Abstract:
:Systemic lupus erythematosus (SLE) is a very heterogeneous systemic autoimmune disease, in which autoantibody synthesis against nuclear constituents is the main immunological characteristic. These autoantibodies underwent affinity maturation and isotype switching. Additionally, T-cell tolerance against nuclear autoantigens should be affected in these autoimmune patients. Nuclear material derived from apoptotic and/or necrotic cells may serve as an important source of autoantigens. However, dead and dying cells as well as cellular debris are rapidly removed from tissues by phagocytes without eliciting inflammation or immune responses under healthy conditions. During apoptosis nuclear components are strongly modified through enzymatic reactions. If these cells are not timely cleared, those autoantigens may be released, taken up, and presented by dendritic cells in tissues or presented by follicular dendritic cells in lymph nodes to T and B cells, respectively. This could be a mechanism for breaking the peripheral self-tolerance. In this article we focus on the deficient clearance of apoptotic cells in SLE patients and its importance in development of this autoimmune disease.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Grossmayer GE,Munoz LE,Gaipl US,Franz S,Sheriff A,Voll RE,Kalden JR,Herrmann Mdoi
10.1007/s10165-005-0430-xsubject
Has Abstractpub_date
2005-01-01 00:00:00pages
383-90issue
6eissn
1439-7595issn
1439-7609journal_volume
15pub_type
杂志文章abstract::Blau syndrome/early-onset sarcoidosis (Blau/EOS) is an autoinflammatory disease characterized by granulomatous arthritis, uveitis, and skin rash. It has been shown that gain-of-function NOD2 mutations cause Blau/EOS. In this paper, we describe a patient with a gain-of-function NOD2 mutation who developed infantile Tak...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0720-z
更新日期:2013-07-01 00:00:00
abstract::Objectives: Overactive bladder (OAB) is a clinical diagnosis defined with the presence of urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence. Objective was to evaluate the demographic and clinical characteristics of Japanese systemic sclerosis (SSc) patients wi...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1589913
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Cryopyrin-associated periodic syndrome (CAPS) is caused by unrestricted IL-1β release due to mutation of the gene coding NLRP3. This study aimed to clarify whether NLRP3-related IL-1β release is dependent on the NF-κB pathway. METHODS:Peripheral blood mononuclear cells (PBMCs) from healthy subjects or patie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.844298
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:This study was performed to better know diagnosis associated with serum IgG4 concentration, and to explore the possibility for development of a serum IgG4 for IgG4-related disease (IgG4-RD) in Chinese populations. METHODS:We studied retrospectively 497 IgG4 serum subclass measurements from Peking Union Medic...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1117171
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVES:We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS:Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joi...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1253813
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To assess the utilities of ultrasonography (US) and low-field magnetic resonance imaging (compacTscan, cMRI) in the diagnosis of subclinical synovitis of hand joints of patients with rheumatoid arthritis (RA). METHODS:A total of 1,540 joints of 77 RA patients were examined clinically, using US, using cMRI, a...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.854050
更新日期:2014-01-01 00:00:00
abstract::Hyperimmunoglobulin E syndrome (HIES) is a primary immunodeficiency disorder with multisystem abnormalities including the vascular system. We report a child with autosomal recessive (AR)-HIES secondary to dedicator of cytokinesis 8 (DOCK8) deficiency who developed critical aortic aneurysm involving the ascending aorta...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.874735
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVES:The introduction of powerful antirheumatic drugs has dramatically improved the treatment of rheumatoid arthritis (RA), leading clinicians to reconsider the benefits of joint preservation for rheumatoid forefoot deformities. We have employed joint-preserving forefoot surgeries, including rotational closing-we...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0776-9
更新日期:2013-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1170958
更新日期:2017-01-01 00:00:00
abstract::Abstract Twenty-six patients with systemic lupus erythematosus (SLE) showing systemic lupus activity measure (SLAM) and SLE disease activity index (SLEDAI) scores ≤2, as well as a lower C4 concentration than the mean C4 levels of healthy controls, were selected to evaluate the C4 levels of SLE patients in remission. S...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200037
更新日期:2002-09-01 00:00:00
abstract::Relapsing polychondritis (RP) is a rare disease of unknown etiology causing systematic inflammation and resulting in destruction of cartilaginous tissues. We describe here an 18-year-old Japanese woman who developed severe airway stenosis as the initial symptom with auricular, nasal, and ocular inflammation. The effec...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0548-5
更新日期:2007-01-01 00:00:00
abstract::Objectives: Delayed wound healing is one of the most common complications following forefoot surgery in patients with rheumatoid arthritis. We aimed to identify the risk factors for delayed wound healing following rheumatoid forefoot surgery.Methods: Consecutive patients who underwent primary rheumatoid forefoot surge...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1775960
更新日期:2020-06-16 00:00:00
abstract::Abstract We report two cases of bone marrow hemophagocytosis. One patient had adult-onset Still's disease, and the other had herpes zoster associated with potential autoimmune abnormalities. Our findings suggested a pos-sible role of cytokines and/or antibodies in the induction of hemophagocytosis in patients with con...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-001-8066-y
