Abstract:
OBJECTIVES:To assess changes in salivary epidermal growth factor (EGF) levels within three years and investigate the correlation between these changes and the severity of intraoral manifestations in patients with Sjögren's syndrome (SS). METHODS:Twenty-three SS patients (14 primary SS and 9 secondary SS) and 14 controls were followed up for three years. Salivary EGF concentration was measured using an enzyme-linked immunosorbent assay, and intraoral manifestations were evaluated using a short version of the Oral Health Impact Profile (OHIP-14). Changes in salivary flow rate, EGF level, and severity of intraoral manifestations were analyzed, along with associations among them. RESULTS:The OHIP-14 score significantly increased and the total salivary EGF output significantly decreased after three years in the SS group (10.2 ± 8.8 vs. 12.6 ± 9.2, p = 0.040; 10158.4 ± 9820.9 vs. 8352.8 ± 7813.3 pg/10 min, p = 0.032), though the salivary flow rate did not change. The decrease in total EGF output was especially high in patients with long disease duration and poor oral health-related quality of life (OHRQoL). In patients with poor OHRQoL, the change in total EGF output significantly correlated with the OHIP-14 score (r = - 0.847, p = 0.008). However, there was no correlation between the change in salivary flow rate and the OHIP-14 score. CONCLUSIONS:The rapid decrease in salivary EGF level contributes to the progression of intraoral manifestations of SS.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Azuma N,Katada Y,Kitano S,Sekiguchi M,Kitano M,Nishioka A,Hashimoto N,Matsui K,Iwasaki T,Sano Hdoi
10.3109/14397595.2015.1034941subject
Has Abstractpub_date
2015-01-01 00:00:00pages
876-82issue
6eissn
1439-7595issn
1439-7609journal_volume
25pub_type
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journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Modern rheumatology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/s10165-012-0711-0
更新日期:2013-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2014.881709
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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