Successful treatment of macrophage activation syndrome in a patient with dermatomyositis by combination with immunosuppressive therapy and plasmapheresis.

abstract：:Abstract To clarify the effect of leukemia inhibitory factor (LIF) on the destruction of rheumatoid arthritis (RA) joints, we investigated the production of LIF and the expression of LIF mRNA in synovial tissues from patients with RA and osteoarthritis (OA). Synovial fluids from RA were used to measure the LIF concent...

journal_title：Modern rheumatology

authors： Enomoto H,Saito S,Yabe H,Toyama Y,Tomatu T

更新日期：2003-06-01 00:00:00

abstract：:The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet's disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were ...

journal_title：Modern rheumatology

authors： Nanke Y,Kotake S,Goto M,Ujihara H,Matsubara M,Kamatani N

更新日期：2008-01-01 00:00:00

abstract：:Here, we report the case of a 69-year-old man with limited granulomatosis with polyangiitis (GPA; formerly Wegener's granulomatosis) who developed papillary thyroid cancer, adenocarcinoma of the stomach, and myelodysplastic syndrome following glucocorticoid treatment. This is the first report to present multiple malig...

journal_title：Modern rheumatology

authors： Cheon YH,Kim MG,Kim JE,Ha CY,Lee SI,Kim HO

更新日期：2016-01-01 00:00:00

abstract：:We report a patient with the extremely rare familial multiple lipomatosis syndrome, who developed the uncommon autoimmune disease cytophagic histiocytic panniculitis, manifested as inflammation of preexisting lipomas. Despite his initial critical condition and unsuccessful treatment with steroids, he responded to cycl...

journal_title：Modern rheumatology

authors： Krilis M,Miyakis S

更新日期：2012-02-01 00:00:00

abstract：:We performed this study to investigate the differences in radiological and laboratory findings between systemic juvenile idiopathic arthritis (s-JIA) and polyarthritis (p-JIA). Twenty-two patients with s-JIA and 18 with p-JIA were enrolled. Their laboratory findings and radiographs were examined retrospectively. Plain...

journal_title：Modern rheumatology

authors： Ozawa R,Inaba Y,Mori M,Hara R,Kikuchi M,Higuchi R,Miyamae T,Imagawa T,Fujiwara T,Saito T,Yokota S

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety and efficacy of reducing the duration of infliximab infusion for rheumatoid arthritis (RA) treatment. METHODS:The first 6 infliximab infusions were each administered over a 2-h period. If no adverse reaction was observed, infusion times were shortened to 1 h starting with the seventh i...

journal_title：Modern rheumatology

authors： Fukuyo S,Saito K,Yamaoka K,Sawamukai N,Hirata S,Nawata M,Iwata S,Tanaka Y

更新日期：2014-03-01 00:00:00

abstract：:The number of patients with juvenile-onset Sjögren's syndrome (SS) has recently increased. However, there is no drug that is safe and effective for the xerostomia that occurs in patients of this age group. We evaluated the efficacy and safety of orally administered pilocarpine hydrochloride for juvenile-onset SS patie...

journal_title：Modern rheumatology

authors： Tomiita M,Takei S,Kuwada N,Nonaka Y,Saito K,Shimojo N,Kohno Y

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:The aim of our study is to clarify the association of myositis-specific autoantibodies (MSAs) with clinical and laboratory features in Japanese patients with juvenile idiopathic inflammatory myopathies (JIIMs). METHODS:We retrospectively analyzed the frequency of MSAs and their association with clinical or ...

journal_title：Modern rheumatology

authors： Ueki M,Kobayashi I,Takezaki S,Tozawa Y,Okura Y,Yamada M,Kuwana M,Ariga T

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:To provide evidence for the revision of clinical practice guideline (CPG) for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) by the Japan Research Committee for Intractable Vasculitis. METHODS:PubMed, CENTRAL, and the Japan Medical Abstracts Society were searched fo...

journal_title：Modern rheumatology

authors： Nagasaka K,Harigai M,Hagino N,Hara A,Horita T,Hayashi T,Itabashi M,Ito S,Katsumata Y,Kawashima S,Naniwa T,Sada KE,Nango E,Nakayama T,Tsutsumino M,Yamagata K,Homma S,Arimura Y

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Avascular necrosis of bone (AVN) is an important complication of systemic lupus erythematosus (SLE). Corticosteroid therapy has been underlined as a main risk factor for osteonecrosis. However, AVN development in patients who have never received corticosteroid and the absence of AVN in the majority of the pat...

journal_title：Modern rheumatology

authors： Faezi ST,Hoseinian AS,Paragomi P,Akbarian M,Esfahanian F,Gharibdoost F,Akhlaghi M,Nadji A,Jamshidi AR,Shahram F,Nejadhosseinian M,Davatchi F

