Abstract:
:Research into the bone destruction associated with rheumatoid arthritis has highlighted the importance of the interplay of the immune and skeletal systems. Arthritic bone destruction is attributable to the defective control of osteoclastogenesis by T cells. We revealed that excessive expression of receptor activator of NF-kappaB ligand (RANKL) and a paucity of interferon-gamma underlie the enhanced osteoclastogenesis in arthritis. The interdisciplinary research field called osteoimmunology has attracted further attention after identification of a number of unexpected bone phenotypes in mice lacking immunomodulatory molecules. Accumulating evidence suggests that the immune and skeletal systems share not only cytokines but also various signaling molecules, transcription factors, and membrane receptors. Thus, bone turns out to be a dynamic tissue that is constantly renewed, where the immune system participates to a hitherto unexpected extent. This emerging field will be of great importance for a better understanding and treatment of rheumatic diseases.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Takayanagi Hdoi
10.1007/s10165-005-0398-6subject
Has Abstractpub_date
2005-01-01 00:00:00pages
225-31issue
4eissn
1439-7595issn
1439-7609journal_volume
15pub_type
杂志文章abstract::Periaortitis and periarteritis are one of the clinical features of IgG4-related disease. Such vascular manifestations are reported to be present in 10-30% of overall IgG4-related disease, and they may also appear as an isolated lesion of IgG4-related disease. As other types of large vessel vasculitis, IgG4-related vas...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1546367
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To evaluate, through a systematic review of the literature, the association between the use of biological disease-modifying antirheumatic drugs (bDMARDs) and surgical site infection (SSI) or wound healing delay after orthopedic surgery in patients with rheumatoid arthritis (RA). METHODS:A systematic review ...
journal_title:Modern rheumatology
pub_type: 杂志文章,meta分析,评审
doi:10.3109/14397595.2015.1014302
更新日期:2015-09-01 00:00:00
abstract::Abstract We report a case of hypocalcemic myopathy confounded by polymyositis due to an elevated level of serum creatine kinase (CK). A 30-year-old man was referred to our hospital for the treatment of provisionally diagnosed polymyositis. His presentation with tetany, hyporeflexia, and general fatigue, in addition to...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200032
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVES:The present study aimed to conduct an epidemiological survey of Central Sensitization Inventory (CSI) scores in an older adult population and to investigate the association between the CSI scores, age, sex, pain intensity, site of pain, and health-related quality of life (QOL). METHODS:Participants were 373...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1822983
更新日期:2020-10-02 00:00:00
abstract:OBJECTIVES:The objective of this study is to evaluate the efficacy and safety of long-term (64 weeks; 52-week extension of a 12-week study) baricitinib treatment in Japanese patients with active rheumatoid arthritis (RA) despite methotrexate therapy. METHODS:Patients (N = 145) with active RA were randomized to placebo...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.1080/14397595.2017.1307899
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Neutrophil extracellular traps (NETs) are peculiar structures composed of the externalized chromatin with intracellular proteins and formed by activated neutrophils in a reactive oxygen species (ROS)-dependent manner. Aberrant NETs are considered to be autoantigens for anti-neutrophil cytoplasmic antibodies (...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1367116
更新日期:2018-05-01 00:00:00
abstract::Bucillamine (Buc) is a disease-modifying antirheumatic drug (DMARD) developed in Japan, which has been used as one of the first-line DMARDs for the treatment of rheumatoid arthritis (RA) in Japan. However, direct comparison of this drug with standard DMARDs including sulfasalazine (SASP) and methotrexate (MTX) has bee...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-006-0527-x
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to analyze the score of fatigue in a large cohort of Brazilian patients with SpA, comparing different disease patterns and its association with demographic and disease-specific variables. METHODS:A common protocol of investigation was prospectively applied to 1492 Brazilian ...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.3109/14397595.2014.906049
更新日期:2014-11-01 00:00:00
abstract::We investigated the association between cigarette smoking and the risk of developing rheumatoid arthritis (RA) in the Malaysian population. A total of 1,056 RA patients and 1,416 matched controls aged 18-70 years within a defined area of Peninsular Malaysia were evaluated in a case-control study between August 2005 an...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10165-011-0544-2
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVES:In this study, we aimed to assess the effect of combination of proliferative and membranous lesions (Class III + V or IV + V) on renal outcomes as an independent category distinct from Class III and IV. METHODS:We retrospectively analyzed 103 Japanese patients (14 male and 89 female) with Class III/IV LN, w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1158896
更新日期:2016-11-01 00:00:00
abstract::The objective of this study was to show whether the disease activity of rheumatoid arthritis (RA) patients had improved in Japan, and whether the improvement of disease activity had resulted in a better outcome of patients. In a single-institute-based prospective observational cohort of RA patients (Institute of Rheum...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0587-6
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:We aimed to analyze clinical features and treatment outcomes of otitis media caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), i.e. otitis media with AAV (OMAAV). METHODS:This survey was performed between December 2013 and February 2014. The study began with a preliminary surv...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1177926
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:This pilot multicenter exercise aimed to evaluate the inter-observer reproducibility of synovial power Doppler (PD) signals in rheumatoid arthritis (RA) patients and to determine the factors influencing the measurements. METHODS:Two representative RA patients were assessed by four independent experienced so...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.3109/14397595.2013.843763
