Abstract:
:Objectives: Thrombocytopenia is frequently observed in antiphospholipid antibody (aPL) carriers. Due to the paradoxical risks of thrombosis and hemorrhage, the management of aPL-associated thrombocytopenia (APAT) is often deductive. We aimed to investigate the efficacy and safety of therapeutic approaches for APAT through a systematic review.Methods: Four therapeutic approaches for APAT, including antiplatelet agents, glucocorticoids, splenectomy and thrombopoietin receptor agonists, were selected. Clinical trials evaluating therapeutic outcomes including the remission, complications, mortality and relapse, were searched in MEDLINE, EMBASE and CENTRAL from the inception dates to 28 November 2016. A meta-analysis was performed to calculate risk ratios (RRs) and 95% confidence intervals (CIs) using random-effects models.Results: Out of 1407 papers, eight controlled clinical trials were included. In patients with APAT, the remission rates were higher in patients on glucocorticoids (RR 8.33 [95% CI 3.07-22.6]) or splenectomy (RR 8.37 [95% CI 1.61-43.7]) than in patients without those treatments. There was no significant association between glucocorticoids and thrombosis (RR 1.57 [95% CI, 0.17-14.9]) or between splenectomy and hemorrhage (RR 0.17 [95% CI 0.02-1.28]). The extracted data of mortality and relapse rate were not available for synthesis.Conclusion: Glucocorticoids or splenectomy seemed suitable therapeutic approaches for APAT.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Abe N,Oku K,Amengual O,Fujieda Y,Kato M,Bohgaki T,Yasuda S,Mori R,Morishita E,Suzuki-Inoue K,Atsumi Tdoi
10.1080/14397595.2018.1558934subject
Has Abstractpub_date
2020-01-01 00:00:00pages
116-124issue
1eissn
1439-7595issn
1439-7609journal_volume
30pub_type
杂志文章,meta分析abstract:OBJECTIVE:Aspects of health-related quality of life (HRQoL) are important for assessing perceived health status and treatment burden. We evaluated HRQoL using Short Form 36 Health Survey (SF-36) and factors associated with HRQoL. METHODS:We collected basic and lifestyle-related, clinical, and treatment characteristics...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1060668
更新日期:2016-01-01 00:00:00
abstract::Abstract A 17-year-old woman who was being treated with prednisolone for cutaneous vasculitis developed recurrent massive melena and abdominal pain. An emergency resection was performed because of uncontrollable melena, revealing many small intestinal ulcers with cytomegalic inclusion bodies, which were found by immun...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200047
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVES:To assess the efficacy and safety of intravenous (IV) belimumab plus standard systemic lupus erythematosus (SLE) therapy standard of care (SoC) in Japanese patients with SLE. METHODS:A Phase 3, multicenter, double-blind, placebo-controlled, 52-week study (BEL 113750; NCT01345253) in patients with SLE, rando...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/14397595.2018.1480915
更新日期:2019-05-01 00:00:00
abstract::Objectives: To assess the middle-term outcome of iguratimod (IGU) in rheumatoid arthritis (RA) patients. Methods: Sixty-nine RA patients (14 males and 55 females, mean age of 64.0 years) receiving IGU-containing therapies were enrolled. We divided these patients into three groups based on the treatment at the baseline...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1510879
更新日期:2019-09-01 00:00:00
abstract::To investigate the role of interleukin (IL)-33 in rheumatoid arthritis (RA) patients, we measured the serum levels of IL-33 in RA patients before and after the administration of etanercept. Twenty-four patients with RA were treated with etanercept. Clinical and laboratory examinations, including serum levels of C-reac...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-011-0480-1
更新日期:2012-02-01 00:00:00
abstract::The involvement of valgus hindfoot deformity in hallux valgus deformity was confirmed in a rheumatoid arthritis case with a destructive valgus hindfoot deformity. Correction of severe valgus, calcaneal lateral offset, and pronated foot deformity instantly normalized hallux valgus deformities postoperatively. Thus, car...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.874738
更新日期:2014-09-01 00:00:00
abstract::We report the case of a 73-year-old man with myelodysplastic syndrome (MDS) who developed Weber-Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple ten...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-003-0270-5
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:To determine the availability of bioelectrical impedance analysis (BIA), computed tomography (CT), and magnetic resonance imaging (MRI) for measurement of skeletal muscle mass in patients with rheumatic diseases and quantitatively assess skeletal muscle loss after glucocorticoid (GC) treatment. METHODS:The ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.935078
更新日期:2015-03-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Although hematological anomalies are commonly found in SLE, severe polymorphonuclear leukocyte depletion is rare. Most episodes of severe granulocytopenia in SLE patients tend to occur as part of drug toxicity-induced medullar hypoplasia,...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0740-8
更新日期:2013-11-01 00:00:00
abstract::Abstract To determine the specificities of autoantibodies targeting cell cycle-associated antigens in rheumatic diseases, we studied 30 sera which were obtained from patients visiting our hospital and which exhibited a variegated speckled pattern in indirect immunofluorescence (IF). The immunoreactivities of the sera ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170008
更新日期:2001-09-01 00:00:00
abstract::Skeletal injury is one of the most prevalent clinical problems that jeopardize the activities of daily life, especially in our aging society. Mesenchymal stem cells (MSCs) play pivotal roles in regenerating bones after bone injury. MSCs come from the surrounding tissues and/or circulation. Cell sources may be the bone...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10165-010-0357-8
更新日期:2011-04-01 00:00:00
abstract::We report a patient with the extremely rare familial multiple lipomatosis syndrome, who developed the uncommon autoimmune disease cytophagic histiocytic panniculitis, manifested as inflammation of preexisting lipomas. Despite his initial critical condition and unsuccessful treatment with steroids, he responded to cycl...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10165-011-0487-7
