Influenza virus B-associated hemophagocytic syndrome and recurrent pericarditis in a patient with systemic lupus erythematosus.

abstract：:The expression of CD25 or CD28 on T cells was examined in patients with rheumatic diseases associated with interstitial pneumonitis (IP), in order to investigate the conditions of CD4+CD25+ regulatory T cells and CD8+CD28- suppressor T cells. Fifty-five patients with various rheumatic diseases and 23 normal controls w...

journal_title：Modern rheumatology

authors： Katagiri A,Morimoto S,Nakiri Y,Nakano S,Mitsuo A,Suzuki J,Amano H,Nozawa K,Asano M,Tokano Y,Hashimoto H,Takasaki Y

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:Several biological disease-modifying antirheumatic drugs (bDMARDs) are currently available for the treatment of rheumatoid arthritis (RA). Increasing evidence indicates that second-line bDMARDs are effective for inadequate responders to first-line bDMARDs. However, all previous studies investigated the use o...

journal_title：Modern rheumatology

authors： Matsuno H,Katayama K

更新日期：2017-03-01 00:00:00

abstract：:Abstract  Osteoarthritis (OA) is considered to be a complex illness in which the tissues of the joint play a significant role in the initiation and/or progression of the pathophysiology. We still do not completely understand what initiates the degradation and loss of cartilage. However, it has been suggested that incr...

journal_title：Modern rheumatology

authors： Lajeunesse D,Massicotte F,Pelletier JP,Martel-Pelletier J

更新日期：2003-03-01 00:00:00

abstract：:Cyclosporin A (CsA) has various adverse effects including neurotoxicity. We report the case of a 49-year-old Japanese woman with dermatomyositis who showed CsA-induced cortical blindness. The patient demonstrated cortical blindness despite having a normal blood concentration of CsA. The risk factors of CsA-induced cor...

journal_title：Modern rheumatology

authors： Sawabe T,Imafuku S

更新日期：2004-01-01 00:00:00

abstract：:Abstract Five cases of flexor tendon rupture in surgically treated rheumatoid wrists were studied. The tendon ruptures occurred in the thumb and index finger, and the ruptures site was in the carpal tunnel in all five cases. The main cause of rupture was the formation of bony irregularities in the form of bony spurs i...

journal_title：Modern rheumatology

authors： Kobayashi A,Futami T,Tsukamoto Y

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the effect and potential mechanism of Cysteine-rich 61 (Cyr61) on stimulating MMP-3 expression by fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. METHODS:Primarily cultured RA FLS were treated with exogenous Cyr61 protein or Cyr61-siRNA, t...

journal_title：Modern rheumatology

authors： Zhai T,Gao C,Huo R,Sheng H,Sun S,Xie J,He Y,Gao H,Li H,Zhang J,Li H,Sun Y,Lin J,Shen B,Xiao L,Li N

更新日期：2017-05-01 00:00:00

abstract：:We investigated the association between cigarette smoking and the risk of developing rheumatoid arthritis (RA) in the Malaysian population. A total of 1,056 RA patients and 1,416 matched controls aged 18-70 years within a defined area of Peninsular Malaysia were evaluated in a case-control study between August 2005 an...

journal_title：Modern rheumatology

authors： Yahya A,Bengtsson C,Lai TC,Larsson PT,Mustafa AN,Abdullah NA,Muhamad N,Hussein H,Klareskog L,Alfredsson L,Murad S

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:To understand the status of mizoribine use in patients with lupus nephritis (LN) and to collect safety- and efficacy-related data on 2-year treatment with mizoribine. METHODS:A continuous survey was conducted between March 2010 and July 2015. RESULTS:The analysis set included 559 patients (mean age 39.5 ye...

journal_title：Modern rheumatology

authors： Takeuchi T,Okada K,Yoshida H,Yagi N

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:To obtain safety and efficacy data on combination treatment with iguratimod and methotrexate (MTX) in an open-label extension study in patients with active rheumatoid arthritis (RA). METHODS:Following a 28-week, randomized, double-blind trial of adding iguratimod or placebo to stable MTX therapy, patients en...

journal_title：Modern rheumatology

authors： Hara M,Ishiguro N,Katayama K,Kondo M,Sumida T,Mimori T,Soen S,Nagai K,Yamaguchi T,Yamamoto K,Iguratimod-Clinical Study Group.

