Abstract:
OBJECTIVES:To assess the influence of golimumab dosage and disease activity on joint destruction in patients with active rheumatoid arthritis (RA) in the GO-FORTH study. METHODS:Efficacy was compared among groups given basal methotrexate plus placebo, golimumab (50 mg), or golimumab (100 mg) with stratification by high (HDA) or moderate (MDA) baseline disease activity and by high or low baseline C-reactive protein (CRP). RESULTS:Among HDA or high CRP patients, the mean change of the total Sharp score was 3.48 and 3.41 in the placebo group, 1.94 and 2.71 in the 50 mg group, and 0.39 and 1.15 in the 100 mg group, respectively. The percentage of progression-free patients with HDA or high CRP was 40.4% and 40.0%, 43.1% and 38.2%, and 69.8% and 61.5%, respectively. Among MDA or low CRP patients, both golimumab doses showed similar prevention of joint destruction. Among HDA or high CRP patients, a shorter disease duration and higher TSS/disease duration ratio were associated with joint destruction. CONCLUSION:Both doses of golimumab (50 or 100 mg) prevented joint destruction in MDA or low CRP patients, but 100 mg was better for HDA or high CRP patients with a shorter disease duration or higher TSS/disease duration ratio.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Tanaka Y,Harigai M,Takeuchi T,Yamanaka H,Ishiguro N,Yamamoto K,Ishii Y,Nakajima H,Baker D,Miyasaka N,Koike Tdoi
10.3109/14397595.2015.1086041subject
Has Abstractpub_date
2016-01-01 00:00:00pages
323-30issue
3eissn
1439-7595issn
1439-7609journal_volume
26pub_type
杂志文章,随机对照试验abstract:OBJECTIVES:Several biological disease-modifying antirheumatic drugs (bDMARDs) are currently available for the treatment of rheumatoid arthritis (RA). Increasing evidence indicates that second-line bDMARDs are effective for inadequate responders to first-line bDMARDs. However, all previous studies investigated the use o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1206242
更新日期:2017-03-01 00:00:00
abstract::One of the severe adverse effects of intra-articular injection in the knee is septic arthritis of the knee joint. Staphylococcus aureus is the most frequent pathogen of septic arthritis. Staphylococcal scalded skin syndrome (SSSS) refers to a spectrum of blistering skin diseases caused by S. aureus exfoliative toxins....
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0391-6
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:Our primary objective was to retrospectively analyze whether bisphosphonates initiated in combination with immunosuppressive drugs and/or intravenous immunoglobulin (IVIG) resulted in a radiological and clinical improvement of dystrophic calcinosis in six female juvenile dermatomyositis (JDM) patients. METH...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.988197
更新日期:2015-07-01 00:00:00
abstract::We report a 24-year-old male with systemic lupus erythematosus (SLE) who developed influenza virus B-associated hemophagocytic syndrome and cardiac tamponade. Although the patient's general condition improved after steroid pulse therapy and pericardiocentesis, pericardial effusion re-accumulated. Colchicine and aspiri...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0241-6
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVES:A nationwide survey was conducted to assess the number of patients, clinical aspects, treatment, and prognosis of adult Still's disease (ASD) in Japan. METHODS:A primary questionnaire was sent to randomly selected medical institutions in order to estimate the number of patients. We sent a secondary question...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.974881
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:We seek to evaluate the opinions of nurses and doctors in Japan regarding EULAR recommendations for nurses' roles in the management of chronic inflammatory arthritis. METHODS:This is a cross-sectional survey within Japan. We randomly selected nurses and doctors engaged in consultation of patients with rheuma...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1260199
更新日期:2017-09-01 00:00:00
abstract::Cutaneous polyarteritis nodosa (CPAN) is a form of necrotizing vasculitis of small and medium-sized arteries. It is limited to the skin and has a recurrent and chronic course, possibly associated with fever, arthralgia, myalgia and neuropathy, but without visceral involvement. We report the clinical case of a 7-year-o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.874737
更新日期:2014-07-01 00:00:00
abstract::Idiopathic inflammatory myopathies (IIMs) are heterogeneous disorders that affect the skeletal muscles. Polymyositis, dermatomyositis, and inclusion body myositis are major IIM subsets. Immune-mediated necrotizing myopathy became recognized as a potentially new IIM subset. Since the new classification criteria publish...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1467257
更新日期:2018-11-01 00:00:00
abstract::Objectives: To assess the effects of belimumab on disease activity across multiple organ domains in Japanese patients from the Phase 3 randomized, double-blind, North-East Asia study, BEL113750 (NCT01345253).Methods: Patients, aged ≥18 years, with American College of Rheumatology-defined systemic lupus erythematosus (...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1080/14397595.2019.1630897
更新日期:2020-03-01 00:00:00
abstract::Abstract This work was undertaken to evaluate clinical and immunological features in patients with systemic lupus erythematosus (SLE) complicated by Jaccoud's arthropathy. Patients diagnosed with SLE between 1985 and 1999, and who met the criteria of Villiaumey et al., were checked for Jaccoud's arthropathy. Clinical ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170043
更新日期:2001-03-01 00:00:00
abstract::Tumor necrosis factor alpha (TNFalpha)-blocking agents have been used increasingly in the treatment of severe refractory juvenile idiopathic arthritis (JIA). However, some patients have been forced to discontinue these agents because of the lack of efficacy or adverse events. In these situations, cases of switching fr...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0634-3
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to analyze the score of fatigue in a large cohort of Brazilian patients with SpA, comparing different disease patterns and its association with demographic and disease-specific variables. METHODS:A common protocol of investigation was prospectively applied to 1492 Brazilian ...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.3109/14397595.2014.906049
更新日期:2014-11-01 00:00:00
