A case of Degos disease: demonstration of C5b-9-mediated vascular injury.

abstract：:'Immunoglobulin G4 (IgG4)-related disease' is a new clinical concept of multi-organ diseases, with Mikulicz's disease (MD) being a clinical phenotype of IgG4-related disease. To clarify the clinical characteristics of respiratory involvement associated with IgG4-related MD, we retrospectively assessed 25 patients with...

journal_title：Modern rheumatology

authors： Matsui S,Taki H,Shinoda K,Suzuki K,Hayashi R,Tobe K,Tokimitsu Y,Ishida M,Fushiki H,Seto H,Fukuoka J,Ishizawa S

更新日期：2012-02-01 00:00:00

abstract：:The number of patients with juvenile-onset Sjögren's syndrome (SS) has recently increased. However, there is no drug that is safe and effective for the xerostomia that occurs in patients of this age group. We evaluated the efficacy and safety of orally administered pilocarpine hydrochloride for juvenile-onset SS patie...

journal_title：Modern rheumatology

authors： Tomiita M,Takei S,Kuwada N,Nonaka Y,Saito K,Shimojo N,Kohno Y

更新日期：2010-10-01 00:00:00

abstract：:Abstract To determine the specificities of autoantibodies targeting cell cycle-associated antigens in rheumatic diseases, we studied 30 sera which were obtained from patients visiting our hospital and which exhibited a variegated speckled pattern in indirect immunofluorescence (IF). The immunoreactivities of the sera ...

journal_title：Modern rheumatology

authors： Fujinaga H,Takeuchi K,Kaneda K,Takasaki Y,Hashimoto H

更新日期：2001-09-01 00:00:00

abstract：:Objectives: The Childhood Health Assessment Questionnaire (CHAQ) is one of the most widely used self- report questionnaires to measure functional status in Juvenile idiopathic arthritis (JIA). The Japanese version of the CHAQ (JCHAQ) has been revised to meet requirements of clinical international trials which need the...

journal_title：Modern rheumatology

authors： Miyamae T,Tani Y,Kishi T,Yamanaka H,Singh G

更新日期：2020-09-01 00:00:00

abstract：:Hyperimmunoglobulin E syndrome (HIES) is a primary immunodeficiency disorder with multisystem abnormalities including the vascular system. We report a child with autosomal recessive (AR)-HIES secondary to dedicator of cytokinesis 8 (DOCK8) deficiency who developed critical aortic aneurysm involving the ascending aorta...

journal_title：Modern rheumatology

authors： Al Mutairi M,Al-Mousa H,AlSaud B,Hawwari A,AlJoufan M,AlWesaibi A,AlHalees Z,Al-Mayouf SM

更新日期：2014-07-01 00:00:00

abstract：:Aseptic abscess (AA) is characterized by accumulation of neutrophils without evidence of infection, no response to antibiotics, and rapid response to corticosteroids. We report a case of multiple abscesses in the subcutaneous tissues and joints, and severe mitral valve regurgitation. Although AA did not respond to ant...

journal_title：Modern rheumatology

authors： Fukuda S,Nanki T,Morio T,Hasegawa H,Koike R,Miyasaka N

更新日期：2014-05-01 00:00:00

abstract：AIM:The aim of this study was to analyze the effect of 18-week functional training (FT) program consisting in two sessions a week of in-water exercise and one of on-land exercise on pain, strength, and balance in women with fibromyalgia. METHODS:A sample consisting of 36 fibromyalgia patients was included in the study...

journal_title：Modern rheumatology

authors： Latorre Román PÁ,Santos E Campos MA,García-Pinillos F

更新日期：2015-01-01 00:00:00

abstract：:The involvement of valgus hindfoot deformity in hallux valgus deformity was confirmed in a rheumatoid arthritis case with a destructive valgus hindfoot deformity. Correction of severe valgus, calcaneal lateral offset, and pronated foot deformity instantly normalized hallux valgus deformities postoperatively. Thus, car...

journal_title：Modern rheumatology

authors： Yamada S,Hirao M,Tsuboi H,Akita S,Matsushita M,Ohshima S,Saeki Y,Hashimoto J

更新日期：2014-09-01 00:00:00

abstract：:Abstract To clarify the effect of leukemia inhibitory factor (LIF) on the destruction of rheumatoid arthritis (RA) joints, we investigated the production of LIF and the expression of LIF mRNA in synovial tissues from patients with RA and osteoarthritis (OA). Synovial fluids from RA were used to measure the LIF concent...

journal_title：Modern rheumatology

authors： Enomoto H,Saito S,Yabe H,Toyama Y,Tomatu T

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVE:No available anti-osteoporotic medication has been shown to completely prevent declines in bone mineral density (BMD) and the resulting increased risk of fracture. The objective of this study was to investigate the risk factors for treatment failure in osteoporotic patients with rheumatoid arthritis (RA). ME...

