Therapeutic angiogenesis in patients with systemic sclerosis by autologous transplantation of bone-marrow-derived cells.

abstract：OBJECTIVE:To evaluate the safety of peficitinib for the treatment of rheumatoid arthritis (RA) in Asian patients. METHODS:Safety data from one Phase 2b, two Phase 3, and one open-label long-term extension study [data cut-off 31 May 2018] were pooled into Phase 3 studies (peficitinib 100 and 150 mg/day, and placebo) an...

journal_title：Modern rheumatology

authors： Takeuchi T,Tanaka Y,Rokuda M,Izutsu H,Kaneko Y,Fukuda M,Kato D

更新日期：2020-11-09 00:00:00

abstract：:Abstract We report the case of a 52-year-old man with Wegener's granulomatosis complicated with seropneumothorax. Pneumothorax or seropneumothorax has previously been reported as a rare complication of Wegener's granulomatosis. The patient was successfully treated with prednisolone and cyclophosphamide, and seropneumo...

journal_title：Modern rheumatology

authors： Shimizu T,Ohara T,Ito S,Nakano M,Tsutsui N,Sato T,Suzuki E,Gejyo F

更新日期：2003-06-01 00:00:00

abstract：:Objectives: The Childhood Health Assessment Questionnaire (CHAQ) is one of the most widely used self- report questionnaires to measure functional status in Juvenile idiopathic arthritis (JIA). The Japanese version of the CHAQ (JCHAQ) has been revised to meet requirements of clinical international trials which need the...

journal_title：Modern rheumatology

authors： Miyamae T,Tani Y,Kishi T,Yamanaka H,Singh G

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Although "clinical remission" has been a realistic goal of treatment in rheumatoid arthritis (RA), there is evidence that subclinical synovitis is associated with ongoing structural damage even after clinical remission is achieved. In the study reported here, we assessed whether ultrasonography (US) can pred...

journal_title：Modern rheumatology

authors： Yoshimi R,Hama M,Takase K,Ihata A,Kishimoto D,Terauchi K,Watanabe R,Uehara T,Samukawa S,Ueda A,Takeno M,Ishigatsubo Y

更新日期：2013-05-01 00:00:00

abstract：:Abstract Three cases of childhood-onset systemic lupus erythematosus (childhood SLE) with long-term remission are reported. These cases were not complicated with collagen diseases and had no SLE disease activity index scores either 3 or 5 years after onset. We suggest that some patients with childhood SLE may be able ...

journal_title：Modern rheumatology

authors： Mori M,Kobayashi Y,Miyamae T,Imagawa T,Katakura S,Mitsuda T,Aihara Y,Yokota S

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Neutrophil extracellular traps (NETs) are peculiar structures composed of the externalized chromatin with intracellular proteins and formed by activated neutrophils in a reactive oxygen species (ROS)-dependent manner. Aberrant NETs are considered to be autoantigens for anti-neutrophil cytoplasmic antibodies (...

journal_title：Modern rheumatology

authors： Kimura H,Matsuyama Y,Araki S,Koizumi A,Kariya Y,Takasuga S,Eguchi S,Nakanishi H,Sasaki J,Sasaki T

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:To determine the frequency of Th2-mediated allergic diseases (AD) in mainly Th1-driven juvenile idiopathic arthritis (JIA) subtypes. METHODS:Ninety-nine JIA patients and 128 control subjects were enrolled in a prospective case-control study. All subjects were assessed with standard allergy questionnaire, co...

journal_title：Modern rheumatology

authors： Avar-Aydin PO,Nepesov S,Barut K,Sahin S,Adrovic A,Cokugras HC,Kasapcopur O

更新日期：2020-09-07 00:00:00

abstract：OBJECTIVES:The objective of this study is to clarify the surgical indication for rheumatoid forefoot deformity according to background characteristics and plantar pressure. METHODS:Patients with rheumatoid arthritis were divided into a non-surgical group (group N) and a surgical group (group S). The former consisted o...

journal_title：Modern rheumatology

authors： Lee H,Ishikawa H,Miyagawa Y,Takai C,Nomura Y,Nemoto T,Kobayashi D,Abe A,Otani H,Ito S,Nakazono K,Ishii T,Saito S,Tokuhashi Y,Murasawa A

更新日期：2017-11-01 00:00:00

abstract：:Clinical squeal of the treatment of rheumatoid arthritis patients with methotrexate (MTX) according to the Japanese government recommended dose of 8 mg/week was evaluated prospectively. A total of 176 patients with active RA attending Konan Kakogawa Hospital and Kobe University Hospital were enrolled. Patients' profil...

journal_title：Modern rheumatology

authors： Hashiramoto A,Shiozawa K,Tanaka Y,Yamane T,Murata M,Tanaka C,Terashima Y,Koyama K,Nakagawa N,Abe S,Yoshihara R,Saegusa Y,Tsumiyama K,Komai K,Sakai Y,Shiozawa S

