Abstract:
OBJECTIVES:To assess gout and asymptomatic hyperuricemia in Japan and review treatment conditions. METHODS:This retrospective cross-sectional study analyzed the prevalence of hyperuricemia and gout, and characteristics and treatment of patients with those conditions, using Japanese health insurance claims and medical check-up data collected from April 2016 through March 2017. RESULTS:Among 2,531,383 persons registered in the database, 1.1% (men 1.9%, women <0.1%) were diagnosed with gout and 2.6% (4.1%, 0.4%) with asymptomatic hyperuricemia. Medical check-ups showed 13.4% (19.6%, 1.0%) of patients with hyperuricemia (serum uric acid [sUA] > 7.0 mg/dL). Urate-lowering therapy (ULT) was prescribed for 80.7% of patients identified with gout and 72.4% identified with asymptomatic hyperuricemia. ULT adherence was satisfactory, but most patients were treated with low-dose ULT. Less than half of patients receiving ULT achieved the sUA target (≤6.0 mg/dL). In gout patients, the incidence of gout flare was 47.8% (0.74 flares/person-year). CONCLUSIONS:Although hyperuricemia prevalence is similar in Japan and worldwide, gout is comparatively rare in Japan. Gout and asymptomatic hyperuricemia are often treated with low-dose ULT, and many patients fail to reach target sUA, suggesting that gout management is suboptimal in Japan. Patients would benefit from stricter focus on a treat-to-target approach for gout management.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Koto R,Nakajima A,Horiuchi H,Yamanaka Hdoi
10.1080/14397595.2020.1784556subject
Has Abstractpub_date
2021-01-01 00:00:00pages
261-269issue
1eissn
1439-7595issn
1439-7609journal_volume
31pub_type
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journal_title:Modern rheumatology
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journal_title:Modern rheumatology
pub_type: 杂志文章
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journal_title:Modern rheumatology
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