High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis.

abstract：:Abstract Twenty-six patients with systemic lupus erythematosus (SLE) showing systemic lupus activity measure (SLAM) and SLE disease activity index (SLEDAI) scores ≤2, as well as a lower C4 concentration than the mean C4 levels of healthy controls, were selected to evaluate the C4 levels of SLE patients in remission. S...

journal_title：Modern rheumatology

authors： Yasuda M,Suenaga Y,Nishimukai H,Nobunaga M

更新日期：2002-09-01 00:00:00

abstract：:A 79-year-old man was diagnosed with relapsing polychondritis, from symptoms of bilateral auricular deformity and pigmentation, polyarthralgia, and audiovestibular damage, and from histological examination of the left auricular cartilage. The left auricular cartilage biopsy specimen revealed cartilage destruction with...

journal_title：Modern rheumatology

authors： Horai Y,Miyamura T,Arase H,Kimura D,Shimada K,Ishida M,Takahama S,Kiyasu J,Minami R,Yamamoto M,Suematsu E,Nakayama Y

更新日期：2011-10-01 00:00:00

abstract：:A female rheumatoid arthritis patient was admitted for productive cough and general fatigue that had gradually developed after leflunomide therapy. Side effects including severe hypoxia, thrombocytopenia, lymphocytopenia, and macrocytic anemia with schistocytes (probably drug-induced megaloblastic anemia) were noted. ...

journal_title：Modern rheumatology

authors： Toyokawa Y,Kingetsu I,Yasuda C,Yasuda J,Yoshida K,Kurosaka D,Yamada A

更新日期：2007-01-01 00:00:00

abstract：:Risk of knee osteoarthritis (OA) was assessed in a population-based case-control study of Japanese men. The study covered three health districts in Wakayama and Osaka prefectures, Japan. Subjects were male individuals >or=45 years old diagnosed radiographically with knee OA, and who did not display any established cau...

journal_title：Modern rheumatology

authors： Yoshimura N,Kinoshita H,Hori N,Nishioka T,Ryujin M,Mantani Y,Miyake M,Takeshita T,Ichinose M,Yoshiida M,Oka H,Kawaguchi H,Nakamura K,Cooper C

更新日期：2006-01-01 00:00:00

abstract：:The aim of this study was to evaluate the incidence of morphologic and functional cardiac abnormalities in patients with systemic lupus erythematosus (SLE) and to correlate the findings with levels of anti-Ro/SS-A, anti-La/SS-B, and anti-cardiolipin antibody (aCL). Sixty-two patients with SLE were enrolled in this stu...

journal_title：Modern rheumatology

authors： Shahin AA,Shahin HA,Hamid MA,Amin MA

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Evaluate the association between the multi-biomarker disease activity (MBDA) score and radiographic progression in patients with rheumatoid arthritis (RA) treated with tumor necrosis factor (TNF)-α inhibitors. METHODS:Change (Δ) in modified total Sharp score (mTSS) over 52 weeks and disease activity scores w...

journal_title：Modern rheumatology

authors： Hirata S,Li W,Kubo S,Fukuyo S,Mizuno Y,Hanami K,Sawamukai N,Yamaoka K,Saito K,Defranoux NA,Tanaka Y

更新日期：2016-11-01 00:00:00

abstract：:A 52-year-old woman with a 6-year history of systemic lupus erythematosus (SLE) developed acute abdominal pain, nausea, vomiting, and diarrhea accompanied by hypocomplementemia. Herpes simplex virus (HSV) esophagitis and lupus enteritis were diagnosed on the basis of the results of endoscopic and histological examinat...

journal_title：Modern rheumatology

authors： Wakui H,Togashi M,Omokawa A,Okuyama S,Masai R,Komatsuda A,Ogasawara H,Sawada K

更新日期：2010-02-01 00:00:00

abstract：:The aim of this study was to investigate the reliability and the validity of the Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia (ACR 2010-J), and its quantification scale, the Fibromyalgia Symptom Scale (FS-J). In this study, we divided patients with chro...

journal_title：Modern rheumatology

authors： Usui C,Hatta K,Aratani S,Yagishita N,Nishioka K,Kanazawa T,Ito K,Yamano Y,Nakamura H,Nakajima T,Nishioka K

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVES:To assess the efficacy of tocilizumab for preventing damage to the joints of systemic juvenile idiopathic arthritis (sJIA) patients, we examined serial radiographs of the hands and large weight-bearing joints of these patients before and after treatment with this agent. METHODS:Nine patients with sJIA recei...

journal_title：Modern rheumatology

authors： Inaba Y,Ozawa R,Aoki C,Imagawa T,Mori M,Hara R,Miyamae T,Saito T,Yokota S

更新日期：2013-07-01 00:00:00

abstract：AIM:The purpose of this study was to assess morphological changes in the paravertebral muscles in patients with ankylosing spondylitis. MATERIALS AND METHODS:Fifty-one patients diagnosed with ankylosing spondylitis and a 50 member control group were included in the study. The surface area of the multifidus and erector...

