Abstract:
OBJECTIVES:Pathogenesis and risk factors of scleroderma associated calcinosis is poorly understood and there is no effective treatment. This study was performed to better understand the prevalence and clinical features associated with calcinosis in a cohort of SSc outpatients. METHODS:In this cross-sectional study, we compared clinical characteristics of SSc patients with (SSc-calcinosis) and without calcinosis (SSc-control) seen in the outpatient Rutgers-RWJ Scleroderma Program between 2012 and 2015. Our analysis included clinical characteristics, comorbidities (i.e. osteoporosis), autoantibodies and imaging results. We performed univariable and multivariable regression analyses to determine common factors associated with calcinosis. RESULTS:There were 215 SSc patients, including 65 SSc-calcinosis (81.5% females) and 150 SSc-without calcinosis (controls, 77% females). SSc-calcinosis patients were older (p = .026) with significantly longer disease duration (20 ± 10.5 years versus 12 ± 8 years, p < .0001). Limited cutaneous scleroderma was more common (54%) in the calcinosis group. Longer disease duration from non-Raynaud symptoms (OR 3.77; 95%CI 1.26, 11.27) and osteoporosis (OR 3.43; 95%CI 1.15, 10.36) remained independently associated with calcinosis. CONCLUSIONS:Calcinosis was common in both limited and diffuse systemic sclerosis; both longer disease duration and osteoporosis were independently associated with calcinosis. Prospective studies are needed to confirm our findings.
journal_name
Mod Rheumatoljournal_title
Modern rheumatologyauthors
Pai S,Hsu Vdoi
10.1080/14397595.2017.1349594subject
Has Abstractpub_date
2018-05-01 00:00:00pages
518-522issue
3eissn
1439-7595issn
1439-7609journal_volume
28pub_type
杂志文章abstract::'Immunoglobulin G4 (IgG4)-related disease' is a new clinical concept of multi-organ diseases, with Mikulicz's disease (MD) being a clinical phenotype of IgG4-related disease. To clarify the clinical characteristics of respiratory involvement associated with IgG4-related MD, we retrospectively assessed 25 patients with...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-011-0504-x
更新日期:2012-02-01 00:00:00
abstract::Peripheral neuropathies should be recognized as the adverse effects of biological agents, especially anti-TNF agents. However, no solid clinical databases for biological agent-associated peripheral neuropathies (BAPN) have been established in Japan. Here we report two cases of peripheral neuropathy associated with ant...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2013.859770
更新日期:2016-01-01 00:00:00
abstract::Spontaneous flexor tendon rupture is an unusual complication of systemic lupus erythematosus (SLE) and has not previously been reported. While tendon ruptures in association with SLE have been focused on the previous studies, upper extremity tendon ruptures are infrequently reported in the literature. Here, we present...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.924193
更新日期:2016-09-01 00:00:00
abstract::We report a novel case of eosinophilic orbital myositis associated with Churg-Strauss syndrome. A 56-year-old man with a 20-year history of chronic sinusitis and seasonal allergic rhinitis was admitted because of fever, swelling of cheeks and extremities, diplopia, and eosinophilia. With findings from gadolinium-enhan...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-009-0252-3
更新日期:2010-04-01 00:00:00
abstract::Abstract Gout is a disease caused by an inflammatory response to an aggregation of monosodium urate crystals that develop secondary to hyperuricemia. Throughout its natural history it has four stages: asymptomatic hyperuricemia, acute gouty arthritis, intercritical gout, and chronic tophaceous gout. In this article, w...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-004-0314-5
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to clarify the long-term outcome of patients with polymyositis and dermatomyositis (PM/DM) and to elucidate prognostic factors using statistical analysis. METHODS:We enrolled patients with PM/DM who visited our department between 1990 and 2014. Diagnoses of PM/DM and clinically a...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1054081
