A case of an SLE patient with febrile neutropenia who experienced exacerbation of cutaneous manifestations after the administration of G-CSF.

abstract：OBJECTIVES:To determine the frequency of Th2-mediated allergic diseases (AD) in mainly Th1-driven juvenile idiopathic arthritis (JIA) subtypes. METHODS:Ninety-nine JIA patients and 128 control subjects were enrolled in a prospective case-control study. All subjects were assessed with standard allergy questionnaire, co...

journal_title：Modern rheumatology

authors： Avar-Aydin PO,Nepesov S,Barut K,Sahin S,Adrovic A,Cokugras HC,Kasapcopur O

更新日期：2020-09-07 00:00:00

abstract：OBJECTIVES:We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS:Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joi...

journal_title：Modern rheumatology

authors： Nishino A,Kawashiri SY,Shimizu T,Umeda M,Fukui S,Koga T,Iwamoto N,Ichinose K,Tamai M,Nakamura H,Origuchi T,Nagata Y,Maeda T,Aoyagi K,Kawakami A

更新日期：2017-07-01 00:00:00

abstract：:Despite a number of published reports, including from our own laboratory, suggesting that adeno-associated virus (AAV) transduces mouse synovium, a careful analysis demonstrated transduction predominantly of the subsynovial muscle tissue, while the synovial lining is poorly transduced. To investigate the potential of ...

journal_title：Modern rheumatology

authors： Katakura S,Jennings K,Watanabe S,Adachi E,Thornton S,Gao GP,Wilson JM,Burstein H,Trapnell B,Hirsch R

更新日期：2004-01-01 00:00:00

abstract：:Abstract The synovium in a knee joint has an extensive neural network in the somatic and autonomic nervous systems. In medial compartmental osteoarthritis of the knee, neuropeptides were most abundant, with an especially large number of substance P and calcitonin gene-related peptide-immunoreactive free nerve endings....

journal_title：Modern rheumatology

authors： Saito T

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVES:Anti-cytokine therapy is reportedly useful in amyloid A (AA) amyloidosis complicating rheumatic diseases. However, to date no studies have directly compared the utility of tumour necrosis factor (TNF) inhibition to that of interleukin-6. The aim of our retrospective study was to compare the clinical utility ...

journal_title：Modern rheumatology

authors： Okuda Y,Ohnishi M,Matoba K,Jouyama K,Yamada A,Sawada N,Mokuda S,Murata Y,Takasugi K

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To determine the availability of bioelectrical impedance analysis (BIA), computed tomography (CT), and magnetic resonance imaging (MRI) for measurement of skeletal muscle mass in patients with rheumatic diseases and quantitatively assess skeletal muscle loss after glucocorticoid (GC) treatment. METHODS:The ...

journal_title：Modern rheumatology

authors： Hosono O,Yoshikawa N,Shimizu N,Kiryu S,Uehara M,Kobayashi H,Matsumiya R,Kuribara A,Maruyama T,Tanaka H

更新日期：2015-03-01 00:00:00

abstract：:We report a case of a 60-year-old female with cutaneous polyarteritis nodosa (CPN) of the left ankle, accompanied by elevated serum interleukin (IL)-6 levels. Computed tomographic angiography revealed severe narrowing of medium-sized arteries in her left leg. Destructive arthropathy in the left ankle was identified by...

journal_title：Modern rheumatology

authors： Horai Y,Tokuyama A,Sumiyoshi R,Nakashima Y,Suzuki T,Okada A,Kawashiri SY,Ichinose K,Izumi Y,Miyashita T,Tamai M,Yamasaki S,Nakamura H,Hayashi T,Origuchi T,Kawakami A

更新日期：2014-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha)-blocking agents have been used increasingly in the treatment of severe refractory juvenile idiopathic arthritis (JIA). However, some patients have been forced to discontinue these agents because of the lack of efficacy or adverse events. In these situations, cases of switching fr...

journal_title：Modern rheumatology

authors： Nerome Y,Imanaka H,Nonaka Y,Takei S

更新日期：2007-01-01 00:00:00

abstract：:Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his diseas...

journal_title：Modern rheumatology

authors： Ito T,Ozaki Y,Shimamoto K,Amuro H,Tanijiri T,Yokoi T,Son Y,Tajima K,Fukuhara S

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:To establish a new assessment tool for ulnar drift (UD) in rheumatoid arthritis (RA). METHODS:We established an observational cohort of 67 patients (134 rheumatoid hands) beginning in 2004. Fifty-two patients (100 hands) had follow-up in 2009 and 37 patients (63 hands) completed follow-up in 2015. UD was ev...

journal_title：Modern rheumatology

authors： Toyama S,Oda R,Tokunaga D,Taniguchi D,Nakamura S,Asada M,Fujiwara H,Kubo T

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:Modern three-component total ankle arthroplasty (TAA) has favorable clinical results and survival rates. However, radiographic deterioration and worsening of clinical symptoms may occur in patients with rheumatoid arthritis (RA) or non-inflammatory arthritis (NA). The associations between outcomes and clinic...

