Acceptability and usefulness of mizoribine in the management of rheumatoid arthritis in methotrexate-refractory patients and elderly patients, based on analysis of data from a large-scale observational cohort study.

abstract：OBJECTIVES:To understand the status of mizoribine use in patients with lupus nephritis (LN) and to collect safety- and efficacy-related data on 2-year treatment with mizoribine. METHODS:A continuous survey was conducted between March 2010 and July 2015. RESULTS:The analysis set included 559 patients (mean age 39.5 ye...

journal_title：Modern rheumatology

authors： Takeuchi T,Okada K,Yoshida H,Yagi N

更新日期：2018-01-01 00:00:00

abstract：: ...

journal_title：Modern rheumatology

authors： Kajihara I,Jinnin M,Yamada S,Ichihara A,Makino T,Igata T,Masuguchi S,Fukushima S,Ihn H

更新日期：2013-04-04 00:00:00

abstract：OBJECTIVES:To determine whether ultrasonography (US) predicts Boolean remission in rheumatoid arthritis (RA) patients who had achieved disease activity score in 28 joints (DAS28)-based remission criteria. METHODS:Thirty-one RA patients in DAS28-based clinical remission were recruited. US semiquantitatively determined ...

journal_title：Modern rheumatology

authors： Yoshimi R,Hama M,Minegishi K,Kishimoto D,Watanabe T,Kamiyama R,Kirino Y,Asami Y,Ihata A,Tsunoda S,Ueda A,Takeno M,Ishigatsubo Y

更新日期：2014-07-01 00:00:00

abstract：:Objectives: The Childhood Health Assessment Questionnaire (CHAQ) is one of the most widely used self- report questionnaires to measure functional status in Juvenile idiopathic arthritis (JIA). The Japanese version of the CHAQ (JCHAQ) has been revised to meet requirements of clinical international trials which need the...

journal_title：Modern rheumatology

authors： Miyamae T,Tani Y,Kishi T,Yamanaka H,Singh G

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Upper limit of methotrexate (MTX) for patients with rheumatoid arthritis (RA) was recently increased from 8 to 16 mg/week in Japan. We therefore examined the effect of concomitant MTX dose on the efficacy of adalimumab (ADA) in clinical practice. METHOD:Sixty-one consecutive RA patients treated with ADA were...

journal_title：Modern rheumatology

authors： Nakashima Y,Miyahara H,Kondo M,Fukuda T,Harada H,Haraguchi A,Inoue Y,Ishinishi T,Maekawa M,Maeyama A,Nakashima M,Shono E,Suematsu E,Shimauchi T,Tsuru T,Tsukamoto H,Yoshizawa S,Yoshizawa S,Iwamoto Y

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:This study was performed to better know diagnosis associated with serum IgG4 concentration, and to explore the possibility for development of a serum IgG4 for IgG4-related disease (IgG4-RD) in Chinese populations. METHODS:We studied retrospectively 497 IgG4 serum subclass measurements from Peking Union Medic...

journal_title：Modern rheumatology

authors： Li P,Chen H,Deng C,Wu Z,Lin W,Zeng X,Zhang W,Zhang F,Li Y

更新日期：2016-07-01 00:00:00

abstract：INTRODUCTION:Fibromyalgia syndrome (FMS) is a chronic disease characterized by diffuse pain of unknown cause, fatigue, sleep disorders, cognitive dysfunction, and sensitivity. Fibromyalgia was shown to be associated with balance problems and increased incidence of falls. There are many theoretical mechanisms related to...

journal_title：Modern rheumatology

authors： Kasapoğlu Aksoy M,Altan L,Ökmen Metin B

更新日期：2017-09-01 00:00:00

abstract：:Idiopathic inflammatory myopathies (IIMs) are heterogeneous disorders that affect the skeletal muscles. Polymyositis, dermatomyositis, and inclusion body myositis are major IIM subsets. Immune-mediated necrotizing myopathy became recognized as a potentially new IIM subset. Since the new classification criteria publish...

journal_title：Modern rheumatology

authors： Sasaki H,Kohsaka H

更新日期：2018-11-01 00:00:00

abstract：:Abstract  This study examined the pathogenesis of large pseudocysts adjacent to knee joints in rheumatoid arthritis (RA). The radiological and histopathological features of 17 large subarticular pseudocysts in 12 knee joints of 10 patients were analyzed. Nine of the 10 patients were classified as class 2 according to ...

journal_title：Modern rheumatology

authors： Yoshida M,Ichinohe S,Uzuki M,Yoshida W,Sawai T,Shimamura T

更新日期：2002-06-01 00:00:00

abstract：:Abstract This work was undertaken to evaluate clinical and immunological features in patients with systemic lupus erythematosus (SLE) complicated by Jaccoud's arthropathy. Patients diagnosed with SLE between 1985 and 1999, and who met the criteria of Villiaumey et al., were checked for Jaccoud's arthropathy. Clinical ...

