski JL,Nimer S,Saliba RM,Thomas M,Przepiorka D,Giralt S,von Besien K,Mehra R,Andersson B,Chan KW,Ippoliti C,Warkinten D,Feigs S,Territo M,Schiller G,Lebkowski J,Moseley AM,Lloyd K,von Hoeff M,Okarma T,Champli

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Cell therapy has been proposed as a salvage limb procedure in critical limb ischemia (CLI). In spite of the fact that clinical trials found some efficacy, the mechanism of action remains elusive. The objective of this study was to characterize two autologous cell therapy products (CTPs) obtained from patient...

journal_title：Cytotherapy

authors： Tournois C,Pignon B,Sevestre MA,Al-Rifai R,Creuza V,Poitevin G,François C,Nguyen P

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND AIMS:Allogeneic hematopoietic stem cell transplantation is curative for sickle cell disease, and the use of matched related donors, non-myeloablative conditioning and sirolimus immunosuppression results in stable mixed chimerism without graft-versus-host disease (GVHD). However, the time to terminate sirolim...

journal_title：Cytotherapy

authors： Raines LN,Hsieh MM,Nassehi T,Drysdale CM,Tisdale JF,Uchida N

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND AIMS:Cutaneous wound management is a major health problem and imposes a huge economic burden worldwide. Previous studies have demonstrated that wound healing is a highly coordinated process including epithelialization, angiogenesis, remodeling and scarring. This progression requires self-renewal, preservatio...

journal_title：Cytotherapy

authors： Chen X,Yang R,Wang J,Ruan S,Lin Z,Xin Q,Yang R,Xie J

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AIMS:Cytokine-induced killer (CIK) cells have shown cytolytic activity against several tumor cells in vitro and in animal tumor models. Furthermore, CIK cells activated by dendritic cell (DC) stimulation show increased anti-tumor activity. This study aimed to evaluate the clinical efficacy of DC-activated CI...

journal_title：Cytotherapy

authors： Li H,Wang C,Yu J,Cao S,Wei F,Zhang W,Han Y,Ren XB

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The possible functional role of basic fibroblast growth factor (bFGF) in regulating the mitotic and metabolic activity of primary human articular chondrocytes was investigated. METHODS:[EF1]Chondrocytes were enzymatically isolated from femoral head cartilage, and were cultured in vitro in monolayer. bFGF-de...

journal_title：Cytotherapy

authors： Schmal H,Zwingmann J,Fehrenbach M,Finkenzeller G,Stark GB,Südkamp NP,Hartl D,Mehlhorn AT

更新日期：2007-01-01 00:00:00

abstract：:Initially used as an alternative hematopoietic stem cell source for patients without a human leukocyte antigen-matched bone marrow or peripheral blood stem cell donor, unrelated cord blood (UCB) is now the preferred donor source when hematopoietic stem cell transplantation (HSCT) is used to treat patients with lysosom...

journal_title：Cytotherapy

authors： Aldenhoven M,Kurtzberg J

更新日期：2015-06-01 00:00:00