更新日期：2009-01-01 00:00:00

abstract：:We performed this study to investigate the differences in radiological and laboratory findings between systemic juvenile idiopathic arthritis (s-JIA) and polyarthritis (p-JIA). Twenty-two patients with s-JIA and 18 with p-JIA were enrolled. Their laboratory findings and radiographs were examined retrospectively. Plain...

journal_title：Modern rheumatology

authors： Ozawa R,Inaba Y,Mori M,Hara R,Kikuchi M,Higuchi R,Miyamae T,Imagawa T,Fujiwara T,Saito T,Yokota S

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:The present study aimed to conduct an epidemiological survey of Central Sensitization Inventory (CSI) scores in an older adult population and to investigate the association between the CSI scores, age, sex, pain intensity, site of pain, and health-related quality of life (QOL). METHODS:Participants were 373...

journal_title：Modern rheumatology

authors： Ide K,Yasuda T,Hasegawa T,Yamato Y,Yoshida G,Banno T,Arima H,Oe S,Mihara Y,Ushirozako H,Yamada T,Watanabe Y,Nakai K,Hoshino H,Matsuyama Y

更新日期：2020-10-02 00:00:00

abstract：:A retrospective study was performed to investigate the clinical and radiological results of the Sauvé-Kapandji (S-K) procedure for the rheumatoid wrist. One hundred and eight rheumatoid wrists in 98 patients were operated on in our institute from 1992 to 2000, and in 82 wrists we used the S-K procedure. In other cases...

journal_title：Modern rheumatology

authors： Momohara S,Mamizuka K,Yonemoto K,Tomatsu T,Inoue K

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease. METHODS:All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild l...

journal_title：Modern rheumatology

authors： Zhang FJ,Luo W,Gao SG,Su DZ,Li YS,Zeng C,Lei GH

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:To assess gout and asymptomatic hyperuricemia in Japan and review treatment conditions. METHODS:This retrospective cross-sectional study analyzed the prevalence of hyperuricemia and gout, and characteristics and treatment of patients with those conditions, using Japanese health insurance claims and medical ...

journal_title：Modern rheumatology

authors： Koto R,Nakajima A,Horiuchi H,Yamanaka H

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To examine the deterioration of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) treated with abatacept over the long-term. METHODS:We examined 131 patients with RA who had been treated with abatacept for more than 1 year. All patients underwent high-resolution computed tomographic ...

journal_title：Modern rheumatology

authors： Mochizuki T,Ikari K,Yano K,Sato M,Okazaki K

更新日期：2019-05-01 00:00:00

abstract：:Abstract To determine the specificities of autoantibodies targeting cell cycle-associated antigens in rheumatic diseases, we studied 30 sera which were obtained from patients visiting our hospital and which exhibited a variegated speckled pattern in indirect immunofluorescence (IF). The immunoreactivities of the sera ...

journal_title：Modern rheumatology

authors： Fujinaga H,Takeuchi K,Kaneda K,Takasaki Y,Hashimoto H

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVES:In this study, we aimed to assess the effect of combination of proliferative and membranous lesions (Class III + V or IV + V) on renal outcomes as an independent category distinct from Class III and IV. METHODS:We retrospectively analyzed 103 Japanese patients (14 male and 89 female) with Class III/IV LN, w...

journal_title：Modern rheumatology

authors： Ikeuchi H,Hiromura K,Kayakabe K,Tshilela KA,Uchiyama K,Hamatani H,Sakairi T,Kaneko Y,Maeshima A,Nojima Y

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:Psoriasis is a chronic autoimmune disease involving a complex network of cytokines such as interleukin (IL)-6. We tested the hypothesis that serum IL-6 level is a useful indicator of disease activity and predicts the treatment response to biologics in patients with psoriasis. METHODS:We analyzed 113 psorias...

journal_title：Modern rheumatology

authors： Muramatsu S,Kubo R,Nishida E,Morita A

更新日期：2017-01-01 00:00:00

abstract：:A 61-year-old woman was admitted for long-lasting fever and recurrent opportunistic infections during the treatment of SLE. She had been diagnosed as SLE and type-IV nephritis based on a renal biopsy and serological findings. A colonoscopy and liver biopsy revealed disseminated Mycobacterium avium complex infection. H...

journal_title：Modern rheumatology

authors： Ochi S,Kato S,Nakamura-Uchiyama F,Ohnishi K,Saito Y

更新日期：2017-05-01 00:00:00

abstract：:Endogenous lipoid pneumonia is an uncommon inflammatory pulmonary disease that is caused by lipids from an endogenous source, the treatment for which has not been established. We report the first case of endogenous lipoid pneumonia presenting as lung consolidation and which was associated with rheumatoid arthritis. Tr...

journal_title：Modern rheumatology

authors： Morita H,Arai S,Kurasawa K,Okada H,Tanaka A,Yamazaki R,Owada T,Maezawa R

