Validation of the 2010 histopathological classification of ANCA-associated glomerulonephritis in a Japanese single-center cohort.

abstract：:Bucillamine (Buc) is a disease-modifying antirheumatic drug (DMARD) developed in Japan, which has been used as one of the first-line DMARDs for the treatment of rheumatoid arthritis (RA) in Japan. However, direct comparison of this drug with standard DMARDs including sulfasalazine (SASP) and methotrexate (MTX) has bee...

journal_title：Modern rheumatology

authors： Iwatani M,Inoue E,Nakamura T,Nakajima A,Hara M,Tomatsu T,Kamatani N,Yamanaka H

更新日期：2006-01-01 00:00:00

abstract：:Pneumatosis cystoides intestinalis (PCI), which is characterized by the presence of multiple gas-filled mucosal, submucosal, or subserosal cysts located throughout the colon and/or small intestine, is an unusual complication of systemic lupus erythematosus (SLE). We report a case of a 33-year-old woman with a 5-year h...

journal_title：Modern rheumatology

authors： Yamaguchi Y,Ohno S,Yamazaki S,Ideguchi H,Shirai A,Takeno M,Ishigatsubo Y

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:We investigated the characteristics of circulating T-helper (Th) cells and CD4+ regulatory T cells (Tregs) in polyarteritis nodosa (PAN). METHODS:Peripheral blood samples were obtained from 14 patients with PAN. Nine patients having granulomatosis with polyangiitis (GPA) and 11 healthy individuals (HC) were...

journal_title：Modern rheumatology

authors： Shimojima Y,Ishii W,Kishida D,Fukushima K,Ikeda SI

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To assess the long-term safety, immunogenicity, and efficacy of subcutaneous (SC) abatacept in combination with methotrexate (MTX) in Japanese patients with rheumatoid arthritis who were MTX inadequate responders, in a long-term extension (LTE) to a double-dummy, double-blind study (NCT01001832). METHODS:Pat...

journal_title：Modern rheumatology

authors： Amano K,Matsubara T,Tanaka T,Inoue H,Iwahashi M,Kanamono T,Nakano T,Uchimura S,Izumihara T,Yamazaki A,Karyekar CS,Takeuchi T,Japan Abatacept Study Group.

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To investigate which IgG subclasses contribute to the activation of the complement pathway in IgG4-related disease (IgG4RD) patients with hypocomplementemia. METHODS:Sera of IgG4RD patients were analyzed for the binding ability of IgG subclasses to complement component 1q (C1q). Polyethylene glycol (PEG) pre...

journal_title：Modern rheumatology

authors： Sugimoto M,Watanabe H,Asano T,Sato S,Takagi T,Kobayashi H,Ohira H

更新日期：2016-01-01 00:00:00

abstract：:We report a novel case of eosinophilic orbital myositis associated with Churg-Strauss syndrome. A 56-year-old man with a 20-year history of chronic sinusitis and seasonal allergic rhinitis was admitted because of fever, swelling of cheeks and extremities, diplopia, and eosinophilia. With findings from gadolinium-enhan...

journal_title：Modern rheumatology

authors： Fujii T,Norizuki M,Kobayashi T,Yamamoto M,Kishimoto M

更新日期：2010-04-01 00:00:00

abstract：:Leuconostoc infections are rare and usually occur in immunocompromised patients. This report describes a case of Leuconostoc lactis bacteremia in a patient with coexisting rheumatoid arthritis and tuberculosis arthritis. A disrupted gastrointestinal barrier due to gastrointestinal amyloidosis in long-standing rheumato...

journal_title：Modern rheumatology

authors： Shin J,Her M,Moon C,Kim D,Lee S,Jung S

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to clarify the surgical indication for rheumatoid forefoot deformity according to background characteristics and plantar pressure. METHODS:Patients with rheumatoid arthritis were divided into a non-surgical group (group N) and a surgical group (group S). The former consisted o...

journal_title：Modern rheumatology

authors： Lee H,Ishikawa H,Miyagawa Y,Takai C,Nomura Y,Nemoto T,Kobayashi D,Abe A,Otani H,Ito S,Nakazono K,Ishii T,Saito S,Tokuhashi Y,Murasawa A

更新日期：2017-11-01 00:00:00

abstract：:Objectives: Overactive bladder (OAB) is a clinical diagnosis defined with the presence of urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence. Objective was to evaluate the demographic and clinical characteristics of Japanese systemic sclerosis (SSc) patients wi...

journal_title：Modern rheumatology

authors： Motegi SI,Sekiguchi A,Sekine Y,Nakayama H,Suzuki K,Ishikawa O

更新日期：2020-03-01 00:00:00

abstract：:Methotrexate (MTX) is indispensable for the treatment of rheumatoid arthritis (RA). However, a small number of patients treated with MTX occasionally encounter some life-threatening events, including myelosuppression. Renal insufficiency, one of risk factors for these events, is difficult to assess because the serum c...

