Abstract:
:Abstract Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug (DMARD) throughout the world. In Japan, MTX is recommended by the Japanese Ministry of Health, Labour, and Welfare to be given as the second or third DMARD and at a dosage of no more than 8 mg/week. We analyzed the efficacy of MTX in Japanese patients with RA in order to determine whether it is comparable to that in Western countries, where 15-20 mg/week of MTX is used, as well as to elucidate the factors associated with the favorable response to MTX. Around 8 mg/week of MTX was effective in half of the RA patients in the current study, and male sex was the only factor associated with a good response to MTX from a multivariate regression model analysis. Some of the patients who had a poor response to MTX showed an improvement with the addition of bucillamine or prednisolone. For the remaining patients, an increase in the MTX dosage to more than 8 mg/week or the use of biologics such as the anti-tumor necrosis factor (TNF)-α monoclonal antibody may be required.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Kameda H,Amano K,Sekiguchi N,Takei H,Ogawa H,Nagasawa H,Takeuchi Tdoi
10.3109/s10165-004-0340-3subject
Has Abstractpub_date
2004-12-01 00:00:00pages
442-6issue
6eissn
1439-7595issn
1439-7609journal_volume
14pub_type
杂志文章abstract::Systemic lupus erythematosus (SLE) is a very heterogeneous systemic autoimmune disease, in which autoantibody synthesis against nuclear constituents is the main immunological characteristic. These autoantibodies underwent affinity maturation and isotype switching. Additionally, T-cell tolerance against nuclear autoant...
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pub_type: 杂志文章
doi:10.1007/s10165-005-0430-x
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1172999
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pub_type: 杂志文章
doi:10.1007/s10165-012-0776-9
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doi:10.3109/14397595.2013.844402
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pub_type: 杂志文章
doi:10.1007/s10165-005-0450-6
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pub_type: 杂志文章
doi:10.1080/14397595.2016.1218596
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1080/14397595.2017.1387223
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pub_type: 杂志文章
doi:10.1007/s10165-004-0359-5
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3109/s101650050003
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pub_type: 杂志文章
doi:10.3109/s101650170008
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-09-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2013-04-27 00:00:00
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doi:10.1007/s10165-006-0548-5
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