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Cryopyrin-associated periodic syndrome (CAPS) is caused by unrestricted IL-1β release due to mutation of the gene coding NLRP3. This study aimed to clarify whether NLRP3-related IL-1β release is dependent on the NF-κB pathway. METHODS:Peripheral blood mononuclear cells (PBMCs) from healthy subjects or patie...

journal_title：Modern rheumatology

authors： Shimogaki S,Ito S,Komatsu S,Koike R,Miyasaka N,Umezawa K,Kubota T

更新日期：2014-05-01 00:00:00

abstract：:Aortitis, inflammation of the aortic tissue, is most commonly caused by vasculitic rheumatic conditions, and less frequently infectious organisms. Involvement of the aorta is well defined in HLA-B27-associated spondyloarthropathies such as long-standing ankylosing spondylitis and Reiter's syndrome. However, unlike oth...

journal_title：Modern rheumatology

authors： Tufan A,Engin Tezcan M,Kaya A,Mercan R,Oner Y,Ozturk MA

更新日期：2012-09-01 00:00:00

abstract：:A 10-year cohort study was performed, involving all of the 118 patients treated with bucillamine in our hospital between 1988 and 1990. Evaluation was made on the basis of erythrocyte sedimentation rate, grip strength, joint score, duration of morning stiffness, and Lansbury index consisting of the above four paramete...

journal_title：Modern rheumatology

authors： Yokota N,Kuga Y,Kanazawa T,Morishita M,Tanida K,Itou K

更新日期：2007-01-01 00:00:00

abstract：:Abstract Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug (DMARD) throughout the world. In Japan, MTX is recommended by the Japanese Ministry of Health, Labour, and Welfare to be given as the second or third DMARD and at a dosage of no more than 8 mg/week. We analyzed the efficacy of M...

journal_title：Modern rheumatology

authors： Kameda H,Amano K,Sekiguchi N,Takei H,Ogawa H,Nagasawa H,Takeuchi T

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:To assess the influence of golimumab dosage and disease activity on joint destruction in patients with active rheumatoid arthritis (RA) in the GO-FORTH study. METHODS:Efficacy was compared among groups given basal methotrexate plus placebo, golimumab (50 mg), or golimumab (100 mg) with stratification by hig...

journal_title：Modern rheumatology

authors： Tanaka Y,Harigai M,Takeuchi T,Yamanaka H,Ishiguro N,Yamamoto K,Ishii Y,Nakajima H,Baker D,Miyasaka N,Koike T

更新日期：2016-01-01 00:00:00

abstract：:We describe an 81-year-old man with immunoglobulin G4-related disease (IgG4-RD) presenting with submandibular gland, lymph node, lung, kidney, aortic wall, and prostate lesions with concomitant gastric cancer. After curative surgical treatment of the gastric cancer, corticosteroid therapy for progressively decreasing ...

journal_title：Modern rheumatology

authors： Horita S,Fujii H,Mizushima I,Fujisawa Y,Hara S,Yamada K,Inoue D,Nakajima K,Harada K,Kawano M

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:To retrospectively evaluate whether oral glucocorticoid (GC) administration can be tapered or discontinued over a 2-year observation period in patients with rheumatoid arthritis (RA) undergoing a stable oral GC treatment, without deterioration in the disease status. METHODS:Methotrexate (MTX) and prednisolon...

journal_title：Modern rheumatology

authors： Hirata S,Kohno H,Watanabe H,Tokunaga T,Yoshida Y,Sugimoto T,Mokuda S,Oda K,Nojima T,Sugiyama E

更新日期：2020-12-16 00:00:00

abstract：:For surgical treatment of rheumatoid wrists, we have routinely selected the Sauve-Kapandji (S-K) procedure or the Darrach procedure based on predetermined indications. In this study, we conducted a retrospective radiographic comparative evaluation of the changes in the carpus after the two procedures. The S-K group an...

journal_title：Modern rheumatology

authors： Kobayashi A,Futami T,Tadano I,Fujita M,Watanabe T,Moriguchi T

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Locomotive syndrome (LS) encompasses conditions that may lead to the need for nursing services. We aimed to quantify the association between exercise habits during youth or the middle-age years and both physical function and the presence of LS in Japanese elderly people. METHODS:We examined 460 participants...

journal_title：Modern rheumatology

authors： Nishimura A,Ito N,Asanuma K,Akeda K,Ogura T,Sudo A

更新日期：2018-03-01 00:00:00

abstract：:Abstract A woman with Sjögren's syndrome concurrently suffered bilateral fractures of the femoral neck without any proximate cause, while she had aseptic necrosis of the femoral head resulting from the treatment for Sjögren's syndrome. According to previous reports, fractures of the femoral neck following aseptic necr...

journal_title：Modern rheumatology

authors： Kamiya M,Ueno M,Yamaguchi H,Kanata S,Sohen S

更新日期：2004-12-01 00:00:00