Abstract:
OBJECTIVES:To assess the efficacy of tocilizumab for preventing damage to the joints of systemic juvenile idiopathic arthritis (sJIA) patients, we examined serial radiographs of the hands and large weight-bearing joints of these patients before and after treatment with this agent. METHODS:Nine patients with sJIA receiving 8 mg/kg of tocilizumab intravenously every 2 weeks were studied. The mean follow-up period was 82 months. The number of active joints and laboratory markers of inflammation were assessed before and after tocilizumab treatment, together with radiologic evaluation of the hips, knees, ankles, shoulders, and elbows. The latter examination included soft tissue swelling, juxta-articular osteoporosis, epiphyseal irregularity, joint-space narrowing, cyst formation, erosion, and localized growth abnormalities. Modified Larsen scores for the large joints and the Poznanski score were also recorded. RESULTS:After tocilizumab treatment, the number of active joints and serum inflammatory markers decreased (p < 0.01). There was a decrease in radiologic abnormalities at the final follow-up (p < 0.01) with the exception of localized growth abnormalities. Radiologic improvement was observed in 47 joints (52%), but ten (11%) worsened. Total Larsen score was decreased from 15.8 to 10.9 at the final follow-up. Although the Poznanski score did not change after tocilizumab treatment, it was closely correlated with the total Larsen score (r = 0.53, p < 0.05). CONCLUSIONS:We describe radiologic improvement of the majority of damaged large joints in sJIA following tocilizumab therapy, but some deteriorated further despite stabilization of systemic inflammatory responses. Further studies with a larger number of patients are needed.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Inaba Y,Ozawa R,Aoki C,Imagawa T,Mori M,Hara R,Miyamae T,Saito T,Yokota Sdoi
10.1007/s10165-012-0711-0subject
Has Abstractpub_date
2013-07-01 00:00:00pages
667-73issue
4eissn
1439-7595issn
1439-7609journal_volume
23pub_type
杂志文章abstract::Interstitial lung disease (ILD) is a noteworthy condition in the treatment of systemic sclerosis (SSc) because of its associated mortality and morbidity; however, the efficacy of various treatments for ILD has been controversial in previous reports. In this study, we examined the efficacy and safety of intravenous cyc...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-010-0403-6
更新日期:2011-06-01 00:00:00
abstract::Cyclosporin A (CsA) has various adverse effects including neurotoxicity. We report the case of a 49-year-old Japanese woman with dermatomyositis who showed CsA-induced cortical blindness. The patient demonstrated cortical blindness despite having a normal blood concentration of CsA. The risk factors of CsA-induced cor...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0307-4
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:We aimed to analyze clinical features and treatment outcomes of otitis media caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), i.e. otitis media with AAV (OMAAV). METHODS:This survey was performed between December 2013 and February 2014. The study began with a preliminary surv...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1177926
更新日期:2017-01-01 00:00:00
abstract::Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his diseas...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0065-9
更新日期:2008-01-01 00:00:00
abstract::We evaluated the utility of HEp-2 cells transfected with the 60 kDa SS-A/Ro as a substrate for indirect immunofluorescence (IIF-HEp-2000) to compare several methods for screening Japanese serum samples for anti-SS-A/Ro antibodies. Serum samples from 243 Japanese patients were analyzed by IIF for anti-nuclear antibodie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0100-x
更新日期:2008-01-01 00:00:00
abstract::The aim of this study was to investigate the reliability and the validity of the Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia (ACR 2010-J), and its quantification scale, the Fibromyalgia Symptom Scale (FS-J). In this study, we divided patients with chro...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0462-3
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:The introduction of powerful antirheumatic drugs has dramatically improved the treatment of rheumatoid arthritis (RA), leading clinicians to reconsider the benefits of joint preservation for rheumatoid forefoot deformities. We have employed joint-preserving forefoot surgeries, including rotational closing-we...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0776-9
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy of tocilizumab (TCZ) monotherapy for the remission induction of microscopic polyangiitis (MPA) in a prospective single-arm, single-center, cohort, pilot study. METHODS:Eligible patients were aged between 20 and 80 years and were newly diagnosed with MPA according to Watts' classificat...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.3109/14397595.2016.1160968
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:To investigate and compare the risk for malignancy in rheumatoid arthritis (RA) patients treated with biologics in Japan to the general population. METHODS:Data for 14,440 patients from 335 institutions who were given infliximab, etanercept, adalimumab, golimumab, tocilizumab, or abatacept were retrieved fr...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1141740
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:Psoriasis is a chronic autoimmune disease involving a complex network of cytokines such as interleukin (IL)-6. We tested the hypothesis that serum IL-6 level is a useful indicator of disease activity and predicts the treatment response to biologics in patients with psoriasis. METHODS:We analyzed 113 psorias...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1174328
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the improvement of health status in patients with rheumatoid arthritis (RA) treated with tocilizumab. METHODS:Thirty-nine patients were treated with 8 mg/kg tocilizumab every 4 weeks for 24 weeks. Disease activity was assessed by Clinical Disease Activity Index (CDAI) and Simplified Disease Activ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0674-1
更新日期:2013-03-01 00:00:00
abstract::A 49-year-old Japanese woman treated with oral corticosteroids, methotrexate, and infliximab for malignant rheumatoid arthritis was admitted because of fever and low back pain. The white blood cell count and C-reactive protein concentration were elevated. Lumbar and pelvic computed tomography showed enlargement of the...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0493-3
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the effect and potential mechanism of Cysteine-rich 61 (Cyr61) on stimulating MMP-3 expression by fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. METHODS:Primarily cultured RA FLS were treated with exogenous Cyr61 protein or Cyr61-siRNA, t...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1220447
更新日期:2017-05-01 00:00:00
abstract::Abstract The synovium in a knee joint has an extensive neural network in the somatic and autonomic nervous systems. In medial compartmental osteoarthritis of the knee, neuropeptides were most abundant, with an especially large number of substance P and calcitonin gene-related peptide-immunoreactive free nerve endings....
