Abstract:
:To evaluate the composite disease activity indices for rheumatoid arthritis (RA), we compared disease activities and the changes therein calculated using the Disease Activity Score based on 28 joint counts using erythrocyte sedimentation rate (DAS28-ESR), DAS28-CRP (C-reactive protein), Simplified Disease Activity Index (SDAI), and Clinical Disease Activity Index (CDAI) in a cohort of 1,412 patients with RA. The median (1st; 3rd quartile) scores were 4.20 (3.31; 5.14) for DAS28-ESR, 3.44 (2.59; 4.36) for DAS28-CRP, 13.6 (7.49; 21.1) for SDAI, and 12.0 (6.9; 18.9) for CDAI. Absolute scores and their changes were significantly correlated (p < 0.0001) in all combinations among these four disease activity indices; however, their correlations were lower in males than in females. Correlations between disease activity indices and the clinical and acute phase reactant variables were different according to disease activity index, sex and age. A comparison of the number of patients in each disease activity category according to the disease activity indices using kappa-statistics revealed an almost perfect agreement between SDAI and CDAI (κ = 0.871), a moderate agreement between DAS28-ESR and SDAI (κ = 0.415) or CDAI (κ = 0.427), but only fair agreement between DAS28-ESR and DAS28-CRP (κ = 0.329). For the selection of a disease activity index for an evaluation of RA patients, both the convenience and the characteristics of the respective disease activity index should be considered.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Matsui T,Kuga Y,Nishino J,Kaneko A,Eto Y,Tohma Sdoi
10.1007/s10165-010-0367-6subject
Has Abstractpub_date
2011-04-01 00:00:00pages
134-43issue
2eissn
1439-7595issn
1439-7609journal_volume
21pub_type
杂志文章abstract:OBJECTIVE:Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-α inhibitors. METHODS:Change (Δ) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores w...
journal_title:Modern rheumatology
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,随机对照试验
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journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1080/14397595.2016.1259603
更新日期:2017-09-01 00:00:00
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更新日期:2020-12-16 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/14397595.2016.1170946
更新日期:2016-11-01 00:00:00
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2015.1040614
更新日期:2015-01-01 00:00:00
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更新日期:2018-05-01 00:00:00
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doi:10.3109/14397595.2014.974881
更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2019-05-01 00:00:00
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更新日期:2015-01-01 00:00:00