Abstract:
:Cutaneous polyarteritis nodosa (CPAN) is a form of necrotizing vasculitis of small and medium-sized arteries. It is limited to the skin and has a recurrent and chronic course, possibly associated with fever, arthralgia, myalgia and neuropathy, but without visceral involvement. We report the clinical case of a 7-year-old male patient with CPAN refractory to treatment with high doses of corticoids and cyclophosphamide, who was successfully treated with the TNF-α (tumor necrosis factor-alpha) inhibitor, etanercept, in monotherapy.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Valor L,Monteagudo I,de la Torre I,Fernández CG,Montoro M,Longo JL,Carreño Ldoi
10.3109/14397595.2013.874737subject
Has Abstractpub_date
2014-07-01 00:00:00pages
688-9issue
4eissn
1439-7595issn
1439-7609journal_volume
24pub_type
杂志文章abstract::Abstract Three cases of childhood-onset systemic lupus erythematosus (childhood SLE) with long-term remission are reported. These cases were not complicated with collagen diseases and had no SLE disease activity index scores either 3 or 5 years after onset. We suggest that some patients with childhood SLE may be able ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-003-0238-5
更新日期:2003-09-01 00:00:00
abstract::We investigated the clinical efficacy and safety of tocilizumab (a humanized anti-IL-6 receptor antibody) monotherapy in active rheumatoid arthritis (RA) patients with an inadequate response to low dose methotrexate (MTX). In a multicenter, double-blind, randomized, controlled trial, 125 patients were allocated to rec...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s10165-008-0125-1
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Colchicine is the mainstay of the treatment of familial Mediterranean fever (FMF). However, 10% of FMF patients do not respond well to colchicine. Efficacy of interleukin (IL)-1 inhibitors in reducing attacks have been demonstrated in colchicine-resistant FMF (crFMF) patients recently. Colchicine is still th...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1457469
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION:Assessment of synovitis in the metatarsophalangeal (MTP) joints with ultrasound has been shown to improve the accuracy of assessment of rheumatoid arthritis (RA). However, the presence of intraarticular low-echoic synovial area (LESA) in the MTP joints in healthy subjects complicates the sonographic assess...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.970740
更新日期:2015-05-01 00:00:00
abstract::A 19-year-old Japanese woman with a 4-year history of Crohn's disease (CD) developed high fever, polyarthralgia, and painful subcutaneous nodules of the legs. A skin biopsy showed panarteritis with fibrinoid necrosis in the deep dermis. Endoscopic examination showed aphthous lesions in the entire colon. She was diagno...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0110-8
更新日期:2008-01-01 00:00:00
abstract::Abstract Gout is a disease caused by an inflammatory response to an aggregation of monosodium urate crystals that develop secondary to hyperuricemia. Throughout its natural history it has four stages: asymptomatic hyperuricemia, acute gouty arthritis, intercritical gout, and chronic tophaceous gout. In this article, w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-004-0314-5
更新日期:2004-09-01 00:00:00
abstract::We performed this study to investigate the differences in radiological and laboratory findings between systemic juvenile idiopathic arthritis (s-JIA) and polyarthritis (p-JIA). Twenty-two patients with s-JIA and 18 with p-JIA were enrolled. Their laboratory findings and radiographs were examined retrospectively. Plain...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0540-6
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:In recent years, concern has been raised about Juvenile Idiopathic Arthritis (JIA) that it could be associated with an increased risk for malignancies. Therefore, the cancer incidence in the JIA patients was evaluated and compared to the cancer incidence in the German population. METHODS:A retrospective sin...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1204711
更新日期:2017-01-01 00:00:00
abstract::Aortitis, inflammation of the aortic tissue, is most commonly caused by vasculitic rheumatic conditions, and less frequently infectious organisms. Involvement of the aorta is well defined in HLA-B27-associated spondyloarthropathies such as long-standing ankylosing spondylitis and Reiter's syndrome. However, unlike oth...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0566-9
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:Locomotive syndrome (LS) encompasses conditions that may lead to the need for nursing services. We aimed to quantify the association between exercise habits during youth or the middle-age years and both physical function and the presence of LS in Japanese elderly people. METHODS:We examined 460 participants...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1333670
更新日期:2018-03-01 00:00:00
abstract::Tumor necrosis factor (TNF) plays an important role in the host defense mechanism, and anti-TNF antibody therapies may increase the risk of serious infections. We herein report a case of 57-year-old male with rheumatoid arthritis who developed brucellosis during treatment with infliximab in combination with methotrexa...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0388-1
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:Gout is a polygenic auto-inflammatory disease, in which inflammation plays an important role in disease pathogenesis. The cytokine interleukin (IL)-23 promotes inflammation and helps to guide inflammatory cells, while studies have shown that the IL-23R gene is associated with susceptibility to several immune...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.964823
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the improvement of health status in patients with rheumatoid arthritis (RA) treated with tocilizumab. METHODS:Thirty-nine patients were treated with 8 mg/kg tocilizumab every 4 weeks for 24 weeks. Disease activity was assessed by Clinical Disease Activity Index (CDAI) and Simplified Disease Activ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0674-1
更新日期:2013-03-01 00:00:00
