Anticentromere antibody-positive primary Sjögren's syndrome: Epitope analysis of a subset of anticentromere antibody-positive patients.

abstract：OBJECTIVES:To assess the influence of golimumab dosage and disease activity on joint destruction in patients with active rheumatoid arthritis (RA) in the GO-FORTH study. METHODS:Efficacy was compared among groups given basal methotrexate plus placebo, golimumab (50 mg), or golimumab (100 mg) with stratification by hig...

journal_title：Modern rheumatology

authors： Tanaka Y,Harigai M,Takeuchi T,Yamanaka H,Ishiguro N,Yamamoto K,Ishii Y,Nakajima H,Baker D,Miyasaka N,Koike T

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS:Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joi...

journal_title：Modern rheumatology

authors： Nishino A,Kawashiri SY,Shimizu T,Umeda M,Fukui S,Koga T,Iwamoto N,Ichinose K,Tamai M,Nakamura H,Origuchi T,Nagata Y,Maeda T,Aoyagi K,Kawakami A

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:This retrospective study was designed to evaluate the outcomes of four different surgical reconstructions for extensor tendon ruptures in ulnar three fingers in 48 patients with rheumatoid arthritis. METHODS:The following four techniques were performed; palmaris longus tendon grafting (PL group; n = 9), exte...

journal_title：Modern rheumatology

authors： Suzuki T,Iwamoto T,Ikegami H,Sakuma Y,Ikari K,Matsumura N,Ochi K,Sato K,Nakamura M,Matsumoto M,Momohara S

更新日期：2016-01-01 00:00:00

abstract：:To evaluate the efficacy of high-dose leukocytapheresis (LCAP) using a large filter in patients with refractory rheumatoid arthritis (RA), we conducted a multicenter, nonrandomized, open-label clinical study. Thirty patients with highly active RA were treated with high-dose LCAP performed 3-5 sessions at 1-week interv...

journal_title：Modern rheumatology

authors： Eguchi K,Saito K,Kondo M,Hidaka T,Ueki Y,Tanaka Y,LCAP Investigators in Kyushu College of Rheumatology (LIKCR).

更新日期：2007-01-01 00:00:00

abstract：:Management of rheumatoid arthritis (RA) has improved over the last 10 years. These changes have been monitored in the Institute of Rheumatology, Rheumatoid Arthritis (IORRA) observational cohort, and clinical remission has become a realistic goal. However, we should recognize that the ultimate goal of treatment is to ...

journal_title：Modern rheumatology

authors： Yamanaka H,Seto Y,Tanaka E,Furuya T,Nakajima A,Ikari K,Taniguchi A,Momohara S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the relationship between magnetic resonance imaging (MRI) findings before extracorporeal shockwave therapy (ESWT) and the treatment outcome of ESWT. METHODS:This study examined 50 feet with chronic plantar fasciitis. The scores before ESWT and after a six-month f...

journal_title：Modern rheumatology

authors： Maki M,Ikoma K,Imai K,Kido M,Hara Y,Arai Y,Fujiwara H,Kubo T

更新日期：2015-05-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha)-blocking agents have been used increasingly in the treatment of severe refractory juvenile idiopathic arthritis (JIA). However, some patients have been forced to discontinue these agents because of the lack of efficacy or adverse events. In these situations, cases of switching fr...

journal_title：Modern rheumatology

authors： Nerome Y,Imanaka H,Nonaka Y,Takei S

更新日期：2007-01-01 00:00:00

abstract：:OBJECTIVES: To validate the 2010 histopathological classification system of anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (GN) in a Japanese single-center cohort. METHODS: We retrospectively studied 54 patients (28 renally limited pauci-immune GN, 25 microscopic polyangiitis, and one Chur...

journal_title：Modern rheumatology

authors： Togashi M,Komatsuda A,Nara M,Omokawa A,Okuyama S,Sawada K,Wakui H

更新日期：2013-04-12 00:00:00

abstract：:Inflammation has often been considered to be a nonspecific response and to play a bridging role in the activation of adaptive immunity. However, it is now accepted that inflammation is the product of an independent innate immune system closely linked to the adaptive immune system. The key mediators of inflammation are...

journal_title：Modern rheumatology

authors： Yokota S,Kikuchi M,Nozawa T,Kanetaka T,Sato T,Yamazaki K,Sakurai N,Hara R,Mori M

更新日期：2015-01-01 00:00:00

abstract：:We evaluated the prevalence of Helicobacter pylori infection and the association of H. pylori infection and/or nonsteroidal anti-inflammatory drug (NSAID) use with upper gastrointestinal (UGI) ulcers in a cohort of Japanese patients with rheumatoid arthritis (RA). Using the clinical database of the cohort of RA patien...

journal_title：Modern rheumatology

authors： Tanaka E,Singh G,Saito A,Syouji A,Yamada T,Urano W,Nakajima A,Taniguchi A,Tomatsu T,Hara M,Saito T,Kamatani N,Yamanaka H

