Abstract:
:Abstract To clarify the effect of leukemia inhibitory factor (LIF) on the destruction of rheumatoid arthritis (RA) joints, we investigated the production of LIF and the expression of LIF mRNA in synovial tissues from patients with RA and osteoarthritis (OA). Synovial fluids from RA were used to measure the LIF concentrations using enzyme-linked immunosorbent assay (ELISA). Immunohistochemistory and RT-PCR were used to examine the expression of LIF by synovial cells. LIF mRNA was detected in all cases in RA synovial cells. Although LIF protein was detected only in 20 cases (19%) in RA synovial fluids, LIF concentration in the synovial fluids significantly correlated with the peripheral leukocyte count (P < 0.001) and C-reactive protein (CRP) (P < 0.01). Moreover, levels of IL-1β, IL-6, and IL-8, but not TNF-α, were significantly correlated with LIF in the RA synovial fluids. LIF production was promoted by IL-1β and TNF-α stimulation; in contrast, IL-1 ra and IL-4 were found to markedly decrease LIF production by cultured synovial cells. LIF appeared to be a cytokine produced by RA synovium leading to a proinflammatory secretion profile. Moreover, IL-4 and IL-1 ra may represent attenuated activity for reducing the effect of the destruction of joints by LIF.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Enomoto H,Saito S,Yabe H,Toyama Y,Tomatu Tdoi
10.3109/s10165-002-0210-9subject
Has Abstractpub_date
2003-06-01 00:00:00pages
121-8issue
2eissn
1439-7595issn
1439-7609journal_volume
13pub_type
杂志文章abstract::Tocilizumab (TCZ) is an interleukin-6 (IL-6) inhibitor used for the treatment of rheumatoid arthritis (RA). It was developed in 2008, and its effectiveness is supported by evidence from all over the world based on its first decade of use. Although the overall efficacy and safety profiles of TCZ are similar to those of...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1546357
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:The aim of our study is to clarify the association of myositis-specific autoantibodies (MSAs) with clinical and laboratory features in Japanese patients with juvenile idiopathic inflammatory myopathies (JIIMs). METHODS:We retrospectively analyzed the frequency of MSAs and their association with clinical or ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1452353
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:Pathogenesis and risk factors of scleroderma associated calcinosis is poorly understood and there is no effective treatment. This study was performed to better understand the prevalence and clinical features associated with calcinosis in a cohort of SSc outpatients. METHODS:In this cross-sectional study, we...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1349594
更新日期:2018-05-01 00:00:00
abstract::Endogenous lipoid pneumonia is an uncommon inflammatory pulmonary disease that is caused by lipids from an endogenous source, the treatment for which has not been established. We report the first case of endogenous lipoid pneumonia presenting as lung consolidation and which was associated with rheumatoid arthritis. Tr...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1193270
更新日期:2018-11-01 00:00:00
abstract::Abstract This work was undertaken to evaluate clinical and immunological features in patients with systemic lupus erythematosus (SLE) complicated by Jaccoud's arthropathy. Patients diagnosed with SLE between 1985 and 1999, and who met the criteria of Villiaumey et al., were checked for Jaccoud's arthropathy. Clinical ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170043
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVES:To determine the availability of bioelectrical impedance analysis (BIA), computed tomography (CT), and magnetic resonance imaging (MRI) for measurement of skeletal muscle mass in patients with rheumatic diseases and quantitatively assess skeletal muscle loss after glucocorticoid (GC) treatment. METHODS:The ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.935078
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:A self-administered foot evaluation questionnaire (SAFE-Q) was developed by the Japanese Society for Surgery of the Foot (JSSF). The aim of this study is to evaluate the validity and responsiveness of the SAFE-Q in patients with rheumatoid arthritis (RA). METHODS:In total, 180 patients with RA answered the ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.959243
更新日期:2015-05-01 00:00:00
abstract::Abstract We report the case of a 52-year-old man with Wegener's granulomatosis complicated with seropneumothorax. Pneumothorax or seropneumothorax has previously been reported as a rare complication of Wegener's granulomatosis. The patient was successfully treated with prednisolone and cyclophosphamide, and seropneumo...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-002-0220-7
更新日期:2003-06-01 00:00:00
abstract::This report documents the results of a study performed to examine clinical use of mizoribine (MZR), using data from a large-scale prospective cohort study, IORRA (Institute of Rheumatology Rheumatoid Arthritis). The number of patients with RA entered in this study from October 2000 through October 2003 was 6238. Three...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-006-0487-1
更新日期:2006-01-01 00:00:00
abstract::Bucillamine (Buc) is a disease-modifying antirheumatic drug (DMARD) developed in Japan, which has been used as one of the first-line DMARDs for the treatment of rheumatoid arthritis (RA) in Japan. However, direct comparison of this drug with standard DMARDs including sulfasalazine (SASP) and methotrexate (MTX) has bee...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-006-0527-x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:We examined the prevalence and risk factors of vertebral fracture in female Japanese patients with systemic lupus erythematosus (SLE). METHODS:We performed lateral radiographs of the thoracic and lumbar spine and bone mineral density (BMD) measurements and collected demographic, lifestyle, clinical, and trea...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0735-5
更新日期:2013-07-01 00:00:00
abstract::We evaluated the utility of HEp-2 cells transfected with the 60 kDa SS-A/Ro as a substrate for indirect immunofluorescence (IIF-HEp-2000) to compare several methods for screening Japanese serum samples for anti-SS-A/Ro antibodies. Serum samples from 243 Japanese patients were analyzed by IIF for anti-nuclear antibodie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0100-x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:Upper limit of methotrexate (MTX) for patients with rheumatoid arthritis (RA) was recently increased from 8 to 16 mg/week in Japan. We therefore examined the effect of concomitant MTX dose on the efficacy of adalimumab (ADA) in clinical practice. METHOD:Sixty-one consecutive RA patients treated with ADA were...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1170958