abstract::An association between thrombotic thrombocytopenic purpura (TTP) and Sjögren's syndrome (SS) is rare. This is the first report of two patients with TTP who had inhibitory autoantibodies to ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 repeats) complicating primary SS. A rapid diagnosis of...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10165-012-0644-7
更新日期:2013-03-01 00:00:00
abstract::To investigate the role of interleukin (IL)-33 in rheumatoid arthritis (RA) patients, we measured the serum levels of IL-33 in RA patients before and after the administration of etanercept. Twenty-four patients with RA were treated with etanercept. Clinical and laboratory examinations, including serum levels of C-reac...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-011-0480-1
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:Systemic sclerosis (SSc) is an intractable connective tissue disease that causes skin and organ fibrosis. Interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) affect its prognosis. YKL-40 protein impacts inflammation and tissue remodeling. Therefore, we evaluated the utility of YKL-40 bl...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1480256
更新日期:2019-05-01 00:00:00
abstract::To investigate the precise modality of association between SAA1 gene polymorphisms and the development of AA amyloidosis in patients with rheumatoid arthritis (RA), Japanese patients with RA (n=153), among whom 29 were histologically diagnosed as having amyloidosis, were genotyped for three single nucleotide polymorph...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0500-8
更新日期:2006-01-01 00:00:00
abstract::Lower adiponectin levels in circulation are shown to be associated with endothelial dysfunction, which is a crucial feature in the evolution of atherosclerosis. The aim of our study is to evaluate the effect of anti-tumor necrosis factor (TNF) therapy on adiponectin levels with endothelial function and arterial stiffn...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0605-8
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To obtain safety and efficacy data on combination treatment with iguratimod and methotrexate (MTX) in an open-label extension study in patients with active rheumatoid arthritis (RA). METHODS:Following a 28-week, randomized, double-blind trial of adding iguratimod or placebo to stable MTX therapy, patients en...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2013.843756
更新日期:2014-05-01 00:00:00
abstract::A 24-year-old Japanese woman was admitted to our hospital suffering from high fever and progressive paralysis in both legs. Magnetic resonance imaging of the spinal cord showed high-intensity signals from C5 to Th4 and from Th7 to L1 on T2-weighted images. The patient was diagnosed as having acute transverse myelitis ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0376-4
更新日期:2005-01-01 00:00:00
abstract::Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.859770
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to investigate the reliability and the validity of the Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia (ACR 2010-J), and its quantification scale, the Fibromyalgia Symptom Scale (FS-J). In this study, we divided patients with chro...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0462-3
更新日期:2012-02-01 00:00:00
abstract:: ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-013-0884-1
更新日期:2013-04-27 00:00:00
abstract::Abstract Five cases of flexor tendon rupture in surgically treated rheumatoid wrists were studied. The tendon ruptures occurred in the thumb and index finger, and the ruptures site was in the carpal tunnel in all five cases. The main cause of rupture was the formation of bony irregularities in the form of bony spurs i...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170025
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To evaluate total antioxidant capacity (TAC) and total oxidative stress (TOS) values in patients with myofascial pain syndrome (MPS). METHOD:The study comprised 38 patients diagnosed with MPS and 30 healthy volunteers. The age, body mass index (BMI) and pain scores (evaluation by visual analogue scales) of a...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.886984
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:The aims of this study are to determine the incidence of congenital heart block (CHB) in the Japanese population and identify maternal factors predicting fetal CHB in anti-Ro/SSA antibody positive pregnancy. METHODS:A retrospective study was performed using 52,147 clinical records of pregnancies followed in ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1374235
更新日期:2018-07-01 00:00:00
abstract::Abstract A 56-year-old man presented with hyperproteinemia and renal dysfunction associated with antineutrophil cytoplasmic antibodies (ANCA). He had had a ventriculoperitoneal shunt tube made of silicone implanted 4 years earlier. In his renal biopsy, necrotizing crescentic glomerulonephritis was identified: tests fo...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650300011
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy of tocilizumab for preventing damage to the joints of systemic juvenile idiopathic arthritis (sJIA) patients, we examined serial radiographs of the hands and large weight-bearing joints of these patients before and after treatment with this agent. METHODS:Nine patients with sJIA recei...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0711-0
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Aspects of health-related quality of life (HRQoL) are important for assessing perceived health status and treatment burden. We evaluated HRQoL using Short Form 36 Health Survey (SF-36) and factors associated with HRQoL. METHODS:We collected basic and lifestyle-related, clinical, and treatment characteristics...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1060668
更新日期:2016-01-01 00:00:00
abstract::A 20-year-old man presented with recurrent hemoptysis for seven months. A small subpleural nodule in his right lower lobe was found and excised surgically. Based on the presence of antiphospholipid antibodies (aPL) and vascular wall hypertrophy without vasculitis or an intraluminal thrombus, nonthrombotic proliferativ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1218596
更新日期:2019-03-01 00:00:00
abstract::Sarcoidosis is a multisystem disease related to helper T cell responses. We recently experienced the case of a 57-year-old woman with sarcoidosis complicated by crescentic glomerulonephritis with low levels of myeloperoxidase-antineutrophil cytoplasmic antibody. We herein describe the details of her clinical course an...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0614-0
更新日期:2013-01-01 00:00:00