更新日期：2005-01-01 00:00:00

abstract：:Abstract We report the case of a 52-year-old man with Wegener's granulomatosis complicated with seropneumothorax. Pneumothorax or seropneumothorax has previously been reported as a rare complication of Wegener's granulomatosis. The patient was successfully treated with prednisolone and cyclophosphamide, and seropneumo...

journal_title：Modern rheumatology

authors： Shimizu T,Ohara T,Ito S,Nakano M,Tsutsui N,Sato T,Suzuki E,Gejyo F

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVES:We aimed to clarify the characteristics of heme oxygenase (HO)-1 expressing cells in the synovium from rheumatoid arthritis (RA) and osteoarthritis (OA), and to investigate the co-expression of HO-1 and IgG-Fc/HLA-DR complex. METHODS:The characteristics of HO-1 expressing cells in the synovium were investig...

journal_title：Modern rheumatology

authors： Yang S,Ohe R,Aung NY,Kato T,Kabasawa T,Utsunomiya A,Takakubo Y,Takagi M,Yamakawa M

更新日期：2021-01-01 00:00:00

abstract：:Despite a number of published reports, including from our own laboratory, suggesting that adeno-associated virus (AAV) transduces mouse synovium, a careful analysis demonstrated transduction predominantly of the subsynovial muscle tissue, while the synovial lining is poorly transduced. To investigate the potential of ...

journal_title：Modern rheumatology

authors： Katakura S,Jennings K,Watanabe S,Adachi E,Thornton S,Gao GP,Wilson JM,Burstein H,Trapnell B,Hirsch R

更新日期：2004-01-01 00:00:00

abstract：:The influence of estrogen therapy on changes in arthritis and bone mineral density (BMD) was evaluated using an estrogen-replete collagen-induced arthritis (CIA) rat model. Seven-month-old female Sprague-Dawley rats (n = 30) were divided into the three groups; control (CONT), collagen sensitization (CIA), and CIA + 17...

journal_title：Modern rheumatology

authors： Yoshioka T,Hagino H,Yamasaki D,Okano T,Teshima R

更新日期：2008-01-01 00:00:00

abstract：:Research into the bone destruction associated with rheumatoid arthritis has highlighted the importance of the interplay of the immune and skeletal systems. Arthritic bone destruction is attributable to the defective control of osteoclastogenesis by T cells. We revealed that excessive expression of receptor activator o...

journal_title：Modern rheumatology

authors： Takayanagi H

更新日期：2005-01-01 00:00:00

abstract：:Blau syndrome/early-onset sarcoidosis (Blau/EOS) is an autoinflammatory disease characterized by granulomatous arthritis, uveitis, and skin rash. It has been shown that gain-of-function NOD2 mutations cause Blau/EOS. In this paper, we describe a patient with a gain-of-function NOD2 mutation who developed infantile Tak...

journal_title：Modern rheumatology

authors： Inoue Y,Kawaguchi Y,Shimojo N,Yamaguchi K,Morita Y,Nakano T,Arima T,Tomiita M,Kohno Y

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:Lupus enteritis (LE) is a rare but well-known gastrointestinal manifestation of systemic lupus erythematosus (SLE). This study was conducted to identify prognostic factors associated with poor responses in patients with LE. METHODS:We consecutively registered patients diagnosed with LE between January 2009 ...

journal_title：Modern rheumatology

authors： Yoshida Y,Omoto T,Kohno H,Tokunaga T,Kuranobu T,Yukawa K,Watanabe H,Oi K,Sugimoto T,Mokuda S,Nojima T,Hirata S,Sugiyama E

更新日期：2020-09-07 00:00:00

abstract：OBJECTIVES:To understand the status of mizoribine use in patients with lupus nephritis (LN) and to collect safety- and efficacy-related data on 2-year treatment with mizoribine. METHODS:A continuous survey was conducted between March 2010 and July 2015. RESULTS:The analysis set included 559 patients (mean age 39.5 ye...

journal_title：Modern rheumatology

authors： Takeuchi T,Okada K,Yoshida H,Yagi N

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Avascular necrosis of bone (AVN) is an important complication of systemic lupus erythematosus (SLE). Corticosteroid therapy has been underlined as a main risk factor for osteonecrosis. However, AVN development in patients who have never received corticosteroid and the absence of AVN in the majority of the pat...

journal_title：Modern rheumatology

authors： Faezi ST,Hoseinian AS,Paragomi P,Akbarian M,Esfahanian F,Gharibdoost F,Akhlaghi M,Nadji A,Jamshidi AR,Shahram F,Nejadhosseinian M,Davatchi F

更新日期：2015-07-01 00:00:00

abstract：:The purpose of this study was to describe the prevalence of total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment in a large observational cohort in Japan. A total of 5,177 RA patients were studied for the prevalence of TJA, who were enrolled in the NinJa ...