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:No available anti-osteoporotic medication has been shown to completely prevent declines in bone mineral density (BMD) and the resulting increased risk of fracture. The objective of this study was to investigate the risk factors for treatment failure in osteoporotic patients with rheumatoid arthritis (RA). ME...

journal_title：Modern rheumatology

authors： Wen L,Kang JH,Yim YR,Lee JW,Lee KE,Park DJ,Kim TJ,Park YW,Lee SS

更新日期：2016-01-01 00:00:00

abstract：:We evaluated the prevalence of Helicobacter pylori infection and the association of H. pylori infection and/or nonsteroidal anti-inflammatory drug (NSAID) use with upper gastrointestinal (UGI) ulcers in a cohort of Japanese patients with rheumatoid arthritis (RA). Using the clinical database of the cohort of RA patien...

journal_title：Modern rheumatology

authors： Tanaka E,Singh G,Saito A,Syouji A,Yamada T,Urano W,Nakajima A,Taniguchi A,Tomatsu T,Hara M,Saito T,Kamatani N,Yamanaka H

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:A nationwide survey was conducted to assess the number of patients, clinical aspects, treatment, and prognosis of adult Still's disease (ASD) in Japan. METHODS:A primary questionnaire was sent to randomly selected medical institutions in order to estimate the number of patients. We sent a secondary question...

journal_title：Modern rheumatology

authors： Asanuma YF,Mimura T,Tsuboi H,Noma H,Miyoshi F,Yamamoto K,Sumida T

更新日期：2015-05-01 00:00:00

abstract：:Lower adiponectin levels in circulation are shown to be associated with endothelial dysfunction, which is a crucial feature in the evolution of atherosclerosis. The aim of our study is to evaluate the effect of anti-tumor necrosis factor (TNF) therapy on adiponectin levels with endothelial function and arterial stiffn...

journal_title：Modern rheumatology

authors： Komai N,Morita Y,Sakuta T,Kuwabara A,Kashihara N

更新日期：2007-01-01 00:00:00

abstract：:Research into the bone destruction associated with rheumatoid arthritis has highlighted the importance of the interplay of the immune and skeletal systems. Arthritic bone destruction is attributable to the defective control of osteoclastogenesis by T cells. We revealed that excessive expression of receptor activator o...

journal_title：Modern rheumatology

authors： Takayanagi H

更新日期：2005-01-01 00:00:00

abstract：:Objectives: To assess the effects of belimumab on disease activity across multiple organ domains in Japanese patients from the Phase 3 randomized, double-blind, North-East Asia study, BEL113750 (NCT01345253).Methods: Patients, aged ≥18 years, with American College of Rheumatology-defined systemic lupus erythematosus (...

journal_title：Modern rheumatology

authors： Tanaka Y,Bass D,Chu M,Egginton S,Ji B,Roth D

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:To understand the status of mizoribine use in patients with lupus nephritis (LN) and to collect safety- and efficacy-related data on 2-year treatment with mizoribine. METHODS:A continuous survey was conducted between March 2010 and July 2015. RESULTS:The analysis set included 559 patients (mean age 39.5 ye...

journal_title：Modern rheumatology

authors： Takeuchi T,Okada K,Yoshida H,Yagi N

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:Locomotive syndrome (LS) encompasses conditions that may lead to the need for nursing services. We aimed to quantify the association between exercise habits during youth or the middle-age years and both physical function and the presence of LS in Japanese elderly people. METHODS:We examined 460 participants...

journal_title：Modern rheumatology

authors： Nishimura A,Ito N,Asanuma K,Akeda K,Ogura T,Sudo A

更新日期：2018-03-01 00:00:00

abstract：:Abstract Five cases of flexor tendon rupture in surgically treated rheumatoid wrists were studied. The tendon ruptures occurred in the thumb and index finger, and the ruptures site was in the carpal tunnel in all five cases. The main cause of rupture was the formation of bony irregularities in the form of bony spurs i...

journal_title：Modern rheumatology

authors： Kobayashi A,Futami T,Tsukamoto Y

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:Aspects of health-related quality of life (HRQoL) are important for assessing perceived health status and treatment burden. We evaluated HRQoL using Short Form 36 Health Survey (SF-36) and factors associated with HRQoL. METHODS:We collected basic and lifestyle-related, clinical, and treatment characteristics...

journal_title：Modern rheumatology

authors： Furukawa M,Kiyohara C,Horiuchi T,Tsukamoto H,Mitoma H,Kimoto Y,Uchino A,Nakagawa M,Oryoji K,Shimoda T,Akashi K

更新日期：2016-01-01 00:00:00

abstract：:A 43-year-old Japanese woman with systemic lupus erythematosus (SLE) developed rapidly progressive renal failure and nephritic syndrome with a high titer of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA). Methylprednisolone pulse therapy did not suppress the progression of renal failure. Intravenous cy...