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Aspects of health-related quality of life (HRQoL) are important for assessing perceived health status and treatment burden. We evaluated HRQoL using Short Form 36 Health Survey (SF-36) and factors associated with HRQoL. METHODS:We collected basic and lifestyle-related, clinical, and treatment characteristics...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1060668
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To determine whether ultrasonography (US) predicts Boolean remission in rheumatoid arthritis (RA) patients who had achieved disease activity score in 28 joints (DAS28)-based remission criteria. METHODS:Thirty-one RA patients in DAS28-based clinical remission were recruited. US semiquantitatively determined ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.857800
更新日期:2014-07-01 00:00:00
abstract::We report a 24-year-old male with systemic lupus erythematosus (SLE) who developed influenza virus B-associated hemophagocytic syndrome and cardiac tamponade. Although the patient's general condition improved after steroid pulse therapy and pericardiocentesis, pericardial effusion re-accumulated. Colchicine and aspiri...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0241-6
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease. METHODS:All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild l...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0818-3
更新日期:2013-11-01 00:00:00
abstract::Abstract A woman with Sjögren's syndrome concurrently suffered bilateral fractures of the femoral neck without any proximate cause, while she had aseptic necrosis of the femoral head resulting from the treatment for Sjögren's syndrome. According to previous reports, fractures of the femoral neck following aseptic necr...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-004-0346-x
更新日期:2004-12-01 00:00:00
abstract::The patient described here is a 49-year-old woman who had hepatitis C virus (HCV) infection and rheumatoid arthritis (RA). Her RA had been successfully managed with methotrexate for about 10 years. After a sustained virological response was achieved with interferon therapy, treatment with adalimumab was instituted. Th...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0469-9
更新日期:2011-12-01 00:00:00
abstract::Abstract A 56-year-old man presented with hyperproteinemia and renal dysfunction associated with antineutrophil cytoplasmic antibodies (ANCA). He had had a ventriculoperitoneal shunt tube made of silicone implanted 4 years earlier. In his renal biopsy, necrotizing crescentic glomerulonephritis was identified: tests fo...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650300011
更新日期:2003-03-01 00:00:00
abstract::A postoperative lung cancer patient presented with lymphadenopathy, pleural thickening, and 18F-fluorodeoxyglucose (FDG) uptake on a positron emission tomography-computed tomography (PET-CT) scan. Lung cancer recurrence was initially suspected, but bilateral submandibular masses with 18F-FDG uptake indicated the possi...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0580-y
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:A multicenter, randomized, double-blind, placebo-controlled study of the oral calcineurin inhibitor tacrolimus was performed in patients with early rheumatoid arthritis who had responded poorly to disease-modifying antirheumatic drugs (DMARDs), and factors related to suppression of joint destruction were inv...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10165-012-0817-4
更新日期:2013-11-01 00:00:00
abstract:: ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-013-0870-7
更新日期:2013-04-04 00:00:00
abstract::For over 10 years there have been no clinical studies about adult-onset Still's disease (AOSD) in Japan. We aimed to investigate recent clinical features and treatment of AOSD and to evaluate the efficacy of cyclosporin A (CyA) in the treatment of AOSD. The data from 34 patients with AOSD who were admitted to our hosp...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0126-0
更新日期:2009-01-01 00:00:00
abstract::Objectives: To assess the middle-term outcome of iguratimod (IGU) in rheumatoid arthritis (RA) patients. Methods: Sixty-nine RA patients (14 males and 55 females, mean age of 64.0 years) receiving IGU-containing therapies were enrolled. We divided these patients into three groups based on the treatment at the baseline...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1510879
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:To assess changes in salivary epidermal growth factor (EGF) levels within three years and investigate the correlation between these changes and the severity of intraoral manifestations in patients with Sjögren's syndrome (SS). METHODS:Twenty-three SS patients (14 primary SS and 9 secondary SS) and 14 contro...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1034941
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To establish a new assessment tool for ulnar drift (UD) in rheumatoid arthritis (RA). METHODS:We established an observational cohort of 67 patients (134 rheumatoid hands) beginning in 2004. Fifty-two patients (100 hands) had follow-up in 2009 and 37 patients (63 hands) completed follow-up in 2015. UD was ev...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1442171
更新日期:2019-01-01 00:00:00
abstract::Abstract Osteoarthritis (OA) is considered to be a complex illness in which the tissues of the joint play a significant role in the initiation and/or progression of the pathophysiology. We still do not completely understand what initiates the degradation and loss of cartilage. However, it has been suggested that incr...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650300001
更新日期:2003-03-01 00:00:00
abstract::We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron's papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including stero...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0637-6
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:Although "clinical remission" has been a realistic goal of treatment in rheumatoid arthritis (RA), there is evidence that subclinical synovitis is associated with ongoing structural damage even after clinical remission is achieved. In the study reported here, we assessed whether ultrasonography (US) can pred...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0690-1
更新日期:2013-05-01 00:00:00