journal_title：Modern rheumatology

authors： Wen L,Kang JH,Yim YR,Lee JW,Lee KE,Park DJ,Kim TJ,Park YW,Lee SS

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:We examined the prevalence and risk factors of vertebral fracture in female Japanese patients with systemic lupus erythematosus (SLE). METHODS:We performed lateral radiographs of the thoracic and lumbar spine and bone mineral density (BMD) measurements and collected demographic, lifestyle, clinical, and trea...

journal_title：Modern rheumatology

authors： Furukawa M,Kiyohara C,Horiuchi T,Tsukamoto H,Mitoma H,Kimoto Y,Uchino A,Nakagawa M,Oryoji K,Shimoda T,Harada M,Akashi K

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to analyze the score of fatigue in a large cohort of Brazilian patients with SpA, comparing different disease patterns and its association with demographic and disease-specific variables. METHODS:A common protocol of investigation was prospectively applied to 1492 Brazilian ...

journal_title：Modern rheumatology

authors： Bianchi WA,Elias FR,Carneiro S,Bortoluzzo AB,Gonçalves CR,da Silva JA,Ximenes AC,Bértolo MB,Ribeiro SL,Keiserman M,Skare TL,Menin R,Azevedo VF,Vieira WP,Albuquerque EN,Bonfiglioli R,Campanholo C,Carvalho HM,Costa IP,

更新日期：2014-11-01 00:00:00

abstract：:Aortitis, inflammation of the aortic tissue, is most commonly caused by vasculitic rheumatic conditions, and less frequently infectious organisms. Involvement of the aorta is well defined in HLA-B27-associated spondyloarthropathies such as long-standing ankylosing spondylitis and Reiter's syndrome. However, unlike oth...

journal_title：Modern rheumatology

authors： Tufan A,Engin Tezcan M,Kaya A,Mercan R,Oner Y,Ozturk MA

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To retrospectively evaluate whether oral glucocorticoid (GC) administration can be tapered or discontinued over a 2-year observation period in patients with rheumatoid arthritis (RA) undergoing a stable oral GC treatment, without deterioration in the disease status. METHODS:Methotrexate (MTX) and prednisolon...

journal_title：Modern rheumatology

authors： Hirata S,Kohno H,Watanabe H,Tokunaga T,Yoshida Y,Sugimoto T,Mokuda S,Oda K,Nojima T,Sugiyama E

更新日期：2020-12-16 00:00:00

abstract：:Clinical squeal of the treatment of rheumatoid arthritis patients with methotrexate (MTX) according to the Japanese government recommended dose of 8 mg/week was evaluated prospectively. A total of 176 patients with active RA attending Konan Kakogawa Hospital and Kobe University Hospital were enrolled. Patients' profil...

journal_title：Modern rheumatology

authors： Hashiramoto A,Shiozawa K,Tanaka Y,Yamane T,Murata M,Tanaka C,Terashima Y,Koyama K,Nakagawa N,Abe S,Yoshihara R,Saegusa Y,Tsumiyama K,Komai K,Sakai Y,Shiozawa S

更新日期：2009-01-01 00:00:00

abstract：AIM:The purpose of this study was to assess morphological changes in the paravertebral muscles in patients with ankylosing spondylitis. MATERIALS AND METHODS:Fifty-one patients diagnosed with ankylosing spondylitis and a 50 member control group were included in the study. The surface area of the multifidus and erector...

journal_title：Modern rheumatology

authors： Resorlu H,Savas Y,Aylanc N,Gokmen F

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVES:To assess the real-world effectiveness of golimumab in Japanese patients with rheumatoid arthritis who had previously received one or more biologic therapies. METHODS:A post-hoc analysis of post-marketing surveillance was performed. The clinical response to golimumab was analyzed in 1216 patients who had pr...

journal_title：Modern rheumatology

authors： Shimizu H,Kobayashi H,Kanbori M,Ishii Y

更新日期：2020-08-19 00:00:00

abstract：OBJECTIVES:Our primary objective was to retrospectively analyze whether bisphosphonates initiated in combination with immunosuppressive drugs and/or intravenous immunoglobulin (IVIG) resulted in a radiological and clinical improvement of dystrophic calcinosis in six female juvenile dermatomyositis (JDM) patients. METH...

journal_title：Modern rheumatology

authors： Tayfur AC,Topaloglu R,Gulhan B,Bilginer Y

更新日期：2015-07-01 00:00:00

abstract：:Management of rheumatoid arthritis (RA) has improved over the last 10 years. These changes have been monitored in the Institute of Rheumatology, Rheumatoid Arthritis (IORRA) observational cohort, and clinical remission has become a realistic goal. However, we should recognize that the ultimate goal of treatment is to ...

journal_title：Modern rheumatology

authors： Yamanaka H,Seto Y,Tanaka E,Furuya T,Nakajima A,Ikari K,Taniguchi A,Momohara S

更新日期：2013-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha)-blocking agents have been used increasingly in the treatment of severe refractory juvenile idiopathic arthritis (JIA). However, some patients have been forced to discontinue these agents because of the lack of efficacy or adverse events. In these situations, cases of switching fr...

