Abstract:
:We investigated the association between cigarette smoking and the risk of developing rheumatoid arthritis (RA) in the Malaysian population. A total of 1,056 RA patients and 1,416 matched controls aged 18-70 years within a defined area of Peninsular Malaysia were evaluated in a case-control study between August 2005 and December 2009. A case was defined as a person with early diagnosed RA using the 1987 American College of Rheumatology criteria for RA. Controls were randomly selected matched for sex, age, and residential area. Cases and controls answered a questionnaire on a broad range of issues, including lifestyle factors and smoking habits wherein current and former smoking was classified as ever-smoking. The presence of anti-citrullinated peptide antibodies (ACPA) was determined for cases and controls. We found that ever-smokers had an increased risk of developing ACPA-positive RA [odds ratio (OR) = 4.1, 95% confidence interval (CI) 1.9-9.2] but not ACPA-negative RA (OR = 0.7, 95% CI 0.3-2.0), compared with never-smokers. A significant dose-response relationship between cumulative dose of smoking and risk of ACPA-positive RA was observed (<20 pack-years OR = 3.3, 95% CI 1.1-9.8; at least 20 pack-years OR = 5.2, 95% CI 1.6-17.6). Hence, smoking is associated with an increased risk of ACPA-positive RA in the Malaysian population, in which the genetic context is similar to several other Asian countries.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Yahya A,Bengtsson C,Lai TC,Larsson PT,Mustafa AN,Abdullah NA,Muhamad N,Hussein H,Klareskog L,Alfredsson L,Murad Sdoi
10.1007/s10165-011-0544-2subject
Has Abstractpub_date
2012-08-01 00:00:00pages
524-31issue
4eissn
1439-7595issn
1439-7609journal_volume
22pub_type
杂志文章,多中心研究abstract:OBJECTIVE:Avascular necrosis of bone (AVN) is an important complication of systemic lupus erythematosus (SLE). Corticosteroid therapy has been underlined as a main risk factor for osteonecrosis. However, AVN development in patients who have never received corticosteroid and the absence of AVN in the majority of the pat...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.987366
更新日期:2015-07-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0711-0
更新日期:2013-07-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0307-4
更新日期:2004-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650050003
更新日期:2000-06-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1174328
更新日期:2017-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.852853
更新日期:2014-05-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.874761
更新日期:2015-05-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200006
更新日期:2002-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170043
更新日期:2001-03-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/s10165-004-0314-5
更新日期:2004-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1245238
更新日期:2019-05-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0266-x
更新日期:2010-06-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.964823
更新日期:2015-05-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.874735
更新日期:2014-07-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1170946
更新日期:2016-11-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-003-0270-5
更新日期:2004-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0584-9
更新日期:2007-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.886984
更新日期:2014-11-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0818-3
更新日期:2013-11-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
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更新日期:2013-04-27 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.854063
更新日期:2014-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1354431
更新日期:2018-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0315-5
更新日期:2010-12-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0614-0
更新日期:2013-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0674-1
更新日期:2013-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0419-5
更新日期:2005-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200037
更新日期:2002-09-01 00:00:00