Cytomegalovirus-induced small intestinal bleeding complicated with cutaneous vasculitis: a case report.

abstract：OBJECTIVE:We examined the prevalence and risk factors of vertebral fracture in female Japanese patients with systemic lupus erythematosus (SLE). METHODS:We performed lateral radiographs of the thoracic and lumbar spine and bone mineral density (BMD) measurements and collected demographic, lifestyle, clinical, and trea...

journal_title：Modern rheumatology

authors： Furukawa M,Kiyohara C,Horiuchi T,Tsukamoto H,Mitoma H,Kimoto Y,Uchino A,Nakagawa M,Oryoji K,Shimoda T,Harada M,Akashi K

更新日期：2013-07-01 00:00:00

abstract：:Methotrexate (MTX) is indispensable for the treatment of rheumatoid arthritis (RA). However, a small number of patients treated with MTX occasionally encounter some life-threatening events, including myelosuppression. Renal insufficiency, one of risk factors for these events, is difficult to assess because the serum c...

journal_title：Modern rheumatology

authors： Hayashi T,Ito S,Goto D,Matsumoto I,Sumida T

更新日期：2010-12-01 00:00:00

abstract：:Objectives: To assess the clinicopathologic features of Multicentric Castleman disease (MCD) patients in Japan.Methods: We assessed baseline data for 342 Japanese MCD patients with a biopsy-proven diagnosis, enrolled in a prospective, observational study for tocilizumab treatment.Results: Of 342 patients, 86.0% had pl...

journal_title：Modern rheumatology

authors： Murakami M,Johkoh T,Hayashi S,Ohshima S,Mizuki M,Nakatsuka SI,Tomobe M,Kuroyanagi K,Nakasone A,Nishimoto N

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To assess the utilities of ultrasonography (US) and low-field magnetic resonance imaging (compacTscan, cMRI) in the diagnosis of subclinical synovitis of hand joints of patients with rheumatoid arthritis (RA). METHODS:A total of 1,540 joints of 77 RA patients were examined clinically, using US, using cMRI, a...

journal_title：Modern rheumatology

authors： Ogishima H,Tsuboi H,Umeda N,Horikoshi M,Kondo Y,Sugihara M,Suzuki T,Matsumoto I,Sumida T

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To evaluate, through a systematic review of the literature, the association between the use of biological disease-modifying antirheumatic drugs (bDMARDs) and surgical site infection (SSI) or wound healing delay after orthopedic surgery in patients with rheumatoid arthritis (RA). METHODS:A systematic review ...

journal_title：Modern rheumatology

authors： Ito H,Kojima M,Nishida K,Matsushita I,Kojima T,Nakayama T,Endo H,Hirata S,Kaneko Y,Kawahito Y,Kishimoto M,Seto Y,Kamatani N,Tsutani K,Igarashi A,Hasegawa M,Miyasaka N,Yamanaka H

更新日期：2015-09-01 00:00:00

abstract：:Idiopathic inflammatory myopathies (IIMs) are heterogeneous disorders that affect the skeletal muscles. Polymyositis, dermatomyositis, and inclusion body myositis are major IIM subsets. Immune-mediated necrotizing myopathy became recognized as a potentially new IIM subset. Since the new classification criteria publish...

journal_title：Modern rheumatology

authors： Sasaki H,Kohsaka H

更新日期：2018-11-01 00:00:00

abstract：:We evaluated the prevalence of Helicobacter pylori infection and the association of H. pylori infection and/or nonsteroidal anti-inflammatory drug (NSAID) use with upper gastrointestinal (UGI) ulcers in a cohort of Japanese patients with rheumatoid arthritis (RA). Using the clinical database of the cohort of RA patien...

journal_title：Modern rheumatology

authors： Tanaka E,Singh G,Saito A,Syouji A,Yamada T,Urano W,Nakajima A,Taniguchi A,Tomatsu T,Hara M,Saito T,Kamatani N,Yamanaka H

更新日期：2005-01-01 00:00:00

abstract：:Research into the bone destruction associated with rheumatoid arthritis has highlighted the importance of the interplay of the immune and skeletal systems. Arthritic bone destruction is attributable to the defective control of osteoclastogenesis by T cells. We revealed that excessive expression of receptor activator o...

journal_title：Modern rheumatology

authors： Takayanagi H

更新日期：2005-01-01 00:00:00

abstract：:Recently, more than ten cases of thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome or Castleman-Kojima disease exhibiting such symptoms as thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly have been reported in Japan. We have found two cases of TAFRO syndrome...

journal_title：Modern rheumatology

authors： Kawashima M,Usui T,Okada H,Mori I,Yamauchi M,Ikeda T,Kajita K,Kito Y,Miyazaki T,Fujioka K,Ishizuka T,Morita H

更新日期：2017-11-01 00:00:00

abstract：:Management of rheumatoid arthritis (RA) has improved over the last 10 years. These changes have been monitored in the Institute of Rheumatology, Rheumatoid Arthritis (IORRA) observational cohort, and clinical remission has become a realistic goal. However, we should recognize that the ultimate goal of treatment is to ...