更新日期:2012-02-01 00:00:00
abstract::Aortitis, inflammation of the aortic tissue, is most commonly caused by vasculitic rheumatic conditions, and less frequently infectious organisms. Involvement of the aorta is well defined in HLA-B27-associated spondyloarthropathies such as long-standing ankylosing spondylitis and Reiter's syndrome. However, unlike oth...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0566-9
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:Modern three-component total ankle arthroplasty (TAA) has favorable clinical results and survival rates. However, radiographic deterioration and worsening of clinical symptoms may occur in patients with rheumatoid arthritis (RA) or non-inflammatory arthritis (NA). The associations between outcomes and clinic...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1220049
更新日期:2017-05-01 00:00:00
abstract::Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.859770
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To assess changes in salivary epidermal growth factor (EGF) levels within three years and investigate the correlation between these changes and the severity of intraoral manifestations in patients with Sjögren's syndrome (SS). METHODS:Twenty-three SS patients (14 primary SS and 9 secondary SS) and 14 contro...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1034941
更新日期:2015-01-01 00:00:00
abstract::The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet's disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0064-x
更新日期:2008-01-01 00:00:00
abstract::Inflammation has often been considered to be a nonspecific response and to play a bridging role in the activation of adaptive immunity. However, it is now accepted that inflammation is the product of an independent innate immune system closely linked to the adaptive immune system. The key mediators of inflammation are...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.3109/14397595.2014.902747
更新日期:2015-01-01 00:00:00
abstract::Objective: This study aimed to clarify whether plasma acrolein level actually increases in rheumatoid arthritis (RA) patients, and to elucidate whether any relationship exists between the levels and the RA background variables.Methods: Plasma levels of protein-conjugated acrolein (PC-Acro) in 84 patients (RA group) an...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1775921
更新日期:2020-06-16 00:00:00
abstract:AIM:The aim of this study was to analyze the effect of 18-week functional training (FT) program consisting in two sessions a week of in-water exercise and one of on-land exercise on pain, strength, and balance in women with fibromyalgia. METHODS:A sample consisting of 36 fibromyalgia patients was included in the study...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2015.1040614
更新日期:2015-01-01 00:00:00
abstract::Anti-tumor necrosis factor (anti-TNF) biologics are effective in the treatment of rheumatoid arthritis (RA); however, it is still not clear whether this treatment promotes the development of malignancies such as lymphoma. Human T-lymphotropic virus type 1 (HTLV-1), which is a causative agent of adult T-cell lymphoma (...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.844389
更新日期:2015-09-01 00:00:00
abstract::The association of either thrombotic thrombocytopenic purpura (TTP) or crescentic glomerulonephritis with Sjögren's syndrome is rare. We report a case of TTP appearing after the diagnosis of SjOgren's syndrome with crescentic glomerulonephritis and membranous nephropathy. Circulating immune complex was detected, and i...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0287-4
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the effect and potential mechanism of Cysteine-rich 61 (Cyr61) on stimulating MMP-3 expression by fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. METHODS:Primarily cultured RA FLS were treated with exogenous Cyr61 protein or Cyr61-siRNA, t...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1220447
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Gout is a polygenic auto-inflammatory disease, in which inflammation plays an important role in disease pathogenesis. The cytokine interleukin (IL)-23 promotes inflammation and helps to guide inflammatory cells, while studies have shown that the IL-23R gene is associated with susceptibility to several immune...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.964823
更新日期:2015-05-01 00:00:00
abstract::Abstract We report a rare case of a 17-year-old female with overlap syndrome (systemic lupus erythematosus and systemic sclerosis) who developed severe abdominal pain and bloody diarrhea accompanied by central nervous system lupus. Colonoscopy revealed multiple irregular and linear ulcers throughout the colon, which w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-003-0243-8
更新日期:2003-12-01 00:00:00
abstract::A 19-year-old Japanese woman with a 4-year history of Crohn's disease (CD) developed high fever, polyarthralgia, and painful subcutaneous nodules of the legs. A skin biopsy showed panarteritis with fibrinoid necrosis in the deep dermis. Endoscopic examination showed aphthous lesions in the entire colon. She was diagno...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0110-8
更新日期:2008-01-01 00:00:00
abstract::The objective of this study was to show whether the disease activity of rheumatoid arthritis (RA) patients had improved in Japan, and whether the improvement of disease activity had resulted in a better outcome of patients. In a single-institute-based prospective observational cohort of RA patients (Institute of Rheum...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0587-6
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:The objective of this study is to develop clinical practice guideline (CPG) for Sjögren's syndrome (SS) based on recently available clinical and therapeutic evidences. METHODS:The CPG committee for SS was organized by the Research Team for Autoimmune Diseases, Research Program for Intractable Disease of the...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1438093
更新日期:2018-05-01 00:00:00
abstract::Abstract Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug (DMARD) throughout the world. In Japan, MTX is recommended by the Japanese Ministry of Health, Labour, and Welfare to be given as the second or third DMARD and at a dosage of no more than 8 mg/week. We analyzed the efficacy of M...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-004-0340-3
更新日期:2004-12-01 00:00:00
abstract:: ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-013-0870-7
更新日期:2013-04-04 00:00:00