Use of anti-tumor necrosis factor biologics in the treatment of rheumatoid arthritis does not change human T-lymphotropic virus type 1 markers: a case series.

abstract：OBJECTIVES:Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis. Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) affect its prognosis. YKL-40 protein impacts inflammation and tissue remodeling. Therefore, we evaluated the utility of YKL-40 bl...

journal_title：Modern rheumatology

authors： Furukawa T,Matsui K,Kitano M,Yokoyama Y,Sekiguchi M,Azuma N,Imai Y,Hirota S,Yamanishi K,Sano H

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:Joint space narrowing and osteophyte formation, radiographic features of knee osteoarthritis (OA), are not necessarily synchronous processes. We evaluated the relationship between medial minimum joint space width (mJSW) and osteophyte formation. METHODS:We conducted a retrospective study of 1050 individuals...

journal_title：Modern rheumatology

authors： Komatsu D,Hasegawa Y,Kojima T,Seki T,Higuchi Y,Ishiguro N

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to clarify the surgical indication for rheumatoid forefoot deformity according to background characteristics and plantar pressure. METHODS:Patients with rheumatoid arthritis were divided into a non-surgical group (group N) and a surgical group (group S). The former consisted o...

journal_title：Modern rheumatology

authors： Lee H,Ishikawa H,Miyagawa Y,Takai C,Nomura Y,Nemoto T,Kobayashi D,Abe A,Otani H,Ito S,Nakazono K,Ishii T,Saito S,Tokuhashi Y,Murasawa A

更新日期：2017-11-01 00:00:00

abstract：:The purpose of this study was to describe the prevalence of total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment in a large observational cohort in Japan. A total of 5,177 RA patients were studied for the prevalence of TJA, who were enrolled in the NinJa ...

journal_title：Modern rheumatology

authors： Nishino J,Tanaka S,Matsui T,Mori T,Nishimura K,Eto Y,Kaneko A,Saisho K,Yasuda M,Chiba N,Yoshinaga Y,Saeki Y,Seki A,Tohma S

更新日期：2009-01-01 00:00:00

abstract：:Abstract We investigated the role of nuclear factor (NF)-κB on tumor necrosis factor (TNF)-α-induced regulated upon activation, normal T-cell expressed and secreted (RANTES) expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis (RA). Using cultured human fibroblast-like synoviocytes from p...

journal_title：Modern rheumatology

authors： Hirano F,Kobayashi A,Hirano Y,Nomura Y,Fukawa E,Makino I

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVES:A self-administered foot evaluation questionnaire (SAFE-Q) was developed by the Japanese Society for Surgery of the Foot (JSSF). The aim of this study is to evaluate the validity and responsiveness of the SAFE-Q in patients with rheumatoid arthritis (RA). METHODS:In total, 180 patients with RA answered the ...

journal_title：Modern rheumatology

authors： Yano K,Ikari K,Ochi K,Ishida O,Sakuma Y,Yoshida S,Koyama T,Koenuma N,Momohara S

更新日期：2015-05-01 00:00:00

abstract：:We aimed to retrospectively review the incidence of pre-diabetes mellitus (preDM), one of the factors in metabolic syndrome screening, in patients with rheumatic diseases. We examined the levels of hemoglobin A1c (HbA1c) in a total of 498 patients with rheumatic diseases between April 2007 and March 2008 at the Depart...

journal_title：Modern rheumatology

authors： Origuchi T,Yamaguchi S,Inoue A,Kazaura Y,Matsuo N,Abiru N,Kawakami A,Eguchi K

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To retrospectively evaluate whether oral glucocorticoid (GC) administration can be tapered or discontinued over a 2-year observation period in patients with rheumatoid arthritis (RA) undergoing a stable oral GC treatment, without deterioration in the disease status. METHODS:Methotrexate (MTX) and prednisolon...

journal_title：Modern rheumatology

authors： Hirata S,Kohno H,Watanabe H,Tokunaga T,Yoshida Y,Sugimoto T,Mokuda S,Oda K,Nojima T,Sugiyama E

更新日期：2020-12-16 00:00:00

abstract：:Here, we report the case of a 69-year-old man with limited granulomatosis with polyangiitis (GPA; formerly Wegener's granulomatosis) who developed papillary thyroid cancer, adenocarcinoma of the stomach, and myelodysplastic syndrome following glucocorticoid treatment. This is the first report to present multiple malig...

journal_title：Modern rheumatology

authors： Cheon YH,Kim MG,Kim JE,Ha CY,Lee SI,Kim HO

更新日期：2016-01-01 00:00:00

abstract：:Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...