journal_title：Modern rheumatology

authors： Iwata T,Ito H,Furu M,Ishikawa M,Azukizawa M,Yoshitomi H,Fujii T,Akiyama H,Matsuda S

更新日期：2017-05-01 00:00:00

abstract：:Objectives: To assess the middle-term outcome of iguratimod (IGU) in rheumatoid arthritis (RA) patients. Methods: Sixty-nine RA patients (14 males and 55 females, mean age of 64.0 years) receiving IGU-containing therapies were enrolled. We divided these patients into three groups based on the treatment at the baseline...

journal_title：Modern rheumatology

authors： Suto T,Yonemoto Y,Okamura K,Sakane H,Takeuchi K,Tamura Y,Kaneko T,Ayabe K,Chikuda H

更新日期：2019-09-01 00:00:00

abstract：:Objectives: Thrombocytopenia is frequently observed in antiphospholipid antibody (aPL) carriers. Due to the paradoxical risks of thrombosis and hemorrhage, the management of aPL-associated thrombocytopenia (APAT) is often deductive. We aimed to investigate the efficacy and safety of therapeutic approaches for APAT thr...

journal_title：Modern rheumatology

authors： Abe N,Oku K,Amengual O,Fujieda Y,Kato M,Bohgaki T,Yasuda S,Mori R,Morishita E,Suzuki-Inoue K,Atsumi T

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:The early diagnosis and treatment of rheumatoid arthritis (RA) is important to reduce joint destruction. Many of the current imaging techniques have disadvantages, such as the need for contrast agents and interpretation by specialists. Fluorescence imaging is an emerging technique that overcomes some of thes...

journal_title：Modern rheumatology

authors： Onishi S,Sakane M,Tsukanishi T,Funayama T,Ozeki E,Hara I,Yamazaki M

更新日期：2016-11-01 00:00:00

abstract：:We investigated the expression and localization of heme oxygenase-1 (HO-1) in synovial fluid and synovial tissue, and examined the stimulation of HO-1 production in rheumatoid synovial fibroblasts (RASFs). Synovial fluid samples were obtained from knee joints of 20 rheumatoid arthritis (RA) and 20 osteoarthritis (OA) ...

journal_title：Modern rheumatology

authors： Kitamura A,Nishida K,Komiyama T,Doi H,Kadota Y,Yoshida A,Ozaki T

更新日期：2011-04-01 00:00:00

abstract：:Objectives: To evaluate the effectiveness of add-on iguratimod (IGU) in patients with rheumatoid arthritis (RA) who showed an inadequate response to tocilizumab (TCZ), especially patients who were intolerant of an effective dose of methotrexate (MTX). Methods: Thirty-one patients with RA (22 women, age 62.4 years, dis...

journal_title：Modern rheumatology

authors： Ebina K,Miyama A,Tsuboi H,Kaneshiro S,Nishikawa M,Owaki H,Tsuji S,Hirao M,Etani Y,Goshima A,Hashimoto J,Yoshikawa H

更新日期：2019-07-01 00:00:00

abstract：:Pneumatosis cystoides intestinalis (PCI), which is characterized by the presence of multiple gas-filled mucosal, submucosal, or subserosal cysts located throughout the colon and/or small intestine, is an unusual complication of systemic lupus erythematosus (SLE). We report a case of a 33-year-old woman with a 5-year h...

journal_title：Modern rheumatology

authors： Yamaguchi Y,Ohno S,Yamazaki S,Ideguchi H,Shirai A,Takeno M,Ishigatsubo Y

更新日期：2005-01-01 00:00:00

abstract：:Recently, more than ten cases of thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome or Castleman-Kojima disease exhibiting such symptoms as thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly have been reported in Japan. We have found two cases of TAFRO syndrome...

journal_title：Modern rheumatology

authors： Kawashima M,Usui T,Okada H,Mori I,Yamauchi M,Ikeda T,Kajita K,Kito Y,Miyazaki T,Fujioka K,Ishizuka T,Morita H

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:Pathogenesis and risk factors of scleroderma associated calcinosis is poorly understood and there is no effective treatment. This study was performed to better understand the prevalence and clinical features associated with calcinosis in a cohort of SSc outpatients. METHODS:In this cross-sectional study, we...

journal_title：Modern rheumatology

authors： Pai S,Hsu V

更新日期：2018-05-01 00:00:00

abstract：:Abstract Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug (DMARD) throughout the world. In Japan, MTX is recommended by the Japanese Ministry of Health, Labour, and Welfare to be given as the second or third DMARD and at a dosage of no more than 8 mg/week. We analyzed the efficacy of M...

journal_title：Modern rheumatology

authors： Kameda H,Amano K,Sekiguchi N,Takei H,Ogawa H,Nagasawa H,Takeuchi T

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To investigate which IgG subclasses contribute to the activation of the complement pathway in IgG4-related disease (IgG4RD) patients with hypocomplementemia. METHODS:Sera of IgG4RD patients were analyzed for the binding ability of IgG subclasses to complement component 1q (C1q). Polyethylene glycol (PEG) pre...

