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Impact of methotrexate dose on efficacy of adalimumab in Japanese patients with rheumatoid arthritis: Results from registered data analyses.

Abstract：

OBJECTIVE:Upper limit of methotrexate (MTX) for patients with rheumatoid arthritis (RA) was recently increased from 8 to 16 mg/week in Japan. We therefore examined the effect of concomitant MTX dose on the efficacy of adalimumab (ADA) in clinical practice. METHOD:Sixty-one consecutive RA patients treated with ADA were followed for minimum 52 weeks and retrospectively compared by MTX dose; patients receiving concomitant MTX of 10 mg/week or more (MTX ≥10 mg group) and <10 mg/week (MTX <10 mg group). Disease activity and remission were evaluated by the disease activity score 28 (DAS28) criteria. RESULTS:The MTX ≥10 mg group consistently showed better improvement in DAS28 and resulted in more patients (52.8%) with DAS28-remission compared with the MTX <10 mg group (26.1%). Multivariate analysis showed that MTX ≥10 mg had a significant effect on DAS28 remission with odds ratio of 5.12. ADA retention rate was 72.2% in MTX ≥10 mg group compared with 52.0% in MTX <10 mg group. Discontinuation of ADA due to adverse events were comparable in the MTX ≥10 mg and MTX <10 mg groups (11.1% vs. 12.0%). CONCLUSIONS:These findings support the critical role of concomitant MTX in the efficacy of ADA, and recommend use of MTX ≥10 mg in Japanese RA patients.

journal_name

Mod Rheumatol

journal_title

Modern rheumatology

authors

Nakashima Y,Miyahara H,Kondo M,Fukuda T,Harada H,Haraguchi A,Inoue Y,Ishinishi T,Maekawa M,Maeyama A,Nakashima M,Shono E,Suematsu E,Shimauchi T,Tsuru T,Tsukamoto H,Yoshizawa S,Yoshizawa S,Iwamoto Y

doi

10.3109/14397595.2016.1170958

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

15-21

issue

1

eissn

1439-7595

issn

1439-7609

journal_volume

27

pub_type

杂志文章

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