更新日期:2014-05-01 00:00:00
abstract::Abstract Five cases of flexor tendon rupture in surgically treated rheumatoid wrists were studied. The tendon ruptures occurred in the thumb and index finger, and the ruptures site was in the carpal tunnel in all five cases. The main cause of rupture was the formation of bony irregularities in the form of bony spurs i...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170025
更新日期:2001-06-01 00:00:00
abstract::Macrophage activation syndrome (MAS), also known as secondary hemophagocytic lymphohistiocytosis, is mediated by cytokine overproduction from excessive activation of T lymphocytes and macrophages. We present a dermatomyositis patient with MAS, caused by hypercytokinemia. The combination of tacrolimus and plasma exchan...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.844402
更新日期:2015-01-01 00:00:00
abstract::A female rheumatoid arthritis patient was admitted for productive cough and general fatigue that had gradually developed after leflunomide therapy. Side effects including severe hypoxia, thrombocytopenia, lymphocytopenia, and macrocytic anemia with schistocytes (probably drug-induced megaloblastic anemia) were noted. ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0613-8
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS:Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joi...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1253813
更新日期:2017-07-01 00:00:00
abstract::A 43-year-old Japanese woman with systemic lupus erythematosus (SLE) developed rapidly progressive renal failure and nephritic syndrome with a high titer of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA). Methylprednisolone pulse therapy did not suppress the progression of renal failure. Intravenous cy...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0266-x
更新日期:2010-06-01 00:00:00
abstract::We report the case of a 73-year-old man with myelodysplastic syndrome (MDS) who developed Weber-Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple ten...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-003-0270-5
更新日期:2004-01-01 00:00:00
abstract::We investigated the clinical efficacy and safety of tocilizumab (a humanized anti-IL-6 receptor antibody) monotherapy in active rheumatoid arthritis (RA) patients with an inadequate response to low dose methotrexate (MTX). In a multicenter, double-blind, randomized, controlled trial, 125 patients were allocated to rec...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s10165-008-0125-1
更新日期:2009-01-01 00:00:00
abstract::Objectives: The Childhood Health Assessment Questionnaire (CHAQ) is one of the most widely used self- report questionnaires to measure functional status in Juvenile idiopathic arthritis (JIA). The Japanese version of the CHAQ (JCHAQ) has been revised to meet requirements of clinical international trials which need the...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1660027
更新日期:2020-09-01 00:00:00
abstract::Abstract Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug (DMARD) throughout the world. In Japan, MTX is recommended by the Japanese Ministry of Health, Labour, and Welfare to be given as the second or third DMARD and at a dosage of no more than 8 mg/week. We analyzed the efficacy of M...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-004-0340-3
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy and safety of intravenous (IV) belimumab plus standard systemic lupus erythematosus (SLE) therapy standard of care (SoC) in Japanese patients with SLE. METHODS:A Phase 3, multicenter, double-blind, placebo-controlled, 52-week study (BEL 113750; NCT01345253) in patients with SLE, rando...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/14397595.2018.1480915
更新日期:2019-05-01 00:00:00
abstract::Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.859770
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To evaluate joint inflammation using 3-T MRI in rheumatoid arthritis (RA) patients treated with conventional disease modifying anti-rheumatic drugs (cDMARDs) as compared to inhibitors for tumor necrosis factor α (TNFi) over 12 months. METHODS:Prospective epidemiologic clinical pilot study using the RA MRI s...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1467525
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:Although "clinical remission" has been a realistic goal of treatment in rheumatoid arthritis (RA), there is evidence that subclinical synovitis is associated with ongoing structural damage even after clinical remission is achieved. In the study reported here, we assessed whether ultrasonography (US) can pred...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0690-1
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:Assessment of synovitis in the metatarsophalangeal (MTP) joints with ultrasound has been shown to improve the accuracy of assessment of rheumatoid arthritis (RA). However, the presence of intraarticular low-echoic synovial area (LESA) in the MTP joints in healthy subjects complicates the sonographic assess...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.970740
更新日期:2015-05-01 00:00:00
abstract::The number of patients with juvenile-onset Sjögren's syndrome (SS) has recently increased. However, there is no drug that is safe and effective for the xerostomia that occurs in patients of this age group. We evaluated the efficacy and safety of orally administered pilocarpine hydrochloride for juvenile-onset SS patie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0313-7
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to develop clinical practice guideline (CPG) for Sjögren's syndrome (SS) based on recently available clinical and therapeutic evidences. METHODS:The CPG committee for SS was organized by the Research Team for Autoimmune Diseases, Research Program for Intractable Disease of the...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1438093
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:We seek to evaluate the opinions of nurses and doctors in Japan regarding EULAR recommendations for nurses' roles in the management of chronic inflammatory arthritis. METHODS:This is a cross-sectional survey within Japan. We randomly selected nurses and doctors engaged in consultation of patients with rheuma...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1260199
更新日期:2017-09-01 00:00:00