journal_title：Modern rheumatology

authors： Nerome Y,Imanaka H,Nonaka Y,Takei S

更新日期：2007-01-01 00:00:00

abstract：:Periaortitis and periarteritis are one of the clinical features of IgG4-related disease. Such vascular manifestations are reported to be present in 10-30% of overall IgG4-related disease, and they may also appear as an isolated lesion of IgG4-related disease. As other types of large vessel vasculitis, IgG4-related vas...

journal_title：Modern rheumatology

authors： Mizushima I,Kasashima S,Fujinaga Y,Kawano M,Ishizaka N

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the improvement of health status in patients with rheumatoid arthritis (RA) treated with tocilizumab. METHODS:Thirty-nine patients were treated with 8 mg/kg tocilizumab every 4 weeks for 24 weeks. Disease activity was assessed by Clinical Disease Activity Index (CDAI) and Simplified Disease Activ...

journal_title：Modern rheumatology

authors： Fusama M,Nakahara H,Hamano Y,Nishide M,Kawamoto K,Hosokawa T,Nozato S,Higa S,Igarashi T,Takeuchi E,Kuroiwa T,Shimaoka Y,Yukioka M,Miura Y,Higashi K,Kuritani T,Maeda K

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:We aimed to analyze clinical features and treatment outcomes of otitis media caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), i.e. otitis media with AAV (OMAAV). METHODS:This survey was performed between December 2013 and February 2014. The study began with a preliminary surv...

journal_title：Modern rheumatology

authors： Harabuchi Y,Kishibe K,Tateyama K,Morita Y,Yoshida N,Kunimoto Y,Matsui T,Sakaguchi H,Okada M,Watanabe T,Inagaki A,Kobayashi S,Iino Y,Murakami S,Takahashi H,Tono T

更新日期：2017-01-01 00:00:00

abstract：:Interstitial lung disease (ILD) is a noteworthy condition in the treatment of systemic sclerosis (SSc) because of its associated mortality and morbidity; however, the efficacy of various treatments for ILD has been controversial in previous reports. In this study, we examined the efficacy and safety of intravenous cyc...

journal_title：Modern rheumatology

authors： Tochimoto A,Kawaguchi Y,Hara M,Tateishi M,Fukasawa C,Takagi K,Nishimagi E,Ota Y,Katsumata Y,Gono T,Tanaka E,Yamanaka H

更新日期：2011-06-01 00:00:00

abstract：:We aimed to retrospectively review the incidence of pre-diabetes mellitus (preDM), one of the factors in metabolic syndrome screening, in patients with rheumatic diseases. We examined the levels of hemoglobin A1c (HbA1c) in a total of 498 patients with rheumatic diseases between April 2007 and March 2008 at the Depart...

journal_title：Modern rheumatology

authors： Origuchi T,Yamaguchi S,Inoue A,Kazaura Y,Matsuo N,Abiru N,Kawakami A,Eguchi K

更新日期：2011-10-01 00:00:00

abstract：:Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...

journal_title：Modern rheumatology

authors： Yagita M,Hamano T,Hatachi S,Fujita M

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:To assess the efficacy and safety of intravenous (IV) belimumab plus standard systemic lupus erythematosus (SLE) therapy standard of care (SoC) in Japanese patients with SLE. METHODS:A Phase 3, multicenter, double-blind, placebo-controlled, 52-week study (BEL 113750; NCT01345253) in patients with SLE, rando...

journal_title：Modern rheumatology

authors： Tanaka Y,Bass D,Chu M,Egginton S,Ji B,Struemper H,Roth D

更新日期：2019-05-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective-tissue disease with a complex phenotype and varying disease course. Although SLE often causes a polyarticular synovitis, there are only a few case reports of abnormalities of the synovial lined sacroiliac joints. We report a case with an overlap...

journal_title：Modern rheumatology

authors： Chandrasekhara PK,Jayachandran NV,Thomas J,Narsimulu G

更新日期：2009-01-01 00:00:00

abstract：:Bucillamine (Bc) is a cysteine derivative with two SH groups, and a homolog of D-penicillamine, a disease-modifying antirheumatic drug (DMARD) widely used in Japan. However, it remains unclear whether Bc repairs bone erosion in patients with RA. Here, we treated three RA patients with Bc who subsequently showed radiog...

journal_title：Modern rheumatology

authors： Nanke Y,Iwatani M,Kobashigawa T,Yago T,Yamanaka H,Kotake S

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:Several biological disease-modifying antirheumatic drugs (bDMARDs) are currently available for the treatment of rheumatoid arthritis (RA). Increasing evidence indicates that second-line bDMARDs are effective for inadequate responders to first-line bDMARDs. However, all previous studies investigated the use o...

journal_title：Modern rheumatology

authors： Matsuno H,Katayama K

更新日期：2017-03-01 00:00:00