A case of eosinophilic orbital myositis associated with CSS.

abstract：OBJECTIVE:To assess the long-term safety, immunogenicity, and efficacy of subcutaneous (SC) abatacept in combination with methotrexate (MTX) in Japanese patients with rheumatoid arthritis who were MTX inadequate responders, in a long-term extension (LTE) to a double-dummy, double-blind study (NCT01001832). METHODS:Pat...

journal_title：Modern rheumatology

authors： Amano K,Matsubara T,Tanaka T,Inoue H,Iwahashi M,Kanamono T,Nakano T,Uchimura S,Izumihara T,Yamazaki A,Karyekar CS,Takeuchi T,Japan Abatacept Study Group.

更新日期：2015-09-01 00:00:00

abstract：:Nintedanib (Ofev™), an oral triple kinase inhibitor targeting pro-fibrotic pathways, has been used for treatment of idiopathic pulmonary fibrosis (IPF). Based on positive results from phase III, placebo-controlled, randomized comparative clinical trial conducted in patients with systemic sclerosis-associated interstit...

journal_title：Modern rheumatology

authors： Kuwana M,Azuma A

更新日期：2020-03-01 00:00:00

abstract：:Cutaneous polyarteritis nodosa (CPAN) is a form of necrotizing vasculitis of small and medium-sized arteries. It is limited to the skin and has a recurrent and chronic course, possibly associated with fever, arthralgia, myalgia and neuropathy, but without visceral involvement. We report the clinical case of a 7-year-o...

journal_title：Modern rheumatology

authors： Valor L,Monteagudo I,de la Torre I,Fernández CG,Montoro M,Longo JL,Carreño L

更新日期：2014-07-01 00:00:00

abstract：:We examined the therapeutic effect of high molecular weight hyaluronic acid (HA) on the progression of joint pain and cartilage degeneration in a rabbit osteoarthritis (OA) model. The OA model was induced by partial meniscectomy. In the time course study, cartilage degeneration was assessed at 3, 7 and 14 days after o...

journal_title：Modern rheumatology

authors： Hashizume M,Koike N,Yoshida H,Suzuki M,Mihara M

更新日期：2010-10-01 00:00:00

abstract：:Management of rheumatoid arthritis (RA) has improved over the last 10 years. These changes have been monitored in the Institute of Rheumatology, Rheumatoid Arthritis (IORRA) observational cohort, and clinical remission has become a realistic goal. However, we should recognize that the ultimate goal of treatment is to ...

journal_title：Modern rheumatology

authors： Yamanaka H,Seto Y,Tanaka E,Furuya T,Nakajima A,Ikari K,Taniguchi A,Momohara S

更新日期：2013-01-01 00:00:00

abstract：:We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron's papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including stero...

journal_title：Modern rheumatology

authors： Horai Y,Isomoto E,Koga T,Okada A,Kawashiri SY,Tamai M,Yamasaki S,Nakamura H,Origuchi T,Hamaguchi Y,Fujimoto M,Kuwana M,Kawakami A

更新日期：2013-01-01 00:00:00

abstract：:Research into the bone destruction associated with rheumatoid arthritis has highlighted the importance of the interplay of the immune and skeletal systems. Arthritic bone destruction is attributable to the defective control of osteoclastogenesis by T cells. We revealed that excessive expression of receptor activator o...

journal_title：Modern rheumatology

authors： Takayanagi H

更新日期：2005-01-01 00:00:00

abstract：:Endogenous lipoid pneumonia is an uncommon inflammatory pulmonary disease that is caused by lipids from an endogenous source, the treatment for which has not been established. We report the first case of endogenous lipoid pneumonia presenting as lung consolidation and which was associated with rheumatoid arthritis. Tr...

journal_title：Modern rheumatology

authors： Morita H,Arai S,Kurasawa K,Okada H,Tanaka A,Yamazaki R,Owada T,Maezawa R

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To clarify the efficacy and safety of abatacept for secondary Sjögren's syndrome (SS) associated with rheumatoid arthritis (RA). METHODS:The primary endpoint of this open-labeled, prospective, observational multicenter study for secondary SS with RA was the remission rate of Simplified Disease Activity Index...

journal_title：Modern rheumatology

authors： Tsuboi H,Matsumoto I,Hagiwara S,Hirota T,Takahashi H,Ebe H,Yokosawa M,Yagishita M,Takahashi H,Kurata I,Ohyama A,Honda F,Asashima H,Miki H,Umeda N,Kondo Y,Hirata S,Saito K,Tanaka Y,Horai Y,Nakamura H,Kawakami A,

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:To assess changes in salivary epidermal growth factor (EGF) levels within three years and investigate the correlation between these changes and the severity of intraoral manifestations in patients with Sjögren's syndrome (SS). METHODS:Twenty-three SS patients (14 primary SS and 9 secondary SS) and 14 contro...

journal_title：Modern rheumatology

authors： Azuma N,Katada Y,Kitano S,Sekiguchi M,Kitano M,Nishioka A,Hashimoto N,Matsui K,Iwasaki T,Sano H

