Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage.

abstract：:Objectives: Delayed wound healing is one of the most common complications following forefoot surgery in patients with rheumatoid arthritis. We aimed to identify the risk factors for delayed wound healing following rheumatoid forefoot surgery.Methods: Consecutive patients who underwent primary rheumatoid forefoot surge...

journal_title：Modern rheumatology

authors： Ohta K,Fukushi JI,Ikemura S,Kamura S,Miyahara HA,Nakashima Y

更新日期：2020-06-16 00:00:00

abstract：:We evaluated the prevalence of Helicobacter pylori infection and the association of H. pylori infection and/or nonsteroidal anti-inflammatory drug (NSAID) use with upper gastrointestinal (UGI) ulcers in a cohort of Japanese patients with rheumatoid arthritis (RA). Using the clinical database of the cohort of RA patien...

journal_title：Modern rheumatology

authors： Tanaka E,Singh G,Saito A,Syouji A,Yamada T,Urano W,Nakajima A,Taniguchi A,Tomatsu T,Hara M,Saito T,Kamatani N,Yamanaka H

更新日期：2005-01-01 00:00:00

abstract：:Abstract This work was undertaken to determine baseline urate metabolism in patients during the intermittent phase of gouty arthritis in order to decide on the best treatment for hyperuricemia. Parameters affecting serum urate levels, including uric acid clearance and urinary urate excretion, were re-evaluated in 30 p...

journal_title：Modern rheumatology

authors： Tsutani H,Kiriba C,Imamura S,Yoshio N,Nakamura T,Ueda T

更新日期：2000-12-01 00:00:00

abstract：:Cyclosporin A (CsA) has various adverse effects including neurotoxicity. We report the case of a 49-year-old Japanese woman with dermatomyositis who showed CsA-induced cortical blindness. The patient demonstrated cortical blindness despite having a normal blood concentration of CsA. The risk factors of CsA-induced cor...

journal_title：Modern rheumatology

authors： Sawabe T,Imafuku S

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Colchicine is the mainstay of the treatment of familial Mediterranean fever (FMF). However, 10% of FMF patients do not respond well to colchicine. Efficacy of interleukin (IL)-1 inhibitors in reducing attacks have been demonstrated in colchicine-resistant FMF (crFMF) patients recently. Colchicine is still th...

journal_title：Modern rheumatology

authors： Varan Ö,Kucuk H,Babaoglu H,Guven SC,Ozturk MA,Haznedaroglu S,Goker B,Tufan A

更新日期：2019-03-01 00:00:00

abstract：:Abstract This work was undertaken to evaluate clinical and immunological features in patients with systemic lupus erythematosus (SLE) complicated by Jaccoud's arthropathy. Patients diagnosed with SLE between 1985 and 1999, and who met the criteria of Villiaumey et al., were checked for Jaccoud's arthropathy. Clinical ...

journal_title：Modern rheumatology

authors： Takeishi M,Mimori A,Suzuki T

更新日期：2001-03-01 00:00:00

abstract：:For over 10 years there have been no clinical studies about adult-onset Still's disease (AOSD) in Japan. We aimed to investigate recent clinical features and treatment of AOSD and to evaluate the efficacy of cyclosporin A (CyA) in the treatment of AOSD. The data from 34 patients with AOSD who were admitted to our hosp...

journal_title：Modern rheumatology

authors： Mitamura M,Tada Y,Koarada S,Inoue H,Suematsu R,Ohta A,Nagasawa K

更新日期：2009-01-01 00:00:00

abstract：:The objective of this study was to show whether the disease activity of rheumatoid arthritis (RA) patients had improved in Japan, and whether the improvement of disease activity had resulted in a better outcome of patients. In a single-institute-based prospective observational cohort of RA patients (Institute of Rheum...

journal_title：Modern rheumatology

authors： Yamanaka H,Inoue E,Singh G,Tanaka E,Nakajima A,Taniguchi A,Hara M,Tomatsu T,Kamatani N

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease. METHODS:All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild l...

journal_title：Modern rheumatology

authors： Zhang FJ,Luo W,Gao SG,Su DZ,Li YS,Zeng C,Lei GH

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVES:The purpose of the present study was to describe our experience with the recombinant Fab' antibody fragment against TNF-α Certolizumab Pegol (CZP) in patients with Behçet's disease (BD) refractory to standardized therapies and previous biologic agents. METHODS:Retrieved data including demographic characteri...

journal_title：Modern rheumatology

authors： Lopalco G,Emmi G,Gentileschi S,Guerriero S,Vitale A,Silvestri E,Becatti M,Cavallo I,Fabiani C,Frediani B,Iannone F,Cantarini L

