Cyr61 participates in the pathogenesis of rheumatoid arthritis via promoting MMP-3 expression by fibroblast-like synoviocytes.

abstract：OBJECTIVES:To assess the efficacy of tocilizumab (TCZ) monotherapy for the remission induction of microscopic polyangiitis (MPA) in a prospective single-arm, single-center, cohort, pilot study. METHODS:Eligible patients were aged between 20 and 80 years and were newly diagnosed with MPA according to Watts' classificat...

journal_title：Modern rheumatology

authors： Sakai R,Kondo T,Kikuchi J,Shibata A,Chino K,Okuyama A,Takei H,Amano K

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Increased femoral neck bone mineral density (BMD) in a hip with osteoarthritis (OA) has been previously reported, however, it is possible that increased BMD at sites other than the hip joint is influenced by the disease process of OA. Therefore, we measured BMD at locations different from the hip joint and de...

journal_title：Modern rheumatology

authors： Okano K,Ito M,Aoyagi K,Osaki M,Enomoto H,Yamaguchi K

更新日期：2014-03-01 00:00:00

abstract：:Abstract We report two cases of bone marrow hemophagocytosis. One patient had adult-onset Still's disease, and the other had herpes zoster associated with potential autoimmune abnormalities. Our findings suggested a pos-sible role of cytokines and/or antibodies in the induction of hemophagocytosis in patients with con...

journal_title：Modern rheumatology

authors： Susuki J,Nawata M,Koike M,Wada R,Sekigawa I,Iida N,Hashimoto H

更新日期：2001-12-01 00:00:00

abstract：:We report a case of acute generalized pustular bacterid (AGPB) concomitant with erythema nodosum (EN), polyarthritis, and Achilles tendinitis. The patient was admitted with a complaint of fever, widespread plural pustules, erythema, and polyarthralgia. Histopathological examination of the skin lesions demonstrated fea...

journal_title：Modern rheumatology

authors： Arita Y,Taguchi H,Hanada R,Tono T,Ohsone Y,Okata U,Irie R,Okano Y

更新日期：2019-01-01 00:00:00

abstract：:Abstract The human major histocompatibility complex (MHC) class I gene HLA-B27 bears a striking association with ankylosing spondylitis and related spondyloarthropathies. This association transcends all ethnic and geographical boundaries. The primary function of HLA-B27 as an MHC class I protein is to form a complex w...

journal_title：Modern rheumatology

authors： Mehra NK,Kanga U

更新日期：2001-12-01 00:00:00

abstract：:We report a patient who had a 4-year history of adult-onset Still's disease (AOSD) and showed a prominent increase in large granular lymphocytes (LGL) when she developed severe Pseudomonas conjunctivitis due to Pseudomonas aeruginosa, skin eruptions, liver damage, and abnormal findings in coagulation studies, without ...

journal_title：Modern rheumatology

authors： Tabata R,Tabata C,Fukuda H,Kotani H

更新日期：2006-01-01 00:00:00

abstract：:Abstract A 17-year-old woman who was being treated with prednisolone for cutaneous vasculitis developed recurrent massive melena and abdominal pain. An emergency resection was performed because of uncontrollable melena, revealing many small intestinal ulcers with cytomegalic inclusion bodies, which were found by immun...

journal_title：Modern rheumatology

authors： Ota Y,Ohashi H,Otani C,Dei Y,Kondo S,Baba S

更新日期：2002-09-01 00:00:00

abstract：:Bucillamine (Bc) is a cysteine derivative with two SH groups, and a homolog of D-penicillamine, a disease-modifying antirheumatic drug (DMARD) widely used in Japan. However, it remains unclear whether Bc repairs bone erosion in patients with RA. Here, we treated three RA patients with Bc who subsequently showed radiog...

journal_title：Modern rheumatology

authors： Nanke Y,Iwatani M,Kobashigawa T,Yago T,Yamanaka H,Kotake S

更新日期：2009-01-01 00:00:00

abstract：:We report a patient with the extremely rare familial multiple lipomatosis syndrome, who developed the uncommon autoimmune disease cytophagic histiocytic panniculitis, manifested as inflammation of preexisting lipomas. Despite his initial critical condition and unsuccessful treatment with steroids, he responded to cycl...

journal_title：Modern rheumatology

authors： Krilis M,Miyakis S

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVES:To assess the real-world effectiveness of golimumab in Japanese patients with rheumatoid arthritis who had previously received one or more biologic therapies. METHODS:A post-hoc analysis of post-marketing surveillance was performed. The clinical response to golimumab was analyzed in 1216 patients who had pr...