journal_title：Modern rheumatology

authors： Takeishi M,Mimori A,Suzuki T

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVES:The aim of our study is to clarify the association of myositis-specific autoantibodies (MSAs) with clinical and laboratory features in Japanese patients with juvenile idiopathic inflammatory myopathies (JIIMs). METHODS:We retrospectively analyzed the frequency of MSAs and their association with clinical or ...

journal_title：Modern rheumatology

authors： Ueki M,Kobayashi I,Takezaki S,Tozawa Y,Okura Y,Yamada M,Kuwana M,Ariga T

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVES:The early diagnosis and treatment of rheumatoid arthritis (RA) is important to reduce joint destruction. Many of the current imaging techniques have disadvantages, such as the need for contrast agents and interpretation by specialists. Fluorescence imaging is an emerging technique that overcomes some of thes...

journal_title：Modern rheumatology

authors： Onishi S,Sakane M,Tsukanishi T,Funayama T,Ozeki E,Hara I,Yamazaki M

更新日期：2016-11-01 00:00:00

abstract：:'Immunoglobulin G4 (IgG4)-related disease' is a new clinical concept of multi-organ diseases, with Mikulicz's disease (MD) being a clinical phenotype of IgG4-related disease. To clarify the clinical characteristics of respiratory involvement associated with IgG4-related MD, we retrospectively assessed 25 patients with...

journal_title：Modern rheumatology

authors： Matsui S,Taki H,Shinoda K,Suzuki K,Hayashi R,Tobe K,Tokimitsu Y,Ishida M,Fushiki H,Seto H,Fukuoka J,Ishizawa S

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the improvement of health status in patients with rheumatoid arthritis (RA) treated with tocilizumab. METHODS:Thirty-nine patients were treated with 8 mg/kg tocilizumab every 4 weeks for 24 weeks. Disease activity was assessed by Clinical Disease Activity Index (CDAI) and Simplified Disease Activ...

journal_title：Modern rheumatology

authors： Fusama M,Nakahara H,Hamano Y,Nishide M,Kawamoto K,Hosokawa T,Nozato S,Higa S,Igarashi T,Takeuchi E,Kuroiwa T,Shimaoka Y,Yukioka M,Miura Y,Higashi K,Kuritani T,Maeda K

更新日期：2013-03-01 00:00:00

abstract：:Objectives: To evaluate the effectiveness of add-on iguratimod (IGU) in patients with rheumatoid arthritis (RA) who showed an inadequate response to tocilizumab (TCZ), especially patients who were intolerant of an effective dose of methotrexate (MTX). Methods: Thirty-one patients with RA (22 women, age 62.4 years, dis...

journal_title：Modern rheumatology

authors： Ebina K,Miyama A,Tsuboi H,Kaneshiro S,Nishikawa M,Owaki H,Tsuji S,Hirao M,Etani Y,Goshima A,Hashimoto J,Yoshikawa H

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To investigate which IgG subclasses contribute to the activation of the complement pathway in IgG4-related disease (IgG4RD) patients with hypocomplementemia. METHODS:Sera of IgG4RD patients were analyzed for the binding ability of IgG subclasses to complement component 1q (C1q). Polyethylene glycol (PEG) pre...

journal_title：Modern rheumatology

authors： Sugimoto M,Watanabe H,Asano T,Sato S,Takagi T,Kobayashi H,Ohira H

更新日期：2016-01-01 00:00:00

abstract：:We performed total hip arthroplasty using the non-cement impaction auto-bone-grafting method with the resected femoral head for acetabular protrusion that is not combined with the destruction of acetabular rim or dysplasia of the hip joint. Ten patients (eight women and two men) with rheumatoid arthritis who showed ac...

journal_title：Modern rheumatology

authors： Mochida Y,Saito I,Akamatsu Y,Taki N,Mitsugi N,Saito T

更新日期：2007-01-01 00:00:00

abstract：:We report a case of acute generalized pustular bacterid (AGPB) concomitant with erythema nodosum (EN), polyarthritis, and Achilles tendinitis. The patient was admitted with a complaint of fever, widespread plural pustules, erythema, and polyarthralgia. Histopathological examination of the skin lesions demonstrated fea...

journal_title：Modern rheumatology

authors： Arita Y,Taguchi H,Hanada R,Tono T,Ohsone Y,Okata U,Irie R,Okano Y

更新日期：2019-01-01 00:00:00

abstract：:To evaluate the composite disease activity indices for rheumatoid arthritis (RA), we compared disease activities and the changes therein calculated using the Disease Activity Score based on 28 joint counts using erythrocyte sedimentation rate (DAS28-ESR), DAS28-CRP (C-reactive protein), Simplified Disease Activity Ind...

journal_title：Modern rheumatology

authors： Matsui T,Kuga Y,Nishino J,Kaneko A,Eto Y,Tohma S

更新日期：2011-04-01 00:00:00

abstract：:Endogenous lipoid pneumonia is an uncommon inflammatory pulmonary disease that is caused by lipids from an endogenous source, the treatment for which has not been established. We report the first case of endogenous lipoid pneumonia presenting as lung consolidation and which was associated with rheumatoid arthritis. Tr...