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the relationship between magnetic resonance imaging (MRI) findings before extracorporeal shockwave therapy (ESWT) and the treatment outcome of ESWT. METHODS:This study examined 50 feet with chronic plantar fasciitis. The scores before ESWT and after a six-month f...

journal_title：Modern rheumatology

authors： Maki M,Ikoma K,Imai K,Kido M,Hara Y,Arai Y,Fujiwara H,Kubo T

更新日期：2015-05-01 00:00:00

abstract：:Abstract Interstitial pneumonitis (IP) associated with polymyositis and dermatomyositis (PM/DM) is a serious complication that affects prognosis. We therefore undertook a retrospective multicenter study to examine the efficacy of a combination treatment with cyclosporin A (CsA) and corticosteroids. Fifty-three IP pati...

journal_title：Modern rheumatology

authors： Nagasaka K,Harigai M,Tateishi M,Hara M,Yoshizawa Y,Koike T,Miyasaka N

更新日期：2003-09-01 00:00:00

abstract：:'Immunoglobulin G4 (IgG4)-related disease' is a new clinical concept of multi-organ diseases, with Mikulicz's disease (MD) being a clinical phenotype of IgG4-related disease. To clarify the clinical characteristics of respiratory involvement associated with IgG4-related MD, we retrospectively assessed 25 patients with...

journal_title：Modern rheumatology

authors： Matsui S,Taki H,Shinoda K,Suzuki K,Hayashi R,Tobe K,Tokimitsu Y,Ishida M,Fushiki H,Seto H,Fukuoka J,Ishizawa S

更新日期：2012-02-01 00:00:00

abstract：:Macrophage activation syndrome (MAS), also known as secondary hemophagocytic lymphohistiocytosis, is mediated by cytokine overproduction from excessive activation of T lymphocytes and macrophages. We present a dermatomyositis patient with MAS, caused by hypercytokinemia. The combination of tacrolimus and plasma exchan...

journal_title：Modern rheumatology

authors： Kaieda S,Yoshida N,Yamashita F,Okamoto M,Ida H,Hoshino T,Fukuda T

更新日期：2015-01-01 00:00:00

abstract：:Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...

journal_title：Modern rheumatology

authors： Yagita M,Hamano T,Hatachi S,Fujita M

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Although "clinical remission" has been a realistic goal of treatment in rheumatoid arthritis (RA), there is evidence that subclinical synovitis is associated with ongoing structural damage even after clinical remission is achieved. In the study reported here, we assessed whether ultrasonography (US) can pred...

journal_title：Modern rheumatology

authors： Yoshimi R,Hama M,Takase K,Ihata A,Kishimoto D,Terauchi K,Watanabe R,Uehara T,Samukawa S,Ueda A,Takeno M,Ishigatsubo Y

更新日期：2013-05-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective-tissue disease with a complex phenotype and varying disease course. Although SLE often causes a polyarticular synovitis, there are only a few case reports of abnormalities of the synovial lined sacroiliac joints. We report a case with an overlap...

journal_title：Modern rheumatology

authors： Chandrasekhara PK,Jayachandran NV,Thomas J,Narsimulu G

更新日期：2009-01-01 00:00:00

abstract：:Abstract A 17-year-old woman who was being treated with prednisolone for cutaneous vasculitis developed recurrent massive melena and abdominal pain. An emergency resection was performed because of uncontrollable melena, revealing many small intestinal ulcers with cytomegalic inclusion bodies, which were found by immun...

journal_title：Modern rheumatology

authors： Ota Y,Ohashi H,Otani C,Dei Y,Kondo S,Baba S

更新日期：2002-09-01 00:00:00

abstract：:Abstract We evaluated bone mineral density (BMD) in Japanese female patients with systemic lupus erythematosus (SLE) and assessed the influence of the use of glucocorticoids. Lumbar BMD was measured by dual x-ray absorptiometry (DXA) in 60 premenopausal females who previously had been receiving glucocorticoid therapy....

journal_title：Modern rheumatology

authors： Banno S,Matsumoto Y,Naniwa T,Hayami Y,Sugiura Y,Yoshinouchi T,Ueda R

更新日期：2002-12-01 00:00:00

abstract：:A 68-year-old Japanese male presented with atrophic erythematous white lesions with peripheral dark reddish rims on his back. Multiple ulcers were detected from his stomach to his large intestine using endoscopy. Although the patient was given high doses of a steroid, aspirin, dipyridamole, and intravenous immunoglobu...

journal_title：Modern rheumatology

authors： Umemura M,Miwa Y,Yanai R,Isojima S,Tokunaga T,Tsukamoto H,Takahashi R,Yajima N,Kasama T,Takahashi N,Sueki H,Yamaguchi S,Arai K,Takeuchi Y,Ohike N,Norose T,Yamochi-Onizuka T,Takimoto M

更新日期：2015-05-01 00:00:00

abstract：:We report a case of acute generalized pustular bacterid (AGPB) concomitant with erythema nodosum (EN), polyarthritis, and Achilles tendinitis. The patient was admitted with a complaint of fever, widespread plural pustules, erythema, and polyarthralgia. Histopathological examination of the skin lesions demonstrated fea...