journal_title：Modern rheumatology

authors： Hayashi T,Ito S,Goto D,Matsumoto I,Sumida T

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:This study was performed to better know diagnosis associated with serum IgG4 concentration, and to explore the possibility for development of a serum IgG4 for IgG4-related disease (IgG4-RD) in Chinese populations. METHODS:We studied retrospectively 497 IgG4 serum subclass measurements from Peking Union Medic...

journal_title：Modern rheumatology

authors： Li P,Chen H,Deng C,Wu Z,Lin W,Zeng X,Zhang W,Zhang F,Li Y

更新日期：2016-07-01 00:00:00

abstract：:Abstract Sensitivity and specificity were compared among the American College of Rheumatology (ACR) 1987 classification criteria, the Yamasaki diagnostic criteria, and the Japan Rheumatism Association (JRA) diagnostic criteria for early rheumatoid arthritis (RA). The study included 90 patients who consulted our depart...

journal_title：Modern rheumatology

authors： Yamamoto N,Hagino H,Teshima R

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVES:To assess changes in salivary epidermal growth factor (EGF) levels within three years and investigate the correlation between these changes and the severity of intraoral manifestations in patients with Sjögren's syndrome (SS). METHODS:Twenty-three SS patients (14 primary SS and 9 secondary SS) and 14 contro...

journal_title：Modern rheumatology

authors： Azuma N,Katada Y,Kitano S,Sekiguchi M,Kitano M,Nishioka A,Hashimoto N,Matsui K,Iwasaki T,Sano H

更新日期：2015-01-01 00:00:00

abstract：:A 68-year-old Japanese male presented with atrophic erythematous white lesions with peripheral dark reddish rims on his back. Multiple ulcers were detected from his stomach to his large intestine using endoscopy. Although the patient was given high doses of a steroid, aspirin, dipyridamole, and intravenous immunoglobu...

journal_title：Modern rheumatology

authors： Umemura M,Miwa Y,Yanai R,Isojima S,Tokunaga T,Tsukamoto H,Takahashi R,Yajima N,Kasama T,Takahashi N,Sueki H,Yamaguchi S,Arai K,Takeuchi Y,Ohike N,Norose T,Yamochi-Onizuka T,Takimoto M

更新日期：2015-05-01 00:00:00

abstract：:The development of multiple large tophi in patients with gout is rare. We report magnetic resonance (MR) and histological features of large subcutaneous tophi in a 32-year-old male patient with no known arthritis. His subcutaneous lesions were confused with a neoplastic process, evaluated by MR imaging, and surgically...

journal_title：Modern rheumatology

authors： Ryu K,Takeshita H,Takubo Y,Hirata M,Taniguchi D,Masuzawa N,Kishimoto M,Kubo T

更新日期：2005-01-01 00:00:00

abstract：:Abstract We report a case of hypocalcemic myopathy confounded by polymyositis due to an elevated level of serum creatine kinase (CK). A 30-year-old man was referred to our hospital for the treatment of provisionally diagnosed polymyositis. His presentation with tetany, hyporeflexia, and general fatigue, in addition to...

journal_title：Modern rheumatology

authors： Hirata D,Nagashima T,Saito S,Okazaki H,Kano S,Minota S

更新日期：2002-06-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective-tissue disease with a complex phenotype and varying disease course. Although SLE often causes a polyarticular synovitis, there are only a few case reports of abnormalities of the synovial lined sacroiliac joints. We report a case with an overlap...

journal_title：Modern rheumatology

authors： Chandrasekhara PK,Jayachandran NV,Thomas J,Narsimulu G

更新日期：2009-01-01 00:00:00

abstract：:We report a patient who had a 4-year history of adult-onset Still's disease (AOSD) and showed a prominent increase in large granular lymphocytes (LGL) when she developed severe Pseudomonas conjunctivitis due to Pseudomonas aeruginosa, skin eruptions, liver damage, and abnormal findings in coagulation studies, without ...

journal_title：Modern rheumatology

authors： Tabata R,Tabata C,Fukuda H,Kotani H

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:The characteristics of lymphoproliferative disorders (LPD) in patients with rheumatoid arthritis (RA) remain unclear. Therefore, we retrospectively analyzed the clinical characteristics of these patients in our department. METHODS:Twenty RA patients who developed LPD between April 2003 and August 2016 in ou...

journal_title：Modern rheumatology

authors： Tsukui D,Kanda H,Shinozaki-Ushiku A,Tateishi S,Takeshima Y,Nagafuchi Y,Sasaki O,Iwasaki Y,Harada H,Shibuya M,Sumitomo S,Shoda H,Kubo K,Fujio K,Nakamura F,Kurokawa M,Fukayama M,Yamamoto K

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:To investigate and compare the risk for malignancy in rheumatoid arthritis (RA) patients treated with biologics in Japan to the general population. METHODS:Data for 14,440 patients from 335 institutions who were given infliximab, etanercept, adalimumab, golimumab, tocilizumab, or abatacept were retrieved fr...