journal_title：Modern rheumatology

authors： Resorlu H,Savas Y,Aylanc N,Gokmen F

更新日期：2017-07-01 00:00:00

abstract：:The involvement of valgus hindfoot deformity in hallux valgus deformity was confirmed in a rheumatoid arthritis case with a destructive valgus hindfoot deformity. Correction of severe valgus, calcaneal lateral offset, and pronated foot deformity instantly normalized hallux valgus deformities postoperatively. Thus, car...

journal_title：Modern rheumatology

authors： Yamada S,Hirao M,Tsuboi H,Akita S,Matsushita M,Ohshima S,Saeki Y,Hashimoto J

更新日期：2014-09-01 00:00:00

abstract：:Skeletal injury is one of the most prevalent clinical problems that jeopardize the activities of daily life, especially in our aging society. Mesenchymal stem cells (MSCs) play pivotal roles in regenerating bones after bone injury. MSCs come from the surrounding tissues and/or circulation. Cell sources may be the bone...

journal_title：Modern rheumatology

authors： Ito H

更新日期：2011-04-01 00:00:00

abstract：:Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his diseas...

journal_title：Modern rheumatology

authors： Ito T,Ozaki Y,Shimamoto K,Amuro H,Tanijiri T,Yokoi T,Son Y,Tajima K,Fukuhara S

更新日期：2008-01-01 00:00:00

abstract：:Objectives: Delayed wound healing is one of the most common complications following forefoot surgery in patients with rheumatoid arthritis. We aimed to identify the risk factors for delayed wound healing following rheumatoid forefoot surgery.Methods: Consecutive patients who underwent primary rheumatoid forefoot surge...

journal_title：Modern rheumatology

authors： Ohta K,Fukushi JI,Ikemura S,Kamura S,Miyahara HA,Nakashima Y

更新日期：2020-06-16 00:00:00

abstract：:A 49-year-old Japanese woman treated with oral corticosteroids, methotrexate, and infliximab for malignant rheumatoid arthritis was admitted because of fever and low back pain. The white blood cell count and C-reactive protein concentration were elevated. Lumbar and pelvic computed tomography showed enlargement of the...

journal_title：Modern rheumatology

authors： Oda S,Fujinaga H,Takahashi K

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:The objective of this study is to develop clinical practice guideline (CPG) for Sjögren's syndrome (SS) based on recently available clinical and therapeutic evidences. METHODS:The CPG committee for SS was organized by the Research Team for Autoimmune Diseases, Research Program for Intractable Disease of the...

journal_title：Modern rheumatology

authors： Sumida T,Azuma N,Moriyama M,Takahashi H,Asashima H,Honda F,Abe S,Ono Y,Hirota T,Hirata S,Tanaka Y,Shimizu T,Nakamura H,Kawakami A,Sano H,Ogawa Y,Tsubota K,Ryo K,Saito I,Tanaka A,Nakamura S,Takamura E,Tanaka M

更新日期：2018-05-01 00:00:00

abstract：:Pneumatosis cystoides intestinalis (PCI), which is characterized by the presence of multiple gas-filled mucosal, submucosal, or subserosal cysts located throughout the colon and/or small intestine, is an unusual complication of systemic lupus erythematosus (SLE). We report a case of a 33-year-old woman with a 5-year h...

journal_title：Modern rheumatology

authors： Yamaguchi Y,Ohno S,Yamazaki S,Ideguchi H,Shirai A,Takeno M,Ishigatsubo Y

更新日期：2005-01-01 00:00:00

abstract：:Cutaneous polyarteritis nodosa (cutaneous PAN) is a form of necrotizing vasculitis of small- and medium-sized arteries, primarily involving the skin. In juvenile cases, cutaneous PAN is known to be frequently associated with Group A β-hemolytic Streptococcus (GAS) infections. We herein describe the first reported juve...

journal_title：Modern rheumatology

authors： Yamamoto T,Inoue Y,Tomiita M,Oikawa M,Kambe N,Arima T,Shimojo N,Kohno Y

更新日期：2015-01-01 00:00:00

abstract：:We report the case of a 73-year-old man with myelodysplastic syndrome (MDS) who developed Weber-Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple ten...

journal_title：Modern rheumatology

authors： Hojo N,Hasegawa H,Iwamasa K,Hojo S,Fujita S

更新日期：2004-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Although hematological anomalies are commonly found in SLE, severe polymorphonuclear leukocyte depletion is rare. Most episodes of severe granulocytopenia in SLE patients tend to occur as part of drug toxicity-induced medullar hypoplasia,...

journal_title：Modern rheumatology

authors： Sakai T,Hatano Y,Abe I,Ishii K,Fujiwara S

更新日期：2013-11-01 00:00:00

abstract：:Objectives: To assess the effects of belimumab on disease activity across multiple organ domains in Japanese patients from the Phase 3 randomized, double-blind, North-East Asia study, BEL113750 (NCT01345253).Methods: Patients, aged ≥18 years, with American College of Rheumatology-defined systemic lupus erythematosus (...

