Abstract:
:Objectives: To assess the middle-term outcome of iguratimod (IGU) in rheumatoid arthritis (RA) patients. Methods: Sixty-nine RA patients (14 males and 55 females, mean age of 64.0 years) receiving IGU-containing therapies were enrolled. We divided these patients into three groups based on the treatment at the baseline: an IGU group, a methotrexate (MTX) plus IGU group, and a biologics plus IGU group. The baseline characteristics and clinical course were evaluated over three years. Predictive factors associated with the achievement of low disease activity (LDA) were statistically analyzed. Results: The survival rate of IGU therapy at 3 years was 40.6%. The disease activity was significantly decreased in the IGU group and MTX plus IGU group compared with the baseline. Furthermore, 38 patients (55.1%) were in remission or had LDA at 3 years. The patient gender, use of prednisolone (PSL) and DAS28-CRP at baseline were the factors associated with the achievement of remission or LDA at three years. Conclusion: IGU was effective without MTX or bDMARDs as well as in combination with MTX. A female gender, no use of PSL and a low DAS28-CRP at the initiation of IGU were associated with clinical remission or LDA achievement at three years.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Suto T,Yonemoto Y,Okamura K,Sakane H,Takeuchi K,Tamura Y,Kaneko T,Ayabe K,Chikuda Hdoi
10.1080/14397595.2018.1510879subject
Has Abstractpub_date
2019-09-01 00:00:00pages
775-781issue
5eissn
1439-7595issn
1439-7609journal_volume
29pub_type
杂志文章abstract::Systemic lupus erythematosus (SLE) is a very heterogeneous systemic autoimmune disease, in which autoantibody synthesis against nuclear constituents is the main immunological characteristic. These autoantibodies underwent affinity maturation and isotype switching. Additionally, T-cell tolerance against nuclear autoant...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0430-x
更新日期:2005-01-01 00:00:00
abstract::Abstract Five cases of flexor tendon rupture in surgically treated rheumatoid wrists were studied. The tendon ruptures occurred in the thumb and index finger, and the ruptures site was in the carpal tunnel in all five cases. The main cause of rupture was the formation of bony irregularities in the form of bony spurs i...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170025
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.879416
更新日期:2014-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1117171
更新日期:2016-07-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
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journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2015.1086041
更新日期:2016-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1864914
更新日期:2020-12-16 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1176327
更新日期:2017-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0277-6
更新日期:2004-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1387223
更新日期:2018-07-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0674-1
更新日期:2013-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.978526
更新日期:2015-05-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1245176
更新日期:2017-07-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-002-0210-9
更新日期:2003-06-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1354431
更新日期:2018-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0090-8
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0163-3
更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/14397595.2017.1374235
更新日期:2018-07-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-002-0220-7
更新日期:2003-06-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0372-9
更新日期:2011-04-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.3109/14397595.2013.843763
更新日期:2014-05-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2014.881709
更新日期:2014-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1091123
更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/14397595.2015.1008779
更新日期:2015-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1546357
更新日期:2019-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0110-8
更新日期:2008-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0634-3
更新日期:2007-01-01 00:00:00