journal_title：Modern rheumatology

authors： Yamanaka H,Seto Y,Tanaka E,Furuya T,Nakajima A,Ikari K,Taniguchi A,Momohara S

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Several biological disease-modifying antirheumatic drugs (bDMARDs) are currently available for the treatment of rheumatoid arthritis (RA). Increasing evidence indicates that second-line bDMARDs are effective for inadequate responders to first-line bDMARDs. However, all previous studies investigated the use o...

journal_title：Modern rheumatology

authors： Matsuno H,Katayama K

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety of peficitinib for the treatment of rheumatoid arthritis (RA) in Asian patients. METHODS:Safety data from one Phase 2b, two Phase 3, and one open-label long-term extension study [data cut-off 31 May 2018] were pooled into Phase 3 studies (peficitinib 100 and 150 mg/day, and placebo) an...

journal_title：Modern rheumatology

authors： Takeuchi T,Tanaka Y,Rokuda M,Izutsu H,Kaneko Y,Fukuda M,Kato D

更新日期：2020-11-09 00:00:00

abstract：:Abstract To determine the specificities of autoantibodies targeting cell cycle-associated antigens in rheumatic diseases, we studied 30 sera which were obtained from patients visiting our hospital and which exhibited a variegated speckled pattern in indirect immunofluorescence (IF). The immunoreactivities of the sera ...

journal_title：Modern rheumatology

authors： Fujinaga H,Takeuchi K,Kaneda K,Takasaki Y,Hashimoto H

更新日期：2001-09-01 00:00:00

abstract：AIM:The aim of this study was to analyze the effect of 18-week functional training (FT) program consisting in two sessions a week of in-water exercise and one of on-land exercise on pain, strength, and balance in women with fibromyalgia. METHODS:A sample consisting of 36 fibromyalgia patients was included in the study...

journal_title：Modern rheumatology

authors： Latorre Román PÁ,Santos E Campos MA,García-Pinillos F

更新日期：2015-01-01 00:00:00

abstract：:We examined the efficacy and safety of autologous transplantation of bone-marrow-derived cells in patients with intractable ulcers caused by systemic sclerosis. Eight patients with ulcers resistant to treatment were enrolled. Bone marrow cells were gathered from the bilateral iliac crests with multiple repositioning b...

journal_title：Modern rheumatology

authors： Ishigatsubo Y,Ihata A,Kobayashi H,Hama M,Kirino Y,Ueda A,Takeno M,Shirai A,Ohno S

更新日期：2010-06-01 00:00:00

abstract：:We examined the therapeutic effect of high molecular weight hyaluronic acid (HA) on the progression of joint pain and cartilage degeneration in a rabbit osteoarthritis (OA) model. The OA model was induced by partial meniscectomy. In the time course study, cartilage degeneration was assessed at 3, 7 and 14 days after o...

journal_title：Modern rheumatology

authors： Hashizume M,Koike N,Yoshida H,Suzuki M,Mihara M

更新日期：2010-10-01 00:00:00

abstract：:Tocilizumab (TCZ) is an interleukin-6 (IL-6) inhibitor used for the treatment of rheumatoid arthritis (RA). It was developed in 2008, and its effectiveness is supported by evidence from all over the world based on its first decade of use. Although the overall efficacy and safety profiles of TCZ are similar to those of...

journal_title：Modern rheumatology

authors： Ogata A,Kato Y,Higa S,Yoshizaki K

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Upper limit of methotrexate (MTX) for patients with rheumatoid arthritis (RA) was recently increased from 8 to 16 mg/week in Japan. We therefore examined the effect of concomitant MTX dose on the efficacy of adalimumab (ADA) in clinical practice. METHOD:Sixty-one consecutive RA patients treated with ADA were...

journal_title：Modern rheumatology

authors： Nakashima Y,Miyahara H,Kondo M,Fukuda T,Harada H,Haraguchi A,Inoue Y,Ishinishi T,Maekawa M,Maeyama A,Nakashima M,Shono E,Suematsu E,Shimauchi T,Tsuru T,Tsukamoto H,Yoshizawa S,Yoshizawa S,Iwamoto Y

更新日期：2017-01-01 00:00:00

abstract：:Objective: We conducted a questionnaire survey within a standard clinical setting to clarify that picture superiority effect (PSE) could be obtained by musculoskeletal ultrasound (MSKUS) examination.Methods: One hundred patients with rheumatoid arthritis or arthralgia, who visited the Rheumatology Unit, Department of ...

journal_title：Modern rheumatology

authors： Matsuki-Muramoto Y,Ogasawara M,Kawamoto T,Yamaji K,Tamura N

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to develop clinical practice guideline (CPG) for Sjögren's syndrome (SS) based on recently available clinical and therapeutic evidences. METHODS:The CPG committee for SS was organized by the Research Team for Autoimmune Diseases, Research Program for Intractable Disease of the...

