Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study.

abstract：OBJECTIVE:To assess the utilities of ultrasonography (US) and low-field magnetic resonance imaging (compacTscan, cMRI) in the diagnosis of subclinical synovitis of hand joints of patients with rheumatoid arthritis (RA). METHODS:A total of 1,540 joints of 77 RA patients were examined clinically, using US, using cMRI, a...

journal_title：Modern rheumatology

authors： Ogishima H,Tsuboi H,Umeda N,Horikoshi M,Kondo Y,Sugihara M,Suzuki T,Matsumoto I,Sumida T

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the improvement of health status in patients with rheumatoid arthritis (RA) treated with tocilizumab. METHODS:Thirty-nine patients were treated with 8 mg/kg tocilizumab every 4 weeks for 24 weeks. Disease activity was assessed by Clinical Disease Activity Index (CDAI) and Simplified Disease Activ...

journal_title：Modern rheumatology

authors： Fusama M,Nakahara H,Hamano Y,Nishide M,Kawamoto K,Hosokawa T,Nozato S,Higa S,Igarashi T,Takeuchi E,Kuroiwa T,Shimaoka Y,Yukioka M,Miura Y,Higashi K,Kuritani T,Maeda K

更新日期：2013-03-01 00:00:00

abstract：:Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his diseas...

journal_title：Modern rheumatology

authors： Ito T,Ozaki Y,Shimamoto K,Amuro H,Tanijiri T,Yokoi T,Son Y,Tajima K,Fukuhara S

更新日期：2008-01-01 00:00:00

abstract：:An 8-year-old girl with systemic-onset juvenile idiopathic arthritis (JIA) required surgical reduction for a dislocated left hip joint following failure of skin traction for 1 week. Unaided walking was achieved by 3 months postoperatively. Incongruence and irregularity of the hip joint remained but may resolve with ma...

journal_title：Modern rheumatology

authors： Inui K,Maeno T,Tada M,Takaoka K,Koike T

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:To assess the real-world effectiveness of golimumab in Japanese patients with rheumatoid arthritis who had previously received one or more biologic therapies. METHODS:A post-hoc analysis of post-marketing surveillance was performed. The clinical response to golimumab was analyzed in 1216 patients who had pr...

journal_title：Modern rheumatology

authors： Shimizu H,Kobayashi H,Kanbori M,Ishii Y

更新日期：2020-08-19 00:00:00

abstract：OBJECTIVE:This retrospective study was designed to evaluate the outcomes of four different surgical reconstructions for extensor tendon ruptures in ulnar three fingers in 48 patients with rheumatoid arthritis. METHODS:The following four techniques were performed; palmaris longus tendon grafting (PL group; n = 9), exte...

journal_title：Modern rheumatology

authors： Suzuki T,Iwamoto T,Ikegami H,Sakuma Y,Ikari K,Matsumura N,Ochi K,Sato K,Nakamura M,Matsumoto M,Momohara S

更新日期：2016-01-01 00:00:00

abstract：:Methotrexate (MTX) is indispensable for the treatment of rheumatoid arthritis (RA). However, a small number of patients treated with MTX occasionally encounter some life-threatening events, including myelosuppression. Renal insufficiency, one of risk factors for these events, is difficult to assess because the serum c...

journal_title：Modern rheumatology

authors： Hayashi T,Ito S,Goto D,Matsumoto I,Sumida T

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVES:Gout is a polygenic auto-inflammatory disease, in which inflammation plays an important role in disease pathogenesis. The cytokine interleukin (IL)-23 promotes inflammation and helps to guide inflammatory cells, while studies have shown that the IL-23R gene is associated with susceptibility to several immune...

journal_title：Modern rheumatology

authors： Liu S,He H,Yu R,Han L,Wang C,Cui Y,Li C

更新日期：2015-05-01 00:00:00

abstract：:The aim of this study was to evaluate the incidence of morphologic and functional cardiac abnormalities in patients with systemic lupus erythematosus (SLE) and to correlate the findings with levels of anti-Ro/SS-A, anti-La/SS-B, and anti-cardiolipin antibody (aCL). Sixty-two patients with SLE were enrolled in this stu...

journal_title：Modern rheumatology

authors： Shahin AA,Shahin HA,Hamid MA,Amin MA

更新日期：2004-01-01 00:00:00

abstract：:We evaluated the prevalence of Helicobacter pylori infection and the association of H. pylori infection and/or nonsteroidal anti-inflammatory drug (NSAID) use with upper gastrointestinal (UGI) ulcers in a cohort of Japanese patients with rheumatoid arthritis (RA). Using the clinical database of the cohort of RA patien...

journal_title：Modern rheumatology

authors： Tanaka E,Singh G,Saito A,Syouji A,Yamada T,Urano W,Nakajima A,Taniguchi A,Tomatsu T,Hara M,Saito T,Kamatani N,Yamanaka H