journal_title：Modern rheumatology

authors： Yagita M,Hamano T,Hatachi S,Fujita M

更新日期：2016-01-01 00:00:00

abstract：:A 20-year-old man presented with recurrent hemoptysis for seven months. A small subpleural nodule in his right lower lobe was found and excised surgically. Based on the presence of antiphospholipid antibodies (aPL) and vascular wall hypertrophy without vasculitis or an intraluminal thrombus, nonthrombotic proliferativ...

journal_title：Modern rheumatology

authors： Lee JS,Kim H,Lee EB,Song YW,Park JK

更新日期：2019-03-01 00:00:00

abstract：: ...

journal_title：Modern rheumatology

authors： Kajihara I,Jinnin M,Yamada S,Ichihara A,Makino T,Igata T,Masuguchi S,Fukushima S,Ihn H

更新日期：2013-04-04 00:00:00

abstract：OBJECTIVES:We aimed to clarify the characteristics of heme oxygenase (HO)-1 expressing cells in the synovium from rheumatoid arthritis (RA) and osteoarthritis (OA), and to investigate the co-expression of HO-1 and IgG-Fc/HLA-DR complex. METHODS:The characteristics of HO-1 expressing cells in the synovium were investig...

journal_title：Modern rheumatology

authors： Yang S,Ohe R,Aung NY,Kato T,Kabasawa T,Utsunomiya A,Takakubo Y,Takagi M,Yamakawa M

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS:Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joi...

journal_title：Modern rheumatology

authors： Nishino A,Kawashiri SY,Shimizu T,Umeda M,Fukui S,Koga T,Iwamoto N,Ichinose K,Tamai M,Nakamura H,Origuchi T,Nagata Y,Maeda T,Aoyagi K,Kawakami A

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:This study was performed to better know diagnosis associated with serum IgG4 concentration, and to explore the possibility for development of a serum IgG4 for IgG4-related disease (IgG4-RD) in Chinese populations. METHODS:We studied retrospectively 497 IgG4 serum subclass measurements from Peking Union Medic...

journal_title：Modern rheumatology

authors： Li P,Chen H,Deng C,Wu Z,Lin W,Zeng X,Zhang W,Zhang F,Li Y

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:To establish a new assessment tool for ulnar drift (UD) in rheumatoid arthritis (RA). METHODS:We established an observational cohort of 67 patients (134 rheumatoid hands) beginning in 2004. Fifty-two patients (100 hands) had follow-up in 2009 and 37 patients (63 hands) completed follow-up in 2015. UD was ev...

journal_title：Modern rheumatology

authors： Toyama S,Oda R,Tokunaga D,Taniguchi D,Nakamura S,Asada M,Fujiwara H,Kubo T

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:To assess gout and asymptomatic hyperuricemia in Japan and review treatment conditions. METHODS:This retrospective cross-sectional study analyzed the prevalence of hyperuricemia and gout, and characteristics and treatment of patients with those conditions, using Japanese health insurance claims and medical ...

journal_title：Modern rheumatology

authors： Koto R,Nakajima A,Horiuchi H,Yamanaka H

更新日期：2021-01-01 00:00:00

abstract：:We describe an 81-year-old man with immunoglobulin G4-related disease (IgG4-RD) presenting with submandibular gland, lymph node, lung, kidney, aortic wall, and prostate lesions with concomitant gastric cancer. After curative surgical treatment of the gastric cancer, corticosteroid therapy for progressively decreasing ...

journal_title：Modern rheumatology

authors： Horita S,Fujii H,Mizushima I,Fujisawa Y,Hara S,Yamada K,Inoue D,Nakajima K,Harada K,Kawano M

更新日期：2019-05-01 00:00:00

abstract：:We conducted a comprehensive meta-analysis to quantitatively evaluate the association of cytokine gene polymorphisms with systemic sclerosis (SSc) susceptibility. Electronic databases were used to identify published studies before July 2011. In total, 23 case-control studies including 3524 SSc cases and 6086 healthy c...

journal_title：Modern rheumatology

authors： Peng WJ,Pan HF,Tao JH,Wang BX,Lu MM,Wang S,He Q,Wang J

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:Pathogenesis and risk factors of scleroderma associated calcinosis is poorly understood and there is no effective treatment. This study was performed to better understand the prevalence and clinical features associated with calcinosis in a cohort of SSc outpatients. METHODS:In this cross-sectional study, we...

