Abstract:
:Skeletal injury is one of the most prevalent clinical problems that jeopardize the activities of daily life, especially in our aging society. Mesenchymal stem cells (MSCs) play pivotal roles in regenerating bones after bone injury. MSCs come from the surrounding tissues and/or circulation. Cell sources may be the bone marrow, periosteum, vessel walls, muscle, circulation, and elsewhere, and the migration of MSCs is necessary for bone healing. The mechanism(s) of recruitment and crucial molecules for cell migration are still unclear, but chemokines and their receptors seem to play critical roles. The induction of MSC recruitment from surrounding tissues or from the circulation can be a helpful modality to induce or to support cell-based therapy for bone regeneration.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Ito Hdoi
10.1007/s10165-010-0357-8subject
Has Abstractpub_date
2011-04-01 00:00:00pages
113-21issue
2eissn
1439-7595issn
1439-7609journal_volume
21pub_type
杂志文章,评审abstract::The aim of this study was to investigate the reliability and the validity of the Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia (ACR 2010-J), and its quantification scale, the Fibromyalgia Symptom Scale (FS-J). In this study, we divided patients with chro...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0462-3
更新日期:2012-02-01 00:00:00
abstract::'Immunoglobulin G4 (IgG4)-related disease' is a new clinical concept of multi-organ diseases, with Mikulicz's disease (MD) being a clinical phenotype of IgG4-related disease. To clarify the clinical characteristics of respiratory involvement associated with IgG4-related MD, we retrospectively assessed 25 patients with...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0504-x
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:To establish a new assessment tool for ulnar drift (UD) in rheumatoid arthritis (RA). METHODS:We established an observational cohort of 67 patients (134 rheumatoid hands) beginning in 2004. Fifty-two patients (100 hands) had follow-up in 2009 and 37 patients (63 hands) completed follow-up in 2015. UD was ev...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2018.1442171
更新日期:2019-01-01 00:00:00
abstract::Abstract A woman with Sjögren's syndrome concurrently suffered bilateral fractures of the femoral neck without any proximate cause, while she had aseptic necrosis of the femoral head resulting from the treatment for Sjögren's syndrome. According to previous reports, fractures of the femoral neck following aseptic necr...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-004-0346-x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:Fractalkine (CX3CL1/FKN) is a chemokine that regulates chemotaxis and adhesion of CX3C chemokine receptor 1 (CX3CR1)-expressing inflammatory cells. We conducted the first phase 1/2, open-label, multiple ascending dose study of E6011, a humanized anti-FKN monoclonal antibody, in Japanese rheumatoid arthritis (...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1080/14397595.2017.1337056
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:Gout is a polygenic auto-inflammatory disease, in which inflammation plays an important role in disease pathogenesis. The cytokine interleukin (IL)-23 promotes inflammation and helps to guide inflammatory cells, while studies have shown that the IL-23R gene is associated with susceptibility to several immune...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.964823
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:The international classification criteria (CC) for definite antiphospholipid syndrome (APS) recommend confirmation of the sustained presence, for at least 12 weeks, of both lupus anticoagulant (LA), as determined by aPTT and RVVT, and anti β2glycoprotein I (β2GPI) or anticardiolipin (aCL) IgG and/or IgM. Howe...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1023978
更新日期:2015-01-01 00:00:00
abstract::Objectives: Overactive bladder (OAB) is a clinical diagnosis defined with the presence of urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence. Objective was to evaluate the demographic and clinical characteristics of Japanese systemic sclerosis (SSc) patients wi...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1589913
更新日期:2020-03-01 00:00:00
abstract::Abstract The synovium in a knee joint has an extensive neural network in the somatic and autonomic nervous systems. In medial compartmental osteoarthritis of the knee, neuropeptides were most abundant, with an especially large number of substance P and calcitonin gene-related peptide-immunoreactive free nerve endings....
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-003-0253-6
更新日期:2003-12-01 00:00:00
abstract::Abstract We report the case of a 52-year-old man with Wegener's granulomatosis complicated with seropneumothorax. Pneumothorax or seropneumothorax has previously been reported as a rare complication of Wegener's granulomatosis. The patient was successfully treated with prednisolone and cyclophosphamide, and seropneumo...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-002-0220-7
更新日期:2003-06-01 00:00:00
abstract:: ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-013-0870-7
更新日期:2013-04-04 00:00:00
abstract::Bucillamine (Bc) is a cysteine derivative with two SH groups, and a homolog of D-penicillamine, a disease-modifying antirheumatic drug (DMARD) widely used in Japan. However, it remains unclear whether Bc repairs bone erosion in patients with RA. Here, we treated three RA patients with Bc who subsequently showed radiog...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0209-6
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Assessment of synovitis in the metatarsophalangeal (MTP) joints with ultrasound has been shown to improve the accuracy of assessment of rheumatoid arthritis (RA). However, the presence of intraarticular low-echoic synovial area (LESA) in the MTP joints in healthy subjects complicates the sonographic assess...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.970740
更新日期:2015-05-01 00:00:00
abstract::An 8-year-old girl with systemic-onset juvenile idiopathic arthritis (JIA) required surgical reduction for a dislocated left hip joint following failure of skin traction for 1 week. Unaided walking was achieved by 3 months postoperatively. Incongruence and irregularity of the hip joint remained but may resolve with ma...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0330-5
更新日期:2004-01-01 00:00:00
abstract::We conducted a comprehensive meta-analysis to quantitatively evaluate the association of cytokine gene polymorphisms with systemic sclerosis (SSc) susceptibility. Electronic databases were used to identify published studies before July 2011. In total, 23 case-control studies including 3524 SSc cases and 6086 healthy c...