journal_title：Modern rheumatology

authors： Morita H,Arai S,Kurasawa K,Okada H,Tanaka A,Yamazaki R,Owada T,Maezawa R

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:To evaluate, through a systematic review of the literature, the association between the use of biological disease-modifying antirheumatic drugs (bDMARDs) and surgical site infection (SSI) or wound healing delay after orthopedic surgery in patients with rheumatoid arthritis (RA). METHODS:A systematic review ...

journal_title：Modern rheumatology

authors： Ito H,Kojima M,Nishida K,Matsushita I,Kojima T,Nakayama T,Endo H,Hirata S,Kaneko Y,Kawahito Y,Kishimoto M,Seto Y,Kamatani N,Tsutani K,Igarashi A,Hasegawa M,Miyasaka N,Yamanaka H

更新日期：2015-09-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective-tissue disease with a complex phenotype and varying disease course. Although SLE often causes a polyarticular synovitis, there are only a few case reports of abnormalities of the synovial lined sacroiliac joints. We report a case with an overlap...

journal_title：Modern rheumatology

authors： Chandrasekhara PK,Jayachandran NV,Thomas J,Narsimulu G

更新日期：2009-01-01 00:00:00

abstract：:We report a 24-year-old male with systemic lupus erythematosus (SLE) who developed influenza virus B-associated hemophagocytic syndrome and cardiac tamponade. Although the patient's general condition improved after steroid pulse therapy and pericardiocentesis, pericardial effusion re-accumulated. Colchicine and aspiri...

journal_title：Modern rheumatology

authors： Horai Y,Miyamura T,Takahama S,Sonomoto K,Nakamura M,Ando H,Minami R,Yamamoto M,Suematsu E

更新日期：2010-04-01 00:00:00

abstract：:The objective of this study was to show whether the disease activity of rheumatoid arthritis (RA) patients had improved in Japan, and whether the improvement of disease activity had resulted in a better outcome of patients. In a single-institute-based prospective observational cohort of RA patients (Institute of Rheum...

journal_title：Modern rheumatology

authors： Yamanaka H,Inoue E,Singh G,Tanaka E,Nakajima A,Taniguchi A,Hara M,Tomatsu T,Kamatani N

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To clarify polyarticular juvenile idiopathic arthritis (pJIA) patients who failed to maintain prolonged remission with the first biologic agent. METHODS:Fourteen pJIA patients were observed for 47.5 months (median) after initiating the first biologic agent. RESULTS:Eight maintained sustained clinical remiss...

journal_title：Modern rheumatology

authors： Kubota T,Imanaka H,Takei S,Yamatou T,Nerome Y,Yamasaki Y,Nonaka Y,Akaike H,Takezaki T,Kawano Y

更新日期：2016-01-01 00:00:00

abstract：:Interstitial lung disease (ILD) is a noteworthy condition in the treatment of systemic sclerosis (SSc) because of its associated mortality and morbidity; however, the efficacy of various treatments for ILD has been controversial in previous reports. In this study, we examined the efficacy and safety of intravenous cyc...

journal_title：Modern rheumatology

authors： Tochimoto A,Kawaguchi Y,Hara M,Tateishi M,Fukasawa C,Takagi K,Nishimagi E,Ota Y,Katsumata Y,Gono T,Tanaka E,Yamanaka H

更新日期：2011-06-01 00:00:00

abstract：:Abstract An accumulating body of evidence shows that gene therapy can be successfully used to treat animal models of arthritis. Based on this success, a clinical trial of gene therapy for rheumatoid arthritis has been initiated. We review the methods and genes used for the previous gene transfer experiments, including...

journal_title：Modern rheumatology

authors： Kohsaka H

更新日期：2000-06-01 00:00:00

abstract：:Abstract A 56-year-old man presented with hyperproteinemia and renal dysfunction associated with antineutrophil cytoplasmic antibodies (ANCA). He had had a ventriculoperitoneal shunt tube made of silicone implanted 4 years earlier. In his renal biopsy, necrotizing crescentic glomerulonephritis was identified: tests fo...

journal_title：Modern rheumatology

authors： Bohgaki M,Mukai M,Notoya A,Kohno M,Takada A

更新日期：2003-03-01 00:00:00

abstract：:A female rheumatoid arthritis patient was admitted for productive cough and general fatigue that had gradually developed after leflunomide therapy. Side effects including severe hypoxia, thrombocytopenia, lymphocytopenia, and macrocytic anemia with schistocytes (probably drug-induced megaloblastic anemia) were noted. ...

journal_title：Modern rheumatology

authors： Toyokawa Y,Kingetsu I,Yasuda C,Yasuda J,Yoshida K,Kurosaka D,Yamada A

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:We seek to evaluate the opinions of nurses and doctors in Japan regarding EULAR recommendations for nurses' roles in the management of chronic inflammatory arthritis. METHODS:This is a cross-sectional survey within Japan. We randomly selected nurses and doctors engaged in consultation of patients with rheuma...

journal_title：Modern rheumatology

authors： Fusama M,Nakahara H,van Eijk-Hustings Y,Oliver S,Takeuchi T

更新日期：2017-09-01 00:00:00