Abstract:
OBJECTIVES:Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis. Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) affect its prognosis. YKL-40 protein impacts inflammation and tissue remodeling. Therefore, we evaluated the utility of YKL-40 blood levels in identifying patients with SSc complicated by PAH, as confirmed by immunohistochemistry (IHC) examination. METHODS:We retrospectively analyzed 78 patients with SSc and performed IHC on 7 normal and 7 SSc skin samples in the Japanese population. Age-adjusted YKL-40 serum levels were analyzed. RESULTS:YKL-40 age percentile was significantly elevated in SSc patients. There was no difference between patients with SSc with and without ILD and PAH. YKL-40 age percentile was greater in patients with PAH complication. YKL-40 immunostaining was negative in normal skin and prominent in the subcutaneous vascular wall of all SSc samples. Receiver operating characteristic (ROC) curve analysis indicated that YKL-40 age percentile correctly differentiated between patients with and without PAH with a sensitivity of 80% and a specificity of 94.1%. CONCLUSION:A higher YKL-40 level with PAH may be reflective of angiogenesis due to capillary injury in SSc. YKL-40 may offer a useful and easily applicable diagnostic biomarker of SSc complicated with PAH.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Furukawa T,Matsui K,Kitano M,Yokoyama Y,Sekiguchi M,Azuma N,Imai Y,Hirota S,Yamanishi K,Sano Hdoi
10.1080/14397595.2018.1480256subject
Has Abstractpub_date
2019-05-01 00:00:00pages
476-483issue
3eissn
1439-7595issn
1439-7609journal_volume
29pub_type
杂志文章abstract:OBJECTIVES:To assess the real-world effectiveness of golimumab in Japanese patients with rheumatoid arthritis who had previously received one or more biologic therapies. METHODS:A post-hoc analysis of post-marketing surveillance was performed. The clinical response to golimumab was analyzed in 1216 patients who had pr...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1797283
更新日期:2020-08-19 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1438093
更新日期:2018-05-01 00:00:00
abstract::Interstitial lung disease (ILD) is a noteworthy condition in the treatment of systemic sclerosis (SSc) because of its associated mortality and morbidity; however, the efficacy of various treatments for ILD has been controversial in previous reports. In this study, we examined the efficacy and safety of intravenous cyc...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
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更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:The early diagnosis and treatment of rheumatoid arthritis (RA) is important to reduce joint destruction. Many of the current imaging techniques have disadvantages, such as the need for contrast agents and interpretation by specialists. Fluorescence imaging is an emerging technique that overcomes some of thes...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1170946
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:The aims of this study are to determine the incidence of congenital heart block (CHB) in the Japanese population and identify maternal factors predicting fetal CHB in anti-Ro/SSA antibody positive pregnancy. METHODS:A retrospective study was performed using 52,147 clinical records of pregnancies followed in ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1374235
更新日期:2018-07-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0450-6
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.854063
更新日期:2014-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1704983
更新日期:2020-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1804668
更新日期:2020-09-03 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0367-6
更新日期:2011-04-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2014.881709
更新日期:2014-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1204711
更新日期:2017-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170043
更新日期:2001-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10165-007-0634-3
更新日期:2007-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1153449
更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/14397595.2015.1091123
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-28 00:00:00
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更新日期:2020-12-16 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
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doi:10.1007/s10165-009-0266-x
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pub_type: 杂志文章,多中心研究
doi:10.3109/14397595.2014.906049
更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10165-010-0274-x
更新日期:2010-06-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-11-01 00:00:00
abstract::Clinical squeal of the treatment of rheumatoid arthritis patients with methotrexate (MTX) according to the Japanese government recommended dose of 8 mg/week was evaluated prospectively. A total of 176 patients with active RA attending Konan Kakogawa Hospital and Kobe University Hospital were enrolled. Patients' profil...
journal_title:Modern rheumatology
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1245176
更新日期:2017-07-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1208899
更新日期:2019-01-01 00:00:00
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journal_title:Modern rheumatology
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doi:10.1080/14397595.2016.1259603
更新日期:2017-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.854048
更新日期:2014-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0388-1
更新日期:2011-06-01 00:00:00