journal_title：Modern rheumatology

authors： Harigai M,Nanki T,Koike R,Tanaka M,Watanabe-Imai K,Komano Y,Sakai R,Yamazaki H,Koike T,Miyasaka N

更新日期：2016-09-01 00:00:00

abstract：:For over 10 years there have been no clinical studies about adult-onset Still's disease (AOSD) in Japan. We aimed to investigate recent clinical features and treatment of AOSD and to evaluate the efficacy of cyclosporin A (CyA) in the treatment of AOSD. The data from 34 patients with AOSD who were admitted to our hosp...

journal_title：Modern rheumatology

authors： Mitamura M,Tada Y,Koarada S,Inoue H,Suematsu R,Ohta A,Nagasawa K

更新日期：2009-01-01 00:00:00

abstract：:The objective of this study was to show whether the disease activity of rheumatoid arthritis (RA) patients had improved in Japan, and whether the improvement of disease activity had resulted in a better outcome of patients. In a single-institute-based prospective observational cohort of RA patients (Institute of Rheum...

journal_title：Modern rheumatology

authors： Yamanaka H,Inoue E,Singh G,Tanaka E,Nakajima A,Taniguchi A,Hara M,Tomatsu T,Kamatani N

更新日期：2007-01-01 00:00:00

abstract：:Relapsing polychondritis (RP) is a rare disease of unknown etiology causing systematic inflammation and resulting in destruction of cartilaginous tissues. We describe here an 18-year-old Japanese woman who developed severe airway stenosis as the initial symptom with auricular, nasal, and ocular inflammation. The effec...

journal_title：Modern rheumatology

authors： Yamaoka K,Saito K,Hanami K,Nakayamada S,Nawata M,Iwata S,Azuma T,Tanaka Y

更新日期：2007-01-01 00:00:00

abstract：:Objectives: Thrombocytopenia is frequently observed in antiphospholipid antibody (aPL) carriers. Due to the paradoxical risks of thrombosis and hemorrhage, the management of aPL-associated thrombocytopenia (APAT) is often deductive. We aimed to investigate the efficacy and safety of therapeutic approaches for APAT thr...

journal_title：Modern rheumatology

authors： Abe N,Oku K,Amengual O,Fujieda Y,Kato M,Bohgaki T,Yasuda S,Mori R,Morishita E,Suzuki-Inoue K,Atsumi T

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:To assess the efficacy of tocilizumab (TCZ) monotherapy for the remission induction of microscopic polyangiitis (MPA) in a prospective single-arm, single-center, cohort, pilot study. METHODS:Eligible patients were aged between 20 and 80 years and were newly diagnosed with MPA according to Watts' classificat...

journal_title：Modern rheumatology

authors： Sakai R,Kondo T,Kikuchi J,Shibata A,Chino K,Okuyama A,Takei H,Amano K

更新日期：2016-11-01 00:00:00

abstract：:Abstract We report a rare case of a 17-year-old female with overlap syndrome (systemic lupus erythematosus and systemic sclerosis) who developed severe abdominal pain and bloody diarrhea accompanied by central nervous system lupus. Colonoscopy revealed multiple irregular and linear ulcers throughout the colon, which w...

journal_title：Modern rheumatology

authors： Ota Y,Nozue N,Dei Y,Kondo S,Ohashi H

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVES:To assess the efficacy of tocilizumab for preventing damage to the joints of systemic juvenile idiopathic arthritis (sJIA) patients, we examined serial radiographs of the hands and large weight-bearing joints of these patients before and after treatment with this agent. METHODS:Nine patients with sJIA recei...

journal_title：Modern rheumatology

authors： Inaba Y,Ozawa R,Aoki C,Imagawa T,Mori M,Hara R,Miyamae T,Saito T,Yokota S

更新日期：2013-07-01 00:00:00

abstract：:Objectives: The Childhood Health Assessment Questionnaire (CHAQ) is one of the most widely used self- report questionnaires to measure functional status in Juvenile idiopathic arthritis (JIA). The Japanese version of the CHAQ (JCHAQ) has been revised to meet requirements of clinical international trials which need the...

journal_title：Modern rheumatology

authors： Miyamae T,Tani Y,Kishi T,Yamanaka H,Singh G

更新日期：2020-09-01 00:00:00

abstract：:We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron's papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including stero...

journal_title：Modern rheumatology

authors： Horai Y,Isomoto E,Koga T,Okada A,Kawashiri SY,Tamai M,Yamasaki S,Nakamura H,Origuchi T,Hamaguchi Y,Fujimoto M,Kuwana M,Kawakami A

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:We seek to evaluate the opinions of nurses and doctors in Japan regarding EULAR recommendations for nurses' roles in the management of chronic inflammatory arthritis. METHODS:This is a cross-sectional survey within Japan. We randomly selected nurses and doctors engaged in consultation of patients with rheuma...

journal_title：Modern rheumatology

authors： Fusama M,Nakahara H,van Eijk-Hustings Y,Oliver S,Takeuchi T

更新日期：2017-09-01 00:00:00