journal_title：Modern rheumatology

authors： Sugimoto M,Watanabe H,Asano T,Sato S,Takagi T,Kobayashi H,Ohira H

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To clarify polyarticular juvenile idiopathic arthritis (pJIA) patients who failed to maintain prolonged remission with the first biologic agent. METHODS:Fourteen pJIA patients were observed for 47.5 months (median) after initiating the first biologic agent. RESULTS:Eight maintained sustained clinical remiss...

journal_title：Modern rheumatology

authors： Kubota T,Imanaka H,Takei S,Yamatou T,Nerome Y,Yamasaki Y,Nonaka Y,Akaike H,Takezaki T,Kawano Y

更新日期：2016-01-01 00:00:00

abstract：:Methotrexate (MTX) is indispensable for the treatment of rheumatoid arthritis (RA). However, a small number of patients treated with MTX occasionally encounter some life-threatening events, including myelosuppression. Renal insufficiency, one of risk factors for these events, is difficult to assess because the serum c...

journal_title：Modern rheumatology

authors： Hayashi T,Ito S,Goto D,Matsumoto I,Sumida T

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Fibromyalgia syndrome (FMS) is a chronic disease characterized by diffuse pain of unknown cause, fatigue, sleep disorders, cognitive dysfunction, and sensitivity. Fibromyalgia was shown to be associated with balance problems and increased incidence of falls. There are many theoretical mechanisms related to...

journal_title：Modern rheumatology

authors： Kasapoğlu Aksoy M,Altan L,Ökmen Metin B

更新日期：2017-09-01 00:00:00

abstract：:A 49-year-old Japanese woman treated with oral corticosteroids, methotrexate, and infliximab for malignant rheumatoid arthritis was admitted because of fever and low back pain. The white blood cell count and C-reactive protein concentration were elevated. Lumbar and pelvic computed tomography showed enlargement of the...

journal_title：Modern rheumatology

authors： Oda S,Fujinaga H,Takahashi K

更新日期：2006-01-01 00:00:00

abstract：:We describe an 81-year-old man with immunoglobulin G4-related disease (IgG4-RD) presenting with submandibular gland, lymph node, lung, kidney, aortic wall, and prostate lesions with concomitant gastric cancer. After curative surgical treatment of the gastric cancer, corticosteroid therapy for progressively decreasing ...

journal_title：Modern rheumatology

authors： Horita S,Fujii H,Mizushima I,Fujisawa Y,Hara S,Yamada K,Inoue D,Nakajima K,Harada K,Kawano M

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVES:To determine whether ultrasonography (US) predicts Boolean remission in rheumatoid arthritis (RA) patients who had achieved disease activity score in 28 joints (DAS28)-based remission criteria. METHODS:Thirty-one RA patients in DAS28-based clinical remission were recruited. US semiquantitatively determined ...

journal_title：Modern rheumatology

authors： Yoshimi R,Hama M,Minegishi K,Kishimoto D,Watanabe T,Kamiyama R,Kirino Y,Asami Y,Ihata A,Tsunoda S,Ueda A,Takeno M,Ishigatsubo Y

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:To evaluate the scoring of whole-body magnetic resonance imaging (WBMRI) for efficacy assessment in rheumatoid arthritis (RA) patients receiving biological disease-modifying anti-rheumatic drugs (bDMARDs). METHODS:Thirty consecutive RA patients receiving bDMARDs were included in this retrospective study. Co...

journal_title：Modern rheumatology

authors： Kono M,Kamishima T,Yasuda S,Sakamoto K,Abe S,Noguchi A,Watanabe T,Shimizu Y,Oku K,Bohgaki T,Amengual O,Horita T,Atsumi T

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVES:To evaluate, through a systematic review of the literature, the association between the use of biological disease-modifying antirheumatic drugs (bDMARDs) and surgical site infection (SSI) or wound healing delay after orthopedic surgery in patients with rheumatoid arthritis (RA). METHODS:A systematic review ...

journal_title：Modern rheumatology

authors： Ito H,Kojima M,Nishida K,Matsushita I,Kojima T,Nakayama T,Endo H,Hirata S,Kaneko Y,Kawahito Y,Kishimoto M,Seto Y,Kamatani N,Tsutani K,Igarashi A,Hasegawa M,Miyasaka N,Yamanaka H

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:To evaluate the long-term efficacy and safety of certolizumab pegol (CZP) plus methotrexate treatment and to assess the efficacy of two CZP maintenance dosing schedules in Japanese rheumatoid arthritis (RA) patients with an inadequate response to methotrexate. METHODS:J-RAPID double-blind patients were ente...

journal_title：Modern rheumatology

authors： Tanaka Y,Yamamoto K,Takeuchi T,Yamanaka H,Ishiguro N,Eguchi K,Watanabe A,Origasa H,Shoji T,Miyasaka N,Koike T

更新日期：2014-09-01 00:00:00