Abstract:
OBJECTIVE:This study was performed to better know diagnosis associated with serum IgG4 concentration, and to explore the possibility for development of a serum IgG4 for IgG4-related disease (IgG4-RD) in Chinese populations. METHODS:We studied retrospectively 497 IgG4 serum subclass measurements from Peking Union Medical College Hospital during the four-year period, including 242 IgG4-RD, 130 other diseases and 125 healthy individuals. RESULTS:Serum IgG4 concentrations were significantly higher in IgG4-RD than in other pathologies (1662.9 ± 3760.9 mg/L, p < 0.001) and healthy individuals (538.2 ± 458.6 mg/L, p < 0.001). There were no significant differences in serum IgG4 level between other pathologies group and healthy individuals (p = 0.075). Among the 242 IgG4-RD patients analyzed, serum IgG4 concentrations were normal in 46 patients (19.0%). We found 32 patients (24.6%) with elevated serum IgG4 levels among the 130 patients who suffered from other pathologies. There were seven (5.6%) with serum IgG4 over 1350 mg/L in healthy individuals. The ROC curve analysis revealed that the optimal sensitivity and specificity were 80.0% and 88.2%, respectively, at the concentration of 1575 mg/L for Chinese patients. CONCLUSIONS:Our study demonstrated that serum IgG4 elevation was not specific of IgG4-RD. Further studies are needed to define the sensibility and specificity of IgG4 values for the diagnosis of IgG4-RD.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Li P,Chen H,Deng C,Wu Z,Lin W,Zeng X,Zhang W,Zhang F,Li Ydoi
10.3109/14397595.2015.1117171subject
Has Abstractpub_date
2016-07-01 00:00:00pages
583-7issue
4eissn
1439-7595issn
1439-7609journal_volume
26pub_type
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pub_type: 杂志文章,meta分析,评审
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pub_type: 临床试验,杂志文章
doi:10.1007/s10165-006-0527-x
更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3109/14397595.2013.852840
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
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