更新日期：2017-11-01 00:00:00

abstract：:We examined the therapeutic effect of high molecular weight hyaluronic acid (HA) on the progression of joint pain and cartilage degeneration in a rabbit osteoarthritis (OA) model. The OA model was induced by partial meniscectomy. In the time course study, cartilage degeneration was assessed at 3, 7 and 14 days after o...

journal_title：Modern rheumatology

authors： Hashizume M,Koike N,Yoshida H,Suzuki M,Mihara M

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To assess the utilities of ultrasonography (US) and low-field magnetic resonance imaging (compacTscan, cMRI) in the diagnosis of subclinical synovitis of hand joints of patients with rheumatoid arthritis (RA). METHODS:A total of 1,540 joints of 77 RA patients were examined clinically, using US, using cMRI, a...

journal_title：Modern rheumatology

authors： Ogishima H,Tsuboi H,Umeda N,Horikoshi M,Kondo Y,Sugihara M,Suzuki T,Matsumoto I,Sumida T

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Gout is a polygenic auto-inflammatory disease, in which inflammation plays an important role in disease pathogenesis. The cytokine interleukin (IL)-23 promotes inflammation and helps to guide inflammatory cells, while studies have shown that the IL-23R gene is associated with susceptibility to several immune...

journal_title：Modern rheumatology

authors： Liu S,He H,Yu R,Han L,Wang C,Cui Y,Li C

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-α inhibitors. METHODS:Change (Δ) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores w...

journal_title：Modern rheumatology

authors： Hirata S,Li W,Kubo S,Fukuyo S,Mizuno Y,Hanami K,Sawamukai N,Yamaoka K,Saito K,Defranoux NA,Tanaka Y

更新日期：2016-11-01 00:00:00

abstract：:This report documents the results of a study performed to examine clinical use of mizoribine (MZR), using data from a large-scale prospective cohort study, IORRA (Institute of Rheumatology Rheumatoid Arthritis). The number of patients with RA entered in this study from October 2000 through October 2003 was 6238. Three...

journal_title：Modern rheumatology

authors： Tanaka E,Inoue E,Kawaguchi Y,Tomatsu T,Yamanaka H,Hara M,Kamatani N

更新日期：2006-01-01 00:00:00

abstract：:We conducted a comprehensive meta-analysis to quantitatively evaluate the association of cytokine gene polymorphisms with systemic sclerosis (SSc) susceptibility. Electronic databases were used to identify published studies before July 2011. In total, 23 case-control studies including 3524 SSc cases and 6086 healthy c...

journal_title：Modern rheumatology

authors： Peng WJ,Pan HF,Tao JH,Wang BX,Lu MM,Wang S,He Q,Wang J

更新日期：2012-09-01 00:00:00

abstract：:The purpose of this study was to describe the prevalence of total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment in a large observational cohort in Japan. A total of 5,177 RA patients were studied for the prevalence of TJA, who were enrolled in the NinJa ...

journal_title：Modern rheumatology

authors： Nishino J,Tanaka S,Matsui T,Mori T,Nishimura K,Eto Y,Kaneko A,Saisho K,Yasuda M,Chiba N,Yoshinaga Y,Saeki Y,Seki A,Tohma S

更新日期：2009-01-01 00:00:00

abstract：:We report a case of a 60-year-old female with cutaneous polyarteritis nodosa (CPN) of the left ankle, accompanied by elevated serum interleukin (IL)-6 levels. Computed tomographic angiography revealed severe narrowing of medium-sized arteries in her left leg. Destructive arthropathy in the left ankle was identified by...

journal_title：Modern rheumatology

authors： Horai Y,Tokuyama A,Sumiyoshi R,Nakashima Y,Suzuki T,Okada A,Kawashiri SY,Ichinose K,Izumi Y,Miyashita T,Tamai M,Yamasaki S,Nakamura H,Hayashi T,Origuchi T,Kawakami A

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:No available anti-osteoporotic medication has been shown to completely prevent declines in bone mineral density (BMD) and the resulting increased risk of fracture. The objective of this study was to investigate the risk factors for treatment failure in osteoporotic patients with rheumatoid arthritis (RA). ME...

journal_title：Modern rheumatology

authors： Wen L,Kang JH,Yim YR,Lee JW,Lee KE,Park DJ,Kim TJ,Park YW,Lee SS

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Lupus enteritis (LE) is a rare but well-known gastrointestinal manifestation of systemic lupus erythematosus (SLE). This study was conducted to identify prognostic factors associated with poor responses in patients with LE. METHODS:We consecutively registered patients diagnosed with LE between January 2009 ...

journal_title：Modern rheumatology

authors： Yoshida Y,Omoto T,Kohno H,Tokunaga T,Kuranobu T,Yukawa K,Watanabe H,Oi K,Sugimoto T,Mokuda S,Nojima T,Hirata S,Sugiyama E

