Aortitis in a patient with psoriatic arthritis.

abstract：OBJECTIVE:We examined the prevalence and risk factors of vertebral fracture in female Japanese patients with systemic lupus erythematosus (SLE). METHODS:We performed lateral radiographs of the thoracic and lumbar spine and bone mineral density (BMD) measurements and collected demographic, lifestyle, clinical, and trea...

journal_title：Modern rheumatology

authors： Furukawa M,Kiyohara C,Horiuchi T,Tsukamoto H,Mitoma H,Kimoto Y,Uchino A,Nakagawa M,Oryoji K,Shimoda T,Harada M,Akashi K

更新日期：2013-07-01 00:00:00

abstract：:We evaluated the prevalence of Helicobacter pylori infection and the association of H. pylori infection and/or nonsteroidal anti-inflammatory drug (NSAID) use with upper gastrointestinal (UGI) ulcers in a cohort of Japanese patients with rheumatoid arthritis (RA). Using the clinical database of the cohort of RA patien...

journal_title：Modern rheumatology

authors： Tanaka E,Singh G,Saito A,Syouji A,Yamada T,Urano W,Nakajima A,Taniguchi A,Tomatsu T,Hara M,Saito T,Kamatani N,Yamanaka H

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Fractalkine (CX3CL1/FKN) is a chemokine that regulates chemotaxis and adhesion of CX3C chemokine receptor 1 (CX3CR1)-expressing inflammatory cells. We conducted the first phase 1/2, open-label, multiple ascending dose study of E6011, a humanized anti-FKN monoclonal antibody, in Japanese rheumatoid arthritis (...

journal_title：Modern rheumatology

authors： Tanaka Y,Takeuchi T,Umehara H,Nanki T,Yasuda N,Tago F,Kawakubo M,Kitahara Y,Hojo S,Kawano T,Imai T

更新日期：2018-01-01 00:00:00

abstract：:Aseptic abscess (AA) is characterized by accumulation of neutrophils without evidence of infection, no response to antibiotics, and rapid response to corticosteroids. We report a case of multiple abscesses in the subcutaneous tissues and joints, and severe mitral valve regurgitation. Although AA did not respond to ant...

journal_title：Modern rheumatology

authors： Fukuda S,Nanki T,Morio T,Hasegawa H,Koike R,Miyasaka N

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To evaluate total antioxidant capacity (TAC) and total oxidative stress (TOS) values in patients with myofascial pain syndrome (MPS). METHOD:The study comprised 38 patients diagnosed with MPS and 30 healthy volunteers. The age, body mass index (BMI) and pain scores (evaluation by visual analogue scales) of a...

journal_title：Modern rheumatology

authors： Koca I,Tutoglu A,Boyacı A,Pehlivan Y,Yıldız H,Turkbeyler I,Sarıcicek E,Taysi S,Onat AM

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVES:To assess the real-world effectiveness of golimumab in Japanese patients with rheumatoid arthritis who had previously received one or more biologic therapies. METHODS:A post-hoc analysis of post-marketing surveillance was performed. The clinical response to golimumab was analyzed in 1216 patients who had pr...

journal_title：Modern rheumatology

authors： Shimizu H,Kobayashi H,Kanbori M,Ishii Y

更新日期：2020-08-19 00:00:00

abstract：OBJECTIVES:To establish a new assessment tool for ulnar drift (UD) in rheumatoid arthritis (RA). METHODS:We established an observational cohort of 67 patients (134 rheumatoid hands) beginning in 2004. Fifty-two patients (100 hands) had follow-up in 2009 and 37 patients (63 hands) completed follow-up in 2015. UD was ev...

journal_title：Modern rheumatology

authors： Toyama S,Oda R,Tokunaga D,Taniguchi D,Nakamura S,Asada M,Fujiwara H,Kubo T

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to clarify the characteristics of bony ankylosis of the facet joint of the cervical spine in rheumatoid arthritis (RA) patients who required cervical spine surgery, and its relationship to the clinical findings. METHODS:Eighty consecutive RA patients with cervical spine disorde...

journal_title：Modern rheumatology

authors： Iizuka H,Iizuka Y,Okamura K,Yonemoto Y,Mieda T,Takagishi K

更新日期：2017-09-01 00:00:00

abstract：:The patient described here is a 49-year-old woman who had hepatitis C virus (HCV) infection and rheumatoid arthritis (RA). Her RA had been successfully managed with methotrexate for about 10 years. After a sustained virological response was achieved with interferon therapy, treatment with adalimumab was instituted. Th...

journal_title：Modern rheumatology

authors： Noguchi O,Gibo Y

更新日期：2011-12-01 00:00:00

abstract：:Abstract  Osteoarthritis (OA) is considered to be a complex illness in which the tissues of the joint play a significant role in the initiation and/or progression of the pathophysiology. We still do not completely understand what initiates the degradation and loss of cartilage. However, it has been suggested that incr...