更新日期：2015-01-01 00:00:00

abstract：:Blau syndrome/early-onset sarcoidosis (Blau/EOS) is an autoinflammatory disease characterized by granulomatous arthritis, uveitis, and skin rash. It has been shown that gain-of-function NOD2 mutations cause Blau/EOS. In this paper, we describe a patient with a gain-of-function NOD2 mutation who developed infantile Tak...

journal_title：Modern rheumatology

authors： Inoue Y,Kawaguchi Y,Shimojo N,Yamaguchi K,Morita Y,Nakano T,Arima T,Tomiita M,Kohno Y

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To clarify polyarticular juvenile idiopathic arthritis (pJIA) patients who failed to maintain prolonged remission with the first biologic agent. METHODS:Fourteen pJIA patients were observed for 47.5 months (median) after initiating the first biologic agent. RESULTS:Eight maintained sustained clinical remiss...

journal_title：Modern rheumatology

authors： Kubota T,Imanaka H,Takei S,Yamatou T,Nerome Y,Yamasaki Y,Nonaka Y,Akaike H,Takezaki T,Kawano Y

更新日期：2016-01-01 00:00:00

abstract：:To evaluate the composite disease activity indices for rheumatoid arthritis (RA), we compared disease activities and the changes therein calculated using the Disease Activity Score based on 28 joint counts using erythrocyte sedimentation rate (DAS28-ESR), DAS28-CRP (C-reactive protein), Simplified Disease Activity Ind...

journal_title：Modern rheumatology

authors： Matsui T,Kuga Y,Nishino J,Kaneko A,Eto Y,Tohma S

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate the efficacy of arthroscopic enlargement of unidirectional valvular slits for the treatment of popliteal cysts and to evaluate potential factors affecting the outcomes of our arthroscopic procedure. METHODS:Twenty-nine patients aged 43-77 years with popliteal c...

journal_title：Modern rheumatology

authors： Ohishi T,Takahashi M,Suzuki D,Fujita T,Yamamoto K,Ushirozako H,Banno T,Matsuyama Y

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:To evaluate the scoring of whole-body magnetic resonance imaging (WBMRI) for efficacy assessment in rheumatoid arthritis (RA) patients receiving biological disease-modifying anti-rheumatic drugs (bDMARDs). METHODS:Thirty consecutive RA patients receiving bDMARDs were included in this retrospective study. Co...

journal_title：Modern rheumatology

authors： Kono M,Kamishima T,Yasuda S,Sakamoto K,Abe S,Noguchi A,Watanabe T,Shimizu Y,Oku K,Bohgaki T,Amengual O,Horita T,Atsumi T

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to analyze the score of fatigue in a large cohort of Brazilian patients with SpA, comparing different disease patterns and its association with demographic and disease-specific variables. METHODS:A common protocol of investigation was prospectively applied to 1492 Brazilian ...

journal_title：Modern rheumatology

authors： Bianchi WA,Elias FR,Carneiro S,Bortoluzzo AB,Gonçalves CR,da Silva JA,Ximenes AC,Bértolo MB,Ribeiro SL,Keiserman M,Skare TL,Menin R,Azevedo VF,Vieira WP,Albuquerque EN,Bonfiglioli R,Campanholo C,Carvalho HM,Costa IP,

更新日期：2014-11-01 00:00:00

abstract：:A 24-year-old Japanese woman was admitted to our hospital suffering from high fever and progressive paralysis in both legs. Magnetic resonance imaging of the spinal cord showed high-intensity signals from C5 to Th4 and from Th7 to L1 on T2-weighted images. The patient was diagnosed as having acute transverse myelitis ...

journal_title：Modern rheumatology

authors： Yamanaka F,Migita K,Ichinose K,Ohno N,Kimura H,Ishimaru H,Matsuoka Y,Eguchi K,Ezaki H

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS:J-RAPID double-blind patients were ente...

journal_title：Modern rheumatology

authors： Tanaka Y,Yamamoto K,Takeuchi T,Yamanaka H,Ishiguro N,Eguchi K,Watanabe A,Origasa H,Shoji T,Miyasaka N,Koike T

更新日期：2014-09-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a very heterogeneous systemic autoimmune disease, in which autoantibody synthesis against nuclear constituents is the main immunological characteristic. These autoantibodies underwent affinity maturation and isotype switching. Additionally, T-cell tolerance against nuclear autoant...

journal_title：Modern rheumatology

authors： Grossmayer GE,Munoz LE,Gaipl US,Franz S,Sheriff A,Voll RE,Kalden JR,Herrmann M

更新日期：2005-01-01 00:00:00

abstract：:To investigate the role of interleukin (IL)-33 in rheumatoid arthritis (RA) patients, we measured the serum levels of IL-33 in RA patients before and after the administration of etanercept. Twenty-four patients with RA were treated with etanercept. Clinical and laboratory examinations, including serum levels of C-reac...

