Abstract:
:For over 10 years there have been no clinical studies about adult-onset Still's disease (AOSD) in Japan. We aimed to investigate recent clinical features and treatment of AOSD and to evaluate the efficacy of cyclosporin A (CyA) in the treatment of AOSD. The data from 34 patients with AOSD who were admitted to our hospital between 1994 and 2007 were analyzed retrospectively. Of several immunosuppressive agents, the efficacy of CyA given to seven patients was precisely evaluated. Clinical features observed in this study did not differ from those in our previous study, and serum ferritin levels were elevated in all the patients. Among immunosuppressive agents CyA, used concomitantly with corticosteroids (CS) for seven patients with severe AOSD, proved to be very effective. The disease was led to remission promptly by CyA in six patients, and all the patients except one experienced no recurrence. These results suggest that CyA can be one of the potent candidates to be used next to CS for patients with AOSD that is resistant to CS.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Mitamura M,Tada Y,Koarada S,Inoue H,Suematsu R,Ohta A,Nagasawa Kdoi
10.1007/s10165-008-0126-0subject
Has Abstractpub_date
2009-01-01 00:00:00pages
57-63issue
1eissn
1439-7595issn
1439-7609journal_volume
19pub_type
杂志文章abstract::We investigated the association between cigarette smoking and the risk of developing rheumatoid arthritis (RA) in the Malaysian population. A total of 1,056 RA patients and 1,416 matched controls aged 18-70 years within a defined area of Peninsular Malaysia were evaluated in a case-control study between August 2005 an...
journal_title:Modern rheumatology
pub_type: 杂志文章,多中心研究
doi:10.1007/s10165-011-0544-2
更新日期:2012-08-01 00:00:00
abstract::Objectives: To assess the clinicopathologic features of Multicentric Castleman disease (MCD) patients in Japan.Methods: We assessed baseline data for 342 Japanese MCD patients with a biopsy-proven diagnosis, enrolled in a prospective, observational study for tocilizumab treatment.Results: Of 342 patients, 86.0% had pl...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1704983
更新日期:2020-09-01 00:00:00
abstract::Abstract Twenty-six patients with systemic lupus erythematosus (SLE) showing systemic lupus activity measure (SLAM) and SLE disease activity index (SLEDAI) scores ≤2, as well as a lower C4 concentration than the mean C4 levels of healthy controls, were selected to evaluate the C4 levels of SLE patients in remission. S...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650200037
更新日期:2002-09-01 00:00:00
abstract::Objective: We conducted a questionnaire survey within a standard clinical setting to clarify that picture superiority effect (PSE) could be obtained by musculoskeletal ultrasound (MSKUS) examination.Methods: One hundred patients with rheumatoid arthritis or arthralgia, who visited the Rheumatology Unit, Department of ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2019.1645382
更新日期:2020-07-01 00:00:00
abstract::A 61-year-old woman was admitted for long-lasting fever and recurrent opportunistic infections during the treatment of SLE. She had been diagnosed as SLE and type-IV nephritis based on a renal biopsy and serological findings. A colonoscopy and liver biopsy revealed disseminated Mycobacterium avium complex infection. H...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.997822
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:To investigate CD44 levels in articular cartilage of knee osteoarthritis (OA) and the relationship between CD44 and severity of the disease. METHODS:All 50 cartilage tissues included normal and OA cartilage, and were ascribed to the following four groups on the basis of modified Mankin score: normal, mild l...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0818-3
更新日期:2013-11-01 00:00:00
abstract::Abstract An accumulating body of evidence shows that gene therapy can be successfully used to treat animal models of arthritis. Based on this success, a clinical trial of gene therapy for rheumatoid arthritis has been initiated. We review the methods and genes used for the previous gene transfer experiments, including...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650050003
更新日期:2000-06-01 00:00:00
abstract::We report a patient who had a 4-year history of adult-onset Still's disease (AOSD) and showed a prominent increase in large granular lymphocytes (LGL) when she developed severe Pseudomonas conjunctivitis due to Pseudomonas aeruginosa, skin eruptions, liver damage, and abnormal findings in coagulation studies, without ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-006-0462-x
更新日期:2006-01-01 00:00:00
abstract::Abstract Five cases of flexor tendon rupture in surgically treated rheumatoid wrists were studied. The tendon ruptures occurred in the thumb and index finger, and the ruptures site was in the carpal tunnel in all five cases. The main cause of rupture was the formation of bony irregularities in the form of bony spurs i...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170025
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS:J-RAPID double-blind patients were ente...