journal_title：Modern rheumatology

authors： Morimoto S,Watanabe T,Lee S,Amano H,Kanamaru Y,Ohsawa I,Tomino Y,Takasaki Y

更新日期：2010-06-01 00:00:00

abstract：:Objectives: The Childhood Health Assessment Questionnaire (CHAQ) is one of the most widely used self- report questionnaires to measure functional status in Juvenile idiopathic arthritis (JIA). The Japanese version of the CHAQ (JCHAQ) has been revised to meet requirements of clinical international trials which need the...

journal_title：Modern rheumatology

authors： Miyamae T,Tani Y,Kishi T,Yamanaka H,Singh G

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:To investigate and compare the risk for malignancy in rheumatoid arthritis (RA) patients treated with biologics in Japan to the general population. METHODS:Data for 14,440 patients from 335 institutions who were given infliximab, etanercept, adalimumab, golimumab, tocilizumab, or abatacept were retrieved fr...

journal_title：Modern rheumatology

authors： Harigai M,Nanki T,Koike R,Tanaka M,Watanabe-Imai K,Komano Y,Sakai R,Yamazaki H,Koike T,Miyasaka N

更新日期：2016-09-01 00:00:00

abstract：:Inflammation has often been considered to be a nonspecific response and to play a bridging role in the activation of adaptive immunity. However, it is now accepted that inflammation is the product of an independent innate immune system closely linked to the adaptive immune system. The key mediators of inflammation are...

journal_title：Modern rheumatology

authors： Yokota S,Kikuchi M,Nozawa T,Kanetaka T,Sato T,Yamazaki K,Sakurai N,Hara R,Mori M

更新日期：2015-01-01 00:00:00

abstract：:Endogenous lipoid pneumonia is an uncommon inflammatory pulmonary disease that is caused by lipids from an endogenous source, the treatment for which has not been established. We report the first case of endogenous lipoid pneumonia presenting as lung consolidation and which was associated with rheumatoid arthritis. Tr...

journal_title：Modern rheumatology

authors： Morita H,Arai S,Kurasawa K,Okada H,Tanaka A,Yamazaki R,Owada T,Maezawa R

更新日期：2018-11-01 00:00:00

abstract：:Aortitis, inflammation of the aortic tissue, is most commonly caused by vasculitic rheumatic conditions, and less frequently infectious organisms. Involvement of the aorta is well defined in HLA-B27-associated spondyloarthropathies such as long-standing ankylosing spondylitis and Reiter's syndrome. However, unlike oth...

journal_title：Modern rheumatology

authors： Tufan A,Engin Tezcan M,Kaya A,Mercan R,Oner Y,Ozturk MA

更新日期：2012-09-01 00:00:00

abstract：:Nintedanib (Ofev™), an oral triple kinase inhibitor targeting pro-fibrotic pathways, has been used for treatment of idiopathic pulmonary fibrosis (IPF). Based on positive results from phase III, placebo-controlled, randomized comparative clinical trial conducted in patients with systemic sclerosis-associated interstit...

journal_title：Modern rheumatology

authors： Kuwana M,Azuma A

更新日期：2020-03-01 00:00:00

abstract：:The purpose of this study was to describe the prevalence of total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment in a large observational cohort in Japan. A total of 5,177 RA patients were studied for the prevalence of TJA, who were enrolled in the NinJa ...

journal_title：Modern rheumatology

authors： Nishino J,Tanaka S,Matsui T,Mori T,Nishimura K,Eto Y,Kaneko A,Saisho K,Yasuda M,Chiba N,Yoshinaga Y,Saeki Y,Seki A,Tohma S

更新日期：2009-01-01 00:00:00

abstract：:Interstitial lung disease (ILD) is a noteworthy condition in the treatment of systemic sclerosis (SSc) because of its associated mortality and morbidity; however, the efficacy of various treatments for ILD has been controversial in previous reports. In this study, we examined the efficacy and safety of intravenous cyc...

journal_title：Modern rheumatology

authors： Tochimoto A,Kawaguchi Y,Hara M,Tateishi M,Fukasawa C,Takagi K,Nishimagi E,Ota Y,Katsumata Y,Gono T,Tanaka E,Yamanaka H

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:A multicenter, randomized, double-blind, placebo-controlled study of the oral calcineurin inhibitor tacrolimus was performed in patients with early rheumatoid arthritis who had responded poorly to disease-modifying antirheumatic drugs (DMARDs), and factors related to suppression of joint destruction were inv...

journal_title：Modern rheumatology

authors： Tanaka Y,Kawai S,Takeuchi T,Yamamoto K,Miyasaka N

更新日期：2013-11-01 00:00:00