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-α inhibitors. METHODS:Change (Δ) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores w...

journal_title：Modern rheumatology

authors： Hirata S,Li W,Kubo S,Fukuyo S,Mizuno Y,Hanami K,Sawamukai N,Yamaoka K,Saito K,Defranoux NA,Tanaka Y

更新日期：2016-11-01 00:00:00

abstract：AIM:The purpose of this study was to assess morphological changes in the paravertebral muscles in patients with ankylosing spondylitis. MATERIALS AND METHODS:Fifty-one patients diagnosed with ankylosing spondylitis and a 50 member control group were included in the study. The surface area of the multifidus and erector...

journal_title：Modern rheumatology

authors： Resorlu H,Savas Y,Aylanc N,Gokmen F

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:The present study aimed to conduct an epidemiological survey of Central Sensitization Inventory (CSI) scores in an older adult population and to investigate the association between the CSI scores, age, sex, pain intensity, site of pain, and health-related quality of life (QOL). METHODS:Participants were 373...

journal_title：Modern rheumatology

authors： Ide K,Yasuda T,Hasegawa T,Yamato Y,Yoshida G,Banno T,Arima H,Oe S,Mihara Y,Ushirozako H,Yamada T,Watanabe Y,Nakai K,Hoshino H,Matsuyama Y

更新日期：2020-10-02 00:00:00

abstract：OBJECTIVES:Several biological disease-modifying antirheumatic drugs (bDMARDs) are currently available for the treatment of rheumatoid arthritis (RA). Increasing evidence indicates that second-line bDMARDs are effective for inadequate responders to first-line bDMARDs. However, all previous studies investigated the use o...

journal_title：Modern rheumatology

authors： Matsuno H,Katayama K

更新日期：2017-03-01 00:00:00

abstract：:A 24-year-old Japanese woman was admitted to our hospital suffering from high fever and progressive paralysis in both legs. Magnetic resonance imaging of the spinal cord showed high-intensity signals from C5 to Th4 and from Th7 to L1 on T2-weighted images. The patient was diagnosed as having acute transverse myelitis ...

journal_title：Modern rheumatology

authors： Yamanaka F,Migita K,Ichinose K,Ohno N,Kimura H,Ishimaru H,Matsuoka Y,Eguchi K,Ezaki H

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:The international classification criteria (CC) for definite antiphospholipid syndrome (APS) recommend confirmation of the sustained presence, for at least 12 weeks, of both lupus anticoagulant (LA), as determined by aPTT and RVVT, and anti β2glycoprotein I (β2GPI) or anticardiolipin (aCL) IgG and/or IgM. Howe...

journal_title：Modern rheumatology

authors： Sugiura-Ogasawara M,Atsumi T,Yamada H,Kitaori T,Ozaki Y,Katano K,Murashima A

更新日期：2015-01-01 00:00:00

abstract：:Objectives: Overactive bladder (OAB) is a clinical diagnosis defined with the presence of urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence. Objective was to evaluate the demographic and clinical characteristics of Japanese systemic sclerosis (SSc) patients wi...

journal_title：Modern rheumatology

authors： Motegi SI,Sekiguchi A,Sekine Y,Nakayama H,Suzuki K,Ishikawa O

更新日期：2020-03-01 00:00:00

abstract：:We present the case of a 60-year-old female patient with systemic sclerosis complicated by pulmonary hypertension. Ten days after the initiation of treatment with bosentan, high fever and skin eruptions were noted. In the previous reports, the frequency of drug-induced skin eruptions has not been well documented. Sinc...

journal_title：Modern rheumatology

authors： Nagai Y,Yamanaka M,Nishimura S,Nakano A,Hasegawa A,Ishikawa O

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to evaluate the efficacy and safety of bortezomib for treating systemic lupus erythematosus (SLE), in patients whose disease activity could not be controlled. METHODS:Fourteen SLE patients with persistent disease activity were selected, who required prednisolone doses of >10 m...

journal_title：Modern rheumatology

authors： Ishii T,Tanaka Y,Kawakami A,Saito K,Ichinose K,Fujii H,Shirota Y,Shirai T,Fujita Y,Watanabe R,Chiu SW,Yamaguchi T,Harigae H

更新日期：2018-11-01 00:00:00

abstract：:Tocilizumab (TCZ) is an interleukin-6 (IL-6) inhibitor used for the treatment of rheumatoid arthritis (RA). It was developed in 2008, and its effectiveness is supported by evidence from all over the world based on its first decade of use. Although the overall efficacy and safety profiles of TCZ are similar to those of...

journal_title：Modern rheumatology

authors： Ogata A,Kato Y,Higa S,Yoshizaki K

更新日期：2019-03-01 00:00:00

abstract：: ...