更新日期:2016-01-01 00:00:00
abstract::Objectives: In this study, we aimed to evaluate the level of central sensitization (CS) and its relationship with health profile, including neuropathic pain and sleep quality in Behçet's disease (BD).Method: Eighty-eight patients with BD and 60 healthy controls (HCs) were included in the study between May 2018 and Feb...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1780076
更新日期:2020-07-06 00:00:00
abstract:OBJECTIVES:Gout is a polygenic auto-inflammatory disease, in which inflammation plays an important role in disease pathogenesis. The cytokine interleukin (IL)-23 promotes inflammation and helps to guide inflammatory cells, while studies have shown that the IL-23R gene is associated with susceptibility to several immune...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.964823
更新日期:2015-05-01 00:00:00
abstract::The current study investigates the role of regulatory T (Treg) cells in the pathogenesis of ocular attack in patients with Behcet's disease (BD). Nineteen BD patients with ocular complications (BDo), including 11 BD patients with ocular attack (BDa) and eight BD patients with inactive ocular complications (BDi), were ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0064-x
更新日期:2008-01-01 00:00:00
abstract::The influence of estrogen therapy on changes in arthritis and bone mineral density (BMD) was evaluated using an estrogen-replete collagen-induced arthritis (CIA) rat model. Seven-month-old female Sprague-Dawley rats (n = 30) were divided into the three groups; control (CONT), collagen sensitization (CIA), and CIA + 17...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0011-2
更新日期:2008-01-01 00:00:00
abstract::Abstract The synovium in a knee joint has an extensive neural network in the somatic and autonomic nervous systems. In medial compartmental osteoarthritis of the knee, neuropeptides were most abundant, with an especially large number of substance P and calcitonin gene-related peptide-immunoreactive free nerve endings....
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-003-0253-6
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:In recent years, concern has been raised about Juvenile Idiopathic Arthritis (JIA) that it could be associated with an increased risk for malignancies. Therefore, the cancer incidence in the JIA patients was evaluated and compared to the cancer incidence in the German population. METHODS:A retrospective sin...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1204711
更新日期:2017-01-01 00:00:00
abstract::Adult-onset Still's disease (AOSD) is a rheumatoid disorder characterized by high fever, polyarthritis, leukocytosis, hyperferritinaemia, and mild liver involvement. We describe the case of a patient with AOSD with severe liver dysfunction. His serum levels of interleukin-10 and 18 showed a similar trend to his diseas...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-008-0065-9
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To assess the long-term safety, immunogenicity, and efficacy of subcutaneous (SC) abatacept in combination with methotrexate (MTX) in Japanese patients with rheumatoid arthritis who were MTX inadequate responders, in a long-term extension (LTE) to a double-dummy, double-blind study (NCT01001832). METHODS:Pat...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1012786
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:To evaluate, through a systematic review of the literature, the association between the use of biological disease-modifying antirheumatic drugs (bDMARDs) and surgical site infection (SSI) or wound healing delay after orthopedic surgery in patients with rheumatoid arthritis (RA). METHODS:A systematic review ...
journal_title:Modern rheumatology
pub_type: 杂志文章,meta分析,评审
doi:10.3109/14397595.2015.1014302
更新日期:2015-09-01 00:00:00
abstract::An association between thrombotic thrombocytopenic purpura (TTP) and Sjögren's syndrome (SS) is rare. This is the first report of two patients with TTP who had inhibitory autoantibodies to ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 repeats) complicating primary SS. A rapid diagnosis of...