journal_title：Modern rheumatology

authors： Shimizu H,Kobayashi H,Kanbori M,Ishii Y

更新日期：2020-08-19 00:00:00

abstract：:For over 10 years there have been no clinical studies about adult-onset Still's disease (AOSD) in Japan. We aimed to investigate recent clinical features and treatment of AOSD and to evaluate the efficacy of cyclosporin A (CyA) in the treatment of AOSD. The data from 34 patients with AOSD who were admitted to our hosp...

journal_title：Modern rheumatology

authors： Mitamura M,Tada Y,Koarada S,Inoue H,Suematsu R,Ohta A,Nagasawa K

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:Locomotive syndrome (LS) encompasses conditions that may lead to the need for nursing services. We aimed to quantify the association between exercise habits during youth or the middle-age years and both physical function and the presence of LS in Japanese elderly people. METHODS:We examined 460 participants...

journal_title：Modern rheumatology

authors： Nishimura A,Ito N,Asanuma K,Akeda K,Ogura T,Sudo A

更新日期：2018-03-01 00:00:00

abstract：:Relapsing polychondritis (RP) is a rare disease of unknown etiology causing systematic inflammation and resulting in destruction of cartilaginous tissues. We describe here an 18-year-old Japanese woman who developed severe airway stenosis as the initial symptom with auricular, nasal, and ocular inflammation. The effec...

journal_title：Modern rheumatology

authors： Yamaoka K,Saito K,Hanami K,Nakayamada S,Nawata M,Iwata S,Azuma T,Tanaka Y

更新日期：2007-01-01 00:00:00

abstract：:Objectives: Overactive bladder (OAB) is a clinical diagnosis defined with the presence of urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence. Objective was to evaluate the demographic and clinical characteristics of Japanese systemic sclerosis (SSc) patients wi...

journal_title：Modern rheumatology

authors： Motegi SI,Sekiguchi A,Sekine Y,Nakayama H,Suzuki K,Ishikawa O

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the therapeutic efficacy of a novel inhibitor for IκB kinase alpha (IKKα), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA). METHODS:NAM has been chemically synthesized as reported earlier. CIA was induced in DBA/1JNCrlj mice by int...

journal_title：Modern rheumatology

authors： Ito M,Hamano T,Komatsu T,Asamitsu K,Yamakawa T,Okamoto T

更新日期：2014-09-01 00:00:00

abstract：:Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his diseas...

journal_title：Modern rheumatology

authors： Ito T,Ozaki Y,Shimamoto K,Amuro H,Tanijiri T,Yokoi T,Son Y,Tajima K,Fukuhara S

更新日期：2008-01-01 00:00:00

abstract：:Inflammation has often been considered to be a nonspecific response and to play a bridging role in the activation of adaptive immunity. However, it is now accepted that inflammation is the product of an independent innate immune system closely linked to the adaptive immune system. The key mediators of inflammation are...

journal_title：Modern rheumatology

authors： Yokota S,Kikuchi M,Nozawa T,Kanetaka T,Sato T,Yamazaki K,Sakurai N,Hara R,Mori M

更新日期：2015-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a complex process of chronic and progressive inflammation associated with activation of numerous signaling molecules and transcription factors and hyperproliferation of synoviocytes of the affected joints, although the greater part of its pathophysiological process is explained by activati...

journal_title：Modern rheumatology

authors： Okamoto T

更新日期：2005-01-01 00:00:00

abstract：:We examined the efficacy and safety of autologous transplantation of bone-marrow-derived cells in patients with intractable ulcers caused by systemic sclerosis. Eight patients with ulcers resistant to treatment were enrolled. Bone marrow cells were gathered from the bilateral iliac crests with multiple repositioning b...

journal_title：Modern rheumatology

authors： Ishigatsubo Y,Ihata A,Kobayashi H,Hama M,Kirino Y,Ueda A,Takeno M,Shirai A,Ohno S

更新日期：2010-06-01 00:00:00

abstract：:We report a novel case of eosinophilic orbital myositis associated with Churg-Strauss syndrome. A 56-year-old man with a 20-year history of chronic sinusitis and seasonal allergic rhinitis was admitted because of fever, swelling of cheeks and extremities, diplopia, and eosinophilia. With findings from gadolinium-enhan...

journal_title：Modern rheumatology

authors： Fujii T,Norizuki M,Kobayashi T,Yamamoto M,Kishimoto M

更新日期：2010-04-01 00:00:00

abstract：:We report the case of a 73-year-old man with myelodysplastic syndrome (MDS) who developed Weber-Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple ten...

