Abstract:
OBJECTIVES:The objective of this study is to evaluate the efficacy and safety of bortezomib for treating systemic lupus erythematosus (SLE), in patients whose disease activity could not be controlled. METHODS:Fourteen SLE patients with persistent disease activity were selected, who required prednisolone doses of >10 mg/d despite concomitant immunosuppressive therapy. Patients were randomly administered either bortezomib or a placebo, eight times. The primary and secondary end-points were a change in anti-dsDNA antibody titer at week 24 and the SLE Responder Index (SRI), respectively. RESULTS:In the bortezomib group, four out of eight patients discontinued the trial; three others failed to complete the minimum protocol treatment due to adverse reactions. The changes in anti-dsDNA antibody titers at week 24 were 4.24% and -1.96%, for the bortezomib and placebo groups, respectively, disconfirming bortezomib's efficacy. In contrast, the corresponding SRI at week 12 was 75% and 40%. CONCLUSIONS:As bortezomib therapy for SLE is associated with many adverse reactions, treatment indications should be selected carefully, and protocols should aim to prevent these occurrences. Although the change in anti-dsDNA antibody titer did not support the efficacy of bortezomib as a treatment for SLE, high SRI in the treatment group suggests bortezomib may utilize mechanisms other than inhibition of anti-dsDNA antibody production.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Ishii T,Tanaka Y,Kawakami A,Saito K,Ichinose K,Fujii H,Shirota Y,Shirai T,Fujita Y,Watanabe R,Chiu SW,Yamaguchi T,Harigae Hdoi
10.1080/14397595.2018.1432331subject
Has Abstractpub_date
2018-11-01 00:00:00pages
986-992issue
6eissn
1439-7595issn
1439-7609journal_volume
28pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:No available anti-osteoporotic medication has been shown to completely prevent declines in bone mineral density (BMD) and the resulting increased risk of fracture. The objective of this study was to investigate the risk factors for treatment failure in osteoporotic patients with rheumatoid arthritis (RA). ME...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1069444
更新日期:2016-01-01 00:00:00
abstract::Bucillamine (Buc) is a disease-modifying antirheumatic drug (DMARD) developed in Japan, which has been used as one of the first-line DMARDs for the treatment of rheumatoid arthritis (RA) in Japan. However, direct comparison of this drug with standard DMARDs including sulfasalazine (SASP) and methotrexate (MTX) has bee...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
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更新日期:2006-01-01 00:00:00
abstract::Abstract We report two cases of bone marrow hemophagocytosis. One patient had adult-onset Still's disease, and the other had herpes zoster associated with potential autoimmune abnormalities. Our findings suggested a pos-sible role of cytokines and/or antibodies in the induction of hemophagocytosis in patients with con...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-001-8066-y
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.879416
更新日期:2014-09-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.3109/14397595.2013.843763
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVES:The present study aimed to conduct an epidemiological survey of Central Sensitization Inventory (CSI) scores in an older adult population and to investigate the association between the CSI scores, age, sex, pain intensity, site of pain, and health-related quality of life (QOL). METHODS:Participants were 373...
journal_title:Modern rheumatology
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1054081
更新日期:2016-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.891494
更新日期:2016-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0396-8
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journal_title:Modern rheumatology
pub_type: 杂志文章,评审
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更新日期:2020-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.924193
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pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Modern rheumatology
pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1220049
更新日期:2017-05-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章,meta分析
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0241-6
更新日期:2010-04-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0477-3
更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1265638
更新日期:2017-09-01 00:00:00
abstract::A 49-year-old Japanese woman treated with oral corticosteroids, methotrexate, and infliximab for malignant rheumatoid arthritis was admitted because of fever and low back pain. The white blood cell count and C-reactive protein concentration were elevated. Lumbar and pelvic computed tomography showed enlargement of the...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0493-3
更新日期:2006-01-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1206242
更新日期:2017-03-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-010-0372-9
更新日期:2011-04-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1367116
更新日期:2018-05-01 00:00:00
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journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0469-3
更新日期:2006-01-01 00:00:00