journal_title：Modern rheumatology

authors： Lajeunesse D,Massicotte F,Pelletier JP,Martel-Pelletier J

更新日期：2003-03-01 00:00:00

abstract：:The objective of this study was to show whether the disease activity of rheumatoid arthritis (RA) patients had improved in Japan, and whether the improvement of disease activity had resulted in a better outcome of patients. In a single-institute-based prospective observational cohort of RA patients (Institute of Rheum...

journal_title：Modern rheumatology

authors： Yamanaka H,Inoue E,Singh G,Tanaka E,Nakajima A,Taniguchi A,Hara M,Tomatsu T,Kamatani N

更新日期：2007-01-01 00:00:00

abstract：:The aim of our study was to determine the spectrum of the 12 most common familial Mediterranean fever gene (MEFV) mutations in Iranian patients with heterogeneous ethnicity, using the familial Mediterranean fever (FMF) strip assay test. A total of 36 patients were diagnosed according to established clinical criteria. ...

journal_title：Modern rheumatology

authors： Bidari A,Ghavidel-Parsa B,Najmabadi H,Talachian E,Haghighat-Shoar M,Broumand B,Ghalehbaghi B

更新日期：2010-12-01 00:00:00

abstract：:Here, we report the case of a 69-year-old man with limited granulomatosis with polyangiitis (GPA; formerly Wegener's granulomatosis) who developed papillary thyroid cancer, adenocarcinoma of the stomach, and myelodysplastic syndrome following glucocorticoid treatment. This is the first report to present multiple malig...

journal_title：Modern rheumatology

authors： Cheon YH,Kim MG,Kim JE,Ha CY,Lee SI,Kim HO

更新日期：2016-01-01 00:00:00

abstract：:We report a 24-year-old male with systemic lupus erythematosus (SLE) who developed influenza virus B-associated hemophagocytic syndrome and cardiac tamponade. Although the patient's general condition improved after steroid pulse therapy and pericardiocentesis, pericardial effusion re-accumulated. Colchicine and aspiri...

journal_title：Modern rheumatology

authors： Horai Y,Miyamura T,Takahama S,Sonomoto K,Nakamura M,Ando H,Minami R,Yamamoto M,Suematsu E

更新日期：2010-04-01 00:00:00

abstract：:The expression of CD25 or CD28 on T cells was examined in patients with rheumatic diseases associated with interstitial pneumonitis (IP), in order to investigate the conditions of CD4+CD25+ regulatory T cells and CD8+CD28- suppressor T cells. Fifty-five patients with various rheumatic diseases and 23 normal controls w...

journal_title：Modern rheumatology

authors： Katagiri A,Morimoto S,Nakiri Y,Nakano S,Mitsuo A,Suzuki J,Amano H,Nozawa K,Asano M,Tokano Y,Hashimoto H,Takasaki Y

更新日期：2008-01-01 00:00:00

abstract：:Despite a number of published reports, including from our own laboratory, suggesting that adeno-associated virus (AAV) transduces mouse synovium, a careful analysis demonstrated transduction predominantly of the subsynovial muscle tissue, while the synovial lining is poorly transduced. To investigate the potential of ...

journal_title：Modern rheumatology

authors： Katakura S,Jennings K,Watanabe S,Adachi E,Thornton S,Gao GP,Wilson JM,Burstein H,Trapnell B,Hirsch R

更新日期：2004-01-01 00:00:00

abstract：:Abstract An accumulating body of evidence shows that gene therapy can be successfully used to treat animal models of arthritis. Based on this success, a clinical trial of gene therapy for rheumatoid arthritis has been initiated. We review the methods and genes used for the previous gene transfer experiments, including...

journal_title：Modern rheumatology

authors： Kohsaka H

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVES:To determine the availability of bioelectrical impedance analysis (BIA), computed tomography (CT), and magnetic resonance imaging (MRI) for measurement of skeletal muscle mass in patients with rheumatic diseases and quantitatively assess skeletal muscle loss after glucocorticoid (GC) treatment. METHODS:The ...

journal_title：Modern rheumatology

authors： Hosono O,Yoshikawa N,Shimizu N,Kiryu S,Uehara M,Kobayashi H,Matsumiya R,Kuribara A,Maruyama T,Tanaka H

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:No available anti-osteoporotic medication has been shown to completely prevent declines in bone mineral density (BMD) and the resulting increased risk of fracture. The objective of this study was to investigate the risk factors for treatment failure in osteoporotic patients with rheumatoid arthritis (RA). ME...