journal_title：Modern rheumatology

authors： Nishino J,Tanaka S,Matsui T,Mori T,Nishimura K,Eto Y,Kaneko A,Saisho K,Yasuda M,Chiba N,Yoshinaga Y,Saeki Y,Seki A,Tohma S

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS:J-RAPID double-blind patients were ente...

journal_title：Modern rheumatology

authors： Tanaka Y,Yamamoto K,Takeuchi T,Yamanaka H,Ishiguro N,Eguchi K,Watanabe A,Origasa H,Shoji T,Miyasaka N,Koike T

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:We investigated the relationship between morphological features in the lower limbs and the progression of knee osteoarthritis (OA) in 6-years. METHODS:Volunteer subjects from Toei (101 women and 54 men). Knee OA was evaluated on whole-leg radiographs. Subjects were divided into group 1, no knee OA; group 2,...

journal_title：Modern rheumatology

authors： Tran DH,Hoshino H,Matsuyama Y

更新日期：2020-09-03 00:00:00

abstract：OBJECTIVES:Although "clinical remission" has been a realistic goal of treatment in rheumatoid arthritis (RA), there is evidence that subclinical synovitis is associated with ongoing structural damage even after clinical remission is achieved. In the study reported here, we assessed whether ultrasonography (US) can pred...

journal_title：Modern rheumatology

authors： Yoshimi R,Hama M,Takase K,Ihata A,Kishimoto D,Terauchi K,Watanabe R,Uehara T,Samukawa S,Ueda A,Takeno M,Ishigatsubo Y

更新日期：2013-05-01 00:00:00

abstract：:Objectives: Secondary central nervous system vasculitis (SCNSV) is an extremely rare, refractory, and fatal disease in patients with giant cell arteritis (GCA). We compared the characteristics of GCA patients with and without SCNSV.Methods: This retrospective, single-center, observational cohort study included 35 pati...

journal_title：Modern rheumatology

authors： Abe Y,Harada M,Tada K,Yamaji K,Tamura N

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:This study was performed to better know diagnosis associated with serum IgG4 concentration, and to explore the possibility for development of a serum IgG4 for IgG4-related disease (IgG4-RD) in Chinese populations. METHODS:We studied retrospectively 497 IgG4 serum subclass measurements from Peking Union Medic...

journal_title：Modern rheumatology

authors： Li P,Chen H,Deng C,Wu Z,Lin W,Zeng X,Zhang W,Zhang F,Li Y

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:We examined the prevalence and risk factors of vertebral fracture in female Japanese patients with systemic lupus erythematosus (SLE). METHODS:We performed lateral radiographs of the thoracic and lumbar spine and bone mineral density (BMD) measurements and collected demographic, lifestyle, clinical, and trea...

journal_title：Modern rheumatology

authors： Furukawa M,Kiyohara C,Horiuchi T,Tsukamoto H,Mitoma H,Kimoto Y,Uchino A,Nakagawa M,Oryoji K,Shimoda T,Harada M,Akashi K

更新日期：2013-07-01 00:00:00

abstract：:Abstract  This study examined the pathogenesis of large pseudocysts adjacent to knee joints in rheumatoid arthritis (RA). The radiological and histopathological features of 17 large subarticular pseudocysts in 12 knee joints of 10 patients were analyzed. Nine of the 10 patients were classified as class 2 according to ...

journal_title：Modern rheumatology

authors： Yoshida M,Ichinohe S,Uzuki M,Yoshida W,Sawai T,Shimamura T

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVES:We investigated the characteristics of circulating T-helper (Th) cells and CD4+ regulatory T cells (Tregs) in polyarteritis nodosa (PAN). METHODS:Peripheral blood samples were obtained from 14 patients with PAN. Nine patients having granulomatosis with polyangiitis (GPA) and 11 healthy individuals (HC) were...

journal_title：Modern rheumatology

authors： Shimojima Y,Ishii W,Kishida D,Fukushima K,Ikeda SI

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to clarify the surgical indication for rheumatoid forefoot deformity according to background characteristics and plantar pressure. METHODS:Patients with rheumatoid arthritis were divided into a non-surgical group (group N) and a surgical group (group S). The former consisted o...

journal_title：Modern rheumatology

authors： Lee H,Ishikawa H,Miyagawa Y,Takai C,Nomura Y,Nemoto T,Kobayashi D,Abe A,Otani H,Ito S,Nakazono K,Ishii T,Saito S,Tokuhashi Y,Murasawa A

更新日期：2017-11-01 00:00:00

abstract：:The aim of this study was to investigate the reliability and the validity of the Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia (ACR 2010-J), and its quantification scale, the Fibromyalgia Symptom Scale (FS-J). In this study, we divided patients with chro...

journal_title：Modern rheumatology

authors： Usui C,Hatta K,Aratani S,Yagishita N,Nishioka K,Kanazawa T,Ito K,Yamano Y,Nakamura H,Nakajima T,Nishioka K

更新日期：2012-02-01 00:00:00