journal_title：Modern rheumatology

authors： Kageyama Y,Torikai E,Tsujimura K,Kobayashi M

更新日期：2012-02-01 00:00:00

abstract：:Abstract A woman with Sjögren's syndrome concurrently suffered bilateral fractures of the femoral neck without any proximate cause, while she had aseptic necrosis of the femoral head resulting from the treatment for Sjögren's syndrome. According to previous reports, fractures of the femoral neck following aseptic necr...

journal_title：Modern rheumatology

authors： Kamiya M,Ueno M,Yamaguchi H,Kanata S,Sohen S

更新日期：2004-12-01 00:00:00

abstract：:For over 10 years there have been no clinical studies about adult-onset Still's disease (AOSD) in Japan. We aimed to investigate recent clinical features and treatment of AOSD and to evaluate the efficacy of cyclosporin A (CyA) in the treatment of AOSD. The data from 34 patients with AOSD who were admitted to our hosp...

journal_title：Modern rheumatology

authors： Mitamura M,Tada Y,Koarada S,Inoue H,Suematsu R,Ohta A,Nagasawa K

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:To determine the frequency of Th2-mediated allergic diseases (AD) in mainly Th1-driven juvenile idiopathic arthritis (JIA) subtypes. METHODS:Ninety-nine JIA patients and 128 control subjects were enrolled in a prospective case-control study. All subjects were assessed with standard allergy questionnaire, co...

journal_title：Modern rheumatology

authors： Avar-Aydin PO,Nepesov S,Barut K,Sahin S,Adrovic A,Cokugras HC,Kasapcopur O

更新日期：2020-09-07 00:00:00

abstract：:We present the case of a 60-year-old female patient with systemic sclerosis complicated by pulmonary hypertension. Ten days after the initiation of treatment with bosentan, high fever and skin eruptions were noted. In the previous reports, the frequency of drug-induced skin eruptions has not been well documented. Sinc...

journal_title：Modern rheumatology

authors： Nagai Y,Yamanaka M,Nishimura S,Nakano A,Hasegawa A,Ishikawa O

更新日期：2006-01-01 00:00:00

abstract：:Cutaneous polyarteritis nodosa (cutaneous PAN) is a form of necrotizing vasculitis of small- and medium-sized arteries, primarily involving the skin. In juvenile cases, cutaneous PAN is known to be frequently associated with Group A β-hemolytic Streptococcus (GAS) infections. We herein describe the first reported juve...

journal_title：Modern rheumatology

authors： Yamamoto T,Inoue Y,Tomiita M,Oikawa M,Kambe N,Arima T,Shimojo N,Kohno Y

更新日期：2015-01-01 00:00:00

abstract：:OBJECTIVES: To validate the 2010 histopathological classification system of anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (GN) in a Japanese single-center cohort. METHODS: We retrospectively studied 54 patients (28 renally limited pauci-immune GN, 25 microscopic polyangiitis, and one Chur...

journal_title：Modern rheumatology

authors： Togashi M,Komatsuda A,Nara M,Omokawa A,Okuyama S,Sawada K,Wakui H

更新日期：2013-04-12 00:00:00

abstract：OBJECTIVES:Anticentromere antibody (ACA) is generally considered to be a serological marker for systemic sclerosis (SSc). ACA-positive patients with primary Sjögren's syndrome (pSS) have also been reported. ACA often recognizes centromere proteins (CENPs): CENP-A, CENP-B, and CENP-C, and sometimes reacts to heterochrom...

journal_title：Modern rheumatology

authors： Tanaka N,Muro Y,Suzuki Y,Nishiyama S,Takada K,Sekiguchi M,Hashimoto N,Ohmura K,Shimoyama K,Saito I,Kawano M,Akiyama M

更新日期：2017-01-01 00:00:00

abstract：:Cyclosporin A (CsA) has various adverse effects including neurotoxicity. We report the case of a 49-year-old Japanese woman with dermatomyositis who showed CsA-induced cortical blindness. The patient demonstrated cortical blindness despite having a normal blood concentration of CsA. The risk factors of CsA-induced cor...

journal_title：Modern rheumatology

authors： Sawabe T,Imafuku S

更新日期：2004-01-01 00:00:00

abstract：:We examined the efficacy and safety of autologous transplantation of bone-marrow-derived cells in patients with intractable ulcers caused by systemic sclerosis. Eight patients with ulcers resistant to treatment were enrolled. Bone marrow cells were gathered from the bilateral iliac crests with multiple repositioning b...

journal_title：Modern rheumatology

authors： Ishigatsubo Y,Ihata A,Kobayashi H,Hama M,Kirino Y,Ueda A,Takeno M,Shirai A,Ohno S

更新日期：2010-06-01 00:00:00

abstract：:Abstract We report on a 24-year-old woman with systemic lupus erythematosus and lupus anticoagulant who developed chronic thrombotic microangiopathic hemolytic anemia. The patient responded well to a combination of plasma exchange and anticoagulant therapy. Changes in the molecular markers for coagulation and fibrinol...

journal_title：Modern rheumatology

authors： Asanuma Y,Suzuki Y,Yasumuro Y,Ichikawa Y

更新日期：2000-12-01 00:00:00