journal_title：Modern rheumatology

authors： Wen L,Kang JH,Yim YR,Lee JW,Lee KE,Park DJ,Kim TJ,Park YW,Lee SS

更新日期：2016-01-01 00:00:00

abstract：:We evaluated the utility of HEp-2 cells transfected with the 60 kDa SS-A/Ro as a substrate for indirect immunofluorescence (IIF-HEp-2000) to compare several methods for screening Japanese serum samples for anti-SS-A/Ro antibodies. Serum samples from 243 Japanese patients were analyzed by IIF for anti-nuclear antibodie...

journal_title：Modern rheumatology

authors： Tanaka N,Muro Y,Sugiura K,Tomita Y

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:We investigated the relationship between morphological features in the lower limbs and the progression of knee osteoarthritis (OA) in 6-years. METHODS:Volunteer subjects from Toei (101 women and 54 men). Knee OA was evaluated on whole-leg radiographs. Subjects were divided into group 1, no knee OA; group 2,...

journal_title：Modern rheumatology

authors： Tran DH,Hoshino H,Matsuyama Y

更新日期：2020-09-03 00:00:00

abstract：OBJECTIVES:Several biological disease-modifying antirheumatic drugs (bDMARDs) are currently available for the treatment of rheumatoid arthritis (RA). Increasing evidence indicates that second-line bDMARDs are effective for inadequate responders to first-line bDMARDs. However, all previous studies investigated the use o...

journal_title：Modern rheumatology

authors： Matsuno H,Katayama K

更新日期：2017-03-01 00:00:00

abstract：:Objectives: Secondary central nervous system vasculitis (SCNSV) is an extremely rare, refractory, and fatal disease in patients with giant cell arteritis (GCA). We compared the characteristics of GCA patients with and without SCNSV.Methods: This retrospective, single-center, observational cohort study included 35 pati...

journal_title：Modern rheumatology

authors： Abe Y,Harada M,Tada K,Yamaji K,Tamura N

更新日期：2020-11-01 00:00:00

abstract：:We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with AAV following admi...

journal_title：Modern rheumatology

authors： Murakami M,Shimane K,Takahashi H,Tomiyama J,Nagashima M

更新日期：2013-01-01 00:00:00

abstract：:To investigate the precise modality of association between SAA1 gene polymorphisms and the development of AA amyloidosis in patients with rheumatoid arthritis (RA), Japanese patients with RA (n=153), among whom 29 were histologically diagnosed as having amyloidosis, were genotyped for three single nucleotide polymorph...

journal_title：Modern rheumatology

authors： Ajiro J,Narita I,Sato F,Saga D,Hasegawa H,Kuroda T,Nakano M,Gejyo F

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:To assess the influence of golimumab dosage and disease activity on joint destruction in patients with active rheumatoid arthritis (RA) in the GO-FORTH study. METHODS:Efficacy was compared among groups given basal methotrexate plus placebo, golimumab (50 mg), or golimumab (100 mg) with stratification by hig...

journal_title：Modern rheumatology

authors： Tanaka Y,Harigai M,Takeuchi T,Yamanaka H,Ishiguro N,Yamamoto K,Ishii Y,Nakajima H,Baker D,Miyasaka N,Koike T

更新日期：2016-01-01 00:00:00

abstract：:The purpose of this study was to describe the prevalence of total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment in a large observational cohort in Japan. A total of 5,177 RA patients were studied for the prevalence of TJA, who were enrolled in the NinJa ...

journal_title：Modern rheumatology

authors： Nishino J,Tanaka S,Matsui T,Mori T,Nishimura K,Eto Y,Kaneko A,Saisho K,Yasuda M,Chiba N,Yoshinaga Y,Saeki Y,Seki A,Tohma S

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:To examine the deterioration of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) treated with abatacept over the long-term. METHODS:We examined 131 patients with RA who had been treated with abatacept for more than 1 year. All patients underwent high-resolution computed tomographic ...

journal_title：Modern rheumatology

authors： Mochizuki T,Ikari K,Yano K,Sato M,Okazaki K

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:The prediction of hip osteoarthritis (OA) progression is still a difficult issue. We have adopted (18)F-fluoride positron emission tomography (PET) for the evaluation of hip osteoarthritis, and investigated the prediction utility of (18)F-fluoride PET for both pain worsening and OA progression using a logisti...

journal_title：Modern rheumatology

authors： Kobayashi N,Inaba Y,Yukizawa Y,Ike H,Kubota S,Inoue T,Saito T

更新日期：2015-01-01 00:00:00

abstract：:Skeletal injury is one of the most prevalent clinical problems that jeopardize the activities of daily life, especially in our aging society. Mesenchymal stem cells (MSCs) play pivotal roles in regenerating bones after bone injury. MSCs come from the surrounding tissues and/or circulation. Cell sources may be the bone...

journal_title：Modern rheumatology

authors： Ito H

更新日期：2011-04-01 00:00:00