journal_title：Modern rheumatology

authors： Hatta Y,Hasegawa M,Matsushita T,Hamaguchi Y,Fujimoto M,Takehara K

更新日期：2013-04-27 00:00:00

abstract：:We performed this study to investigate the differences in radiological and laboratory findings between systemic juvenile idiopathic arthritis (s-JIA) and polyarthritis (p-JIA). Twenty-two patients with s-JIA and 18 with p-JIA were enrolled. Their laboratory findings and radiographs were examined retrospectively. Plain...

journal_title：Modern rheumatology

authors： Ozawa R,Inaba Y,Mori M,Hara R,Kikuchi M,Higuchi R,Miyamae T,Imagawa T,Fujiwara T,Saito T,Yokota S

更新日期：2012-08-01 00:00:00

abstract：:Anti-tumor necrosis factor (anti-TNF) biologics are effective in the treatment of rheumatoid arthritis (RA); however, it is still not clear whether this treatment promotes the development of malignancies such as lymphoma. Human T-lymphotropic virus type 1 (HTLV-1), which is a causative agent of adult T-cell lymphoma (...

journal_title：Modern rheumatology

authors： Umekita K,Umeki K,Miyauchi S,Ueno S,Kubo K,Kusumoto N,Takajo I,Nagatomo Y,Okayama A

更新日期：2015-09-01 00:00:00

abstract：:OBJECTIVES: To validate the 2010 histopathological classification system of anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (GN) in a Japanese single-center cohort. METHODS: We retrospectively studied 54 patients (28 renally limited pauci-immune GN, 25 microscopic polyangiitis, and one Chur...

journal_title：Modern rheumatology

authors： Togashi M,Komatsuda A,Nara M,Omokawa A,Okuyama S,Sawada K,Wakui H

更新日期：2013-04-12 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha)-blocking agents have been used increasingly in the treatment of severe refractory juvenile idiopathic arthritis (JIA). However, some patients have been forced to discontinue these agents because of the lack of efficacy or adverse events. In these situations, cases of switching fr...

journal_title：Modern rheumatology

authors： Nerome Y,Imanaka H,Nonaka Y,Takei S

更新日期：2007-01-01 00:00:00

abstract：:Cutaneous polyarteritis nodosa (CPAN) is a form of necrotizing vasculitis of small and medium-sized arteries. It is limited to the skin and has a recurrent and chronic course, possibly associated with fever, arthralgia, myalgia and neuropathy, but without visceral involvement. We report the clinical case of a 7-year-o...

journal_title：Modern rheumatology

authors： Valor L,Monteagudo I,de la Torre I,Fernández CG,Montoro M,Longo JL,Carreño L

更新日期：2014-07-01 00:00:00

abstract：:Synovial vascularization in the knee joints of six patients with rheumatoid arthritis who were treated with infliximab was evaluated by Doppler sonography. Power Doppler sonography demonstrated a significant reduction of color flow signals (P < 0.05), and spectral Doppler sonography demonstrated a significant increase...

journal_title：Modern rheumatology

authors： Takahashi A,Sato A,Yamadera Y,Takeda I,Kanno T,Ohguchi Y,Nishimaki T,Kasukawa R

更新日期：2005-01-01 00:00:00

abstract：:Relapsing polychondritis (RP) is a rare disease of unknown etiology causing systematic inflammation and resulting in destruction of cartilaginous tissues. We describe here an 18-year-old Japanese woman who developed severe airway stenosis as the initial symptom with auricular, nasal, and ocular inflammation. The effec...

journal_title：Modern rheumatology

authors： Yamaoka K,Saito K,Hanami K,Nakayamada S,Nawata M,Iwata S,Azuma T,Tanaka Y

更新日期：2007-01-01 00:00:00

abstract：AIM:The aim of this study was to analyze the effect of 18-week functional training (FT) program consisting in two sessions a week of in-water exercise and one of on-land exercise on pain, strength, and balance in women with fibromyalgia. METHODS:A sample consisting of 36 fibromyalgia patients was included in the study...

journal_title：Modern rheumatology

authors： Latorre Román PÁ,Santos E Campos MA,García-Pinillos F

更新日期：2015-01-01 00:00:00

abstract：:The development of multiple large tophi in patients with gout is rare. We report magnetic resonance (MR) and histological features of large subcutaneous tophi in a 32-year-old male patient with no known arthritis. His subcutaneous lesions were confused with a neoplastic process, evaluated by MR imaging, and surgically...

journal_title：Modern rheumatology

authors： Ryu K,Takeshita H,Takubo Y,Hirata M,Taniguchi D,Masuzawa N,Kishimoto M,Kubo T

更新日期：2005-01-01 00:00:00