abstract:AIM:The aim of this study was to analyze the effect of 18-week functional training (FT) program consisting in two sessions a week of in-water exercise and one of on-land exercise on pain, strength, and balance in women with fibromyalgia. METHODS:A sample consisting of 36 fibromyalgia patients was included in the study...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2015.1040614
更新日期:2015-01-01 00:00:00
abstract::Abstract The human major histocompatibility complex (MHC) class I gene HLA-B27 bears a striking association with ankylosing spondylitis and related spondyloarthropathies. This association transcends all ethnic and geographical boundaries. The primary function of HLA-B27 as an MHC class I protein is to form a complex w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-001-8056-0
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and efficacy of reducing the duration of infliximab infusion for rheumatoid arthritis (RA) treatment. METHODS:The first 6 infliximab infusions were each administered over a 2-h period. If no adverse reaction was observed, infusion times were shortened to 1 h starting with the seventh i...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.843747
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVES:Joint space narrowing and osteophyte formation, radiographic features of knee osteoarthritis (OA), are not necessarily synchronous processes. We evaluated the relationship between medial minimum joint space width (mJSW) and osteophyte formation. METHODS:We conducted a retrospective study of 1050 individuals...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1232775
更新日期:2017-07-01 00:00:00
abstract::To evaluate the composite disease activity indices for rheumatoid arthritis (RA), we compared disease activities and the changes therein calculated using the Disease Activity Score based on 28 joint counts using erythrocyte sedimentation rate (DAS28-ESR), DAS28-CRP (C-reactive protein), Simplified Disease Activity Ind...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0367-6
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to evaluate the efficacy and safety of long-term (64 weeks; 52-week extension of a 12-week study) baricitinib treatment in Japanese patients with active rheumatoid arthritis (RA) despite methotrexate therapy. METHODS:Patients (N = 145) with active RA were randomized to placebo...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1080/14397595.2017.1307899
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To assess the utilities of ultrasonography (US) and low-field magnetic resonance imaging (compacTscan, cMRI) in the diagnosis of subclinical synovitis of hand joints of patients with rheumatoid arthritis (RA). METHODS:A total of 1,540 joints of 77 RA patients were examined clinically, using US, using cMRI, a...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.854050
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis. Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) affect its prognosis. YKL-40 protein impacts inflammation and tissue remodeling. Therefore, we evaluated the utility of YKL-40 bl...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1480256
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to develop clinical practice guideline (CPG) for Sjögren's syndrome (SS) based on recently available clinical and therapeutic evidences. METHODS:The CPG committee for SS was organized by the Research Team for Autoimmune Diseases, Research Program for Intractable Disease of the...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1438093
更新日期:2018-05-01 00:00:00
abstract::A 10-year cohort study was performed, involving all of the 118 patients treated with bucillamine in our hospital between 1988 and 1990. Evaluation was made on the basis of erythrocyte sedimentation rate, grip strength, joint score, duration of morning stiffness, and Lansbury index consisting of the above four paramete...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0533-z
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy and safety of intravenous (IV) belimumab plus standard systemic lupus erythematosus (SLE) therapy standard of care (SoC) in Japanese patients with SLE. METHODS:A Phase 3, multicenter, double-blind, placebo-controlled, 52-week study (BEL 113750; NCT01345253) in patients with SLE, rando...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/14397595.2018.1480915
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the relationship between magnetic resonance imaging (MRI) findings before extracorporeal shockwave therapy (ESWT) and the treatment outcome of ESWT. METHODS:This study examined 50 feet with chronic plantar fasciitis. The scores before ESWT and after a six-month f...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.978526
更新日期:2015-05-01 00:00:00
abstract::The association of either thrombotic thrombocytopenic purpura (TTP) or crescentic glomerulonephritis with Sjögren's syndrome is rare. We report a case of TTP appearing after the diagnosis of SjOgren's syndrome with crescentic glomerulonephritis and membranous nephropathy. Circulating immune complex was detected, and i...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0287-4
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS:Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joi...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1253813
更新日期:2017-07-01 00:00:00
abstract::Abstract This study examined the pathogenesis of large pseudocysts adjacent to knee joints in rheumatoid arthritis (RA). The radiological and histopathological features of 17 large subarticular pseudocysts in 12 knee joints of 10 patients were analyzed. Nine of the 10 patients were classified as class 2 according to ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200022
更新日期:2002-06-01 00:00:00
abstract::Abstract An accumulating body of evidence shows that gene therapy can be successfully used to treat animal models of arthritis. Based on this success, a clinical trial of gene therapy for rheumatoid arthritis has been initiated. We review the methods and genes used for the previous gene transfer experiments, including...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650050003
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:We aimed to analyze clinical features and treatment outcomes of otitis media caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), i.e. otitis media with AAV (OMAAV). METHODS:This survey was performed between December 2013 and February 2014. The study began with a preliminary surv...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1177926
更新日期:2017-01-01 00:00:00