更新日期:2001-12-01 00:00:00
abstract::The expression of CD25 or CD28 on T cells was examined in patients with rheumatic diseases associated with interstitial pneumonitis (IP), in order to investigate the conditions of CD4+CD25+ regulatory T cells and CD8+CD28- suppressor T cells. Fifty-five patients with various rheumatic diseases and 23 normal controls w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0090-8
更新日期:2008-01-01 00:00:00
abstract::We evaluated the utility of HEp-2 cells transfected with the 60 kDa SS-A/Ro as a substrate for indirect immunofluorescence (IIF-HEp-2000) to compare several methods for screening Japanese serum samples for anti-SS-A/Ro antibodies. Serum samples from 243 Japanese patients were analyzed by IIF for anti-nuclear antibodie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0100-x
更新日期:2008-01-01 00:00:00
abstract::OBJECTIVES: To validate the 2010 histopathological classification system of anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (GN) in a Japanese single-center cohort. METHODS: We retrospectively studied 54 patients (28 renally limited pauci-immune GN, 25 microscopic polyangiitis, and one Chur...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-013-0877-0
更新日期:2013-04-12 00:00:00
abstract:OBJECTIVES:To assess the efficacy of tocilizumab (TCZ) monotherapy for the remission induction of microscopic polyangiitis (MPA) in a prospective single-arm, single-center, cohort, pilot study. METHODS:Eligible patients were aged between 20 and 80 years and were newly diagnosed with MPA according to Watts' classificat...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.3109/14397595.2016.1160968
更新日期:2016-11-01 00:00:00
abstract::Abstract A woman with Sjögren's syndrome concurrently suffered bilateral fractures of the femoral neck without any proximate cause, while she had aseptic necrosis of the femoral head resulting from the treatment for Sjögren's syndrome. According to previous reports, fractures of the femoral neck following aseptic necr...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-004-0346-x
更新日期:2004-12-01 00:00:00
abstract::We examined the efficacy and safety of autologous transplantation of bone-marrow-derived cells in patients with intractable ulcers caused by systemic sclerosis. Eight patients with ulcers resistant to treatment were enrolled. Bone marrow cells were gathered from the bilateral iliac crests with multiple repositioning b...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0274-x
更新日期:2010-06-01 00:00:00
abstract::To evaluate the efficacy of high-dose leukocytapheresis (LCAP) using a large filter in patients with refractory rheumatoid arthritis (RA), we conducted a multicenter, nonrandomized, open-label clinical study. Thirty patients with highly active RA were treated with high-dose LCAP performed 3-5 sessions at 1-week interv...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s10165-007-0630-7
更新日期:2007-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1349573
更新日期:2018-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170008
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to clarify the surgical indication for rheumatoid forefoot deformity according to background characteristics and plantar pressure. METHODS:Patients with rheumatoid arthritis were divided into a non-surgical group (group N) and a surgical group (group S). The former consisted o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1301015
更新日期:2017-11-01 00:00:00
abstract::Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his diseas...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0065-9
更新日期:2008-01-01 00:00:00
abstract::Abstract To clarify the effect of leukemia inhibitory factor (LIF) on the destruction of rheumatoid arthritis (RA) joints, we investigated the production of LIF and the expression of LIF mRNA in synovial tissues from patients with RA and osteoarthritis (OA). Synovial fluids from RA were used to measure the LIF concent...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-002-0210-9
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:This pilot multicenter exercise aimed to evaluate the inter-observer reproducibility of synovial power Doppler (PD) signals in rheumatoid arthritis (RA) patients and to determine the factors influencing the measurements. METHODS:Two representative RA patients were assessed by four independent experienced so...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.3109/14397595.2013.843763
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to develop clinical practice guideline (CPG) for Sjögren's syndrome (SS) based on recently available clinical and therapeutic evidences. METHODS:The CPG committee for SS was organized by the Research Team for Autoimmune Diseases, Research Program for Intractable Disease of the...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1438093
更新日期:2018-05-01 00:00:00
abstract::A 79-year-old man was diagnosed with relapsing polychondritis, from symptoms of bilateral auricular deformity and pigmentation, polyarthralgia, and audiovestibular damage, and from histological examination of the left auricular cartilage. The left auricular cartilage biopsy specimen revealed cartilage destruction with...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0439-2
更新日期:2011-10-01 00:00:00
abstract::'Immunoglobulin G4 (IgG4)-related disease' is a new clinical concept of multi-organ diseases, with Mikulicz's disease (MD) being a clinical phenotype of IgG4-related disease. To clarify the clinical characteristics of respiratory involvement associated with IgG4-related MD, we retrospectively assessed 25 patients with...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0504-x
更新日期:2012-02-01 00:00:00
abstract::An 8-year-old girl with systemic-onset juvenile idiopathic arthritis (JIA) required surgical reduction for a dislocated left hip joint following failure of skin traction for 1 week. Unaided walking was achieved by 3 months postoperatively. Incongruence and irregularity of the hip joint remained but may resolve with ma...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0330-5
更新日期:2004-01-01 00:00:00