journal_title：Modern rheumatology

authors： Pai S,Hsu V

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Anti-cytokine therapy is reportedly useful in amyloid A (AA) amyloidosis complicating rheumatic diseases. However, to date no studies have directly compared the utility of tumour necrosis factor (TNF) inhibition to that of interleukin-6. The aim of our retrospective study was to compare the clinical utility ...

journal_title：Modern rheumatology

authors： Okuda Y,Ohnishi M,Matoba K,Jouyama K,Yamada A,Sawada N,Mokuda S,Murata Y,Takasugi K

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Anticentromere antibody (ACA) is generally considered to be a serological marker for systemic sclerosis (SSc). ACA-positive patients with primary Sjögren's syndrome (pSS) have also been reported. ACA often recognizes centromere proteins (CENPs): CENP-A, CENP-B, and CENP-C, and sometimes reacts to heterochrom...

journal_title：Modern rheumatology

authors： Tanaka N,Muro Y,Suzuki Y,Nishiyama S,Takada K,Sekiguchi M,Hashimoto N,Ohmura K,Shimoyama K,Saito I,Kawano M,Akiyama M

更新日期：2017-01-01 00:00:00

abstract：:Abstract The human major histocompatibility complex (MHC) class I gene HLA-B27 bears a striking association with ankylosing spondylitis and related spondyloarthropathies. This association transcends all ethnic and geographical boundaries. The primary function of HLA-B27 as an MHC class I protein is to form a complex w...

journal_title：Modern rheumatology

authors： Mehra NK,Kanga U

更新日期：2001-12-01 00:00:00

abstract：:The aim of our study was to determine the spectrum of the 12 most common familial Mediterranean fever gene (MEFV) mutations in Iranian patients with heterogeneous ethnicity, using the familial Mediterranean fever (FMF) strip assay test. A total of 36 patients were diagnosed according to established clinical criteria. ...

journal_title：Modern rheumatology

authors： Bidari A,Ghavidel-Parsa B,Najmabadi H,Talachian E,Haghighat-Shoar M,Broumand B,Ghalehbaghi B

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:The prediction of hip osteoarthritis (OA) progression is still a difficult issue. We have adopted (18)F-fluoride positron emission tomography (PET) for the evaluation of hip osteoarthritis, and investigated the prediction utility of (18)F-fluoride PET for both pain worsening and OA progression using a logisti...

journal_title：Modern rheumatology

authors： Kobayashi N,Inaba Y,Yukizawa Y,Ike H,Kubota S,Inoue T,Saito T

更新日期：2015-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a complex process of chronic and progressive inflammation associated with activation of numerous signaling molecules and transcription factors and hyperproliferation of synoviocytes of the affected joints, although the greater part of its pathophysiological process is explained by activati...

journal_title：Modern rheumatology

authors： Okamoto T

更新日期：2005-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective-tissue disease with a complex phenotype and varying disease course. Although SLE often causes a polyarticular synovitis, there are only a few case reports of abnormalities of the synovial lined sacroiliac joints. We report a case with an overlap...

journal_title：Modern rheumatology

authors： Chandrasekhara PK,Jayachandran NV,Thomas J,Narsimulu G

更新日期：2009-01-01 00:00:00

abstract：:A 49-year-old Japanese woman treated with oral corticosteroids, methotrexate, and infliximab for malignant rheumatoid arthritis was admitted because of fever and low back pain. The white blood cell count and C-reactive protein concentration were elevated. Lumbar and pelvic computed tomography showed enlargement of the...

journal_title：Modern rheumatology

authors： Oda S,Fujinaga H,Takahashi K

更新日期：2006-01-01 00:00:00

abstract：:Objectives: To assess the effects of belimumab on disease activity across multiple organ domains in Japanese patients from the Phase 3 randomized, double-blind, North-East Asia study, BEL113750 (NCT01345253).Methods: Patients, aged ≥18 years, with American College of Rheumatology-defined systemic lupus erythematosus (...

journal_title：Modern rheumatology

authors： Tanaka Y,Bass D,Chu M,Egginton S,Ji B,Roth D

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety of peficitinib for the treatment of rheumatoid arthritis (RA) in Asian patients. METHODS:Safety data from one Phase 2b, two Phase 3, and one open-label long-term extension study [data cut-off 31 May 2018] were pooled into Phase 3 studies (peficitinib 100 and 150 mg/day, and placebo) an...

journal_title：Modern rheumatology

authors： Takeuchi T,Tanaka Y,Rokuda M,Izutsu H,Kaneko Y,Fukuda M,Kato D

更新日期：2020-11-09 00:00:00