journal_title：Modern rheumatology

authors： Sumida T,Azuma N,Moriyama M,Takahashi H,Asashima H,Honda F,Abe S,Ono Y,Hirota T,Hirata S,Tanaka Y,Shimizu T,Nakamura H,Kawakami A,Sano H,Ogawa Y,Tsubota K,Ryo K,Saito I,Tanaka A,Nakamura S,Takamura E,Tanaka M

更新日期：2018-05-01 00:00:00

abstract：:A 43-year-old Japanese woman with systemic lupus erythematosus (SLE) developed rapidly progressive renal failure and nephritic syndrome with a high titer of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA). Methylprednisolone pulse therapy did not suppress the progression of renal failure. Intravenous cy...

journal_title：Modern rheumatology

authors： Morimoto S,Watanabe T,Lee S,Amano H,Kanamaru Y,Ohsawa I,Tomino Y,Takasaki Y

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:Anti-cytokine therapy is reportedly useful in amyloid A (AA) amyloidosis complicating rheumatic diseases. However, to date no studies have directly compared the utility of tumour necrosis factor (TNF) inhibition to that of interleukin-6. The aim of our retrospective study was to compare the clinical utility ...

journal_title：Modern rheumatology

authors： Okuda Y,Ohnishi M,Matoba K,Jouyama K,Yamada A,Sawada N,Mokuda S,Murata Y,Takasugi K

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:This pilot multicenter exercise aimed to evaluate the inter-observer reproducibility of synovial power Doppler (PD) signals in rheumatoid arthritis (RA) patients and to determine the factors influencing the measurements. METHODS:Two representative RA patients were assessed by four independent experienced so...

journal_title：Modern rheumatology

authors： Ikeda K,Seto Y,Ohno S,Sakamoto F,Henmi M,Fukae J,Narita A,Nakagomi D,Nakajima H,Tanimura K,Koike T

更新日期：2014-05-01 00:00:00

abstract：:Macrophage activation syndrome (MAS), also known as secondary hemophagocytic lymphohistiocytosis, is mediated by cytokine overproduction from excessive activation of T lymphocytes and macrophages. We present a dermatomyositis patient with MAS, caused by hypercytokinemia. The combination of tacrolimus and plasma exchan...

journal_title：Modern rheumatology

authors： Kaieda S,Yoshida N,Yamashita F,Okamoto M,Ida H,Hoshino T,Fukuda T

更新日期：2015-01-01 00:00:00

abstract：:Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...

journal_title：Modern rheumatology

authors： Yagita M,Hamano T,Hatachi S,Fujita M

更新日期：2016-01-01 00:00:00

abstract：:Abstract To clarify the effect of leukemia inhibitory factor (LIF) on the destruction of rheumatoid arthritis (RA) joints, we investigated the production of LIF and the expression of LIF mRNA in synovial tissues from patients with RA and osteoarthritis (OA). Synovial fluids from RA were used to measure the LIF concent...

journal_title：Modern rheumatology

authors： Enomoto H,Saito S,Yabe H,Toyama Y,Tomatu T

更新日期：2003-06-01 00:00:00

abstract：:We report a novel case of eosinophilic orbital myositis associated with Churg-Strauss syndrome. A 56-year-old man with a 20-year history of chronic sinusitis and seasonal allergic rhinitis was admitted because of fever, swelling of cheeks and extremities, diplopia, and eosinophilia. With findings from gadolinium-enhan...

journal_title：Modern rheumatology

authors： Fujii T,Norizuki M,Kobayashi T,Yamamoto M,Kishimoto M

更新日期：2010-04-01 00:00:00

abstract：: ...

journal_title：Modern rheumatology

authors： Kajihara I,Jinnin M,Yamada S,Ichihara A,Makino T,Igata T,Masuguchi S,Fukushima S,Ihn H

更新日期：2013-04-04 00:00:00

abstract：:Abstract Twenty-six patients with systemic lupus erythematosus (SLE) showing systemic lupus activity measure (SLAM) and SLE disease activity index (SLEDAI) scores ≤2, as well as a lower C4 concentration than the mean C4 levels of healthy controls, were selected to evaluate the C4 levels of SLE patients in remission. S...

journal_title：Modern rheumatology

authors： Yasuda M,Suenaga Y,Nishimukai H,Nobunaga M

更新日期：2002-09-01 00:00:00

abstract：:The number of patients with juvenile-onset Sjögren's syndrome (SS) has recently increased. However, there is no drug that is safe and effective for the xerostomia that occurs in patients of this age group. We evaluated the efficacy and safety of orally administered pilocarpine hydrochloride for juvenile-onset SS patie...

journal_title：Modern rheumatology

authors： Tomiita M,Takei S,Kuwada N,Nonaka Y,Saito K,Shimojo N,Kohno Y

更新日期：2010-10-01 00:00:00