journal_title：Modern rheumatology

authors： Arita Y,Taguchi H,Hanada R,Tono T,Ohsone Y,Okata U,Irie R,Okano Y

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Fractalkine (CX3CL1/FKN) is a chemokine that regulates chemotaxis and adhesion of CX3C chemokine receptor 1 (CX3CR1)-expressing inflammatory cells. We conducted the first phase 1/2, open-label, multiple ascending dose study of E6011, a humanized anti-FKN monoclonal antibody, in Japanese rheumatoid arthritis (...

journal_title：Modern rheumatology

authors： Tanaka Y,Takeuchi T,Umehara H,Nanki T,Yasuda N,Tago F,Kawakubo M,Kitahara Y,Hojo S,Kawano T,Imai T

更新日期：2018-01-01 00:00:00

abstract：:Abstract To determine the specificities of autoantibodies targeting cell cycle-associated antigens in rheumatic diseases, we studied 30 sera which were obtained from patients visiting our hospital and which exhibited a variegated speckled pattern in indirect immunofluorescence (IF). The immunoreactivities of the sera ...

journal_title：Modern rheumatology

authors： Fujinaga H,Takeuchi K,Kaneda K,Takasaki Y,Hashimoto H

更新日期：2001-09-01 00:00:00

abstract：:To investigate the role of interleukin (IL)-33 in rheumatoid arthritis (RA) patients, we measured the serum levels of IL-33 in RA patients before and after the administration of etanercept. Twenty-four patients with RA were treated with etanercept. Clinical and laboratory examinations, including serum levels of C-reac...

journal_title：Modern rheumatology

authors： Kageyama Y,Torikai E,Tsujimura K,Kobayashi M

更新日期：2012-02-01 00:00:00

abstract：:A retrospective study was performed to investigate the clinical and radiological results of the Sauvé-Kapandji (S-K) procedure for the rheumatoid wrist. One hundred and eight rheumatoid wrists in 98 patients were operated on in our institute from 1992 to 2000, and in 82 wrists we used the S-K procedure. In other cases...

journal_title：Modern rheumatology

authors： Momohara S,Mamizuka K,Yonemoto K,Tomatsu T,Inoue K

更新日期：2004-01-01 00:00:00

abstract：:Synovial vascularization in the knee joints of six patients with rheumatoid arthritis who were treated with infliximab was evaluated by Doppler sonography. Power Doppler sonography demonstrated a significant reduction of color flow signals (P < 0.05), and spectral Doppler sonography demonstrated a significant increase...

journal_title：Modern rheumatology

authors： Takahashi A,Sato A,Yamadera Y,Takeda I,Kanno T,Ohguchi Y,Nishimaki T,Kasukawa R

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:To establish a new assessment tool for ulnar drift (UD) in rheumatoid arthritis (RA). METHODS:We established an observational cohort of 67 patients (134 rheumatoid hands) beginning in 2004. Fifty-two patients (100 hands) had follow-up in 2009 and 37 patients (63 hands) completed follow-up in 2015. UD was ev...

journal_title：Modern rheumatology

authors： Toyama S,Oda R,Tokunaga D,Taniguchi D,Nakamura S,Asada M,Fujiwara H,Kubo T

更新日期：2019-01-01 00:00:00

abstract：:We report a patient who had a 4-year history of adult-onset Still's disease (AOSD) and showed a prominent increase in large granular lymphocytes (LGL) when she developed severe Pseudomonas conjunctivitis due to Pseudomonas aeruginosa, skin eruptions, liver damage, and abnormal findings in coagulation studies, without ...

journal_title：Modern rheumatology

authors： Tabata R,Tabata C,Fukuda H,Kotani H

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To assess the utilities of ultrasonography (US) and low-field magnetic resonance imaging (compacTscan, cMRI) in the diagnosis of subclinical synovitis of hand joints of patients with rheumatoid arthritis (RA). METHODS:A total of 1,540 joints of 77 RA patients were examined clinically, using US, using cMRI, a...

journal_title：Modern rheumatology

authors： Ogishima H,Tsuboi H,Umeda N,Horikoshi M,Kondo Y,Sugihara M,Suzuki T,Matsumoto I,Sumida T

更新日期：2014-01-01 00:00:00

abstract：:We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron's papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including stero...

journal_title：Modern rheumatology

authors： Horai Y,Isomoto E,Koga T,Okada A,Kawashiri SY,Tamai M,Yamasaki S,Nakamura H,Origuchi T,Hamaguchi Y,Fujimoto M,Kuwana M,Kawakami A

更新日期：2013-01-01 00:00:00

abstract：:Objectives: To assess the effects of belimumab on disease activity across multiple organ domains in Japanese patients from the Phase 3 randomized, double-blind, North-East Asia study, BEL113750 (NCT01345253).Methods: Patients, aged ≥18 years, with American College of Rheumatology-defined systemic lupus erythematosus (...

journal_title：Modern rheumatology

authors： Tanaka Y,Bass D,Chu M,Egginton S,Ji B,Roth D

更新日期：2020-03-01 00:00:00