journal_title:Modern rheumatology
pub_type: 杂志文章,随机对照试验
doi:10.3109/14397595.2014.881709
更新日期:2014-09-01 00:00:00
abstract::Abstract This work was undertaken to evaluate clinical and immunological features in patients with systemic lupus erythematosus (SLE) complicated by Jaccoud's arthropathy. Patients diagnosed with SLE between 1985 and 1999, and who met the criteria of Villiaumey et al., were checked for Jaccoud's arthropathy. Clinical ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170043
更新日期:2001-03-01 00:00:00
abstract:: ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-013-0870-7
更新日期:2013-04-04 00:00:00
abstract:OBJECTIVES:A nationwide survey was conducted to assess the number of patients, clinical aspects, treatment, and prognosis of adult Still's disease (ASD) in Japan. METHODS:A primary questionnaire was sent to randomly selected medical institutions in order to estimate the number of patients. We sent a secondary question...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.974881
更新日期:2015-05-01 00:00:00
abstract::Endogenous lipoid pneumonia is an uncommon inflammatory pulmonary disease that is caused by lipids from an endogenous source, the treatment for which has not been established. We report the first case of endogenous lipoid pneumonia presenting as lung consolidation and which was associated with rheumatoid arthritis. Tr...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1193270
更新日期:2018-11-01 00:00:00
abstract::A 79-year-old man was diagnosed with relapsing polychondritis, from symptoms of bilateral auricular deformity and pigmentation, polyarthralgia, and audiovestibular damage, and from histological examination of the left auricular cartilage. The left auricular cartilage biopsy specimen revealed cartilage destruction with...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0439-2
更新日期:2011-10-01 00:00:00
abstract::An association between thrombotic thrombocytopenic purpura (TTP) and Sjögren's syndrome (SS) is rare. This is the first report of two patients with TTP who had inhibitory autoantibodies to ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 repeats) complicating primary SS. A rapid diagnosis of...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10165-012-0644-7
更新日期:2013-03-01 00:00:00
abstract::The objective of this study was to show whether the disease activity of rheumatoid arthritis (RA) patients had improved in Japan, and whether the improvement of disease activity had resulted in a better outcome of patients. In a single-institute-based prospective observational cohort of RA patients (Institute of Rheum...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0587-6
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Efficacy of anti-tumor necrosis factor (anti-TNF)α treatment in patient with active ankylosing spondylitis (AS) had been proved by many clinical studies. Inflammation and new bone formation in spine were two pivotal aspects in AS. TNF α inhibitor could eliminate inflammation including clinical and laboratory...
journal_title:Modern rheumatology
pub_type: 杂志文章,meta分析
doi:10.1080/14397595.2018.1525017
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:Our primary objective was to retrospectively analyze whether bisphosphonates initiated in combination with immunosuppressive drugs and/or intravenous immunoglobulin (IVIG) resulted in a radiological and clinical improvement of dystrophic calcinosis in six female juvenile dermatomyositis (JDM) patients. METH...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.988197
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To clarify the efficacy and safety of abatacept for secondary Sjögren's syndrome (SS) associated with rheumatoid arthritis (RA). METHODS:The primary endpoint of this open-labeled, prospective, observational multicenter study for secondary SS with RA was the remission rate of Simplified Disease Activity Index...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/14397595.2016.1158773
更新日期:2016-11-01 00:00:00
abstract::Recently, more than ten cases of thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome or Castleman-Kojima disease exhibiting such symptoms as thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly have been reported in Japan. We have found two cases of TAFRO syndrome...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.3109/14397595.2015.1059982
更新日期:2017-11-01 00:00:00
abstract::Despite a number of published reports, including from our own laboratory, suggesting that adeno-associated virus (AAV) transduces mouse synovium, a careful analysis demonstrated transduction predominantly of the subsynovial muscle tissue, while the synovial lining is poorly transduced. To investigate the potential of ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-003-0260-7
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:In recent years, concern has been raised about Juvenile Idiopathic Arthritis (JIA) that it could be associated with an increased risk for malignancies. Therefore, the cancer incidence in the JIA patients was evaluated and compared to the cancer incidence in the German population. METHODS:A retrospective sin...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1204711
更新日期:2017-01-01 00:00:00
abstract::Abstract We report two cases of bone marrow hemophagocytosis. One patient had adult-onset Still's disease, and the other had herpes zoster associated with potential autoimmune abnormalities. Our findings suggested a pos-sible role of cytokines and/or antibodies in the induction of hemophagocytosis in patients with con...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-001-8066-y
更新日期:2001-12-01 00:00:00
abstract::Leuconostoc infections are rare and usually occur in immunocompromised patients. This report describes a case of Leuconostoc lactis bacteremia in a patient with coexisting rheumatoid arthritis and tuberculosis arthritis. A disrupted gastrointestinal barrier due to gastrointestinal amyloidosis in long-standing rheumato...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0465-0
更新日期:2011-12-01 00:00:00
abstract::The development of multiple large tophi in patients with gout is rare. We report magnetic resonance (MR) and histological features of large subcutaneous tophi in a 32-year-old male patient with no known arthritis. His subcutaneous lesions were confused with a neoplastic process, evaluated by MR imaging, and surgically...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0401-2
更新日期:2005-01-01 00:00:00
abstract::Idiopathic inflammatory myopathies (IIMs) are heterogeneous disorders that affect the skeletal muscles. Polymyositis, dermatomyositis, and inclusion body myositis are major IIM subsets. Immune-mediated necrotizing myopathy became recognized as a potentially new IIM subset. Since the new classification criteria publish...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1080/14397595.2018.1467257
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVES:Lupus enteritis (LE) is a rare but well-known gastrointestinal manifestation of systemic lupus erythematosus (SLE). This study was conducted to identify prognostic factors associated with poor responses in patients with LE. METHODS:We consecutively registered patients diagnosed with LE between January 2009 ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1812871
更新日期:2020-09-07 00:00:00
abstract::Blau syndrome/early-onset sarcoidosis (Blau/EOS) is an autoinflammatory disease characterized by granulomatous arthritis, uveitis, and skin rash. It has been shown that gain-of-function NOD2 mutations cause Blau/EOS. In this paper, we describe a patient with a gain-of-function NOD2 mutation who developed infantile Tak...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-012-0720-z
更新日期:2013-07-01 00:00:00
abstract::The association of either thrombotic thrombocytopenic purpura (TTP) or crescentic glomerulonephritis with Sjögren's syndrome is rare. We report a case of TTP appearing after the diagnosis of SjOgren's syndrome with crescentic glomerulonephritis and membranous nephropathy. Circulating immune complex was detected, and i...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-004-0287-4
更新日期:2004-01-01 00:00:00