journal_title：Modern rheumatology

authors： Tanaka Y,Bass D,Chu M,Egginton S,Ji B,Roth D

更新日期：2020-03-01 00:00:00

abstract：:A 19-year-old Japanese woman with a 4-year history of Crohn's disease (CD) developed high fever, polyarthralgia, and painful subcutaneous nodules of the legs. A skin biopsy showed panarteritis with fibrinoid necrosis in the deep dermis. Endoscopic examination showed aphthous lesions in the entire colon. She was diagno...

journal_title：Modern rheumatology

authors： Komatsuda A,Kinoshita K,Togashi M,Maki N,Masai R,Niitsu H,Ohtani S,Sageshima M,Sawada K,Wakui H

更新日期：2008-01-01 00:00:00

abstract：:IgG4-related disease (IgG4-RD) is a fascinating clinical entity first reported in this century in Japan, and includes a wide variety of diseases, such as formerly named Mikulicz's disease (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis and retroperitoneal fibrosis. The Japanese IgG4 team organ...

journal_title：Modern rheumatology

authors： Umehara H,Okazaki K,Kawa S,Takahashi H,Goto H,Matsui S,Ishizaka N,Akamizu T,Sato Y,Kawano M,Research Program for Intractable Disease by the Ministry of Health, Labor and Welfare (MHLW) Japan.

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:Colchicine is the mainstay of the treatment of familial Mediterranean fever (FMF). However, 10% of FMF patients do not respond well to colchicine. Efficacy of interleukin (IL)-1 inhibitors in reducing attacks have been demonstrated in colchicine-resistant FMF (crFMF) patients recently. Colchicine is still th...

journal_title：Modern rheumatology

authors： Varan Ö,Kucuk H,Babaoglu H,Guven SC,Ozturk MA,Haznedaroglu S,Goker B,Tufan A

更新日期：2019-03-01 00:00:00

abstract：:We report a 24-year-old male with systemic lupus erythematosus (SLE) who developed influenza virus B-associated hemophagocytic syndrome and cardiac tamponade. Although the patient's general condition improved after steroid pulse therapy and pericardiocentesis, pericardial effusion re-accumulated. Colchicine and aspiri...

journal_title：Modern rheumatology

authors： Horai Y,Miyamura T,Takahama S,Sonomoto K,Nakamura M,Ando H,Minami R,Yamamoto M,Suematsu E

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:To assess changes in salivary epidermal growth factor (EGF) levels within three years and investigate the correlation between these changes and the severity of intraoral manifestations in patients with Sjögren's syndrome (SS). METHODS:Twenty-three SS patients (14 primary SS and 9 secondary SS) and 14 contro...

journal_title：Modern rheumatology

authors： Azuma N,Katada Y,Kitano S,Sekiguchi M,Kitano M,Nishioka A,Hashimoto N,Matsui K,Iwasaki T,Sano H

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Modern three-component total ankle arthroplasty (TAA) has favorable clinical results and survival rates. However, radiographic deterioration and worsening of clinical symptoms may occur in patients with rheumatoid arthritis (RA) or non-inflammatory arthritis (NA). The associations between outcomes and clinic...

journal_title：Modern rheumatology

authors： Iwata T,Ito H,Furu M,Ishikawa M,Azukizawa M,Yoshitomi H,Fujii T,Akiyama H,Matsuda S

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the therapeutic efficacy of a novel inhibitor for IκB kinase alpha (IKKα), noraristeromycin (NAM), for murine experimental model of rheumatoid arthritis, collagen- induced arthritis (CIA). METHODS:NAM has been chemically synthesized as reported earlier. CIA was induced in DBA/1JNCrlj mice by int...

journal_title：Modern rheumatology

authors： Ito M,Hamano T,Komatsu T,Asamitsu K,Yamakawa T,Okamoto T

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate the efficacy of arthroscopic enlargement of unidirectional valvular slits for the treatment of popliteal cysts and to evaluate potential factors affecting the outcomes of our arthroscopic procedure. METHODS:Twenty-nine patients aged 43-77 years with popliteal c...

journal_title：Modern rheumatology

authors： Ohishi T,Takahashi M,Suzuki D,Fujita T,Yamamoto K,Ushirozako H,Banno T,Matsuyama Y

更新日期：2015-09-01 00:00:00

abstract：:Abstract We report the case of a 52-year-old man with Wegener's granulomatosis complicated with seropneumothorax. Pneumothorax or seropneumothorax has previously been reported as a rare complication of Wegener's granulomatosis. The patient was successfully treated with prednisolone and cyclophosphamide, and seropneumo...

journal_title：Modern rheumatology

authors： Shimizu T,Ohara T,Ito S,Nakano M,Tsutsui N,Sato T,Suzuki E,Gejyo F

更新日期：2003-06-01 00:00:00