journal_title：Modern rheumatology

authors： Hojo N,Hasegawa H,Iwamasa K,Hojo S,Fujita S

更新日期：2004-01-01 00:00:00

abstract：:Objectives: Thrombocytopenia is frequently observed in antiphospholipid antibody (aPL) carriers. Due to the paradoxical risks of thrombosis and hemorrhage, the management of aPL-associated thrombocytopenia (APAT) is often deductive. We aimed to investigate the efficacy and safety of therapeutic approaches for APAT thr...

journal_title：Modern rheumatology

authors： Abe N,Oku K,Amengual O,Fujieda Y,Kato M,Bohgaki T,Yasuda S,Mori R,Morishita E,Suzuki-Inoue K,Atsumi T

更新日期：2020-01-01 00:00:00

abstract：:Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...

journal_title：Modern rheumatology

authors： Yagita M,Hamano T,Hatachi S,Fujita M

更新日期：2016-01-01 00:00:00

abstract：:Abstract Three cases of childhood-onset systemic lupus erythematosus (childhood SLE) with long-term remission are reported. These cases were not complicated with collagen diseases and had no SLE disease activity index scores either 3 or 5 years after onset. We suggest that some patients with childhood SLE may be able ...

journal_title：Modern rheumatology

authors： Mori M,Kobayashi Y,Miyamae T,Imagawa T,Katakura S,Mitsuda T,Aihara Y,Yokota S

更新日期：2003-09-01 00:00:00

abstract：:To investigate the precise modality of association between SAA1 gene polymorphisms and the development of AA amyloidosis in patients with rheumatoid arthritis (RA), Japanese patients with RA (n=153), among whom 29 were histologically diagnosed as having amyloidosis, were genotyped for three single nucleotide polymorph...

journal_title：Modern rheumatology

authors： Ajiro J,Narita I,Sato F,Saga D,Hasegawa H,Kuroda T,Nakano M,Gejyo F

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS:J-RAPID double-blind patients were ente...

journal_title：Modern rheumatology

authors： Tanaka Y,Yamamoto K,Takeuchi T,Yamanaka H,Ishiguro N,Eguchi K,Watanabe A,Origasa H,Shoji T,Miyasaka N,Koike T

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:Fibromyalgia syndrome (FMS) is a chronic disease characterized by diffuse pain of unknown cause, fatigue, sleep disorders, cognitive dysfunction, and sensitivity. Fibromyalgia was shown to be associated with balance problems and increased incidence of falls. There are many theoretical mechanisms related to...

journal_title：Modern rheumatology

authors： Kasapoğlu Aksoy M,Altan L,Ökmen Metin B

更新日期：2017-09-01 00:00:00

abstract：:Pneumatosis cystoides intestinalis (PCI), which is characterized by the presence of multiple gas-filled mucosal, submucosal, or subserosal cysts located throughout the colon and/or small intestine, is an unusual complication of systemic lupus erythematosus (SLE). We report a case of a 33-year-old woman with a 5-year h...

journal_title：Modern rheumatology

authors： Yamaguchi Y,Ohno S,Yamazaki S,Ideguchi H,Shirai A,Takeno M,Ishigatsubo Y

更新日期：2005-01-01 00:00:00

abstract：:Abstract Twenty-six patients with systemic lupus erythematosus (SLE) showing systemic lupus activity measure (SLAM) and SLE disease activity index (SLEDAI) scores ≤2, as well as a lower C4 concentration than the mean C4 levels of healthy controls, were selected to evaluate the C4 levels of SLE patients in remission. S...

journal_title：Modern rheumatology

authors： Yasuda M,Suenaga Y,Nishimukai H,Nobunaga M

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:To clarify the efficacy and safety of abatacept for secondary Sjögren's syndrome (SS) associated with rheumatoid arthritis (RA). METHODS:The primary endpoint of this open-labeled, prospective, observational multicenter study for secondary SS with RA was the remission rate of Simplified Disease Activity Index...

journal_title：Modern rheumatology

authors： Tsuboi H,Matsumoto I,Hagiwara S,Hirota T,Takahashi H,Ebe H,Yokosawa M,Yagishita M,Takahashi H,Kurata I,Ohyama A,Honda F,Asashima H,Miki H,Umeda N,Kondo Y,Hirata S,Saito K,Tanaka Y,Horai Y,Nakamura H,Kawakami A,

更新日期：2016-11-01 00:00:00