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-003-0253-6
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:To evaluate the scoring of whole-body magnetic resonance imaging (WBMRI) for efficacy assessment in rheumatoid arthritis (RA) patients receiving biological disease-modifying anti-rheumatic drugs (bDMARDs). METHODS:Thirty consecutive RA patients receiving bDMARDs were included in this retrospective study. Co...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1276425
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:We seek to evaluate the opinions of nurses and doctors in Japan regarding EULAR recommendations for nurses' roles in the management of chronic inflammatory arthritis. METHODS:This is a cross-sectional survey within Japan. We randomly selected nurses and doctors engaged in consultation of patients with rheuma...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1260199
更新日期:2017-09-01 00:00:00
abstract::Aortitis, inflammation of the aortic tissue, is most commonly caused by vasculitic rheumatic conditions, and less frequently infectious organisms. Involvement of the aorta is well defined in HLA-B27-associated spondyloarthropathies such as long-standing ankylosing spondylitis and Reiter's syndrome. However, unlike oth...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0566-9
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease. METHODS:All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild l...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0818-3
更新日期:2013-11-01 00:00:00
abstract::Anti-tumor necrosis factor (anti-TNF) biologics are effective in the treatment of rheumatoid arthritis (RA); however, it is still not clear whether this treatment promotes the development of malignancies such as lymphoma. Human T-lymphotropic virus type 1 (HTLV-1), which is a causative agent of adult T-cell lymphoma (...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.844389
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To retrospectively evaluate whether oral glucocorticoid (GC) administration can be tapered or discontinued over a 2-year observation period in patients with rheumatoid arthritis (RA) undergoing a stable oral GC treatment, without deterioration in the disease status. METHODS:Methotrexate (MTX) and prednisolon...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1864914
更新日期:2020-12-16 00:00:00
abstract::We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron's papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including stero...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0637-6
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:To determine the availability of bioelectrical impedance analysis (BIA), computed tomography (CT), and magnetic resonance imaging (MRI) for measurement of skeletal muscle mass in patients with rheumatic diseases and quantitatively assess skeletal muscle loss after glucocorticoid (GC) treatment. METHODS:The ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.935078
更新日期:2015-03-01 00:00:00
abstract::Research into the bone destruction associated with rheumatoid arthritis has highlighted the importance of the interplay of the immune and skeletal systems. Arthritic bone destruction is attributable to the defective control of osteoclastogenesis by T cells. We revealed that excessive expression of receptor activator o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0398-6
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:Increased femoral neck bone mineral density (BMD) in a hip with osteoarthritis (OA) has been previously reported, however, it is possible that increased BMD at sites other than the hip joint is influenced by the disease process of OA. Therefore, we measured BMD at locations different from the hip joint and de...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.854078
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to analyze the score of fatigue in a large cohort of Brazilian patients with SpA, comparing different disease patterns and its association with demographic and disease-specific variables. METHODS:A common protocol of investigation was prospectively applied to 1492 Brazilian ...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.3109/14397595.2014.906049
更新日期:2014-11-01 00:00:00
abstract::A female rheumatoid arthritis patient was admitted for productive cough and general fatigue that had gradually developed after leflunomide therapy. Side effects including severe hypoxia, thrombocytopenia, lymphocytopenia, and macrocytic anemia with schistocytes (probably drug-induced megaloblastic anemia) were noted. ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0613-8
更新日期:2007-01-01 00:00:00
abstract::To evaluate the efficacy of high-dose leukocytapheresis (LCAP) using a large filter in patients with refractory rheumatoid arthritis (RA), we conducted a multicenter, nonrandomized, open-label clinical study. Thirty patients with highly active RA were treated with high-dose LCAP performed 3-5 sessions at 1-week interv...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s10165-007-0630-7
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:The aim of our study is to clarify the association of myositis-specific autoantibodies (MSAs) with clinical and laboratory features in Japanese patients with juvenile idiopathic inflammatory myopathies (JIIMs). METHODS:We retrospectively analyzed the frequency of MSAs and their association with clinical or ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1452353
更新日期:2019-03-01 00:00:00
abstract::Risk of knee osteoarthritis (OA) was assessed in a population-based case-control study of Japanese men. The study covered three health districts in Wakayama and Osaka prefectures, Japan. Subjects were male individuals >or=45 years old diagnosed radiographically with knee OA, and who did not display any established cau...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0450-6
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:Lupus enteritis (LE) is a rare but well-known gastrointestinal manifestation of systemic lupus erythematosus (SLE). This study was conducted to identify prognostic factors associated with poor responses in patients with LE. METHODS:We consecutively registered patients diagnosed with LE between January 2009 ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1812871
更新日期:2020-09-07 00:00:00