更新日期：2020-09-07 00:00:00

abstract：:Objectives: To assess the middle-term outcome of iguratimod (IGU) in rheumatoid arthritis (RA) patients. Methods: Sixty-nine RA patients (14 males and 55 females, mean age of 64.0 years) receiving IGU-containing therapies were enrolled. We divided these patients into three groups based on the treatment at the baseline...

journal_title：Modern rheumatology

authors： Suto T,Yonemoto Y,Okamura K,Sakane H,Takeuchi K,Tamura Y,Kaneko T,Ayabe K,Chikuda H

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:This study was performed to better know diagnosis associated with serum IgG4 concentration, and to explore the possibility for development of a serum IgG4 for IgG4-related disease (IgG4-RD) in Chinese populations. METHODS:We studied retrospectively 497 IgG4 serum subclass measurements from Peking Union Medic...

journal_title：Modern rheumatology

authors： Li P,Chen H,Deng C,Wu Z,Lin W,Zeng X,Zhang W,Zhang F,Li Y

更新日期：2016-07-01 00:00:00

abstract：:Objectives: To assess the effects of belimumab on disease activity across multiple organ domains in Japanese patients from the Phase 3 randomized, double-blind, North-East Asia study, BEL113750 (NCT01345253).Methods: Patients, aged ≥18 years, with American College of Rheumatology-defined systemic lupus erythematosus (...

journal_title：Modern rheumatology

authors： Tanaka Y,Bass D,Chu M,Egginton S,Ji B,Roth D

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVES:We aimed to clarify the characteristics of heme oxygenase (HO)-1 expressing cells in the synovium from rheumatoid arthritis (RA) and osteoarthritis (OA), and to investigate the co-expression of HO-1 and IgG-Fc/HLA-DR complex. METHODS:The characteristics of HO-1 expressing cells in the synovium were investig...

journal_title：Modern rheumatology

authors： Yang S,Ohe R,Aung NY,Kato T,Kabasawa T,Utsunomiya A,Takakubo Y,Takagi M,Yamakawa M

更新日期：2021-01-01 00:00:00

abstract：:A 10-year cohort study was performed, involving all of the 118 patients treated with bucillamine in our hospital between 1988 and 1990. Evaluation was made on the basis of erythrocyte sedimentation rate, grip strength, joint score, duration of morning stiffness, and Lansbury index consisting of the above four paramete...

journal_title：Modern rheumatology

authors： Yokota N,Kuga Y,Kanazawa T,Morishita M,Tanida K,Itou K

更新日期：2007-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective-tissue disease with a complex phenotype and varying disease course. Although SLE often causes a polyarticular synovitis, there are only a few case reports of abnormalities of the synovial lined sacroiliac joints. We report a case with an overlap...

journal_title：Modern rheumatology

authors： Chandrasekhara PK,Jayachandran NV,Thomas J,Narsimulu G

更新日期：2009-01-01 00:00:00

abstract：:A 20-year-old man presented with recurrent hemoptysis for seven months. A small subpleural nodule in his right lower lobe was found and excised surgically. Based on the presence of antiphospholipid antibodies (aPL) and vascular wall hypertrophy without vasculitis or an intraluminal thrombus, nonthrombotic proliferativ...

journal_title：Modern rheumatology

authors： Lee JS,Kim H,Lee EB,Song YW,Park JK

更新日期：2019-03-01 00:00:00

abstract：:Hyperimmunoglobulin E syndrome (HIES) is a primary immunodeficiency disorder with multisystem abnormalities including the vascular system. We report a child with autosomal recessive (AR)-HIES secondary to dedicator of cytokinesis 8 (DOCK8) deficiency who developed critical aortic aneurysm involving the ascending aorta...

journal_title：Modern rheumatology

authors： Al Mutairi M,Al-Mousa H,AlSaud B,Hawwari A,AlJoufan M,AlWesaibi A,AlHalees Z,Al-Mayouf SM

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:A nationwide survey was conducted to assess the number of patients, clinical aspects, treatment, and prognosis of adult Still's disease (ASD) in Japan. METHODS:A primary questionnaire was sent to randomly selected medical institutions in order to estimate the number of patients. We sent a secondary question...

journal_title：Modern rheumatology

authors： Asanuma YF,Mimura T,Tsuboi H,Noma H,Miyoshi F,Yamamoto K,Sumida T

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:To understand the status of mizoribine use in patients with lupus nephritis (LN) and to collect safety- and efficacy-related data on 2-year treatment with mizoribine. METHODS:A continuous survey was conducted between March 2010 and July 2015. RESULTS:The analysis set included 559 patients (mean age 39.5 ye...

journal_title：Modern rheumatology

authors： Takeuchi T,Okada K,Yoshida H,Yagi N

更新日期：2018-01-01 00:00:00