Abstract:
:Inflammation has often been considered to be a nonspecific response and to play a bridging role in the activation of adaptive immunity. However, it is now accepted that inflammation is the product of an independent innate immune system closely linked to the adaptive immune system. The key mediators of inflammation are inflammatory cytokines, as determined by multiple lines of evidence both in vitro and in vivo. Due to the crucial role of inflammatory cytokines in the pathogenesis of autoimmune disorders, anti-cytokine treatment has been developed as a therapy for rheumatoid arthritis, juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases. We recently completed several clinical trials of anti-cytokine treatment for children with systemic inflammatory diseases: anti-IL-6 receptor monoclonal antibody (tocilizumab) for children with two subtypes of JIA (poly-JIA and systemic JIA), anti-TNF-α monoclonal antibody (infliximab) for children with Kawasaki disease, and anti-IL-1-β monoclonal antibody (canakinumab) for children with cryopyrin-associated periodic syndrome. This review summarizes the basis of inflammation in terms of innate immunity and adaptive immunity in these systemic inflammatory diseases, clinical efficacy, and tolerability of these biologic agents, and attempts to determine the roles of individual inflammatory cytokines in disease pathogenesis.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Yokota S,Kikuchi M,Nozawa T,Kanetaka T,Sato T,Yamazaki K,Sakurai N,Hara R,Mori Mdoi
10.3109/14397595.2014.902747subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1-10issue
1eissn
1439-7595issn
1439-7609journal_volume
25pub_type
杂志文章,评审abstract::Abstract Three cases of childhood-onset systemic lupus erythematosus (childhood SLE) with long-term remission are reported. These cases were not complicated with collagen diseases and had no SLE disease activity index scores either 3 or 5 years after onset. We suggest that some patients with childhood SLE may be able ...
journal_title:Modern rheumatology
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pub_type: 临床试验,杂志文章
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更新日期:2011-10-01 00:00:00
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更新日期:2020-12-16 00:00:00
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doi:10.1080/14397595.2020.1804668
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pub_type: 杂志文章
doi:10.3109/14397595.2013.854048
更新日期:2014-01-01 00:00:00
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更新日期:2012-09-01 00:00:00
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更新日期:2014-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2008-01-01 00:00:00
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更新日期:2021-01-01 00:00:00