Abstract:
OBJECTIVES:Our primary objective was to retrospectively analyze whether bisphosphonates initiated in combination with immunosuppressive drugs and/or intravenous immunoglobulin (IVIG) resulted in a radiological and clinical improvement of dystrophic calcinosis in six female juvenile dermatomyositis (JDM) patients. METHODS:Medical records of the patients were reviewed. All six patients met the Bohan and Peter diagnostic criteria for JDM. RESULTS:A resolution of calcinosis was observed in four of the six patients with JDM following the use of bisphosphonates and intensive immunosuppressive therapy with or without IVIG. Bisphosphonates were unable to either decelerate the progression of calcinosis or improve calcinosis in cases 5 and 6. In case 5, it took a relatively long time to control the disease activity despite the appropriate immunsuppressive treatment and she experienced multiple flares of active JDM. Case 6 had a long duration of severe active disease before treatment initiation. No important adverse event was observed. CONCLUSIONS:Early commencement of aggressive immunosuppressive agents in combination with bisphosphonate is a choice for the treatment of calcinosis in JDM patients. Concomitant use of IVIG may have an additional effect on the resolution of calcinosis.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Tayfur AC,Topaloglu R,Gulhan B,Bilginer Ydoi
10.3109/14397595.2014.988197subject
Has Abstractpub_date
2015-07-01 00:00:00pages
615-20issue
4eissn
1439-7595issn
1439-7609journal_volume
25pub_type
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journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
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doi:10.1080/14397595.2017.1367116
更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10165-012-0735-5
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