journal_title:Modern rheumatology
pub_type: 杂志文章,meta分析
doi:10.1007/s10165-011-0574-9
更新日期:2012-09-01 00:00:00
abstract::Tocilizumab (TCZ) is an interleukin-6 (IL-6) inhibitor used for the treatment of rheumatoid arthritis (RA). It was developed in 2008, and its effectiveness is supported by evidence from all over the world based on its first decade of use. Although the overall efficacy and safety profiles of TCZ are similar to those of...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1546357
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To assess changes in salivary epidermal growth factor (EGF) levels within three years and investigate the correlation between these changes and the severity of intraoral manifestations in patients with Sjögren's syndrome (SS). METHODS:Twenty-three SS patients (14 primary SS and 9 secondary SS) and 14 contro...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1034941
更新日期:2015-01-01 00:00:00
abstract::Recently, more than ten cases of thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome or Castleman-Kojima disease exhibiting such symptoms as thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly have been reported in Japan. We have found two cases of TAFRO syndrome...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.3109/14397595.2015.1059982
更新日期:2017-11-01 00:00:00
abstract::For over 10 years there have been no clinical studies about adult-onset Still's disease (AOSD) in Japan. We aimed to investigate recent clinical features and treatment of AOSD and to evaluate the efficacy of cyclosporin A (CyA) in the treatment of AOSD. The data from 34 patients with AOSD who were admitted to our hosp...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0126-0
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate whether the level of serum matrix metalloproteinase-3 (MMP-3), a marker of synovium inflammation, is affected by clinical characteristics of patients in rheumatoid arthritis (RA) patients. METHODS:We analyzed data from 1087 female patients with RA. Pearson's correlation coefficie...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2017.1354431
更新日期:2018-03-01 00:00:00
abstract::An association between thrombotic thrombocytopenic purpura (TTP) and Sjögren's syndrome (SS) is rare. This is the first report of two patients with TTP who had inhibitory autoantibodies to ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 repeats) complicating primary SS. A rapid diagnosis of...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10165-012-0644-7
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:To assess the influence of golimumab dosage and disease activity on joint destruction in patients with active rheumatoid arthritis (RA) in the GO-FORTH study. METHODS:Efficacy was compared among groups given basal methotrexate plus placebo, golimumab (50 mg), or golimumab (100 mg) with stratification by hig...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2015.1086041
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:To determine the frequency of Th2-mediated allergic diseases (AD) in mainly Th1-driven juvenile idiopathic arthritis (JIA) subtypes. METHODS:Ninety-nine JIA patients and 128 control subjects were enrolled in a prospective case-control study. All subjects were assessed with standard allergy questionnaire, co...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1812820
更新日期:2020-09-07 00:00:00
abstract::A 10-year cohort study was performed, involving all of the 118 patients treated with bucillamine in our hospital between 1988 and 1990. Evaluation was made on the basis of erythrocyte sedimentation rate, grip strength, joint score, duration of morning stiffness, and Lansbury index consisting of the above four paramete...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0533-z
更新日期:2007-01-01 00:00:00
abstract::Abstract We report a case of hypocalcemic myopathy confounded by polymyositis due to an elevated level of serum creatine kinase (CK). A 30-year-old man was referred to our hospital for the treatment of provisionally diagnosed polymyositis. His presentation with tetany, hyporeflexia, and general fatigue, in addition to...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200032
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVES:The early diagnosis and treatment of rheumatoid arthritis (RA) is important to reduce joint destruction. Many of the current imaging techniques have disadvantages, such as the need for contrast agents and interpretation by specialists. Fluorescence imaging is an emerging technique that overcomes some of thes...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2016.1170946
更新日期:2016-11-01 00:00:00
abstract::We performed total hip arthroplasty using the non-cement impaction auto-bone-grafting method with the resected femoral head for acetabular protrusion that is not combined with the destruction of acetabular rim or dysplasia of the hip joint. Ten patients (eight women and two men) with rheumatoid arthritis who showed ac...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-007-0571-1
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To assess the long-term safety, immunogenicity, and efficacy of subcutaneous (SC) abatacept in combination with methotrexate (MTX) in Japanese patients with rheumatoid arthritis who were MTX inadequate responders, in a long-term extension (LTE) to a double-dummy, double-blind study (NCT01001832). METHODS:Pat...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1012786
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:Several biological disease-modifying antirheumatic drugs (bDMARDs) are currently available for the treatment of rheumatoid arthritis (RA). Increasing evidence indicates that second-line bDMARDs are effective for inadequate responders to first-line bDMARDs. However, all previous studies investigated the use o...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1206242
更新日期:2017-03-01 00:00:00
abstract::We here report a rare case of dual antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in a 38-year-old Japanese woman previously diagnosed with mixed connective tissue disease. The patient was found to be positive for myeloperoxidase- and proteinase 3-ANCA, and was diagnosed with AAV following admi...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0619-8
更新日期:2013-01-01 00:00:00