journal_title:Modern rheumatology
pub_type: 杂志文章,评审
doi:10.1007/s10165-012-0644-7
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to clarify the characteristics of bony ankylosis of the facet joint of the cervical spine in rheumatoid arthritis (RA) patients who required cervical spine surgery, and its relationship to the clinical findings. METHODS:Eighty consecutive RA patients with cervical spine disorde...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2016.1265638
更新日期:2017-09-01 00:00:00
abstract::The objective of this study was to show whether the disease activity of rheumatoid arthritis (RA) patients had improved in Japan, and whether the improvement of disease activity had resulted in a better outcome of patients. In a single-institute-based prospective observational cohort of RA patients (Institute of Rheum...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-007-0587-6
更新日期:2007-01-01 00:00:00
abstract::For surgical treatment of rheumatoid wrists, we have routinely selected the Sauve-Kapandji (S-K) procedure or the Darrach procedure based on predetermined indications. In this study, we conducted a retrospective radiographic comparative evaluation of the changes in the carpus after the two procedures. The S-K group an...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-005-0396-8
更新日期:2005-01-01 00:00:00
abstract::Objective: This study aimed to clarify whether plasma acrolein level actually increases in rheumatoid arthritis (RA) patients, and to elucidate whether any relationship exists between the levels and the RA background variables.Methods: Plasma levels of protein-conjugated acrolein (PC-Acro) in 84 patients (RA group) an...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1775921
更新日期:2020-06-16 00:00:00
abstract::Abstract A 56-year-old man presented with hyperproteinemia and renal dysfunction associated with antineutrophil cytoplasmic antibodies (ANCA). He had had a ventriculoperitoneal shunt tube made of silicone implanted 4 years earlier. In his renal biopsy, necrotizing crescentic glomerulonephritis was identified: tests fo...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650300011
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:A nationwide survey was conducted to assess the number of patients, clinical aspects, treatment, and prognosis of adult Still's disease (ASD) in Japan. METHODS:A primary questionnaire was sent to randomly selected medical institutions in order to estimate the number of patients. We sent a secondary question...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.974881
更新日期:2015-05-01 00:00:00
abstract::To investigate the role of interleukin (IL)-33 in rheumatoid arthritis (RA) patients, we measured the serum levels of IL-33 in RA patients before and after the administration of etanercept. Twenty-four patients with RA were treated with etanercept. Clinical and laboratory examinations, including serum levels of C-reac...
journal_title:Modern rheumatology
pub_type: 临床试验,杂志文章
doi:10.1007/s10165-011-0480-1
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:We investigated the relationship between morphological features in the lower limbs and the progression of knee osteoarthritis (OA) in 6-years. METHODS:Volunteer subjects from Toei (101 women and 54 men). Knee OA was evaluated on whole-leg radiographs. Subjects were divided into group 1, no knee OA; group 2,...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1080/14397595.2020.1804668
更新日期:2020-09-03 00:00:00
abstract::Abstract Interstitial pneumonitis (IP) associated with polymyositis and dermatomyositis (PM/DM) is a serious complication that affects prognosis. We therefore undertook a retrospective multicenter study to examine the efficacy of a combination treatment with cyclosporin A (CsA) and corticosteroids. Fifty-three IP pati...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s10165-003-0205-1
更新日期:2003-09-01 00:00:00
abstract::OBJECTIVES: To validate the 2010 histopathological classification system of anti-neutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (GN) in a Japanese single-center cohort. METHODS: We retrospectively studied 54 patients (28 renally limited pauci-immune GN, 25 microscopic polyangiitis, and one Chur...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.1007/s10165-013-0877-0
更新日期:2013-04-12 00:00:00
abstract:INTRODUCTION:We aimed to identify causes of false-positives in ultrasound scanning of synovial/tenosynovial/bursal inflammation and provide corresponding imaging examples. METHODS:We first performed systematic literature review to identify previously reported causes of false-positives. We next determined causes of fal...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1091123
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The international classification criteria (CC) for definite antiphospholipid syndrome (APS) recommend confirmation of the sustained presence, for at least 12 weeks, of both lupus anticoagulant (LA), as determined by aPTT and RVVT, and anti β2glycoprotein I (β2GPI) or anticardiolipin (aCL) IgG and/or IgM. Howe...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2015.1023978
更新日期:2015-01-01 00:00:00
abstract::Abstract This work was undertaken to evaluate clinical and immunological features in patients with systemic lupus erythematosus (SLE) complicated by Jaccoud's arthropathy. Patients diagnosed with SLE between 1985 and 1999, and who met the criteria of Villiaumey et al., were checked for Jaccoud's arthropathy. Clinical ...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/s101650170043
更新日期:2001-03-01 00:00:00
abstract::Here, we report the case of a 69-year-old man with limited granulomatosis with polyangiitis (GPA; formerly Wegener's granulomatosis) who developed papillary thyroid cancer, adenocarcinoma of the stomach, and myelodysplastic syndrome following glucocorticoid treatment. This is the first report to present multiple malig...
journal_title:Modern rheumatology
pub_type: 杂志文章
doi:10.3109/14397595.2014.891494
更新日期:2016-01-01 00:00:00